TAKAGI Norio

J-GLOBAL         Last updated: Sep 2, 2019 at 19:50
 
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Name
TAKAGI Norio
Affiliation
Tokyo University of Pharmacy and Life Sciences
Section
School of Pharmacy
Job title
Associate Professor
Degree
Ph.D.

Research Areas

 
 

Academic & Professional Experience

 
 
   
 
      Post-doctoral fellow
 
1996
 - 
1999
University of Toronto at Scarboroufh,
 

Education

 
 
 - 
1996
Graduate School, Division of Pharmaceutical Sciences, Tokyo University of Pharmacy and Life Science
 
 
 - 
1991
Faculty of Pharmaceutical Science, Tokyo University of Pharmacy and Life Science
 

Published Papers

 
Furin-mediated cleavage of LRP1 and increase in ICD of LRP1 after cerebral ischemia and after exposure of cultured neurons to NMDA.
Yamada M, Hayashi H, Suzuki K, Sato S, Inoue D, Iwatani Y, Ohata M, Yuan B, Takagi N.
Sci Rep.   9(1) 11782   2019   [Refereed]
The anti-tumor effects of arsenic disulfide on breast cancer cells: effects on cell survival, migration ability, apoptosis and autophagy.
114. Yuxue Zhao, Kenji Onda, Kentaro Sugiyama, Bo Yuan, Sachiko Tanaka, Norio Takagi, Toshihiko Hirano
Oncol. Rep.   41 27-42   2019   [Refereed]
Possible involvement of PI3-K/Akt-dependent GSK-3 signaling in proliferation of neural progenitor cells after hypoxic exposure.
113. Keishi Kisoh, Hideki Hayashi, Miho Arai, Maiko Orita, Bo Yuan, and Norio Takagi
Mol. Neurobiol.   56 1946-1956   2019   [Refereed]
Comparative analysis of hydrophilic ingredients in toad skin and toad venom using the UHPLC-HR-MS/MS and UPLC-QqQ-MS/MS methods together with the anti-inflammatory evaluation of indolealkylamines.
Zhang Y, Yuan B, Takagi N, Wang H, Zhou Y, Si N, Yang J, Wei X, Zhao H,and Bian B.
Molecules   24 86   2019   [Refereed]
The protection of indolealkylamines from LPS-induced inflammation in zebrafish.
Zhang Y, Takagi N, Yuan B, Zhou Y, Si N, Wang H, Yang J, Wei X, Zhao H, Bian B.
J Ethnopharmacol.   243    2019   [Refereed]
Arsenic Disulfide Combined with L-Buthionine-(S, R)-Sulfoximine Induces Synergistic Antitumor Effects in Two-Dimensional and Three-Dimensional Models of MCF-7 Breast Carcinoma Cells.
Zhao Y, Tanaka S, Yuan B, Sugiyama K, Onda K, Kiyomi A, Takagi N, Sugiura M, Hirano T.
Am J Chin Med.   47(5) 1149-1170   2019   [Refereed]
Berberine inhibits NLRP3 Inflammasome pathway in human triple-negative breast cancer MDA-MB-231 cell.
Yao M, Fan X, Yuan B, Takagi N, Liu S, Han X, Ren J, Liu J.
BMC Complement Altern Med.   19(1) 216   2019   [Refereed]
Enhanced cytotoxic effects of arsenite in combination with anthocyanidin compound, delphinidin, against a human leukemia cell line, HL-60
Yuta Yoshino, Bo Yuan, Saki Okusumi, Reiji Aoyama, Ryo Murota, Hidetomo Kikuchi, Norio Takagi, Hiroo Toyoda
Chem. Biol. Interact.   294 9-17   2018   [Refereed]
Antitumor activity of arsenite in combination with tetrandrine against human breast cancer cell line MDA-MB-231 in vitro and in vivo
115. Bo Yuan, Mingjiang Yao, Xiao Wang, Ai Sato, Ayane Okazaki, Hana Komuro, Hideki Hayashi, Hiroo Toyoda, Xiaohua Pei, Xiaomei Hu, Toshihiko Hirano, Norio Takagi
Cancer Cell Int.   18 113   2018   [Refereed]
Cytocidal effects of arenobufagin and hellebrigenin, two active bufadienolide compounds, against human glioblastoma cell line U-87
112. Han L, Yuan B, Shimada R, Hayashi H, Si N, Zhao HY, Bian B, Takagi N
Int. J. Oncol.   53 2488-2502   2018   [Refereed]
111. Hayashi H, Yamada M, Kumai J, Takagi N, Nomizu M
Arch Biochem Biophys   648 53-59   2018   [Refereed]
Arsenic disulfide-induced apoptosis and its potential mechanisms in two- and three-dimensionally cultured human breast cancer MCF-7 cells.
110. Zhao Y, Onda K, Yuan B, Tanaka S, Kiyomi A, Sugiyama K, Sugiura M, Takagi N, Hirano T.
Int. J. Oncol.   52 1959-1971   2018   [Refereed]
Chemo-sensitivity of two-dimensional monolayer and three-dimensional spheroid of breast cancer MCF-7 cells to daunorubicin, docetaxel, and arsenic disulfide
109. Uematsu N, Zhao Y, Kiyomi A, Yuan B, Onda K , Tanaka A, Kentaro Sugiyama K, Sugiura M, Takagi N, Hayakawa A, Hirano T.
Anticancer Res.   38 2102-2108   2018   [Refereed]
Anticancer efficacies of arsenic disulfide through apoptosis induction, cell cycle arrest, and pro-survival signal inhibition in human breast cancer cells.
108. Zhao Y, Yuan B, Onda K, Sugiyama K, Tanaka S, Takagi N, Hirano H.
Am. J. Cancer Res.   8(3) 366-386   2018   [Refereed]
Furin inhibitor protects against neuronal cell death induced by activated NMDA receptors.
107. Yamada M, Hayashi H, Yuuki M, Matsushima N, Yuan B, Takagi N.
Sci. Rep.   8(1) 5212   2018   [Refereed]
The Neuroprotective Effect of Thalidomide against Ischemia through the Cereblon-mediated Repression of AMPK Activity.
106. Sawamura N, Yamada M, Fujiwara M, Yamada H, Hayashi H, Takagi N, Asahi T.
Sci. Rep.   8(1) 2459   2018   [Refereed]
Synergistic cytotoxic effects of arsenite and tetrandrine in human breast cancer cell line MCF-7
105. Yao M, Yuan B, Wang X, Sato A, Sakuma K, Kaneko K, Komuro H, Okazaki A, Hayashi H, Toyoda H, Pei X, Hu X, Hirano T, Takagi N.
Int. J. Oncol.   51(2) 587-598   2017   [Refereed]
Involvement of GSK-3β phosphorylation through PI3-K/Akt in cerebral ischemia-induced neurogenesis in rat
104. Kisoh K, Hayashi H, Itoh T, Asada M, Arai M, Yuan B, Tanonaka K, Takagi N.
Mol. Neurobiol.   54(10) 7917-7927   2017   [Refereed]
Yuan B, Yoshino Y, Fukushima H, Markova S, Takagi N, Toyoda H, Kroetz DL
Oncology reports   35(1) 147-154   Jan 2016   [Refereed]
103. Yuan B, He J, Kisoh K, Hayashi H, Tanaka S, Si N, Zhao HY, Hirano T, Bian B, Takagi N.
Oncol. Rep.   36(3) 1377-1378   2016   [Refereed]
102. Nishimoto S, Suzuki T, Koike S, Yuan B, Takagi N, Ogasawara Y.
Toxicol. Appl. Pharmacol.   305 161-168   2016   [Refereed]
Song MM, Fang S, Tanaka S, Sugiyama K, Kiyomi A, Kato R, Onda K, Yuan B, Takagi N, Hu X, Hirano T
International immunopharmacology   29(2) 832-838   Dec 2015   [Refereed]
Negishi Y, Yamane M, Kurihara N, Endo-Takahashi Y, Sashida S, Takagi N, Suzuki R, Maruyama K
Pharmaceutics   7(3) 344-362   Sep 2015   [Refereed]
Yuan B, Okusumi S, Yoshino Y, Moriyama C, Tanaka S, Hirano T, Takagi N, Toyoda H
Oncology reports   34(1) 431-438   Jul 2015   [Refereed]
Hayashi H, Takagi N
Biological & pharmaceutical bulletin   38(8) 1104-1108   2015   [Refereed]
Tahata S, Yuan B, Kikuchi H, Takagi N, Hirano T, Toyoda H
International journal of oncology   45(4) 1749-1759   Oct 2014   [Refereed]
Kikuchi H, Yuan B, Yuhara E, Imai M, Furutani R, Fukushima S, Hazama S, Hirobe C, Ohyama K, Takagi N, Toyoda H
International journal of oncology   45(2) 843-852   Aug 2014   [Refereed]
Marunouchi T, Inomata S, Sanbe A, Takagi N, Tanonaka K
European journal of pharmacology   730 140-147   May 2014   [Refereed]
Iriyama N, Yuan B, Yoshino Y, Hatta Y, Horikoshi A, Aizawa S, Takei M, Takeuchi J, Takagi N, Toyoda H
International journal of oncology   44(3) 865-873   Mar 2014   [Refereed]
Endo-Takahashi Y, Negishi Y, Nakamura A, Ukai S, Ooaku K, Oda Y, Sugimoto K, Moriyasu F, Takagi N, Suzuki R, Maruyama K, Aramaki Y
Scientific reports   4 3883   Jan 2014   [Refereed]
Takagi N
Journal of pharmacological sciences   125(4) 333-339   2014   [Refereed]
Kikuchi H, Yuan B, Yuhara E, Takagi N, Toyoda H
International journal of oncology   43(6) 2046-2056   Dec 2013   [Refereed]
Kikuchi H, Yuan B, Nishimura Y, Imai M, Furutani R, Kamoi S, Seno M, Fukushima S, Hazama S, Hirobe C, Ohyama K, Hu XM, Takagi N, Hirano T, Toyoda H
International journal of oncology   43(6) 1976-1984   Dec 2013   [Refereed]
Kon A, Yuan B, Hanazawa T, Kikuchi H, Sato M, Furutani R, Takagi N, Toyoda H
Oncology reports   30(4) 1965-1970   Oct 2013   [Refereed]
Moriyama Y, Takagi N, Itokawa C, Tanonaka K
Neuroscience letters   543 152-156   May 2013   [Refereed]
Endo-Takahashi Y, Negishi Y, Nakamura A, Suzuki D, Ukai S, Sugimoto K, Moriyasu F, Takagi N, Suzuki R, Maruyama K, Aramaki Y
Biomaterials   34(11) 2807-2813   Apr 2013   [Refereed]
Moriyama Y, Takagi N, Hashimura K, Itokawa C, Tanonaka K
Brain and behavior   3(2) 43-53   Mar 2013   [Refereed]
Marunouchi T, Abe Y, Murata M, Inomata S, Sanbe A, Takagi N, Tanonaka K
Biological & pharmaceutical bulletin   36(4) 529-539   2013   [Refereed]
Marunouchi T, Murata M, Takagi N, Tanonaka K
Biological & pharmaceutical bulletin   36(8) 1332-1340   2013   [Refereed]
Marunouchi T, Araki M, Murata M, Takagi N, Tanonaka K
Journal of pharmacological sciences   123(4) 336-346   2013   [Refereed]
Takagi N, Besshoh S, Marunouchi T, Takeo S, Tanonaka K
Neuroscience letters   530(1) 91-96   Nov 2012   [Refereed]
Negishi Y, Endo-Takahashi Y, Matsuki Y, Kato Y, Takagi N, Suzuki R, Maruyama K, Aramaki Y
Molecular pharmaceutics   9(6) 1834-1840   Jun 2012   [Refereed]
Murotomi K, Takagi N, Muroyama A, Kaji N, Takeo S, Tanonaka K
Neuroscience letters   515(1) 92-96   Apr 2012   [Refereed]
Tanonaka K, Motegi K, Arino T, Marunouchi T, Takagi N, Takeo S
Biological & pharmaceutical bulletin   35(10) 1661-1668   2012   [Refereed]
Takagi N, Besshoh S, Marunouchi T, Takeo S, Tanonaka K
Biological & pharmaceutical bulletin   35(12) 2224-2229   2012   [Refereed]
Negishi Y, Matsuo K, Endo-Takahashi Y, Suzuki K, Matsuki Y, Takagi N, Suzuki R, Maruyama K, Aramaki Y
Pharmaceutical research   28(4) 712-719   Apr 2011   [Refereed]
Murotomi K, Takagi N, Takeo S, Tanonaka K
Molecular and cellular neurosciences   46(3) 681-688   Mar 2011   [Refereed]
Hiratsuka K, Momose A, Takagi N, Sasaki H, Yin SA, Fujita M, Ohtomo T, Tanonaka K, Toyoda H, Suzuki H, Kurosawa T, Yamada J
Histochemistry and cell biology   135(3) 229-238   Mar 2011   [Refereed]
Mochizuki N, Moriyama Y, Takagi N, Takeo S, Tanonaka K
Biological & pharmaceutical bulletin   34(2) 260-265   2011   [Refereed]

Association Memberships

 
 

Research Grants & Projects

 
Pharmacological and Biochemical study on cerebral ischemia
The role of tyrosine phosphorylation of the NMDA receptor after brain ischemia