MISC

1999年1月

Correlations of bcl-2 and p53 expression with the clinicopathological features in tongue squamous cell carcinomas

Oral Oncology
  • L. Yao
  • ,
  • M. Iwai
  • ,
  • I. Furuta

35
1
開始ページ
56
終了ページ
62
記述言語
英語
掲載種別
DOI
10.1016/S1368-8375(98)00055-4

bcl-2 oncogene prolongs cell survival by inhibition of apoptosis. p53 tumor suppressor gene participates not only in cell proliferation control but also in induction of apoptosis. The expression of both bcl-2 and p53 proteins in 52 primary tongue squamous cell carcinomas (SCCs) was immunohistochemically explored in correlations with clinico-pathological features, patient's prognosis and apoptosis index (AI) of this tumor type. bcl-2 and p53 expression were identified in 26/52 (50%) cases and 31/52 (60%) cases, respectively. The frequency of bcl-2 expression was associated with tumor histologic grade (P = 0.0128) and marginally with mode of tumor invasion (P = 0.0671) but not with lymph nodal involvement. The frequency of p53 expression was associated with mode of tumor invasion (P = 0.0458) and pN status (P = 0.0224) but not with tumor histologic grade. Moreover, the three combined bcl-2/p53 staining patterns of bcl-2-/p53-, bcl-2 +/p53- and bcl-2- /p53 +, and bcl-2 +/p53 + were significantly correlated with tumor histologic grade (P = 0.0299), mode of tumor invasion (P = 0.0022) and pN status (P = 0.0024). In addition, the frequent appearance of bcl-2 protein expression was associated with a decrease in AI (P = 0.0290). Our results suggest that the combined investigation on the two biological markers may have value in assessment of tumor aggressiveness, and that the suppressing mechanism of bcl-2 oncogene in regulation of apoptosis preserves in tongue SCC.

リンク情報
DOI
https://doi.org/10.1016/S1368-8375(98)00055-4
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/10211311

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