Masaki Ueno

Profile Information

Affiliation: Professor, Faculty of Medicine, Kagawa University

Degree: 医学士(京都大学)
医学博士(京都大学)

J-GLOBAL ID: 200901044728565689
researchmap Member ID: 1000302196

External link

Research Interests

Research Areas

Research History

2013

- 香川大学医学研究院, 教授
2013

- 香川大学医学研究院, 教授
1999 - 2002

Kagawa Medical University
2002

- 香川医科大学医学部病理学講座(現香川大学医学部炎症病理学）, 助教授
1995 - 1999

赤心会赤沢病院, 医師
1993 - 1994

康生会武田病院, 医師
1994

ニューヨーク州立発達障害基礎研究所
1992 - 1993

医仁会武田総合病院, 医師
1988 - 1992

京都大学医学部大学院医学研究科, 大学院生
1986 - 1988

宇部興産中央病院, 医師
1985 - 1986

京都大学医学部神経内科, 研修医

Education

Committee Memberships

Jun, 2021 - Present

Executive Committee, The Japanese Society of Neuropathology
Apr, 2005 - Present

Councilor, The Japanese Society of Pathology

Awards

2011

日本病理学会学術研究賞

Papers

165

Partially hydrolyzed guar gum alleviates hepatic steatosis and alters specific gut microbiota in a murine liver injury model

Takayuki Fujii, Haruyuki Nakayama-Imaohji, Aya Tanaka, Hiroto Katami, Kazuya Tanaka, Yoichi Chiba, Machi Kawauchi, Masaki Ueno, Tomomi Kuwahara, Ryuichi Shimono

Pediatric Surgery International, Sep 12, 2022
Formation of N-acyl-phosphatidylethanolamines by cytosolic phospholipase A2ε in an ex vivo murine model of brain ischemia.

S M Khaledur Rahman, Zahir Hussain, Katsuya Morito, Naoko Takahashi, Mohammad Mamun Sikder, Tamotsu Tanaka, Ken-Ichi Ohta, Masaki Ueno, Hiroo Takahashi, Tohru Yamamoto, Makoto Murakami, Toru Uyama, Natsuo Ueda

Biochimica et biophysica acta. Molecular and cell biology of lipids, 1867(12) 159222-159222, Aug 18, 2022
Cerebral hemodynamic response during the resuscitation period after hypoxic-ischemic insult predicts brain injury on day 5 after insult in newborn piglets.

Yasuhiro Nakao, Shinji Nakamura, Yinmon Htun, Tsutomu Mitsuie, Kosuke Koyano, Kenichi Ohta, Yukihiko Konishi, Takanori Miki, Masaki Ueno, Takashi Kusaka

Scientific reports, 12(1) 13157-13157, Aug 1, 2022
Metabolites and Biomarker Compounds of Neurodegenerative Diseases in Cerebrospinal Fluid

Keiji Wakamatsu, Yoichi Chiba, Ryuta Murakami, Yumi Miyai, Koichi Matsumoto, Masaki Kamada, Wakako Nonaka, Naoya Uemura, Ken Yanase, Masaki Ueno

Metabolites, 12(4) 343-343, Apr 12, 2022 Peer-reviewedInvitedLast author
Immunohistochemical expression of osteopontin and collagens in choroid plexus of human brains

Keiji Wakamatsu, Yoichi Chiba, Ryuta Murakami, Koichi Matsumoto, Yumi Miyai, Machi Kawauchi, Ken Yanase, Naoya Uemura, Masaki Ueno

Neuropathology, 42(2) 117-125, Apr, 2022 Peer-reviewedLast authorCorresponding author
Hypothermia cannot ameliorate renal fibrosis after asphyxia in the newborn piglet.

Takayuki Wakabayashi, Shinji Nakamura, Yasuhiro Nakao, Satoshi Yamato, Yinmon Htun, Tsutomu Mitsuie, Aya Morimoto, Makoto Arioka, Kosuke Koyano, Yukihiko Konishi, Takanori Miki, Masaki Ueno, Takashi Kusaka

Pediatrics international : official journal of the Japan Pediatric Society, 64(1) e14961, Jan, 2022
Perianal alveolar rhabdomyosarcoma with pulmonary lymphangitic sarcomatosis: Report of an autopsy case

Koichi Matsumoto, Ryou Ishikawa, Noriko Fuke, Takayuki Yokota, Takayuki Wakabayashi, Yoichi Chiba, Machi Kawauchi, Hitoshi Okada, Takako Yoshioka, Masaki Ueno

Human Pathology: Case Reports, 25 200544-200544, Sep, 2021 Peer-reviewedLast authorCorresponding author
Polymorphic SERPINA3 prolongs oligomeric state of amyloid beta

Maruf Mohammad Akbor, Nobuyuki Kurosawa, Hiroki Nakayama, Ayumi Nakatani, Koji Tomobe, Yoichi Chiba, Masaki Ueno, Masashi Tanaka, Yasuyuki Nomura, Masaharu Isobe

PLOS ONE, 16(3) e0248027-e0248027, Mar 4, 2021 Peer-reviewed
Immunoreactivity of receptor and transporters for lactate located in astrocytes and epithelial cells of choroid plexus of human brain

Ryuta Murakami, Yoichi Chiba, Nozomu Nishi, Koichi Matsumoto, Keiji Wakamatsu, Ken Yanase, Naoya Uemura, Wakako Nonaka, Masaki Ueno

Neuroscience Letters, 741 135479-135479, Jan, 2021 Peer-reviewedLast authorCorresponding author
悪性症候群後に小脳失調症を呈した一症例のHSP免疫染色を含む病理学的検討

太田仁士, 吉井りつ, 野中和香子, 千葉陽一, 上野正樹

臨床神経学, 60(Suppl.) S382-S382, Nov, 2020
Spontaneously generated large adipose flaps in vivo tissue engineering chambers

Yoshio Tanaka, Motogi Tamai, Noriyuki Taguchi, Aizezi Niyazi, Masaki Ueno, Tomohisa Nagasao

Journal of Plastic, Reconstructive & Aesthetic Surgery, 73(10) 1889-1896, Oct, 2020 Peer-reviewed
Sodium/glucose cotransporter 2 is expressed in choroid plexus epithelial cells and ependymal cells in human and mouse brains

Yoichi Chiba, Yasunori Sugiyama, Nozomu Nishi, Wakako Nonaka, Ryuta Murakami, Masaki Ueno

Neuropathology, 40(5) 482-491, Oct, 2020 Peer-reviewedLast authorCorresponding author
Glucose, Fructose, and Urate Transporters in the Choroid Plexus Epithelium

Yoichi Chiba, Ryuta Murakami, Koichi Matsumoto, Keiji Wakamatsu, Wakako Nonaka, Naoya Uemura, Ken Yanase, Masaki Kamada, Masaki Ueno

International Journal of Molecular Sciences, 21(19) 7230-7230, Sep 30, 2020 Peer-reviewedInvitedLast authorCorresponding author
Retinal ganglion cell loss in kinesin-1 cargo Alcadein α deficient mice.

Yuki Nakano, Kazuyuki Hirooka, Yoichi Chiba, Masaki Ueno, Daiki Ojima, Md Razib Hossain, Hiroo Takahashi, Tohru Yamamoto, Yoshiaki Kiuchi

Cell death & disease, 11(3) 166-166, Mar 3, 2020 Peer-reviewed
脈絡叢上皮細胞と脳室上衣細胞におけるナトリウム・グルコース共輸送体2(SGLT2)の発現

千葉陽一, 杉山康憲, 西望, 野中和香子, 河内真知, 上野正樹

日本病理学会会誌, 109(1) 318-318, Mar, 2020
Immunoreactivities for hepcidin, ferroportin, and hephaestin in astrocytes and choroid plexus epithelium of human brains

Ken Yanase, Naoya Uemura, Yoichi Chiba, Ryuta Murakami, Ryuji Fujihara, Koichi Matsumoto, Gotaro Shirakami, Nobukazu Araki, Masaki Ueno

Neuropathology, 40(1) 75-83, Feb, 2020 Peer-reviewedLast authorCorresponding author
Intravenous Edaravone plus Therapeutic Hypothermia Offers Limited Neuroprotection in the Hypoxic-Ischaemic Newborn Piglet

Satoshi Hamano Yamato, Shinji Nakamura, Yinmon Htun, Makoto Nakamura, Wataru Jinnai, Yasuhiro Nakao, Tsutomu Mitsuie, Kosuke Koyano, Takayuki Wakabayashi, Aya Hashimoto Morimoto, Masashiro Sugino, Takashi Iwase, Sonoko Ijichi Kondo, Saneyuki Yasuda, Masaki Ueno, Takanori Miki, Takashi Kusaka

Neonatology, 117(6) 713-720, 2020 Peer-reviewed
Partially hydrolyzed guar gum alleviates small intestinal mucosal damage after massive small bowel resection along with changes in the intestinal microbiota.

Fujii T, Chiba Y, Nakayama-Imaohji H, Onishi S, Tanaka A, Katami H, Kaji T, Ieiri S, Miki T, Ueno M, Kuwahara T, Shimono R

Journal of pediatric surgery, 54(12) 2514-2519, Dec, 2019 Peer-reviewed
Neuroprotective activation of astrocytes by methylmercury exposure in the inferior colliculus

Ishihara, Yasuhiro, Itoh, Kouichi, Oguro, Ami, Chiba, Yoichi, Ueno, Masaki, Tsuji, Mayumi, Vogel, Christoph F. A, Yamazaki, Takeshi

SCIENTIFIC REPORTS, 9, Sep 25, 2019 Peer-reviewed
Disturbance of Intracerebral Fluid Clearance and Blood–Brain Barrier in Vascular Cognitive Impairment

Masaki Ueno, Yoichi Chiba, Ryuta Murakami, Koichi Matsumoto, Ryuji Fujihara, Naoya Uemura, Ken Yanase, Masaki Kamada

International Journal of Molecular Sciences, 20(10) 2600-2600, May 27, 2019 Peer-reviewedInvitedLead authorCorresponding author

Misc.

悪性症候群後に小脳失調症を呈した一症例のHSP免疫染色を含む病理学的検討

太田仁士, 吉井りつ, 野中和香子, 千葉陽一, 上野正樹

日本神経学会学術大会プログラム・抄録集, 61st, 2020
Sodium/glucose cotransporter 2 is expressed in choroid plexus epithelial cells and ependymal cells

千葉陽一, 杉山康憲, 西望, 野中和香子, 河内真知, 上野正樹

日本病理学会会誌, 109(1), 2020
Cerebral amyloid angiopathy－血管周囲領域を介した脳組織間液ならびに脳脊髄液の排出との関連で

上野正樹, 千葉陽一, 村上龍太, 松本晃一, 藤原龍史, 植村直哉

病理と臨床, 35(8) 724-728, Aug, 2017 Invited
血液脳脊髄液関門におけるアミロイドベータおよび糖等の輸送体の局在について

上野正樹, 千葉陽一, 村上龍太, 松本晃一

香川県医師会誌, 69, 2016
前頭側頭葉優位の脳萎縮と広範なLewy小体の出現をみたNiemann-Pick病C型の一剖検例

千葉陽一, 小森拓, 吉田太, 足立香織, 難波栄二, 武井史郎, 石井さなえ, 上野正樹, 細川昌則, 島田厚良

日本病理学会会誌, 104(1) 435-435, Mar, 2015
アルツハイマー病モデルマウスの認知機能に対する外傷性脳損傷の影響

KISHIMOTO YASUSHI, SHISHIDO HAJIME, KUBOTA TAKASHI, UENO MASAKI, TAMIYA TAKASHI, KAWAI NOBUYUKI, KIRINO YUTAKA

日本薬学会年会要旨集(CD-ROM), 134th(3) ROMBUNNO.28PMM-096-149, Mar, 2014
低酸素性虚血性脳症における脳循環・代謝の病態生理とこれからの治療戦略

日下隆, 安田真之, 小谷野耕佑, 中村信嗣, 中村信, 神内済, 三木崇範, 上野正樹, 磯部健一, 伊藤進

日本周産期・新生児医学会雑誌, 49(4) 1172-1175, Dec, 2013
Gene analyses in vessels with blood-brain barrier impairment

M. Ueno, M. Onodera, H. Sakamoto

BRAIN PATHOLOGY, 20 75-75, Sep, 2010
Gene analyses in vessels with BBB impairment

M. Ueno, M. Onodera, H. Sakamoto

XVII INTERNATIONAL CONGRESS OF NEUROPATHOLOGY (ICN), 93-95, 2010 Peer-reviewed
Aggresomal property of glial cytoplasmic inclusions

Yoichi Chiba, Atsuyoshi Shimada, Shiro Takei, Noriko Kawamura, Sanae Ishii, Ayako Furukawa, Kensuke Sasaki, Toru Iwaki, Masanori Hosokawa

NEUROSCIENCE RESEARCH, 65 S245-S245, 2009
Microglial defects and neurodegeneration in SAMP10 mice: a model of brain aging

Atsuyoshi Shimada, Sanae Ishii, Shiro Takei, Noriko Kawamura, Ayako Furukawa, Yoichi Chiba, Masanori Hosokawa

NEUROSCIENCE RESEARCH, 65 S38-S38, 2009
Generation of oxidatively damaged proteins in excitotoxicity-induced hippocampal injury

Ayako Furukawa, Atsuyoshi Shimada, Noriko Kawamura, Shiro Takei, Yoichi Chiba, Sanae Ishii, Masanori Hosokawa

NEUROSCIENCE RESEARCH, 65 S251-S251, 2009
Defective microglia response and vulnerability to excitotoxic insults in the hippocampus of SAMP10 mouse: a model of age-related cerebral degeneration

Sanae Ishii, Atsuyoshi Shimada, Yoichi Chiba, Keisuke Yoshikawa, Ayako Furukawa, Noriko Kawamura, Masanori Hosokawa

NEUROSCIENCE RESEARCH, 61 S151-S151, 2008
Neurite retraction in cultured cortical neurons from SAMP10 mice induced by the formation of aggresome-related ubiquitin-positive inclusions

Yoichi Chiba, Atsuyoshi Shimada, Noriko Kawamura, Keisuke Yoshikawa, Sanae Ishii, Ayako Furukawa, Masanori Hosokawa

NEUROSCIENCE RESEARCH, 61 S121-S121, 2008
1. 新規リソソーム酵素としてのN-アシルエタノールアミン水解酸性アミダーゼの性状解析(第318回会議研究発表要旨,脂溶性ビタミン総合研究委員会)

上田夏生, 趙麗穎, 坪井一人, 岡本安雄, 荒木伸一, 上野正樹

ビタミン, 82(5) 353-353, 2008
Reduced expression of the 6B4-epitope in perineuronal nets of the cerebral cortex of SAMP10 mice

Fumiko Matsui, Yuko Saito, Noriko Kawamura, Hiromi Keino, Yoichi Chiba, Naoko Kumagai, Sanae Ishii, Keisuke Yoshikawa, Atsuyoshi Shimada, Nobuaki Maeda, Atsuhiko Oohira, Masanori Hosokawa

NEUROSCIENCE RESEARCH, 58 S117-S117, 2007
Dual phase prostanoid production during excitotoxic hippocampal injury: A comprehensive lipidomics analysis

Keisuke Yoshikawa, Yoshihiro Kita, Atsuyoshi Shimada, Masanori Hosokawa, Takao Shimizu

NEUROSCIENCE RESEARCH, 58 S50-S50, 2007
Early onset of microglial dystrophy in SAMP10 mice

Sanae Ishii, Atsuyoshi Shimada, Keisuke Yoshikawa, Youichi Chiba, Noriko Kawamura, Naoko Kamagai, Ayako Furukawa, Masanori Hosokawa

NEUROSCIENCE RESEARCH, 58 S117-S117, 2007
Vulnerability to excitotoxic insults and defective microglial response in SAMP10 mouse

Atsuyoshi Shimada, Sanae Ishii, Keisuke Yoshikawa, Yoichi Chiba, Noriko Kawamura, Naoko Kumagai, Ayako Furukawa, Masanori Hosokawa

NEUROSCIENCE RESEARCH, 58 S118-S118, 2007
Impact of proteasomal inhibition and formation of ubiquitinated inclusions on cultured neurons from SAMP10 mice

Yoichi Chiba, Atsuyoshi Shimada, Naoko Kumagai, Noriko Kawamura, Keisuke Yoshikawa, Sanae Ishii, Ayako Furukawa, Masanori Hosokawa

NEUROSCIENCE RESEARCH, 58 S118-S118, 2007

Books and Other Publications

Glymphatic system

上野正樹 (Role: Contributor, Glymphatic system 総論)

中外医学社, Jan, 2019
血管生物学と疾患

上野正樹 (Role: Contributor, Cerebral amyloid angiopathyー血管周囲領域を介した脳組織間液ならびに脳脊髄液の排出との関連で)

文光堂, Aug, 2017
認知症

高尾, 昌樹 (Role: Contributor, 認知症の動物モデルに関して教えてください)

中外医学社, Dec, 2016 (ISBN: 9784498129863)
Pediatric cancer

Springer, 2012
The pineal gland and melatonin

NOVA, 2012 (ISBN: 9781608767175)
Alzheimer's disease pathogenesis

InTech, 2011

Presentations

血液脳関門障害血管における分子メカニズム解明から血管性認知症の治療へ

第57回日本病理学会秋期特別総会, 2011
The mechanism of blood-brain barrier dysfunction in vascular dementia.

The Second Congress of Asian Society of Neuropathology, 2011
Therapeutic targets for vascular dementia

NeuroTalk-2010, 2010
Gene analyses in vessels with blood-brain barrier impairment

XVIIth International Congress of Neuropathology, 2010
稀な肉眼像を呈した回盲部原発のdiffuse large B cell lymphomaの一例

第95回日本病理学会総会, 2006
新生仔豚の海馬脳血管におけるアミロイドベータ蛋白様triosephosphate isomerase の沈着について

第95回日本病理学会総会, 2006
右第3指に発生した皮下腫瘤の一切除例

第90回日本病理学会中四国支部学術集会, 2006
Listeria monocytogenes敗血症による化膿性脳脊髄膜炎、心外膜炎の１剖検例

第94回日本病理学会総会, 2005
抗炎症脂質N-アシルエタノールアミンを生成する新規ホスホリパーゼD型酵素(NAPE-PLD)のcDNAクローニングと発現部位の解析

生体防御機能異常ワークショップ2005, 2005
Hypoxia Inducible Factor (HIF-1) によるT細胞機能の制御

第２６回日本炎症・再生医学会, 2005

Teaching Experience

Apr, 2013 - Present

Pathology (Faculty of Medicine, Kagawa University)

Professional Memberships

Research Projects

New therapy for neonatal resuscitation using hydrogen gas

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022
Advanced Animal Model Support

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas ― Platforms for Advanced Technologies and Research Resources, Japan Society for the Promotion of Science, 2016 - 2021
Identification of CSC-specific markers for non-small cell lung cancer and development of lung cancer root therapy

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

Liu Dage
Elucidation of the mechanism of promoting dementia caused by diabetes mellitus, focusing on the transport dynamics of glucose through the choroid plexus

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

Ueno Masaki
Could neuronal cell senescence be a pathogenetic factor for age-associated neurodegenerative diseases?

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Chiba Yoichi
Effects of overdose of fructose on dementia

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

UENO Masaki
Development of new therapies for vascular dementia

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2010 - 2012

UENO Masaki, SAKAMOTO Haruhiko, KOH Seiryu
Combined therapy using TS-suppressing vector and 5-FU

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2006 - 2007

UENO Masaki, HUANG Cheng-long, ISHIKAWA Shinya, YOKOMISE Hiroyasu
Blood-brain barrier and dementia

1988
認知症性疾患における血液脳関門機能の役割
Blood-Brain Barrier dysfunction in dementing disorders

Academic Activities

第34回老化促進モデルマウス学会学術大会

Planning, management, etc.

香川大学医学部・炎症病理学, Jul 14, 2019 - Jul 15, 2019

Social Activities

Elucidation of pathogenesis of Dementia

Lecturer

Kagawa University, May 12, 2022

Profile Information

Research Interests

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Education

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Misc.

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