浅井 知浩

J-GLOBALへ         更新日: 18/11/15 14:28
 
アバター
研究者氏名
浅井 知浩
 
アサイ トモヒロ
所属
静岡県立大学
部署
薬学部 医薬生命化学教室
職名
教授
学位
博士(薬学)

研究キーワード

 
 

研究分野

 
 

経歴

 
1999年4月
 - 
2002年3月
日本学術振興会特別研究員DC1
 
2002年4月
 - 
2004年1月
三菱ウェルファーマ株式会社製薬研究所・研究員
 
2004年2月
 - 
2013年3月
静岡県立大学薬学部、大学院薬学研究院 講師
 
2005年10月
 - 
2005年12月
University of North Carolina・Visiting Scholar
 
2011年7月
 - 
2012年6月
University of North Carolina・Visiting Scholar
 
2013年4月
 - 
2018年3月
静岡県立大学薬学部、大学院薬学研究院 准教授
 
2018年4月
 - 
現在
静岡県立大学薬学部、大学院薬学研究院 教授
 

受賞

 
2000年4月
The 7th Liposome Research Days Conference Poster Award
 
2000年6月
第9回がん転移研究会総会 Presentation Award
 
2000年11月
静岡県立大学はばたき賞
 
2003年7月
第28回製剤セミナー Postdoctoral Presentation Award
 
2009年10月
The APSTJ Global Education Seminar Presentation Award 2009
 
2011年3月
日本薬学会奨励賞
 
2011年7月
日本薬学会東海支部奨励賞
 
2014年5月
日本薬剤学会奨励賞
 
2016年3月
静岡県立大学教員活動評価学長表彰
 

論文

 
Systemic administration of siRNA with anti-HB-EGF antibody-modified lipid nanoparticles for the treatment of triple-negative breast cancer.
Okamoto A, Asai T, Hirai Y, Shimizu K, Koide H, Minamino T, Oku N
Mol Pharm.   (15) 1495-1504   2018年   [査読有り]
Prediction of the oral pharmacokinetics and food effects of gabapentin enacarbil extended-release tablets using biorelevant dissolution tests.
Yamaguchi Ikeuchi S, Kambayashi A, Kojima H, Oku N, Asai T
Biol. Pharm. Bull.   41 1708-1715   2018年   [査読有り]
Anticancer Efficacy of the Combination of berberine and PEGylated liposomal doxorubicin in Meth A sarcoma-bearing mice.
Yahuafai J, Asai T, Oku N, Siripong P
Biol. Pharm. Bull.   41 1103-1106   2018年   [査読有り]
Co-administration of liposomal fasudil and tissue plasminogen activator ameliorated ischemic brain damage in occlusion model rats prepared by photochemically induced thrombosis.
Fukuta T, Yanagida Y, Asai T, Oku N
Biochem. Biophys. Res. Commun.   495(495) 873-877   2018年   [査読有り]
Process optimization by use of design of experiments: Application for liposomalization of FK506.
Toyota H, Asai T, Oku N
J. Pharm. Sci.   (102) 196-202   2017年   [査読有り]
Rational designing of an antidote nanoparticle decorated with abiotic polymer ligands for capturing and neutralizing target toxins.
J. Control. Release.   (68) 335-342   2017年   [査読有り]
Combination therapy with liposomal neuroprotectants and tissue plasminogen activator for treatment of ischemic stroke
Fukuta T, Asai T, Yanagida Y, Namba M, Koide H, Shimizu K, Oku N
FASEB J.   (31) 1879-1890   2017年   [査読有り]
Targeted delivery of anticancer drugs to tumor vessels by use of liposomes modified with a peptide identified by phage biopanning with human endothelial progenitor cells.
Fukuta T§, Asai T§, Kiyokawa Y, Nakada T, Bessyo-Hirashima K, Fukaya N, Hyodo K, Takase K, Kikuchi H, Oku N
(524) 364-372   2017年   [査読有り]
Enhanced efficacy of doxorubicin by microRNA-499-mediated improvement of tumor blood flow.
Okamoto A, Asai T, Ryu S, Ando H, Maeda N, Dewa T, Oku N
J. Clin. Med.   (5) 10   2016年   [査読有り]
Specific delivery of an immunosuppressive drug to splenic B cells by antigen-modified liposomes and its anti-allergic effect.
Shimizu K, Miyauchi H, Urakami T, Yamamura-Ichikawa K, Yonezawa S, Asai T, Oku N
J. Drug Target.   1-29   2016年   [査読有り]
Targeted Therapy for Acute Autoimmune Myocarditis with Nano-Sized Liposomal FK506 in Rats.
Okuda K, Fu HY, Matsuzaki T, Araki R, Tsuchida S, Thanikachalam PV, Fukuta T, Asai T, Yamato M, Sanada S, Asanuma H, Asano Y, Asakura M, Hanawa H, Hao H, Oku N, Takashima S, Kitakaze M, Sakata Y, Minamino T
PLoS One.   (11) e0160944   2016年   [査読有り]
Ameliorating effects of sphingomyelin-based liposomes on sarcopenia in senescence-accelerated mice.
Ishida Y, Kiyokawa Y, Asai T, and Oku N
Biol. Pharm. Bull.   (39) 786-793   2016年   [査読有り]
One-step encapsulation of siRNA between lipid-layers of multi-layer polycation liposomes by lipoplex freeze-thawing.
Koide H, Okamoto A, Tsuchida H, Ando H, Ariizumi S, Kiyokawa C, Hashimoto M, Asai T, Dewa T, Oku N
J. Control. Release   (228) 1-8   2016年   [査読有り]
Neuroprotection against cerebral ischemia/reperfusion injury by intravenous administration of liposomal fasudil.
Fukuta T, Asai T, Sato A, Namba M, Yanagida Y, Kikuchi T, Koide H, Shimizu K, Oku N
Int. J. Pharm.   (506) 129-137   2016年   [査読有り]
Non-invasive evaluation of neuroprotective drug candidates for cerebral infarction by PET imaging of mitochondrial complex-I activity.
Fukuta T, Asai T, Ishii T, Koide H, Kiyokawa C, Hashimoto M, Kikuchi T, Shimizu K, Harada N, Tsukada H, Oku N
Sci. Rep   (6) 30127   2016年   [査読有り]
Susceptibility of PTEN-positive metastatic tumors to small interfering RNA targeting the mammalian target of rapamycin.
Koide H, Asai T, Kato H, Yonenaga N, Yokota M, Ando H, Dewa T, Nango M, Maeda N, Oku N
Nanomedicine   (11) 185-194   2015年   [査読有り]
Treatment of stroke with liposomal neuroprotective agents under cerebral ischemia conditions.
Fukuta T, Ishii T, Asai T, Sato A, Kikuchi T, Shimizu K, Minamino T, Oku N
Eur. J. Pharm. Biopharm.   (97) 1-7   2015年   [査読有り]
Use of positron emission tomography for real-time imaging of biodistribution of green tea catechin.
Shimizu K, Asakawa T, Harada N, Fukumoto D, Asai T, Yamada S, Kan T, Oku N
PLoS One.   (9) e85520   2014年   [査読有り]
Cell-penetrating peptide-conjugated lipid nanoparticles for siRNA delivery.
Asai T, Tsuzuku T, Takahashi S, Okamoto A, Dewa T, Nango M, Hyodo K, Ishihara H, Kikuchi H, Oku N
Biochem. Biophys. Res. Commun   (444) 599-604   2014年   [査読有り]
Advanced cancer therapy by integrative antitumor actions via systemic administration of miR-499.
Ando H, Asai T, Koide H, Okamoto A, Maeda N, Tomita K, Dewa T, Minamino T, Oku N
J. Control. Release   (181) 32-39   2014年   [査読有り]
Antibody-modified lipid nanoparticles for selective delivery of siRNA to tumors expressing membrane-anchored form of HB-EGF.
Okamoto A, Asai T, Kato H, Shimizu K, Ando H, Minamino T, Mekada E, Oku N
Biochem. Biophys. Res. Commun.   (449) 460-465   2014年   [査読有り]
Real-time trafficking of PEGylated liposomes in the rodent focal brain ischemia analyzed by positron emission tomography.
Fukuta T, Ishii T, Asai T, Nakamura G, Takeuchi Y, Sato A, Agato Y, Shimizu K, Akai S, Fukumoto D, Harada N, Tsukada H, Kawaguchi AT, Oku N
Artif. Organs   (38) 662-666   2014年   [査読有り]
Neuroprotective effect of nobiletin on cerebral ischemia-reperfusion injury in transient middle cerebral artery-occluded rats
Yasuda N, Ishii T, Oyama D, Fukuta T, Agato Y, Sato A, Shimizu K, Asai T, Asakawa T, Kan T, Yamada S, Ohizumi Y, Oku N
Brain Res.   (1559) 46-54   2014年   [査読有り]
Suppression in mice of immunosurveillance against PEGylated liposomes by encapsulated doxorubicin.
Yahuafai J, Asai T, Nakamura G, Fukuta T, Siripong P, Hyodo K, Ishihara H, Kikuchi H, Oku N
J. Control. Release   (192) 163-173   2014年   [査読有り]
Development of miR-92a delivery system for antiangiogenesis-based cancer therapy.
Ando H, Okamoto A, Yokota M, Shimizu K, Asai T, Dewa T, Oku N
J. Gene Med.   (15) 20-27   2013年   [査読有り]
Systemic delivery of small interfering RNA by use of targeted polycation liposomes for cancer therapy.
Kenjo E, Asai T, Yonenaga N, Ando H, Ishii T, Hatanaka K, Shimizu K, Urita U, Dewa T, Nango M, Tsukada H, Oku N
Biol. Pharm. Bull.   (36) 287-291   2013年   [査読有り]
Nanoparticles accumulate in ischemic core and penumbra region even when cerebral perfusion is reduced.
Ishii T, Fukuta T, Agato Y, Oyama D, Yasuda N, Shimizu K, Kawaguchi AT, Asai T, Oku N
Biochem. Biophys. Res. Commun.   (430) 1201-1205   2013年   [査読有り]
Liposomal Amiodarone Augments Anti-arrhythmic Effects and Reduces Hemodynamic Adverse Effects in an Ischemia/Reperfusion Rat Model.
Takahama H, Shigematsu H, Asai T, Matsuzaki T, Sanada S, Fu HY, Okuda K, Yamato M, Asanuma H, Asano Y, Asakura M, Oku N
Cardiovasc. Drugs Ther.   (27) 125-132   2013年   [査読有り]
Suppression of immune response by antigen-modified liposomes encapsulating model agents: A novel strategy for the treatment of allergy.
Ichikawa K, Asai T, Shimizu K, Yonezawa S, Urakami T, Miyauchi H, Kawashima H, Ishida T, Kiwada H, Oku N
J. Control. Release   (167) 284-289   2013年   [査読有り]
Treatment of cerebral ischemia-reperfusion injury with PEGylated liposomes encapsulating FK506.
Ishii T, Asai T, Oyama D, Agato Y, Yasuda N, Fukuta T, Shimizu K, Minamino T, Oku N
FASEB J.   (27) 1362-1370   2013年   [査読有り]
Enhanced active targeting via cooperative binding of ligands on liposomes to target receptors.
Sugiyama T, Asai T, Nedachi MY, Katanasaka Y, Shimizu K, Maeda N Oku N
PLoS One.   (8) e67550   2013年   [査読有り]
Polycation liposomes as a vector for potential intracellular delivery of microRNA.
Ando H, Okamoto A, Yokota M, Asai T, Dewa T, Oku N
J. Gene Med.   (15) 375-383   2013年   [査読有り]
Design and synthesis of high-avidity tetravalent glycoclusters as probes for sambucus sieboldiana agglutinin and characterization of their binding properties.
Ogata M, Yano M, Umemura S, Murata T, Park EY, Kobayashi Y, Asai T, Oku N, Nakamura N, Matsuo I, Usui T
Bioconjug. Chem.   (23) 97-105   2012年   [査読有り]
Ability of fibrinogen γ-derived dodecapeptides with different sequences to bind to rat platelets.
Tokutomi K, Tagawa T, Korenaga M, Chiba M, Asai T, Watanabe N, Takeoka S, Handa M, Ikeda Y, Oku N
Int J Pharm.   (438) 296-301   2012年   [査読有り]
Development of anti-HB-EGF immunoliposomes for the treatment of breast cancer.
Nishikawa K, Asai T, Shigematsu H, Shimizu K, Kato H, Asano Y, Takashima S, Mekada E, Oku N, Minamino T
J. Control. Release   (160) 274-280   2012年   [査読有り]
RGD-based active targeting of novel polycation liposomes bearing siRNA for cancer treatment.
Yonenaga N, Kenjo E, Asai T, Tsuruta A, Shimizu K, Dewa T, Nango M, Oku N
J. Control. Release   (160) 177-181   2012年   [査読有り]
Amelioration of cerebral ischemia-reperfusion injury based on liposomal drug delivery system with asialo-erythropoietin.
Ishii T, Asai T, Oyama D, Fukuta T, Yasuda N, Shimizu K, Minamino T, Oku N
J. Control. Release   (160) 81-87   2012年   [査読有り]
Size-dependent induction of accelerated blood clearance phenomenon by repeated injections of polymeric micelles.
Koide H, Asai T, Kato H, Ando H, Shiraishi K, Yokoyama M, Oku N
Int. J. Pharm.   (432) 75-79   2012年   [査読有り]
A single injection of liposomal asialo-erythropoietin improves motor function deficit caused by cerebral ischemia/reperfusion.
Ishii T, Asai T, Fukuta T, Oyama D, Yasuda N, Agato Y, Shimizu K, Minamino T, Oku N31) Ishii T, Asai T, Fukuta T, Oyama D, Yasuda N, Agato Y, Shimizu K, Minamino T, Oku N31) Ishii T, Asai T, Fukuta T, Oyama D, Yasuda N, Agato Y, Shimizu K, Minamino T, Oku N
Int. J. Pharm.   (439) 269-274   2012年   [査読有り]
PET imaging of brain cancer with positron emitter-labeled liposomes.
Oku N, Yamashita M, Katayama Y, Urakami T, Hatanaka K, Shimizu K, Asai T, Tsukada H, Akai S, Kanazawa H
Int. J. Pharm.   (403) 170-177   2011年   [査読有り]
Decoration of fibrinogen γ-chain peptide on adenosine diphosphate-encapsulated liposomes enhances binding of the liposomes to activated platelets.
Tokutomi K, Tagawa T, Korenaga M, Chiba M, Asai T, Watanabe N, Takeoka S, Handa M, Ikeda Y, Oku N
Int. J. Pharm.   (407) 151-157   2011年   [査読有り]
Suppression of choroidal neovascularization by intravitreal injection of liposomal SU5416.
Honda M, Asai T, Umemoto T, Araki Y, Oku N, Tanaka M
Arch. Ophthalmol.   (129) 317-321   2011年   [査読有り]
Agitation during lipoplex formation improves the gene knockdown effect of siRNA.
Barichello JM, Kizuki S, Tagami T, Asai T, Ishida T, Kikuchi H, Oku N, Kiwada H
Int. J. Pharm.   (410) 153-160   2011年   [査読有り]
Proapoptotic action of p53-Tom5 in p53-resistant A549 human non-small cell lung cancer cells through direct mitochondrial dysfunction.
Umemoto T, Asai T, Hirashima K, Shimizu K, Mihara M, Yamamoto K, Kubota K, Miyagawa S, Oku N
Biol. Pharm. Bull.   (34) 551-554   2011年   [査読有り]
Inhibition of Akt (ser473) phosphorylation and rapamycin-resistant cell growth by knockdown of mammalian target of rapamycin with siRNA in VEGFR-1-targeting vector.
Koide H, Asai T, Furuya K, Tsuzuku T, Kato H, Dewa T, Nango M, Maeda N, Oku N
Biol. Pharm. Bull.   (34) 602-608   2011年   [査読有り]
Dicetyl phosphate-tetraethylenepentamine-based liposomes for systemic siRNA delivery.
Asai T, Matsushita S, Kenjo E, Tsuzuku T, Yonenaga N, Koide H, Hatanaka K, Dewa T, Nango M, Maeda N, Kikuchi H, Oku N
Bioconjug. Chem.   (22) 429-435   2011年   [査読有り]
Preventive effect of green tea catechins on experimental tumor metastasis in senescence-accelerated mice.
Shimizu K, Kinouchi Shimizu N, Hakamata W, Unno K, Asai T, Oku N
Biol. Pharm. Bull.   (33) 117-121   2010年   [査読有り]
Temperature-dependent transfer of amphotericin B from liposomal membrane of AmBisome to fungal cell membrane.
Shimizu K, Osada M, Takemoto K, Yamamoto Y, Asai T, Oku N
J. Control. Release   (141) 208-215   2010年   [査読有り]
A novel DDS strategy, "dual-targeting", and its application for antineovascular therapy.
Murase Y, Asai T, Katanasaka Y, Sugiyama T, Shimizu K, Maeda N, Oku N
Cancer Lett.   (287) 165-171   2010年   [査読有り]
Accumulation of macromolecules in brain parenchyma in acute phase of cerebral infarction/reperfusion
Ishii T, Asai T, Urakami T, Oku N
Brain Res.   (1321) 164-168   2010年   [査読有り]
Development of double-stranded siRNA labeling method using positron emitter and its in vivo trafficking analyzed by positron emission tomography.
Hatanaka K, Asai T, Koide H, Kenjo E, Tsuzuku T, Harada N, Tsukada H, Oku N
Bioconjug. Chem.   (21) 756-763   2010年   [査読有り]
T cell-independent B cell response is responsible for ABC phenomenon induced by repeated injection of PEGylated liposomes.
Koide H, Asai T, Hatanaka K, Akai S, Ishii T, Kenjo E, Ishida T, Kiwada H, Tsukada H, Oku N
Int. J. Pharm.   (392) 218-223   2010年   [査読有り]
Liposomal polyamine-dialkyl phosphate conjugates as effective gene carriers: chemical structure, morphology, and gene transfer activity.
Koide H, Asai T, Hatanaka K, Akai S, Ishii T, Kenjo E, Ishida T, Kiwada H, Tsukada H, Oku N
Bioconjug. Chem.   (21) 844-852   2010年   [査読有り]
Cancer antineovascular therapy with liposome drug delivery systems targeted to BiP/GRP78.
Katanasaka Y, Ishii T, Asai T, Naitou H, Maeda N, Koizumi F, Miyagawa S, Ohashi N, Oku N
Int. J. Cancer   (127) 2685-2698   2010年   [査読有り]
Anti-obesity effect of phosphatidylinositol on diet-induced obesity in mice.
Shimizu K, Ida T, Tsutsui H, Asai T, Otsubo K, Oku N
J. Agric. Food Chem.   (58) 11218-11225   2010年   [査読有り]
In vivo distribution of liposome-encapsulated hemoglobin determined by positron emission tomography.
Urakami T, Kawaguchi AT, Akai S, Hatanaka K, Koide H, Shimizu K, Asai T, Fukumoto D, Harada N, Tsukada H, Oku N
(53) 709-717   2009年   [査読有り]
Prolonged targeting of ischemic/reperfused myocardium by liposomal adenosine augments cardioprotection in rats.
J. Am. Coll. Cardiol.   (53) 709-717   2009年   [査読有り]
Evaluation of O-[(18)F] fluoromethyl-D-tyrosine as a radiotracer for tumor imaging with positron emission tomography.
Urakami T, Sakai K, Asai T, Fukumoto D, Tsukada H, Oku N
Nucl. Med. Biol.   (36) 295-303   2009年   [査読有り]
Chronopharmacologic cancer treatment with an angiogenic vessel-targeted liposomal drug.
Shimizu K, Sawazaki Y, Tanaka T, Asai T, Oku N
Biol. Pharm. Bull.   (31) 95-98   2008年   [査読有り]
Antiangiogenic cancer therapy using tumor vasculature-targeted liposomes encapsulating 3-(3,5-dimethyl-1H-pyrrol-2-ylmethylene) -1,3-dihydro-indol-2-one, SU5416.
Katanasaka Y, Ida T, Asai T, Shimizu K, Koizumi F, Maeda N, Baba K, Oku N
Cancer Lett.   (270) 260-268   2008年   [査読有り]
Chemoprevention of tumor metastasis by liposomal beta-sitosterol intake.
Imanaka H, Koide H, Shimizu K, Asai T, Kinouchi Shimizu N, Ishikado A, Makino T, Oku N
Biol. Pharm. Bull   (31) 400-404   2008年   [査読有り]
Disappearance of the angiogenic potential of endothelial cells caused by Argonaute2 knockdown.
Asai T, Suzuki Y, Matsushita S, Yonezawa S, Yokota J, Katanasaka Y, Ishida T, Dewa T, Kiwada H, Nango M, Oku N
Biochem. Biophys. Res. Commun.   (368) 243-248   2008年   [査読有り]
Antineovascular therapy with angiogenic vessel-targeted polyethyleneglycol-shielded liposomal DPP-CNDAC.
Asai T, Miyazawa S, Maeda N, Hatanaka K, Katanasaka Y, Shimizu K, Shuto S, Oku N
Cancer Sci   (99) 1029-1033   2008年   [査読有り]
Enhanced experimental tumor metastasis with age in senescence-accelerated mouse.
Shimizu K, Kinouchi Shimizu N, Asai T, Tsukada H, Oku N
Biol. Pharm. Bull.   (31) 847-851   2008年   [査読有り]
Effective delivery of an angiogenesis inhibitor by neovessel-targeted liposomes.
Katanasaka Y, Ida T, Asai T, Maeda N, Oku N
Int. J. Pharm.   (360) 219-224   2008年   [査読有り]
Particle size-dependent triggering of accelerated blood clearance phenomenon.
Koide H, Asai T, Hatanaka K, Urakami T, Ishii T, Kenjo E, Nishihara M, Yokoyama M, Ishida T, Kiwada H, Oku N
Int. J. Pharm.   (362) 197-200   2008年   [査読有り]
In vitro efficacy of a sterically stabilized immunoliposomes targeted to membrane type 1 matrix metalloproteinase (MT1-MMP)
Atobe K, Ishida T, Ishida E, Hashimoto K, Kobayashi H, Yasuda J, Aoki T, Obata K, Kikuchi H, Akita H, Asai T, Harashima H, Oku N, Kiwada H
Biol. Pharm. Bull.   (30) 972-978   2007年   [査読有り]
Proteomic characterization of angiogenic endothelial cells stimulated with cancer cell-conditioned medium.
Katanasaka Y, Asai T, Naitou H, Ohashi N, Oku N
Biol. Pharm. Bull.   (30) 2300-2307   2007年   [査読有り]
Junctional adhesion molecule-C promotes metastatic potential of HT1080 human fibrosarcoma
Fuse C, Ishida Y, Hikita T, Asai T, Oku N
J. Biol. Chem.   (282) 8276-8283   2007年   [査読有り]
Enhanced desensitization efficacy by liposomal conjugation of a specific antigen.
Ichikawa K, Urakami T, Yonezawa S, Miyauchi H, Shimizu K, Asai T, Oku N
Int. J. Pharm.   (336) 391-395   2007年   [査読有り]
Effective tumor regression by anti-neovascular therapy in hypovascular orthotopic pancreatic tumor model.
Yonezawa S, Asai T, Oku N
J. Control. Release   (118) 303-309   2007年   [査読有り]
Enhancement of anticancer activity in antineovascular therapy is based on the intratumoral distribution of the active targeting carrier for anticancer drugs.
Maeda N, Miyazawa S, Shimizu K, Asai T, Yonezawa S, Kitazawa S, Namba Y, Tsukada H, Oku N
Biol. Pharm. Bull.   (29) 1936-1940   2006年   [査読有り]
Identification of oligopeptides binding to peritoneal tumors of gastric cancer.
Akita N, Maruta F, Seymour LW, Kerr DJ, Parker AL, Asai T, Oku N, Nakayama J, Miyagawa S
Cancer Sci.   (97) 1075-1081   2006年   [査読有り]
Induction of apoptosis in tumor cells by three naphthoquinone esters isolated from thai medicinal plant: Rhinacanthus nasutus KURZ.
71) Siripong P, Yahuafai J, Shimizu K, Ichikawa K, Yonezawa S, Asai T, Kanokmedakul K, Ruchirawat S, Oku N
Biol. Pharm. Bull.   (29) 2070-2076   2006年   [査読有り]
Antitumor activity of liposomal naphthoquinone esters isolated from thai medicinal plant: Rhinacanthus nasutus Kurz
Siripong P, Yahuafai J, Shimizu K, Ichikawa K, Yonezawa S, Asai T, Kanokmedakul K, Ruchirawat S, Oku N
Biol. Pharm. Bull   (29) 2279-2283   2006年   [査読有り]
Enhanced antitumor activity of xanthohumol, a diacylglycerol acyltransferase inhibitor, under hypoxia.
Goto K, Asai T, Hara S, Namatame I, Tomoda H, Ikemoto M, Oku N
Cancer Lett.   (219) 215-222   2005年   [査読有り]
Antiangiogenic photodynamic therapy (PDT) by using long-circulating liposomes modified with peptide specific to angiogenic vessels.
Ichikawa K, Hikita T, Maeda N, Yonezawa S, Takeuchi Y, Asai T, Namba Y, Oku N
Biochim. Biophys. Acta   (1669) 69-74   2005年   [査読有り]
Applicability of anti-neovascular therapy to drug-resistant tumor: Suppression of drug-resistant P388 tumor growth with neovessel-targeted liposomal adriamycin.
Shimizu K, Asai T, Fuse C, Sadzuka Y, Sonobe T, Ogino K, Taki T, Tanaka T, Oku N:
Int. J. Pharm.   (296) 133-141   2005年   [査読有り]
Anti-neovascular therapy by liposomal drug targeted to membrane type-1 matrix metalloproteinase.
Kondo M, Asai T, Katanasaka Y, Sadzuka Y, Tsukada H, Ogino K, Taki T, Baba K, Oku N
Int. J. Cancer   (108) 301-306   2004年   [査読有り]
(-)-Epigallocatechin gallate inhibits membrane-type 1 matrix metalloproteinase, MT1-MMP, and tumor angiogenesis.
Yamakawa S, Asai T, UchidaT, Matsukawa M, Akizawa T, Oku N
Cancer Lett.   (210) 47-55   2004年   [査読有り]
Inhibitory effect of green tea polyphenols on membrane-type 1 matrix metalloproteinase, MT1-MMP.
Oku N, Matsukawa M, Yamakawa S, Asai T, Yahara S, Hashimoto F, Akizawa T
Biol. Pharm. Bull.   (26) 1235-1238   2003年   [査読有り]
Suppression of tumor growth by novel peptides homing to tumor-derived new blood vessels.
Asai T, Nagatsuka M, Kuromi K, Yamakawa S, Kurohane K, Ogino K, Tanaka M, Taki T, Oku N
FEBS Lett.   (510) 206-210   2002年   [査読有り]
Anti-neovascular therapy using novel peptides homing to angiogenic vessels.
Oku N, Asai T, Watanabe K, Kuromi K, Nagatsuka M, Kurohane K, Kikkawa H, Ogino K, Tanaka M, Ishikawa D, Tsukada H, Momose M, Nakayama J, Taki T
Oncogene   (21) 2662-2669   2002年   [査読有り]
Anti-neovascular therapy by liposomal DPP-CNDAC targeted to angiogenic vessels.
Asai T, Shimizu K, Kondo M, Kuromi K, Watanabe K, Ogino K, Taki T, Shuto S, Matsuda A, Oku N
FEBS Lett.   (520) 167-170   2002年   [査読有り]
Potential usage of liposomal 4-aminoalkyl-4'-O-demethyl-4-desoxypodophyllotoxin (TOP-53) for cancer chemotherapy.
Shimizu K, Takada M, Asai T, Irimura K, Baba K, Oku N
Biol. Pharm. Bull.   (25) 783-786   2002年   [査読有り]
Isolation of a novel peptide homing to tumor-derived neovasculature that suppresses tumor growth.
Asai T, Fukatsu H, Kuromi K, Ogino K, Tanaka M, Oku N, Taki T
Biol. Pharm. Bull.   (25) 904-906   2002年   [査読有り]
Cancer chemotherapy by liposomal 6-[12-(dimethylamino)ethyl]aminol-3-hydroxy-7H-indeno [2,1-c]quinolin-7-one dihydrochloride (TAS-103), a novel anti-cancer agent.
Shimizu K, Takada M, Asai T, Kuromi K, Baba K, Oku N
Biol. Pharm. Bull.   (25) 1385-1387   2002年   [査読有り]
Targeting and anti-tumor efficacy of liposomal 5'-O-dipalmitoylphosphatidyl 2'-C-cyano-2'-deoxy-1--D-arabino-pentofuranosylcytosine in mice lung bearing B16BL6 melanoma.
Asai T, Shuto S, Matsuda A, Kakiuchi T, Ohba H, Tsukada H, Oku N
Cancer Lett.   (162) 49-56   2001年   [査読有り]
Suppression of GD1 ganglioside-mediated tumor metastasis by liposomalized WHW-peptide.
Takikawa M, Kikkawa H, Asai T, Yamaguchi N, Ishikawa D, Tanaka M, Taki T, Oku N
FEBS Lett.   (466) 381-384   2000年   [査読有り]
Antitumor activity of 5'-O-dipalmitoylphosphatidyl 2'-C-cyano-2'-deoxy-1--D-arabino-pentofuranosylcytosine is enhanced by long-circulating liposomalization.
Asai T, Kurohane K, Shuto S, Awano H, Matsuda A, Tsukada H, Namba Y, Okada S, Oku N
Biol. Pharm. Bull.   (21) 766-771   1998年   [査読有り]

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