Yoshinori Onuki

Profile Information

Affiliation: Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama

J-GLOBAL ID: 200901091193947984
researchmap Member ID: 5000018791

External link: http://www.pha.u-toyama.ac.jp/pharmtech/index/HOME.html

Research Interests

Research Areas

Research History

Apr, 2015 - Present

Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama
Jan, 2015 - Mar, 2015

Hoshi University
Apr, 2014 - Jan, 2015

Hoshi University
Apr, 2007 - Mar, 2014

Hoshi University
Jul, 2002 - Mar, 2007

Hoshi University
Apr, 2000 - Jun, 2002

Lintec Corporation

Education

- 2000

Hoshi University, Hoshi University

Awards

2022

The Most Published Author Award 2017-2021 in Cham. Pharm. Bull., 日本薬学会
2019

日本薬剤学会優秀論文賞

大貫義則
2016

Best paper prize for 2016 in the International Journal of Cosmetic Science

Papers

A review of the biocompatibility of implantable devices: current challenges to overcome foreign body response.

Onuki Y, Bhardwaj U, Papadimitrakopoulos F, Burgess DJ

Journal of diabetes science and technology, 2(6) 1003-1015, Nov, 2008 Peer-reviewed
Novel Preparation of Intercellular Lipid Models of the Stratum Corneum Containing Stereoactive Ceramide

Hiroshi Watanabe, Yasuko Obata, Yoshinori Onuki, Kenya Ishida, Kozo Takayama

CHEMICAL & PHARMACEUTICAL BULLETIN, 58(3) 312-317, Mar, 2010 Peer-reviewed
Impact of the State of Water on the Dispersion Stability of a Skin Cream Formulation Elucidated by Magnetic Resonance Techniques

Masato Nishikawa, Yoshinori Onuki, Yoshihide Okuno, Kozo Takayama

CHEMICAL & PHARMACEUTICAL BULLETIN, 59(3) 332-337, Mar, 2011 Peer-reviewed
Latent Structure Analysis in Pharmaceutical Formulations Using Kohonen's Self-Organizing Map and a Bayesian Network

Shingo Kikuchi, Yoshinori Onuki, Akihito Yasuda, Yoshihiro Hayashi, Kozo Takayama

JOURNAL OF PHARMACEUTICAL SCIENCES, 100(3) 964-975, Mar, 2011 Peer-reviewed
Reliability Evaluation of the Design Space of the Granulation Process of Mefenamic Acid Tablets Using a Bootstrap Resampling Technique

Hiroaki Arai, Tatsuya Suzuki, Shuichi Yada, Chosei Kaseda, Yoshinori Onuki, Kozo Takayama

CHEMICAL & PHARMACEUTICAL BULLETIN, 59(5) 608-617, May, 2011 Peer-reviewed
A 5% Glucose Infusion Fluid Provokes Significant Precipitation of Phenytoin Sodium Injection via Interruption of the Cosolvent Effect of Propylene Glycol

Yoshinori Onuki, Mayumi Ikegami-Kawai, Kazumi Ishitsuka, Yoshihiro Hayashi, Kozo Takayama

CHEMICAL & PHARMACEUTICAL BULLETIN, 60(1) 86-93, Jan, 2012 Peer-reviewed
Reliability evaluation of nonlinear design space in pharmaceutical product development

Yoshihiro Hayashi, Shingo Kikuchi, Yoshinori Onuki, Kozo Takayama

JOURNAL OF PHARMACEUTICAL SCIENCES, 101(1) 333-341, Jan, 2012 Peer-reviewed
Change in the Drug Release Behavior of Theophylline Sustained-release Tablets after Division into Two Halves

Kazumi Ishitsuka, Yoshinori Onuki, Kozo Takayama

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 132(2) 225-230, Feb, 2012 Peer-reviewed
Relationship between Diffusivity of Water Molecules Inside Hydrating Tablets and Their Drug Release Behavior Elucidated by Magnetic Resonance Imaging

Shingo Kikuchi, Yoshinori Onuki, Hideto Kuribayashi, Kozo Takayama

CHEMICAL & PHARMACEUTICAL BULLETIN, 60(4) 536-542, Apr, 2012 Peer-reviewed
Contribution of the Physicochemical Properties of Active Pharmaceutical Ingredients to Tablet Properties Identified by Ensemble Artificial Neural Networks and Kohonen's Self-Organizing Maps

Yoshinori Onuki, Shota Kawai, Hiroaki Arai, Jin Maeda, Keisuke Takagaki, Kozo Takayama

JOURNAL OF PHARMACEUTICAL SCIENCES, 101(7) 2372-2381, Jul, 2012 Peer-reviewed
Menthosomes, Novel Ultradeformable Vesicles for Transdermal Drug Delivery: Optimization and Characterization

Sureewan Duangjit, Yasuko Obata, Hiromu Sano, Shingo Kikuchi, Yoshinori Onuki, Praneet Opanasopit, Tanasait Ngawhirunpat, Yoshie Maitani, Kozo Takayama

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 35(10) 1720-1728, Oct, 2012 Peer-reviewed
Latent Structure Analysis of the Process Variables and Pharmaceutical Responses of an Orally Disintegrating Tablet

Yoshihiro Hayashi, Etsuko Oshima, Jin Maeda, Yoshinori Onuki, Yasuko Obata, Kozo Takayama

CHEMICAL & PHARMACEUTICAL BULLETIN, 60(11) 1419-1425, Nov, 2012 Peer-reviewed
A Novel Approach to Establishing the Design Space for the Oral Formulation Manufacturing Process

Tadashi Norioka, Yoshihiro Hayashi, Yoshinori Onuki, Hirotaka Andou, Daisuke Tsunashima, Kazunari Yamashita, Kozo Takayama

CHEMICAL & PHARMACEUTICAL BULLETIN, 61(1) 39-49, Jan, 2013 Peer-reviewed
Self-Organizing Map Analysis Using Multivariate Data from Theophylline Tablets Predicted by a Thin-Plate Spline Interpolation

Akihito Yasuda, Yoshinori Onuki, Yasuko Obata, Rie Yamamoto, Kozo Takayama

CHEMICAL & PHARMACEUTICAL BULLETIN, 61(3) 304-309, Mar, 2013 Peer-reviewed
Prediction of Tablet Characteristics from Residual Stress Distribution Estimated by the Finite Element Method

Yoshihiro Hayashi, Takahiro Miura, Takuya Shimada, Yoshinori Onuki, Yasuko Obata, Kozo Takayama

JOURNAL OF PHARMACEUTICAL SCIENCES, 102(10) 3678-3686, Oct, 2013 Peer-reviewed
Mechanistic Study of the Uptake/Permeation of Cell-Penetrating Peptides Across a Caco-2 Monolayer and Their Stimulatory Effect on Epithelial Insulin Transport

Noriyasu Kamei, Yoshinori Onuki, Kozo Takayama, Mariko Takeda-Morishita

JOURNAL OF PHARMACEUTICAL SCIENCES, 102(11) 3998-4008, Nov, 2013 Peer-reviewed
Practical syntheses of D-erythro- and L-threo-ceramide [NDS] and difference in contribution of each isomer in microstructure of stratum corneum intercellular lipids

K. Ishida, Y. Obata, C. Akagi, Y. Onuki, K. Takayama

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 24(6) 689-693, 2014 Peer-reviewed
Comparative Study of Novel Ultradeformable Liposomes: Menthosomes, Transfersomes and Liposomes for Enhancing Skin Permeation of Meloxicam

Sureewan Duangjit, Yasuko Obata, Hiromu Sano, Yoshinori Onuki, Praneet Opanasopit, Tanasait Ngawhirunpat, Tsubasa Miyoshi, Satoru Kato, Kozo Takayama

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 37(2) 239-247, Feb, 2014 Peer-reviewed
Comparative pharmaceutical evaluation of brand and generic clobetasone butyrate ointments

Yoshihisa Yamamoto, Toshiro Fukami, Tatsuo Koide, Yoshinori Onuki, Toyofumi Suzuki, Koichi Metori, Noriko Katori, Yukio Hiyama, Kazuo Tomono

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 463(1) 62-67, Mar, 2014 Peer-reviewed
Non-destructive monitoring of creaming of oil-in-water emulsion-based formulations using magnetic resonance imaging

Yoshinori Onuki, Akihiro Horita, Hideto Kuribayashi, Yoshihide Okuno, Yasuko Obata, Kozo Takayama

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 40(7) 937-943, Jul, 2014 Peer-reviewed

Misc.

ジアゼパム注射剤を輸液で希釈した時の析出現象の解明希釈液中のジアゼパムの溶解状態と析出物の分析

黄田千尋, 長谷川直毅, 大貫義則, 池上眞由美, 白水俊介, 小幡誉子, 高山幸三

日本薬学会年会要旨集, 134年会(4) 107-107, Mar, 2014
Development of Topical/Transdermal Drug Delivery Based on Structure Analysis of Stratum Corneum

OBATA Yasuko, OHTA Noboru, YAGI Naoto, ONUKI Yoshinori, TAKAYAMA Kozo

J. Surf. Sci. Soc. Jpn., 35(1) 34-39, 2014
グルコース輸液で希釈したフェニトイン注射剤における析出現象の機構解明

長谷川直毅, 大貫義則, 池上眞由美, 白水俊介, 小幡誉子, 高山幸三

日本薬剤学会年会講演要旨集, 28年会 200-200, Apr, 2013
ジアゼパム注射剤の輸液との混合に伴う配合変化の機構解明

長谷川直毅, 坪井聡美, 黄田千尋, 大貫義則, 白水俊介, 小幡誉子, 高山幸三

日本薬学会年会要旨集, 133年会(4) 148-148, Mar, 2013
Optimization of the manufacturing process for oral formulations using multivariate statistical methods

Tadashi Norioka, Tadashi Norioka, Shingo Kikuchi, Yoshinori Onuki, Kozo Takayama, Keiji Imai

Journal of Pharmaceutical Innovation, 6 157-169, Sep 1, 2011
Lectin-functionalized carboxymethylated kappa-carrageenan microparticles for oral insulin delivery

Kok Hoong Leong, Lip Yong Chung, Mohamed Ibrahim Noordin, Yoshinori Onuki, Mariko Morishita, Kozo Takayama

Carbohydrate Polymers, 86 555-565, Aug 15, 2011
Latent Structure Analysis in Pharmaceutical Formulations Using Kohonen's Self-Organizing Map and a Bayesian Network

Shingo Kikuchi, Yoshinori Onuki, Akihito Yasuda, Yoshihiro Hayashi, Kozo Takayama

JOURNAL OF PHARMACEUTICAL SCIENCES, 100(3) 964-975, Mar, 2011
Carboxymethylation of kappa-carrageenan for intestinal-targeted delivery of bioactive macromolecules

Kok Hoong Leong, Lip Yong Chung, Mohamed Ibrahim Noordin, Khalit Mohamad, Masato Nishikawa, Yoshinori Onuki, Mariko Morishita, Kozo Takayama

CARBOHYDRATE POLYMERS, 83(4) 1507-1515, Feb, 2011
Different effects of l-and d-menthol on the microstructure of ceramide 5/cholesterol/palmitic acid bilayers

Hiroshi Watanabe, Yasuko Obata, Yoshinori Onuki, Kenya Ishida, Kozo Takayama

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 402(1-2) 146-152, Dec, 2010
Self-Organizing Map Analysis Using Multivariate Data from Theophylline Powders Predicted by a Thin-Plate Spline Interpolation

Akihito Yasuda, Yoshinori Onuki, Shingo Kikuchi, Kozo Takayama

JOURNAL OF PHARMACEUTICAL SCIENCES, 99(11) 4535-4542, Nov, 2010
Noninvasive visualization of in vivo release and intratumoral distribution of surrogate MR contrast agent using the dual MR contrast technique

Yoshinori Onuki, Igor Jacobs, Dmitri Artemov, Yoshinori Kato

BIOMATERIALS, 31(27) 7132-7138, Sep, 2010
Role of individual test samples in optimal solutions in pharmaceuticals predicted using a nonlinear response surface method

Yoshinori Onuki, Shingo Kikuchi, Akihito Yasuda, Kozo Takayama

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 396(1-2) 75-82, Aug, 2010
Improving rheological characteristics of hydrophilic ointment base by treatment with a high-pressure wet-type jet mill

Masato Nishikawa, Yoshinori Onuki, Yoshihide Okuno, Kozo Takayama

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 36(6) 625-631, Jun, 2010
Novel Preparation of Intercellular Lipid Models of the Stratum Corneum Containing Stereoactive Ceramide

Hiroshi Watanabe, Yasuko Obata, Yoshinori Onuki, Kenya Ishida, Kozo Takayama

CHEMICAL & PHARMACEUTICAL BULLETIN, 58(3) 312-317, Mar, 2010
Phase behavior in a ternary lipid membrane estimated using a nonlinear response surface method and Kohonen's self-organizing map

Yoshinori Onuki, Kozo Takayama

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 343(2) 628-633, Mar, 2010
Impact of state of water in skin cream base on its dispersion stability elucidated by magnetic resonance techniques

Nishikawa, M, Onuki, Y, Okuno, Y, Takayama, K

Chem. Pharm. Bull, in press, 2010
Noninvasive monitoring of drug release from PLGA nanoparticles

Igor Jacobs, Yoshinori Onuki, Dmitri Artemov, Nicole Benoit, Yoshinori Kato

CANCER RESEARCH, 69, May, 2009
Prediction of permeability of FD-4 through porous poly (2-hydroxyethyl methacrylate) membrane by multiple linear regression and artificial neural network

F. Yanagawa, Y. Onuki, M. Morishita, K. Takayama

PHARMAZIE, 64(5) 311-315, May, 2009
Displacement of tight junction proteins from detergent-resistant membrane domains by treatment with sodium caprate

Ko Sugibayashi, Yoshinori Onuki, Kozo Takayama

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 36(2-3) 246-253, Feb, 2009
Formulation Optimization of an Indomethacin-Containing Photocrosslinked Polyacrylic Acid Hydrogel as an Anti-inflammatory Patch

Masato Nishikawa, Yoshinori Onuki, Koichi Isowa, Kozo Takayama

AAPS PHARMSCITECH, 9(3) 1038-1045, Sep, 2008

Professional Memberships

日本薬学会／日本薬剤学会／日本ＤＤＳ学会／製剤機械技術学会

Research Projects

Usefulness of time-domain NMR as a monitoring tool for pharmaceutical process analytical technology

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2023
Precise prediction of destabilization kinetics of a pharmaceutical emulsion using magnetic resonance imaging

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2016 - 2019

Onuki Yoshinori
MRIと時間温度換算則を応用したエマルション化粧品の高精度乳化安定性予測

公益財団法人コスメトロジー研究振興財団, 2017

大貫義則
Formulation design of pharmaceutical emulsions based on magnetic resonance imaging and quality-by-design approach

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2013 - 2015

Onuki Yoshinori
Quality by Designアプローチに基づいた固形製剤の処方設計：崩壊剤の物質特性による製剤特性への寄与解明

公益財団法人田村科学技術振興財団, 2015

大貫義則
MRIを利用したエマルション製剤の乳化安定性評価と処方設計

公益財団法人薬学研究奨励財団, 2014

大貫義則
MRIの分子イメージング技術を応用した外用消炎鎮痛剤のための非破壊的物性評価手法

公益財団法人一般用医薬品セルフメディケーション振興財団, 2013

大貫義則
磁気共鳴法を利用した半固形製剤中の水分子運動性の解析と製剤安定性への寄与

科学研究費助成金[若手研究(B)], 日本学術振興会, 2011 - 2012

大貫義則
多価不飽和脂肪酸によるマイクロドメイン形成と消化管薬物吸収促進作用との関連性

文部科学省科学研究費補助金 [若手研究 (B)], 2005 - 2006

大貫義則
Photocrosslinked hydrogel, lipid raft, intestinal absorption

Other

第一種放射線取扱主任者 (登録番号第27484号)

Dec, 2013 - Dec, 2013

Profile Information

Research Interests

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Research History

Education

Awards

Papers

Misc.

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