SHIMIZU Takahiro

J-GLOBAL         Last updated: Oct 18, 2019 at 17:58
 
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Name
SHIMIZU Takahiro
E-mail
shimizukochi-u.ac.jp
Affiliation
Kochi University
Section
Research and Education Faculty, Medical Sciences Cluster Basic Medicine Unit
Job title
Associate Professor
Degree
Ph.D.(Kochi University)
Research funding number
00363276

Research Areas

 
 

Academic & Professional Experience

 
2012
 - 
Today
:Associate Professor, Department of Pharmacology, Kochi Medical School, Kochi University
 
Oct 2014
 - 
Sep 2016
Postdoctoral Research Associate, Department of Urology, University of Pittsburgh School of Medicine
 
2011
 - 
2012
: Lecturer, Department of Pharmacology, Kochi Medical School, Kochi University
 
2007
 - 
2011
: Assistant Professor, Department of Pharmacology, Kochi Medical School, Kochi University
 
2003
 - 
2007
: Research Associate, Department of Pharmacology, Kochi Medical School, Kochi University
 

Education

 
 
 - 
2008
Graduate School, Division of Medical Sciences, Kochi University
 
 
 - 
2003
Graduate School, Division of Pharmaceutical Sciences, Hokkaido University
 
 
 - 
2001
Faculty of Pharmaceutical Science, Hokkaido University
 

Published Papers

 
PSYCHOLOGICAL STRESS INDUCED BY WATER AVOIDANCE STRESS INCREASES UROTHELIAL PERMEABILITY AND BLADDER PAIN SENSATION IN RATS
Saito T, Tyagi P, Hitchens T, Foley L, Shimizu T, Mizoguchi S, Kurobe M, Gotoh D, Ishizuka O, Yoshimura N
Neurourol. Urodyn.   38 S305-S307   2019   [Refereed]
IVERMECTIN-INDUCED ACTIVATION OF MUTANT GLYCINE RECEPTORS DELIVERED TO AΔ-FIBER BLADDER AFFERENTS BY HERPES SIMPLEX VIRUS VECTORS DRIVEN BY A SUBPOPULATION-SPECIFIC NEUROFILAMENT PROMOTER IMPROVES DETRUSOR- SPHINCTER DYSSYNERGIA AND INEFFICIENT VOIDING IN
Saito T, Shimizu N, Goins W, Suzuki T, Shimizu T, Wada N, Ishizuka O, Glorioso J, Yoshimura N
Neurourol. Urodyn.   38 S237-S238   2019   [Refereed]
GENE THERAPY WITH HERPES SIMPLEX VIRUS VECTORS ENCODING MUTANT GLYCINE RECEPTORS ACTIVATED BY EXOGENOUS APPLICATION OF IVERMECTIN IMPROVES LOWER URINARY TRACT DYSFUNCTION IN MICE WITH SPINAL CORD INJURY
Suzuki T, Saito T, Shimizu T, Shimizu N, Goins W, de Groat W, Glorioso J, Yoshimura N
Neurourol. Urodyn.   38 S146-S148   2019   [Refereed]
Therapeutic effects of PDE9 inhibitor on lower urinary tract dysfunction (LUTD) in mice with spinal cord injury (SCI).
Shimizu N, Suzuki T, Takaoka E, Shimizu T, Hirayama A, Uemura H, Kanai AJ, de Groat WC, Yoshimura N
Eur. Urol. Suppl.   2019 e109-e110   2019   [Refereed]
Therapeutic effects of p38 MAP kinase inhibitor in storage and voiding dysfunction in mice with spinal cord injury (SCI).
Shimizu N, Suzuki T, Takaoka E, Shimizu T, Hirayama A, Uemura H, Kanai AJ, de Groat WC, Yoshimura N
Eur. Urol. Suppl.   18 e5-e6   2019   [Refereed]
Therapeutic effects of inhibition of brain-derived neurotrophic factor (BDNF) on voiding dysfunction in mice with spinal cord injury.
Wada N, Shimizu T, Shimizu N, Kurobe M, de Groat W, Tyagi P, Kakizaki H, Yoshimura N
Am. J. Physiol. Renal Physiol.      2019   [Refereed]
Role of p38 MAP kinase signaling pathways in storage and voiding dysfunction in mice with spinal cord injury
Shimizu N, Wada N, Shimizu T, Suzuki T, Kurobe M, Kanai AJ, de Groat WC, Hashimoto M, Hirayama A, Uemura H, Yoshimura N
Neurourol. Urodyn.      2019   [Refereed]
Central angiotensin II type 1 receptor as a therapeutic target against frequent urination
Shimizu S, Shimizu T, Nagao Y, Higashi Y, Saito M.
Neurourol. Urodyn.      2019   [Refereed]
Analysis of Continence Reflexes by Dynamic Urethral Pressure Recordings in a Rat Sress Urinary Incontinence Model induced by Multiple Simulated Birth Traumas
Kwon J, Suzuki T, Takaoka E, Shimizu N, Shimizu T, Takai S, Yoshikawa S, de Groat W, Yoshimura N
Am. J. Physiol. Renal Physiol.   317 F781-F788   2019   [Refereed]
Hydrogen sulfide-induced relaxation of the bladder is attenuated in spontaneously hypertensive rats
Zou S, Shimizu T, Yamamoto M, Shimizu S, Higashi Y, Saito M.
Int Urol Nephrol   51 1507-1515   2019   [Refereed]
The effect of neutralization of nerve growth factor (NGF) on bladder and urethral dysfunction in mice with spinal cord injury
Wada N, Shimizu T, Shimizu N, de Groat WC, Kanai AJ, Tyagi P, Kakizaki H, Yoshimura N
Neurourol. Urodyn.   37 132-137   2018   [Refereed]
Inhibition of phosphodiesterase type 9 (PDE9) improves storage and voiding dysfunction in mice with spinal cord injury
Shimizu N, Hashimoto M, Suzuki T, Takaoka E, Kwon J, Shimizu T, Wada N, Hirayama A, Uemura H, Kanai AJ, de Groat WC, Yoshimura N
Neurourol. Urodyn.   37 S96-S97   2018   [Refereed]
Role of p38 mitogen-activated protein kinase in hyperexcitability of capsaicin sensitive bladder afferent neurons in mice with spinal cord injury
Suzuki T, Shimizu T, Majima T, Shimizu N, Ni J, Mizoguchi S, Takaoka E, Miyake H, Kanai A, Yoshimura N
Neurourol. Urodyn.   37 S163-S164   2018   [Refereed]
Activation of serotonin 5-HT2C and 5-HT7 receptors enhances the urethral closure reflex during sneezing in rats
Suzuki T, Shimizu T, Kwon J, Takaoka E, Satoru Y, Sumino Y, Kitta T, Miyazato M, Miyake H, Yoshimura N
Neurourol. Urodyn.   37 S339-S340   2018   [Refereed]
Central angiotensin II induces frequent urination through inhibition of GABAergic nervous system and stimulation of angiotensin II type 1 receptor downstream signaling in rats
Shimizu S, Shimizu T, Nakamura K, Higashi Y, Aratake T, Zou S, Hamada T, Nagao Y, Ueba Y, Yamamoto M, Honda M, Saito M
Neurourol. Urodyn.   37 S94-S95   2018   [Refereed]
Hydrogen sulfide has a role as an endogenous relaxation factor in the bladder and prostate of male rats
Shimizu T, Zou S, Shimizu S, Higashi Y, Nakamura K, Ono H, Aratake T, Yamamoto M, Honda M, Saito M
Neurourol. Urodyn.   37 S102-S103   2018   [Refereed]
Brain corticotropin-releasing factor receptor type 1 is involved in centrally administered bombesin-induced frequent urination in rats
Shimizu T, Zou S, Shimizu S, Wada N, Takai S, Shimizu N, Yamamoto M, Higashi Y, Yoshimura N, Saito M
Neurourol. Urodyn.   37 S100-S101   2018   [Refereed]
Wada N, Kadekawa K, Majima T, Shimizu T, Tyagi P, Kakizaki H, Yoshimura N
Neurourol. Urodyn.   37 132-137   2018   [Refereed]
Role of the serotonergic system in urethral continence reflexes during sneezing in rats
Suzuki T, Shimizu T, Kwon J, Takaoka E, Yoshikawa S, Sumino Y, Kitta T, Miyazato M, Miyake H, Yoshimura N
Am. J. Physiol. Renal Physiol.   315 F79-F85   2018   [Refereed]
Nerve growth factor-dependent hyperexcitability of capsaicin sensitive bladder afferent neurones in mice with spinal cord injury
Shimizu T, Majima T, Suzuki T, Shimizu N, Wada N, Kadekawa K, Takai S, Takaoka E, Kwon J, Kanai AJ, de Groat WC, Tyagi P, Saito M, Yoshimura N
Exp. Physiol.   103 896-904   2018   [Refereed]
Effects of nerve growth factor neutralization on TRP channel expression in laser-captured bladder afferent neurons in mice with spinal cord injury
Shimizu N, Wada N, Shimizu T, Suzuki T, Takaoka EI, Kanai AJ, de Groat WC, Hirayama A, Hashimito M, Uemura H, Yoshimura N
Neurosci Lett.   683 100-103   2018   [Refereed]
Possible role of hydrogen sulfide as an endogenous relaxation factor in the rat bladder and prostate
Zou S, Shimizu T, Shimizu S, Higashi Y, Nakamura K, Ono H, Aratake T, Saito M
Neurourol. Urodyn.   37 2519-2526   2018   [Refereed]
Angiotensin II, a stress-related neuropeptide in the CNS, facilitates micturition reflex in rats
Shimizu S, Shimizu T, Nakamura K, Higashi Y, Saito M
Br. J. Pharmacol.   175 3727-3737   2018   [Refereed]
Stimulation of brain nicotinic acetylcholine receptors activates adrenomedullary outflow via brain inducible NO synthase-mediated S-nitrosylation
Higashi Y, Shimizu T, Yamamoto M, Tanaka K, Yawata T, Shimizu S, Zou S, Ueba T, Yuri K, Saito M
Br. J. Pharmacol.   175 3758-3772   2018   [Refereed]
The inhibitory role of intracellular free zinc in the regulation of Arg-1 expression in interleukin-4-induced activation of M2 microglia
Aratake T, Higashi Y, Ueba Y, Hamada T, Shimizu T, Shimizu S, Yawata T, Ueba T, Saito M
Metallomics   10 1501-1509   2018   [Refereed]
Attenuation of zinc-enhanced inflammatory M1 phenotype of microglia by peridinin protects against short-term spatial-memory impairment following cerebral ischemia in mice
Ueba Y, Higashi Y, Aratake T, Onodera K, Hamada T, Shimizu T, Shimizu S, Yawata T, Nakamura R, Akizawa T, Ueba T, Saito M
Biochem. Biophys. Res. Commun.      2018   [Refereed]
THERAPEUTIC EFFECTS OF TRPV1TARGETING GENE THERAPY ON BLADDER OVERACTIVITY AND NOCICEPTION IN A RAT MODEL OF EXPERIMENTAL COLITIS
Takai S, Majima T, Shimizu T, Wada N, Shimizu N, Suzuki T, Takaoka E, Kwon J, Gonis W, Glorioso J, Gotoh M, Yoshimura N
Neurourol. Urodyn.   36 S215-S216   2017   [Refereed]
Role of β3-adrenoceptors in the control of the urethral continence function in female rats
Kwon J, Suzuki T, Takaoka E, Shimizu N, Takai S, Shimizu T, Cho D, Yoshimura N
Neurourol. Urodyn.   36 S334-S335   2017   [Refereed]
Role of p38 MAP kinase signaling pathways in storage and voiding dysfunction in mice with spinal cord injury
Shimizu N, Suzuki T, Takaoka E, Kwon J, Wada N, Shimizu T, Hirayama A, Uemura H, Kanai AJ, de Groat WC, Yoshimura N
Neurourol. Urodyn.   36 S538-S540   2017   [Refereed]
Influence of extracellular zinc on M1 microglial activation
Higashi Y, Aratake T, Shimizu S, Shimizu T, Nakamura K, Tsuda M, Yawata T, Ueba T, Saito M
Sci. Rep.   7 43778   2017   [Refereed]
Kadekawa K, Yoshizawa T, Wada N, Shimizu T, Majima T, Tyagi P, de Groat WC, Sugaya K, Yoshimura N
Exp. Neurol.   291 44-50   2017   [Refereed]
Wada N, Shimizu T, Takai S, Shimizu N, Tyagi P, Kakizaki H, Yoshimura N
Neurourol Urodyn.   36 1039-1045   2017   [Refereed]
Wada N, Shimizu T, Takai S, Shimizu N, Kanai AJ, Tyagi P, Kakizaki H, Yoshimura N
Neurourol. Urodyn.   36 1301-1305   2017   [Refereed]
The role of capsaicin-sensitive C-fiber afferent pathways in the control of micturition in spinal intact and spinal cord injured mice
Kadekawa K, Majima T, Shimizu T, Wada N, de Groat WC, Kanai AJ, Goto M, Yoshiyama M, Sugaya K, Yoshimura N
Am. J. Physiol. Renal Physiol.   313 F796-F804   2017   [Refereed]
Shimizu T, Shimizu S, Wada N, Takai S, Shimizu N, Higashi Y, Kadekawa K, Majima T, Saito M, Yoshimura N
Br. J. Pharmacol.   174 3072-3080   2017   [Refereed]
The Transcription Factor HOXB7 Regulates ERK Kinase Activity and Thereby Stimulates the Motility and Invasiveness of Pancreatic Cancer Cells
Tsuboi M, Taniuchi K, Shimizu T, Saito M, Saibara T
J. Biol. Chem.   27 17681-17702   2017   [Refereed]
The inhibitory effect of neuropeptide Y Y1 receptor agonist on micturition reflex in rats
Honda M, Yoshimura N, Kimiura Y, Kawamoto B, Tsounapi P, Hikita K, Shimizu S, Shimizu T, Saito M, Chancellor M, Takenaka A
Eur. Urol. Suppl.   16 e524-e525   2017   [Refereed]
Supraspinal effects of dopamine uptake inhibitor on the micturition reflex in rats
Honda M, Yoshimura N, Kimura Y, Kawamoto B, Tsounapi P, Hikita K, Shimizu S, Shimizu T, Saito M, Chancellor M, Takenaka A
Eur. Urol. Suppl.   16 e340-e341   2017   [Refereed]
Role of nerve growth factor in hyperexcitability of capsaicin sensitive bladder afferent neurons in spinal cord injured mice
Shimizu T, Majima T, Suzuki T, Shimizu N, Wada N, Kadekawa K, Takai S, Takaoka E, Kwon J, Tyagi P, Saito M, Yoshimura N
Neurourol. Urodyn.   36 S339-S341   2017   [Refereed]
INVOLVEMENT OF BRAIN GABAA RECEPTOR FOR ANGIOTENSIN II-INDUCED FREQUENT URINATION IN THE RAT
Shimizu S, Shimizu T, Nakamura K, Aratake T, Zou S, Hamada T, Nagao Y, Yamamoto M, Honda M, Higashi Y, Saito M
Neurourol. Urodyn.   36 S485-S486   2017   [Refereed]
SUPRASPINAL DOPAMINE UPTAKE INHIBITION INFLUENCES THE MICTURITION REFLEX IN URETHANE-ANESTHETIZED RATS
Tsounapi P, Yoshimura N, Kawamoto B, Hikita K, Shimizu T, Honda M, Saito M, Chancellor M, Takenaka A
Neurourol. Urodyn.   35 S106-S106   2016   [Refereed]
THE ROLE OF CAPSAICIN-SENSITIVE C-FIBER AFFERENT PATHWAYS IN THE CONTROL OF MICTURITION IN NORMAL MICE AND LOWER URINARY TRACT DYSFUNCTION IN MICE WITH SPINAL CORD INJURY
Kadekawa K, Yoshiyama M, Wada N, Shimizu T, Majima T, Tyagi P, Kanai A J, de Groat W C, Sugaya K, Yoshimura N
Neurourol. Urodyn.   35 S121-S123   2016   [Refereed]
THE THERAPEUTIC EFFECTS OF GENE THERAPY WITH REPLICATION-DEFICIENT HERPES SIMPLEX VIRUS (HSV) VECTORS ENCODING PORELESS TRPV1 OR PROTEIN PHOSPHATE 1Α (PP1Α) ON BLADDER OVERACTIVITY AND NOCICEPTION IN A RAT MODEL OF CYSTITIS INDUCED BY HYDROGEN PEROXIDE
Takai S, Majima T, Shimizu N, Shimizu T, Wada N, Gotoh M, Goins W, Cohen J, Glorioso J, Yoshimura N
Neurourol. Urodyn.   35 S245-S246   2016   [Refereed]
HERPES SIMPLEX VIRUS (HSV) VECTOR-MEDIATED TRACING AND LABELLING OF DIFFERENT POPULATIONS OF BLADDER AFFERENT NEURONS IN NORMAL AND SPINAL CORD INJURED MICE
Shimizu N, Goins WF, Takai S, Shimizu T, Wada N, Hirayama A, Uemura H, Tyagi P, Glorioso JC, Yoshimura N
Neurourol. Urodyn.   35 S115-S116   2016   [Refereed]
COMBINATIONAL EFFECTS OF MUSCARINIC RECEPTOR INHIBITION AND Β3-ADRENOCEPTOR SIMULATION ON NEUROGENIC BLADDER DYSFUNCTION IN RATS WITH SPINAL CORD INJURY (SCI)
Wada N, Shimizu T, Shimizu N, Takai S, Tyagi P, Kakizaki H, Yoshimura N
Neurourol. Urodyn.   35 S125-S126   2016   [Refereed]
Wada N, Shimizu T, Shimizu N, Takai S, Tyagi P, Kakizaki H, Yoshimura N
Neurourol. Urodyn.   35 S108-S109   2016   [Refereed]
THE ROLE OF BRAIN BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) AND NERVE GROWTH FACTOR (NGF) IN BLADDER AND URETHRAL DYSFUNCTION IN MICE WITH SPINAL CORD INJURY
Wada N, Shimizu T, Shimizu N, Tyagi P, Kanai A, de Groat W, Kakizaki H, Yoshimura N
Neurourol. Urodyn.   35 S104-S105   2016   [Refereed]
EFFECT OF ALPHA1 ADRENOCEPTOR ANTAGONIST NAFTOPIDIL ON THE ARGININE-VASOPRESSIN SECRETION AND URINE VOLUME IN CENTRALLY NORADRENALINE-ADMINISTERED RATS
Shimizu S, Shimizu T, Yamamoto M, Higashi Y, Nakamura K, Tsounapi P, Liu N, Honda M, Takenaka A, Saito M
Neurourol. Urodyn.   35 S100-S101   2016   [Refereed]
HYPEREXCITABILITY OF CAPSAICIN SENSITIVE BLADDER AFFERENT NEURONS FROM MICE WITH NEUROGENIC DETRUSOR OVERACTIVITY INDUCED BY SPINAL CORD INJURY
Shimizu T, Majima T, Kadekawa K, Shimizu N, Wada N, Takai S, Tyagi P, Saito M, Yoshimura N
Neurourol. Urodyn.   35 S113-S114   2016   [Refereed]
Yawata T, Higashi Y, Shimizu T, Shimizu S, Nakamura K, Taniuchi K, Ueba T, Saito M
Mol. Cell. Biochem.   411 201-211   2016   [Refereed]
Kawamoto B, Shimizu S, Shimizu T, Higashi Y, Hikita K, Muraoka K, Honda M, Sejima M, Takenaka A, Saito M
Life Sci.   144 202-207   2016   [Refereed]
Kawamoto B, Shimizu S, Shimizu T, Higashi Y, Honda M, Sejima T, Saito M, Takenaka A
Sci. Rep.   6 22213   2016   [Refereed]
Shimizu T, Shimizu S, Higashi Y, Nakamura K, Yoshimura N, Saito M
J. Pharmacol. Exp. Ther.   356 693-701   2016   [Refereed]
Kadekawa K, Yoshimura N, Majima T, Wada N, Shimizu T, Birder L, Kanai A, de Groat WC, Sugaya K, Yoshiyama M
Am. J. Physiol. Regul. Integr. Comp. Physiol.   310 R752-R758   2016   [Refereed]
Tsuboi M, Taniuchi K, Furihata M, Naganuma S, Kimura S, Watanabe R, Shimizu T, Saito M, Dabanaka K, Hanazaki K, Saibara T
Pancreatology   16 905-916   2016   [Refereed]
Liu N, Shimizu S, Shimizu T, Nakamura K, Yamamoto M, Higashi Y, Saito M
J. Pharmacol. Sci.   132 71-77   2016   [Refereed]
Yamamoto M, Shimizu T, Shimizu S, Higashi Y, Nakamura K, Fujieda M, Saito M
J. Pharmacol. Sci.   132 86-91   2016   [Refereed]
Tanouchi A, Taniuchi K, Furihata M, Naganuma S, Dabanaka K, Kimura M, Watanabe R, Kohsaki T, Shimizu T, Saito M, Hanazaki K, Saibara T
J. Exp. Clin. Cancer Res.   35 190   2016   [Refereed]
PHARMACOLOGICAL CHARACTERIZATION OF BRAIN SEROTONIN RECEPTOR SUBTYPES INVOLVED IN BOMBESIN-INDUCED FREQUENT URINATION IN RATS
Shimizu T, Shimizu S, Wada N, Takai S, Shimizu N, Higashi Y, Kadekawa K, Majima T, Saito M, Yoshimura N
Neurourol. Urodyn.   35 S102-S103   2016   [Refereed]
Prdx1 promotes pancreatic cancer cell motility and invasion by modulating p38 MAPK activity
Taniuchi K, Furihata M, Hanazaki K, Iwasaki S, Tanaka K, Shimizu T, Saito M, Saibara T
Pancreas   44 331-340   2015   [Refereed]
Shimizu T, Tanaka K, Shimizu S, Higashi Y, Yawata T, Nakamura K, Taniuchi K, Ueba T, Yuri K, Saito M
Neuropharmacology   95 278-289   2015   [Refereed]
Shimizu S, Shimizu T, Tsounapi P, Higashi Y, Martin DT, Nakamura K, Honda M, Inoue K, Saito M
PLos ONE   10 e0133797   2015   [Refereed]
Holmström F, Shimizu S, Shimizu T, Higashi Y, Martin DT, Honda M, Saito M
Prostate   75 1774-1782   2015   [Refereed]
BOMBESIN, A STRESS-RELATED NEUROPEPTIDE, CENTRALLY INDUCES FREQUENT URINATION IN THE RAT
Shimizu T, Shimizu S, Higashi Y, Nakamura K, Kadekawa K, Wada N, Majima T, Honda M, Yoshimura N, Saito M
Neurourol. Urodyn.   34 S94-S96   2015   [Refereed]
VESICOVASCULAR REFLEX IN THE SPONTANEOUSLY HYPERTENSIVE RAT
Kawamoto B, Shimizu S, Hikita K, Muraoka K, Honda M, Sejima T, Higashi Y, Shimizu T, Takenaka A, Saito M
Neurourol. Urodyn.   34 S89-S90   2015   [Refereed]
Characterization of bladder and external urethral sphincter activity in mice with or without spinal cord injury- A comparison study with rats
Kadekawa K Yoshiyama M, Majima T, Wada N, Shimizu T, Tyagi P, Sugaya K, Yoshimura N
Neurourol. Urodyn.   34 S85-S86   2015   [Refereed]
Kadekawa K, Kawamorita N, Shimizu T, Turnbull P, Russell A, Chandra S, Barton J, Yoshimura N
Effect of Selective Androgen Receptor Modulator (SARM), GSK2849446A on Stress Urinary Incontinence and Bladder Activity in Rats with Ovarieictomy-induced Estrogen Deficiency
Neurourol. Urodyn.   34 S140-S141   2015   [Refereed]
The effect of intravesical liposome-based NGF antisense therapy on bladder overactivity and nociception in a rat model of cystitis induced by hydrogen peroxide
Majima T, Tyagi P, Dogishi K, Kadekawa K, Kashyap M, Wada N, Takai S, Shimizu T, Gotoh M, Chancellor M, Yoshimura N
Neurourol. Urodyn.   34 S201-S203   2015   [Refereed]
Urodynamic effect of intravesical and intrathecal administration of selective E-series prostaglandin 4 receptor antagonist, ONO-AE3-208, on cyclophosphamide induced cystitis rats
Wada N, Kadekawa K, Majima T, Shimizu T, Okada H, Tyagi P, Kakizaki H, Yoshimura N
Neurourol. Urodyn.   34 S134-S135   2015   [Refereed]
Urodynamic effects of intravenous and intrathecal administration of E-series prostaglandin 1 receptor antagonist on detrusor overactivity in rats with spinal cord injury
Wada N, Kadekawa K, Majima T, Shimizu T, Tyagi P, Kakizaki H, Yoshimura N
Neurourol. Urodyn.   34 S296-S298   2015   [Refereed]
Central angiotensin II increases urinary frequency by acting on brain AT1 receptors in rats
Kawamoto B, Shimizu S, Hikita K, Muraoka K, Honda M, Sejima T, Higashi Y, Shimizu T, Saito M, Takenaka A
Neurourol. Urodyn.   34 S102-S103   2015   [Refereed]
Nakamura K, Shimizu T, Yanagita T, Nemoto T, Taniuchi K, Shimizu S, Dimitriadis F, Yawata T, Higashi Y, Ueba T, Saito M
Sci. Rep.   4 7248   2014   [Refereed]
Higashi Y, Hoshijima M, Yawata T, Nbumoto A, Tsuda M, Shimizu T, Saito M, Ueba T
J. Neurotrauma   31 1689-1699   2014   [Refereed]
Shimizu S, Tsounapi P, Honda M, Dimitriadis F, Taniuchi K, Shimizu T, Inoue K, Saito M
Biomed. Res.   35 215-221   2014   [Refereed]
Taniuchi K, Furihata M, Iwasaki S, Tanaka K, Shimizu T, Saito M, Saibara T
Int. J. Oncol   44 1945-1954   2014   [Refereed]
Shimizu T, Tanaka K, Nakamura K, Taniuchi K, Yawata T, Higashi Y, Ueba T, Dimitriadis F, Shimizu S, Yokotani K, Saito M
Neuropharmacology   82 19-27   2014   [Refereed]
Shimizu S, Oikawa R, Tsounapi P, Inoue K, Shimizu T, Tanaka K, Martin DT, Honda M, Seijima T, Tomita S, Saito M
Andrology   2 458-465   2014   [Refereed]
Tanaka K, Shimizu T, Higashi Y, Nakamura K, Taniuchi K, Dimitriadis F, Shimizu S, Yokotani K, Saito M
Life Sci.   100 85-96   2014   [Refereed]
Tanaka K, Shimizu T, Yanagita T, Nemoto T, Nakamura K, Taniuchi K, Dimitriadis F, Yokotani K, Saito M
Br. J. Pharmacol.   171 202-213   2014   [Refereed]
The effect of an ARB, olmesartan on hypertension related corpus cavernsartanosum dysfunction in the spontenously hypertensive rat
Saito M, Shimizu S, Shimizu T
Neurourol. Urodyn.   33 731-732   2014   [Refereed]
Nakamura K, Shimizu T, Tanaka K, Taniuchi K, Yokotani K.
Eur. J. Pharmacol.,   694(1-3) 98-103   2012
Tanaka K, Shimizu T, Lu L, Nakamura K, Yokotani K.
Auton. Neurosci.   169 63-69   2012
Shimizu T, Tanaka K, Hasegawa T, Yokotani K.
Eur. J. Pharmacol.   654(3) 241-248   2011
Usui D, Yamaguchi-Shima N, Okada S, Shimizu T, Wakiguchi H, Yokotani K.
Auton. Neurosci.   147 33-37   2009
Usui D, Yamaguchi-Shima N, Okada S, Shimizu T, Wakiguchi H, Yokotani K.
Auton. Neurosci.   146 111-114   2009
Sasaki T, Shimizu T, Wakiguchi H, Yokotani K.
Eur. J. Pharmacol.   592 81-86   2008
Arai J, Okada S, Yamaguchi-Shima N, Shimizu T, Sasaki T, Yorimitsu M, Wakiguchi H, Yokotani K.
Clin. Exp. Phamacol. Physiol.   35 965-970   2008
Okada S, Yamaguchi-Shima N, Shimizu T, Arai J, Lu L, Wakiguchi H, Yokotani K.
Eur. J. Pharmacol.   587 322-329   2008
Okada S, Yamaguchi-Shima N, Shimizu T, Arai J, Yorimitsu M, Yokotani K.
Eur. J. Pharmacol.   586 145-150   2008
Okada S, Yamaguchi-Shima N, Shimizu T, Arai J, Yorimitsu M, Yokotani K.
Eur. J. Pharmacol.   584 207-212   2008
Bidirectional roles of the brain 2-arachidonoyl-sn-glycerol in the centrally administered vasopressin-induced adrenomedullary outflow in rats.
Shimizu T, Yokotani K.
Eur. J. Pharmacol.   582 62-69   2008

Misc

 
Brain zinc dyshomeostasis and glial cells in ischemic stroke
Higashi Y, Aratake T, Shimizu S, Shimizu T, Saito M
Nihon Yakurigaku Zasshi   154 138-142   2019   [Refereed][Invited]
Testicular torsion-detorsion and potential therapeutic treatments: a possible role for ischemic postconditioning
Shimizu S, Tsounapi P, Dimitriadis F, Higashi Y, Shimizu T, Saito M
Int. J. Urol.   23 454-463   2016   [Refereed]
Lower urinary tract symptoms as a vascular dysfunction: the effect of nicorandil as a vasodilator
Shimizu S, Shimizu T, Higashi Y, Saito M
Nihon Yakurigaku Zasshi   146 21-26   2015   [Refereed]
ヘモグロビン由来ペプチド・ヘモプレッシンによる交感神経—副腎髄質系賦活に対する中枢性制御
The Autonomic Nervous System (Journal of the Japan Society of Neurovegetative Research)   52 60-64   2015   [Refereed][Invited]
Shimizu S, Tsounapi P, Shimizu T, Honda M, Inoue K, Dimitriadis F, Saito M
Int. J. Urol.   21 856-864   2014   [Refereed]

Conference Activities & Talks

 
Blocking of central angiotensin II type 1 receptors inhibits micturition reflex in rats
Shimizu S, Shimizu T, Nagao Y, Kataoka T, Kamada S, Higashi Y, Aratake T, Zou S, Hamada T, Yamamoto M, Saito M
International Continence Society (ICS) 2019   Sep 2019   
Hydrogen sulfide-induced relaxation of the bladder is impaired in spontaneously hypertensive male rats
Zou S, Shimizu T, Yamamoto M, Shimizu S, Higashi Y, Saito M.
International Continence Society (ICS) 2019   Sep 2019   
Stimulation of brain nicotinic acetylcholine receptors can inhibit the micturition reflex in rats
Shimizu T, Shimizu Y, Ono H, Zou S, Yamamoto M, Shimizu S, Higashi Y, Aratake T, Hamada T, Nagao Y, Honda M, Saito M
International Continence Society (ICS) 2019   Sep 2019   
Possible role of hydrogen sulfide as an endogenous relaxation factor in the bladder and prostate of male rats
Zou S, Shimizu T, Shimizu S, Higashi Y, Ono H, Nakamura K, Aratake T, Yamamoto M, Hamada T, Nagao Y, Ueba Y, Saito M
The 7th China-Japan Joint Meeting of Basic and Clinical Pharmacology   Aug 2019   
Roles of brain nicotinic acetylcholine receptors in the rat micturition reflex
Shimizu T, Shimizu Y, Ono H, Zou S, Yamamoto M, Shimizu S, Higashi Y, Aratake T, Saito M
The 7th China-Japan Joint Meeting of Basic and Clinical Pharmacology   Aug 2019   
Brain nicotinic acetylcholine receptors stimulation inhibits the micturition reflex in rats
Shimizu T, Shimizu Y, Ono H, Zou S, Yamamoto M, Shimizu S, Higashi Y, Aratake T, Hamada T, Nagao Y, Saito M
The 14th Pan-Pacific Continence Society (PPCS) Meeting   Jul 2019   
Blocking of central angiotensin II type 1 receptors suppress micturition reflex in rats
Shimizu S, Shimizu T, Nagao Y, Nakamura K, Higashi Y, Aratake T, Zou S, Hamada T, Ueba Y, Yamamoto M, Honda M, Saito M
American Urological Association (AUA) Annual Meeting   May 2019   
Centrally administered bombesin induces frequent urination via brain corticotropin-releasing factor receptor type 1 in rats
Shimizu T, Zou S, Shimizu S, Wada N, Takai S, Shimizu N, Yamamoto M, Higashi Y, Yoshimura N, Saito M
American Urological Association (AUA) Annual Meeting   May 2019   
Activation of brain nicotinic acetylcholine receptors can suppress micturition reflex in rats
Shimizu T, Shimizu Y, Ono H, Zou S, Yamamoto M, Shimizu S, Higashi Y, Aratake T, Hamada T, Nagao Y, Ueba Y, Honda M, Saito M
American Urological Association (AUA) Annual Meeting   May 2019   
Possible role of endogenous hydrogen sulfide as a relaxation factor in the rat bladder and prostate
Zou S, Shimizu T, Shimizu S, Higashi Y, Ono H, Nakamura K, Aratake T, Yamamoto M, Hamada T, Nagao Y, Ueba Y, Saito M
The 13rd Pan-Pacific Continence Society (PPCS) Meeting   Oct 2018   
Nitric oxide in the brain induces frequent urination in rats
Ono H, Shimizu T, Shimizu S, Higashi Y, Zou S, Yamamoto M, Aratake T, Hamada T, Nagao Y, Ueba Y, Saito M
The 13rd Pan-Pacific Continence Society (PPCS) Meeting   Oct 2018   
Brain corticotropin-releasing factor receptor type 1 is involved in centrally administered bombesin-induced frequent urination in rats
Shimizu T, Zou S, Shimizu S, Wada N, Takai S, Shimizu N, Yamamoto M, Higashi Y, Yoshimura N, Saito M
International Continence Society (ICS) 2018   Aug 2018   
Hydrogen sulfide has a role as an endogenous relaxation factor in the bladder and prostate of male rats
Shimizu T, Zou S, Shimizu S, Higashi Y, Nakamura K, Ono H, Aratake T, Yamamoto M, Honda M, Saito M
International Continence Society (ICS) 2018   Aug 2018   
Nitric oxide centrally induces frequent urination in rats
Shimizu T, Ono H, Shimizu S, Higashi Y, Zou S, Yamamoto M, Aratake T, Hamada T, Nagao Y, Ueba Y, Honda M, Saito M
International Continence Society (ICS) 2018   Aug 2018   
Roles of brain nitric oxide in micturition of rats
Ono H, Shimizu T, Shimizu S, Higashi Y, Zou S, Yamamoto M, Aratake T, Hamada T, Nagao Y, Saito M
WCP2018 18th world congress of basic&clinical pharmacology   Jul 2018   
Endogenous hydrogen sulfide can function as a relaxation factor in the bladder and prostate of male rats
Zou S, Shimizu T, Shimizu S, Higashi Y, Ono H, Aratake T, Yamamoto M, Hamada T, Nagao Y, Saito M
WCP2018 18th world congress of basic&clinical pharmacology   Jul 2018   
Pharmacological studies on central regulation mechanisms for stress response. (The 33rd Encouragement of Young Investigator Award Lecture) [Invited]
SHIMIZU Takahiro
WCP2018 18th world congress of basic&clinical pharmacology   Jul 2018   
Stimulation of brain nicotinic acetylcholine receptors induces activation of central adrenomedullary outflow through protein S-nitrosylation in the rat brain
Shimizu T, Higashi Y, Yamamoto M, Tanaka K, Nakamura K, Yawata T, Zou S, Ueba T, Yuri K, Saito M
WCP2018 18th world congress of basic&clinical pharmacology   Jul 2018   
Hydrogen sulfide can function as an endogenous relaxation factor in the rat bladder and prostate
Shimizu T, Zou S, Shimizu S, Higashi Y, Ono H, Nakamura K, Aratake T, Yamamoto M, Hamada T, Nagao Y, Honda M, Saito M
American Urological Association (AUA) Annual Meeting   May 2018   
Brain nitric oxide can induce frequent urination in rats
Shimizu T, Ono H, Shimizu S, Higashi Y, Zou S, Yamamoto M, Aratake T, Hamada T, Nagao Y, Ueba Y, Honda M, Saito M
American Urological Association (AUA) Annual Meeting   May 2018   
Role of nerve growth factor in hyperexcitability of capsaicin sensitive bladder afferent neurons in spinal cord injured mice
Shimizu T, Majima T, Suzuki T, Shimizu N, Wada N, Kadekawa K, Takai S, Takaoka E, Kwon J, Tyagi P, Saito M, Yoshimura N
International Continence Society (ICS) 2017   Sep 2017   
Hydrogen sulfide can be an endogenous relaxation factor in the rat bladder and prostate
Shimizu T, Zou S, Shimizu S, Higashi Y, Nakamura K, Aratake T, Yamamoto M, Hamada T, Nagao Y, Saito M
International Continence Society (ICS) 2017   Sep 2017   
Nitric oxide-mediated S-nitrosylation can be involved in brain nicotinic acetylcholine receptors-mediated activation of central adrenomedullary outflow in rats
Shimizu T, Higashi Y, Yamamoto M, Tanaka K, Nakamura K, Shimizu S, Zou S, Yawata T, Ueba T, Yuri K, Saito M
The 15th Congress of the International Society for Autonomic Neuroscience held in conjunction with the 70th Annual Meeting of the Japan Society of Neurovegetative Research   Aug 2017   
Brain Serotoninergic Nervous System Is Involved in Bombesin-induced Frequent Urination in Rats. (2017 Diokno-Lapides Award Presentation) [Invited]
SHIMIZU Takahiro
American Urological Association (AUA) Annual Meeting   May 2017   
Effects of nerve growth factor neutralization on hyperexcitability of capsaicin sensitive bladder afferent neurons in mice with spinal cord injury
Shimizu T, Majima T, Suzuki T, Shimizu N, Wada N, Takai S, Takaoka E, Kwon J, Tyagi P, Yoshimura N
American Urological Association (AUA) Annual Meeting   May 2017   
Brain zinc modulates microglial activation phenotype via zinc-induced signaling pathway
Youichirou Higashi, Shogo Shimizu, Takahiro Shimizu, Motoaki Saito
2017   
HYPEREXCITABILITY OF CAPSAICIN SENSITIVE BLADDER AFFERENT NEURONS FROM MICE WITH NEUROGENIC DETRUSOR OVERACTIVITY INDUCED BY SPINAL CORD INJURY
Shimizu T, Majima T, Kadekawa K, Shimizu N, Wada N, Takai S, Tyagi P, Saito M, Yoshimura N
International Continence Society (ICS) 2016   Sep 2016   
PHARMACOLOGICAL CHARACTERIZATION OF BRAIN SEROTONIN RECEPTOR SUBTYPES INVOLVED IN BOMBESIN-INDUCED FREQUENT URINATION IN RATS
Shimizu T, Shimizu S, Wada N, Takai S, Shimizu N, Higashi Y, Kadekawa K, Majima T, Saito M, Yoshimura N
International Continence Society (ICS) 2016   Sep 2016   
Effects of a selective androgen receptor modulator, GSK2849466A and testosterone on stress urinary incontinence in ovariectomized rats
Shimizu T, Kadekawa K, Kawamorita N, Turnbull P, Russell A, Yoshimura N
American Urological Association (AUA) Annual Meeting   May 2016   
Effect of naftopidil on the brain noradrenaline-induced decrease of arginine-vasopressin secretion in rats
Shimizu T, Shimizu S, Higashi Y, Yamamoto M, Nakamura K, Yoshimura N, Saito M
American Urological Association (AUA) Annual Meeting   May 2016   
Brain serotonin and corticotropin-releasing factor are involved in bombesin-induced frequent urination in rats
Shimizu T, Shimizu S, Wada N, Takai S, Shimizu N, Kadekawa K, Majima T, Higashi Y, Saito M, Yoshimura N
American Urological Association (AUA) Annual Meeting   May 2016   
Bombesin, a Stress-related Neuropeptide, Centrally Induces Frequent Urination in Rats. (2016 Diokno-Lapides Award Presentation) [Invited]
SHIMIZU Takahiro
American Urological Association (AUA) Annual Meeting   May 2016   
Bombesin, a Stress-related Neuropeptide, Centrally Induces Frequent Urination in Rats. (2016 Diokno-Lapides Award Presentation) [Invited]
SHIMIZU Takahiro
Society of Urodynamics, Female pelivic medicine & Urogenital reconstruction (SUFU) 2016 Winter Meeting   Feb 2016   
BOMBESIN, A STRESS-RELATED NEUROPEPTIDE, CENTRALLY INDUCES FREQUENT URINATION IN THE RAT
Shimizu T, Shimizu S, Higashi Y, Nakamura K, Kadekawa K, Wada N, Majima T, Honda M, Yoshimura N, Saito M
International Continence Society (ICS) 2015   Oct 2015   
Endogenous hydrogen sulfide can function as a potent relaxing factor in the rat bladder and prostate
Shimizu T, Shimizu S, Nakamura K, Honda M, Inoue K, Saito M
The 10th Pan-Pacific Continence Society (PPCS) Meeting   Sep 2015   
Hydrogen sulfide is a potent relaxing factor in the rat bladder and prostate
Shimizu T, Shimizu S, Nakamura K, Honda M, Inoue K, Saito M
American Urological Association (AUA) Annual Meeting   May 2015   
Inhibitory involvement of brain cannabinoid CB1 receptors in central activation of sympatho-adrenomedullary outflow induced by bombesin microinjected into the rat hypothalamic paraventricular nucleus
Shimizu T, Tanaka K, Nakamura K, Taniuchi K, Shimizu S, Yawata T, Higashi Y, Ueba T, Yokotani K, Saito M
WCP2014 17th world congress of basic&clinical pharmacology   Jul 2014   
Endogenously generated 2-arachidonoylglycerol plays an inhibitory role in the bombesin-induced activation of central adrenomedullary outflow in rats.
5th International Peptide Symposium in conjunction with 47th Japanese Peptide Symposium   2010   
Possible inhibitory roles of endogenous 2-arachidonoylglycerol during corticotropin-releasing factor-induced activation of central sympatho-adrenomedullary outflow in anesthetized rats.
Keystone Symposia Conference: Bioactive lipids: Biochemistry and Diseases   2010   
Endogenously generated 2-arachidonoylglycerol plays an inhibitory role in corticotropin-releasing factor-induced activation of central sympatho-adrenomedullary outflow in rats.
The 14th International Congress of Endocrinology   2010   
Noradrenaline release in the hypothalamic paraventricular nucleus is involved in the NMDA-induced elevation of adrenomedullary outflow in rats.
NEUROSCIENCE 2007 SfN 37th Annual Meeting   2007   
Activation of spinally projecting neurons expressing cyclooxygenase isozymes by centrally administered corticotropin-releasing factor in the rat brain.
NEUROSCIENCE 2007 SfN 37th Annual Meeting   2007   
Roles of brain PI-PLC/diacylglycerol lipase in centrally administered histamine-induced adrenomedullary outflow in rats.
The 5th Congress of the International Society for Autonomic Neuroscience held in conjunction with the 60th Annual Meeting of the Japan Society of Neurovegetative Research   2007   
Role of K+ channels in prostanoid EP3 and TP receptors-mediated inhibition of noradrenaline release fro the rat stomach.
The 15th World Congress of Pharmacology   2006   
Characterization of brain cyclooxygenase involved in CRF-induced central activation of sympathoadrenomedullary outflow in rats.
The 15th World Congress of Pharmacology   2006   
Adrenal and sympathetic noradrenaline release were separately controlled by centrally administered arginine-vasopressin and corticotropin-releasing factor in rats.
The 3rd Takeda Science Foundation Symposium on PharmaScience   2005   
Involvement of brain phospholipase C and diacylglycerol lipase in the bombesin BB2 receptor-mediated activation of adrenomedullary outflow in rats.
The 3rd Takeda Science Foundation Symposium on PharmaScience   2005   
Centrally applied corticotropin-releasing factor elevates plasma corticosterone by activation of α3β2 nicotinic acetylcholine receptor- and prostaglandin-mediated noradrenergic neuron projection to the hypothalamic paraventricular nucleus in rats.
NEUROSCIENCE 2005 SfN 35th Annual Meeting   2005   
Brain prostanoid TP receptor-mediated adrenal noradrenaline secretion and EP3 receptor-mediated sympathetic noradrenaline release in rats.
NEUROSCIENCE 2005 SfN 35th Annual Meeting   2005   
Adrenal and sympathetic noradrenaline release were separately controlled by centrally administered arginine-vasopressin and corticotropin-releasing factor in rats.
NEUROSCIENCE 2005 SfN 35th Annual Meeting   2005   
Brain phospholipase C/diacylglycerol lipase are involved in the bombesin BB2 receptor-mediated activation of adrenomedullary outflow in rats.
NEUROSCIENCE 2005 SfN 35th Annual Meeting   2005   
Extrahypothalamic corticotropin-releasing factor activates the hypothalamic-pituitary-adrenal axis by activation of the noradrenergic system originated from locus coeruleus in rats.
20th Biennial Meeting of the International Society for Neurochemistry jointly with the European Society for Neurochemistry   2005   
Centrally administered bombesin elicits adrenal noradrenaline release by brain thromboxane A2-mediated mechanisms in rats.
5th WORLD CONGRESS ON STRESS   2004   
Centrally administered arginine-vasopressin elicites adrenal noradrenaline release by brain thromboxane A2-mediated mechanisms in rats.
5th WORLD CONGRESS ON STRESS   2004   
Involvement of brain phospholipase C and diacylglycerol lipase in the arginine-vasopressin-induced activation of the central sympatho-adrenomedullary outflow in rats.
5th WORLD CONGRESS ON STRESS   2004   

Research Grants & Projects

 
Mechanisms for the activation of the central sympatho-adrenomedullary outflow
Basic Science Research on Life Science
Project Year: 2003   
The sympatho-adrenomedullary system plays an important role in physiological and pathophysiological responses to stressors. We have already reported that the brain prostanoids, especially prostaglandin E2 and thromboxane A2, play a critical role i...