西原利治 (Toshiji Saibara) - マイポータル

基本情報

所属: 高知大学医学部特任教授

学位: 医学博士(京都大学)
Dr. Med. Sci (Thesis) Kyoto University Digestive organs internal medicine(Kyoto University)
Assessment of Lymphokine Activated Killer Cell Activity and its Clinical Application in Adoptive Immunotherapy in Hepatocellular Carcinoma

J-GLOBAL ID: 200901073137794158
researchmap会員ID: 5000062506

外部リンク: http://www.kochi1nai.jp/

研究キーワード

研究分野

経歴

2003年 - 2009年

高知大学助教授
2009年

- 高知大学教授
2003年 - 2003年

高知医科大学助教授

委員歴

論文

Epidemiological survey of hemoglobin A1c and liver fibrosis in a general population with non-alcoholic fatty liver disease.

Tanaka K, Takahashi H, Hyogo H, Ono M, Oza N, Kitajima Y, Kawanaka M, Chayama K, Saibara T, Anzai K …

Hepatology research : the official journal of the Japan Society of Hepatology 49(3) 296-303 2019年3月査読有り
Clinical features of hepatocellular carcinoma in nonalcoholic fatty liver disease patients without advanced fibrosis.

Kodama K, Kawaguchi T, Hyogo H, Nakajima T, Ono M, Seike M, Takahashi H, Nozaki Y, Kawanaka M, Tanaka S …

Journal of gastroenterology and hepatology 34(9) 1626-1632 2019年1月査読有り
The novel cutoff points for the FIB4 index categorized by age increase the diagnostic accuracy in NAFLD: a multi-center study.

Ishiba H, Sumida Y, Tanaka S, Yoneda M, Hyogo H, Ono M, Fujii H, Eguchi Y, Suzuki Y, Yoneda M …

Journal of gastroenterology 53(11) 1216-1224 2018年11月査読有り
Correction to: The novel cutoff points for the FIB4 index categorized by age increase the diagnostic accuracy in NAFLD: a multi-center study.

Ishiba H, Sumida Y, Tanaka S, Yoneda M, Hyogo H, Ono M, Fujii H, Eguchi Y, Suzuki Y, Yoneda M …

Journal of gastroenterology 53(11) 1225 2018年11月査読有り
A Data Mining-based Prognostic Algorithm for NAFLD-related Hepatoma Patients: A Nationwide Study by the Japan Study Group of NAFLD.

Kawaguchi T, Tokushige K, Hyogo H, Aikata H, Nakajima T, Ono M, Kawanaka M, Sawada K, Imajo K, Honda K …

Scientific reports 8(1) 10434-10434 2018年7月査読有り
New scoring system combining the FIB-4 index and cytokeratin-18 fragments for predicting steatohepatitis and liver fibrosis in patients with nonalcoholic fatty liver disease

Toshifumi Tada, Takashi Kumada, Hidenori Toyoda, Toshiji Saibara, Masafumi Ono, Masayoshi Kage

Biomarkers 23(4) 328-334 2018年5月19日査読有り
Prevalence of pruritus in patients with chronic liver disease: A multicenter study.

Satoshi Oeda, Hirokazu Takahashi, Hisako Yoshida, Yuji Ogawa, Kento Imajo, Masato Yoneda, Yuichi Koshiyama, Masafumi Ono, Hideyuki Hyogo, Takumi Kawaguchi …

Hepatology research : the official journal of the Japan Society of Hepatology 48(3) E252-E262-E262 2018年2月査読有り
Evaluation of postprandial hypoglycemia in patients with nonalcoholic fatty liver disease by oral glucose tolerance testing and continuous glucose monitoring

Yusuke Oki, Masafumi Ono, Hideyuki Hyogo, Tsunehiro Ochi, Kensuke Munekage, Yasuko Nozaki, Akira Hirose, Kosei Masuda, Hiroshi Mizuta, Nobuto Okamoto …

European Journal of Gastroenterology and Hepatology 30(7) 797-805 2018年査読有り
Use of Mac-2 binding protein as a biomarker for nonalcoholic fatty liver disease diagnosis.

Yoshihiro Kamada, Masafumi Ono, Hideyuki Hyogo, Hideki Fujii, Yoshio Sumida, Makoto Yamada, Kojiroh Mori, Saiyu Tanaka, Tomohiro Maekawa, Yusuke Ebisutani …

Hepatology communications 1(8) 780-791 2017年10月査読有り
Analysis of factors influencing glucose tolerance in Japanese patients with non-alcoholic fatty liver disease

Satoko Ohmi, Masafumi Ono, Hiroshi Takata, Seiki Hirano, Shogo Funakoshi, Yuichi Nishi, Kumiko Yoshimura, Eri Amano, Yoshio Terada, Toshiji Saibara …

DIABETOLOGY & METABOLIC SYNDROME 9 65 2017年9月査読有り
Clinical efficacy of combination therapy with ME3738 and pegylated interferon-alpha-2a in patients with hepatitis C virus genotype 1

Toshiji Saibara, Nobuyuki Enomoto, Shuichi Kaneko, Kazuaki Chayama, Michio Sata, Michio Imawari, Saburo Onishi, Kiwamu Okita

HEPATOLOGY RESEARCH 44(4) 410-419 2014年4月査読有り
Noninvasive scoring systems in patients with nonalcoholic fatty liver disease with normal alanine aminotransferase levels

Masato Yoneda, Kento Imajo, Yuichiro Eguchi, Hideki Fujii, Yoshio Sumida, Hideyuki Hyogo, Masafumi Ono, Yasuaki Suzuki, Takumi Kawaguchi, Noriaki Aoki …

JOURNAL OF GASTROENTEROLOGY 48(9) 1051-1060 2013年9月査読有り
Liver acid sphingomyelinase inhibits growth of metastatic colon cancer

Yosuke Osawa, Atsushi Suetsugu, Rie Matsushima-Nishiwaki, Ichiro Yasuda, Toshiji Saibara, Hisataka Moriwaki, Mitsuru Seishima, Osamu Kozawa

Journal of Clinical Investigation 123(2) 834-843 2013年2月1日査読有り
17β-Estradiol is critical for the preovulatory induction of prostaglandin E(2) synthesis in mice.

Toda K, Ono M, Yuhki K, Ushikubi F, Saibara T

Molecular and cellular endocrinology 362(1-2) 176-182 2012年10月査読有り
Clinical and pathological progression of non-alcoholic steatohepatitis to hepatocellular carcinoma

Kohichiroh Yasui, Etsuko Hashimoto, Katsutoshi Tokushige, Kazuhiko Koike, Toshihide Shima, Yoshihiro Kanbara, Toshiji Saibara, Hirofumi Uto, Shiro Takami, Miwa Kawanaka …

HEPATOLOGY RESEARCH 42(8) 767-773 2012年8月査読有り
[Glucose intolerance in chronic liver disease].

Saibara T, Hashiba M, Ono M

Nihon rinsho. Japanese journal of clinical medicine 70 Suppl 5 165-169 2012年7月査読有り
Genetic Polymorphisms of the Human PNPLA3 Gene Are Strongly Associated with Severity of Non-Alcoholic Fatty Liver Disease in Japanese

Takahisa Kawaguchi, Yoshio Sumida, Atsushi Umemura, Keitaro Matsuo, Meiko Takahashi, Toshinari Takamura, Kohichiroh Yasui, Toshiji Saibara, Etsuko Hashimoto, Miwa Kawanaka …

PLOS ONE 7(6) e38322 2012年6月査読有り
BART Inhibits Pancreatic Cancer Cell Invasion by Rac1 Inactivation through Direct Binding to Active Rac1

Keisuke Taniuchi, Kunihiko Yokotani, Toshiji Saibara

NEOPLASIA 14(5) 440-+ 2012年5月査読有り
BART inhibits pancreatic cancer cell invasion by PKCα inactivation through binding to ANX7.

Taniuchi K, Yokotani K, Saibara T

PloS one 7(4) e35674 2012年4月査読有り
Abnormality in Expression Levels of Gluconeogenesis Related Genes by High-Dose Supplementation with Pyridoxamine in Mice

Huong Thi Viet Do, Katsumi Toda, Toshiji Saibara, Toshiharu Yagi

INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH 82(1) 34-40 2012年2月査読有り

MISC

Noninvasive scoring systems in patients with nonalcoholic fatty liver disease with normal alanine aminotransferase levels

Masato Yoneda, Kento Imajo, Yuichiro Eguchi, Hideki Fujii, Yoshio Sumida, Hideyuki Hyogo, Masafumi Ono, Yasuaki Suzuki, Takumi Kawaguchi, Noriaki Aoki …

JOURNAL OF GASTROENTEROLOGY 48(9) 1051-1060 2013年9月
17β-Estradiol is critical for the preovulatory induction of prostaglandin E(2) synthesis in mice.

Toda K, Ono M, Yuhki K, Ushikubi F, Saibara T

Mol Cell Endocrinol. 362(1-2) 176-182 2012年10月
Clinical and pathological progression of non-alcoholic steatohepatitis to hepatocellular carcinoma

Kohichiroh Yasui, Etsuko Hashimoto, Katsutoshi Tokushige, Kazuhiko Koike, Toshihide Shima, Yoshihiro Kanbara, Toshiji Saibara, Hirofumi Uto, Shiro Takami, Miwa Kawanaka …

HEPATOLOGY RESEARCH 42(8) 767-773 2012年8月
Genetic Polymorphisms of the Human PNPLA3 Gene Are Strongly Associated with Severity of Non-Alcoholic Fatty Liver Disease in Japanese

Takahisa Kawaguchi, Yoshio Sumida, Atsushi Umemura, Keitaro Matsuo, Meiko Takahashi, Toshinari Takamura, Kohichiroh Yasui, Toshiji Saibara, Etsuko Hashimoto, Miwa Kawanaka …

PLOS ONE 7(6) e38322. 2012年6月
BART Inhibits Pancreatic Cancer Cell Invasion by Rac1 Inactivation through Direct Binding to Active Rac1

Keisuke Taniuchi, Kunihiko Yokotani, Toshiji Saibara

NEOPLASIA 14(5) 440-+ 2012年5月
Prevalence and associated metabolic factors of nonalcoholic fatty liver disease in the general population from 2009 to 2010 in Japan: a multicenter large retrospective study

Yuichiro Eguchi, Hideyuki Hyogo, Masafumi Ono, Toshihiko Mizuta, Naofumi Ono, Kazuma Fujimoto, Kazuaki Chayama, Toshiji Saibara

JOURNAL OF GASTROENTEROLOGY 47(5) 586-595 2012年5月
BART inhibits pancreatic cancer cell invasion by PKCα inactivation through binding to ANX7.

Taniuchi K, Yokotani K, Saibara T

PLoS One. 7(4) e35674 2012年4月
Is impaired Kupffer cell function really important to the pathogenesis of nonalcoholic steatohepatitis?

Masafumi Ono, Toshiji Saibara

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 27(4) 622-624 2012年4月
Usefulness of Technetium-99 m-2-methoxy-isobutyl-isonitrile liver scintigraphy for evaluating disease activity of non-alcoholic fatty liver disease

Kosei Masuda, Masafumi Ono, Mitsutaka Fukumoto, Akira Hirose, Kensuke Munekage, Tsunehiro Ochi, Nobuto Okamoto, Naoki Akagi, Yasuhiro Ogawa, Toshiji Saibara

HEPATOLOGY RESEARCH 42(3) 273-279 2012年3月
Abnormality in Expression Levels of Gluconeogenesis Related Genes by High-Dose Supplementation with Pyridoxamine in Mice

Huong Thi Viet Do, Katsumi Toda, Toshiji Saibara, Toshiharu Yagi

INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH 82(1) 34-40 2012年2月
Liver acid sphingomyelinase inhibits growth of metastatic colon cancer.

Osawa Y, Suetsugu A, Matsushima-Nishiwaki R, Yasuda I, Saibara T, Moriwaki H, Seishima M, Kozawa O

J Clin Invest 2012年
Validation of the FIB4 index in a Japanese nonalcoholic fatty liver disease population

Yoshio Sumida, Masato Yoneda, Hideyuki Hyogo, Yoshito Itoh, Masafumi Ono, Hideki Fujii, Yuichiro Eguchi, Yasuaki Suzuki, Noriaki Aoki, Kazuyuki Kanemasa …

BMC GASTROENTEROLOGY 12 2 2012年1月
Impact of Ovarian Sex Steroids on Ovulation and Ovulatory Gene Induction in Aromatase-Null Mice

Katsumi Toda, Yoshihiro Hayashi, Masafumi Ono, Toshiji Saibara

ENDOCRINOLOGY 153(1) 386-394 2012年1月
Angiotensinogen gene haplotype is associated with the prevalence of Japanese non-alcoholic steatohepatitis

Masafumi Ono, Tsunehiro Ochi, Kensuke Munekage, Mitsunari Ogasawara, Akira Hirose, Yasuko Nozaki, Masaya Takahashi, Nobuto Okamoto, Toshiji Saibara

HEPATOLOGY RESEARCH 41(12) 1223-1229 2011年12月
Overexpression of GalNAc-transferase GalNAc-T3 promotes pancreatic cancer cell growth

K. Taniuchi, R. L. Cerny, A. Tanouchi, K. Kohno, N. Kotani, K. Honke, T. Saibara, M. A. Hollingsworth

ONCOGENE 30(49) 4843-4854 2011年12月
BART inhibits pancreatic cancer cell invasion by inhibiting ARL2-mediated RhoA inactivation

Keisuke Taniuchi, Shinji Iwasaki, Toshiji Saibara

INTERNATIONAL JOURNAL OF ONCOLOGY 39(5) 1243-1252 2011年11月
Platelet count for predicting fibrosis in nonalcoholic fatty liver disease

Masato Yoneda, Hideki Fujii, Yoshio Sumida, Hideyuki Hyogo, Yoshito Itoh, Masafumi Ono, Yuichiro Eguchi, Yasuaki Suzuki, Noriaki Aoki, Kazuyuki Kanemasa …

JOURNAL OF GASTROENTEROLOGY 46(11) 1300-1306 2011年11月
Characteristics of Patients With Nonalcoholic Steatohepatitis Who Develop Hepatocellular Carcinoma

Kohichiroh Yasui, Etsuko Hashimoto, Yasuji Komorizono, Kazuhiko Koike, Shigeki Arii, Yasuharu Imai, Toshihide Shima, Yoshihiro Kanbara, Toshiji Saibara, Takahiro Mori …

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY 9(5) 428-433 2011年5月
A novel and comprehensive mouse model of human non-alcoholic steatohepatitis with the full range of dysmetabolic and histological abnormalities induced by gold thioglucose and a high-fat diet

Mitsunari Ogasawara, Akira Hirose, Masafumi Ono, Kosuke Aritake, Yasuko Nozaki, Masaya Takahashi, Nobuto Okamoto, Shuji Sakamoto, Shinji Iwasaki, Taketoshi Asanuma …

LIVER INTERNATIONAL 31(4) 542-551 2011年4月
A simple clinical scoring system using ferritin, fasting insulin, and type IV collagen 7S for predicting steatohepatitis in nonalcoholic fatty liver disease

Yoshio Sumida, Masato Yoneda, Hideyuki Hyogo, Kanji Yamaguchi, Masafumi Ono, Hideki Fujii, Yuichiro Eguchi, Yasuaki Suzuki, Shunsuke Imai, Kazuyuki Kanemasa …

JOURNAL OF GASTROENTEROLOGY 46(2) 257-268 2011年2月

もっとみる

書籍等出版物

NASH診療best approach

中外医学社 2008年 (ISBN: 9784498142022)
NASH診療ハンドブック

中外医学社 2007年 (ISBN: 9784498042926)

所属学協会

共同研究・競争的資金等の研究課題

非アルコール性脂肪肝炎発症機序の解明及び治療法に関する日米協力プログラム

国際共同研究 2000年 - 2005年
NASH Project

International Joint Research Projects 2000年 - 2005年

産業財産権

Provisional US patent application (Method for detecting a risk of lipid metabolism deficiency, and a test agent used thereafter.）