論文

査読有り
2015年12月

Liquid-theory analogy of direct-coupling analysis of multiple-sequence alignment and its implications for protein structure prediction

Biophysics and Physicobiology
  • Akira R. Kinjo

12
開始ページ
117
終了ページ
119
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.2142/biophysico.12.0_117
出版者・発行元
一般社団法人 日本生物物理学会

The direct-coupling analysis is a powerful method for protein contact prediction, and enables us to extract "direct" correlations between distant sites that are latent in "indirect" correlations observed in a protein multiple-sequence alignment. I show that the direct correlation can be obtained by using a formulation analogous to the Ornstein-Zernike integral equation in liquid theory. This formulation intuitively illustrates how the indirect or apparent correlation arises from an infinite series of direct correlations, and provides interesting insights into protein structure prediction.

リンク情報
DOI
https://doi.org/10.2142/biophysico.12.0_117
CiNii Articles
http://ci.nii.ac.jp/naid/130005131091
URL
https://jlc.jst.go.jp/DN/JLC/20018518281?from=CiNii
ID情報
  • DOI : 10.2142/biophysico.12.0_117
  • ISSN : 2189-4779
  • CiNii Articles ID : 130005131091

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