2015年12月
Liquid-theory analogy of direct-coupling analysis of multiple-sequence alignment and its implications for protein structure prediction
Biophysics and Physicobiology
- 巻
- 12
- 号
- 開始ページ
- 117
- 終了ページ
- 119
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.2142/biophysico.12.0_117
- 出版者・発行元
- 一般社団法人 日本生物物理学会
The direct-coupling analysis is a powerful method for protein contact prediction, and enables us to extract "direct" correlations between distant sites that are latent in "indirect" correlations observed in a protein multiple-sequence alignment. I show that the direct correlation can be obtained by using a formulation analogous to the Ornstein-Zernike integral equation in liquid theory. This formulation intuitively illustrates how the indirect or apparent correlation arises from an infinite series of direct correlations, and provides interesting insights into protein structure prediction.
- リンク情報
- ID情報
-
- DOI : 10.2142/biophysico.12.0_117
- ISSN : 2189-4779
- CiNii Articles ID : 130005131091