論文

査読有り
1999年

Involvement of nitric oxide in itch-scratch response of NC mice

Folia Pharmacologica Japonica
  • Y. Tsukumo
  • ,
  • T. Andoh
  • ,
  • T. Yamaguchi
  • ,
  • H. Nojima
  • ,
  • Y. Kuraishi

114
1
開始ページ
17P
終了ページ
21P
記述言語
日本語
掲載種別
研究論文(学術雑誌)
DOI
10.1254/fpj.114.supplement_17

NC mice, a model for atopic dermatitis, showed scratching behavior when kept under conventional environment. The scratching behavior of NC mice was suppressed by distraction or by the administration of naltrexone (1 mg/kg, s.c.), an opioid antagonist. These results suggest that such scratching behavior is itch-associated response. The itch-associated response of the NC mice was significantly suppressed by an intravenous injection of nitric oxide (NO) synthase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME, 10 mg/kg), but not D-NAME (10 mg/kg) and saline. Intracutaneous NO production in the rostral back, a region which the NC mice mainly scratched, was markedly increased as compared with thc caudal back, a non-scratched region. The increased NO production in the rostral back of NC mice was decreased by the intravenous injection of L-NAME (10 mg/kg). These results suggest that NO and NO sythase are now target in the treatment of atopic pruritus.

リンク情報
DOI
https://doi.org/10.1254/fpj.114.supplement_17
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/10629849
ID情報
  • DOI : 10.1254/fpj.114.supplement_17
  • ISSN : 0015-5691
  • PubMed ID : 10629849
  • SCOPUS ID : 0032705618

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