1999年
Involvement of nitric oxide in itch-scratch response of NC mice
Folia Pharmacologica Japonica
- ,
- ,
- ,
- ,
- 巻
- 114
- 号
- 1
- 開始ページ
- 17P
- 終了ページ
- 21P
- 記述言語
- 日本語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1254/fpj.114.supplement_17
NC mice, a model for atopic dermatitis, showed scratching behavior when kept under conventional environment. The scratching behavior of NC mice was suppressed by distraction or by the administration of naltrexone (1 mg/kg, s.c.), an opioid antagonist. These results suggest that such scratching behavior is itch-associated response. The itch-associated response of the NC mice was significantly suppressed by an intravenous injection of nitric oxide (NO) synthase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME, 10 mg/kg), but not D-NAME (10 mg/kg) and saline. Intracutaneous NO production in the rostral back, a region which the NC mice mainly scratched, was markedly increased as compared with thc caudal back, a non-scratched region. The increased NO production in the rostral back of NC mice was decreased by the intravenous injection of L-NAME (10 mg/kg). These results suggest that NO and NO sythase are now target in the treatment of atopic pruritus.
- リンク情報
- ID情報
-
- DOI : 10.1254/fpj.114.supplement_17
- ISSN : 0015-5691
- PubMed ID : 10629849
- SCOPUS ID : 0032705618