YOSHIKAWA Yoko

J-GLOBAL         Last updated: Sep 26, 2019 at 09:04
 
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Name
YOSHIKAWA Yoko
Nickname
yokoyosh
E-mail
yokoyoshmed.kobe-u.ac.jp
Affiliation
Kobe University
Section
Graduate School of Medicine
Job title
Assistant Professor
Degree
PhD.(Kobe University)

Research Interests

 
 

Research Areas

 
 

Academic & Professional Experience

 
2011
 - 
Mar 2016
Assistant Professor, Graduate School of Medicine, Kobe University
 
Apr 2007
 - 
Mar 2011
Postdoctoral Fellow, Graduae Shool of Medicine, Kobe University
 

Education

 
Apr 1985
 - 
Mar 1989
Biolgy, Faculty of Science, Kobe Univerity
 
Apr 1989
 - 
Mar 1991
Biology, Graduate School of Science, Kob Univesity
 
Apr 2003
 - 
Sep 2007
Molecular Biology, Graduate School of Medicine, Kobe University
 

Awards & Honors

 
Jul 2019
Ras inhibitors: Potential agents having both anti-proliferative and anti-metastatic properties, Outstanding research achivement and contribution to APSBMS, Asia Pacific Society for Biology and Medical Sciences
 
Oct 2013
新規Ras機能阻害剤Kobe0065ファミリー化合物のがん転移抑制メカニズムの解析, 第1回新緑会ヤングインベスティゲーターアワード優秀賞, 神戸大学 新緑会
Winner: Yoshikawa Yoko
 
Feb 2008
低分子量GTP結合蛋白質Rasを標的とした新規抗癌剤の探索, 神戸大学大学院医学系研究科 優秀賞, 神戸大学大学院医学系研究科
Winner: Yoshikawa Yoko
 
Dec 2006
RA-GEF-2 mediates a crosstalk between small GTPases M-Ras and Rap1 to control integrin-dependent cell adhesion in lymphocytes, The Best Presentation Award, Kobe University 21th Century COE Program International Symposium
Winner: Yoshikawa Yoko
 

Published Papers

 
Phospholipase Cε plays a crucial role in neutrophilic inflammation accompanying acute lung injury through augmentation of CXC chemokine production from alveolar epithelial cells
Umezawa K, Nagano Tatsuya, Kobayashi Kazuyuki, Dokuni R, Katsurada M, Yamamoto Masatsugu, Yoshikawa Yoko, Kataoka T, Nishimura Yoshihiro
Respir Res   20(1) 9   Jan 2019   [Refereed]
UMEZAWA KANOKO, NAGANO TATSUYA, KOBAYASHI KAZUYUKI, DOKUNI RYOTA, KATSURADA MASAHIRO, YAMAMOTO MASATSUGU, YOSHIKAWA YOKO, KATAOKA TOHRU, NISHIMURA YOSHIHIRO
Respiratory Research   20(9) 1-12   Jan 2019   [Refereed]
Background: We have shown that phospholipase Cε (PLCε), an effector of Ras and Rap1 small GTPases, plays pivotal roles in inflammation and inflammation-associated carcinogenesis by augmenting proinflammatory cytokine production from epithelial cel...
Molecular Basis for Allosteric Inhibition of GTP-Bound H-Ras Protein by a Small-Molecule Compound Carrying a Naphthalene Ring.
Matsumoto S, Hiraga T, Hayashi Y, Yoshikawa Yoko, Tsuda C, Araki M, Neya M, SHIMA FUMI, Kataoka Tohru
Biochemistry   57(36) 5350-5358   Sep 2018   [Refereed]
Yoshikawa Yoko, TakanoO, KatoI, TakahashiY, Shima Fumi, Kataoka Tohru
Cancer Lett   410 82-91   Dec 2017   [Refereed]

Misc

 
Shima Fumi, MatsumotoS, Yoshikawa Yoko, Kawamura Takashi, Isa Masayuki, Kataoka Tohru
J Biochem   158(2) 91-99   Aug 2015   [Refereed]
rasがん遺伝子産物の新規立体構造情報を利用した分子標的がん治療薬の開発
Shima Fumi, 熊坂崇, Matsumoto Shigeyuki, Yoshikawa Yoko, 山本雅貴, Kataoka Tohru
日本放射光学会誌 放射光   27(1) 3-9   2014   [Refereed]

Books etc

 
ras がん遺伝子産物 Ras を分子標的としたがん治療薬開発の現状
SHIMA FUMI, Matsumoto Shigeyuki, Yoshikawa Yoko, Kataoka Tohru (Part:Joint Work)
がん分子標的治療   2015   
The Enzymes, Vol. 34, Inhibitors of the Ras superfamily G-proteins, Part B / Discovery of Small-Molecule Ras Inhibitors that Display Antitumor Activity by Interfering with Ras・GTP?Effector Interaction
Yoshikawa Yoko, Matsumoto Shigeyuki, Kataoka Tohru
Elsevier Inc.   Dec 2013   

Conference Activities & Talks

 
Development of Anti-Cancer and Anti-Inflammatory Drugs Targeting Phospholipase Cε
Yoshikawa Yoko, Naoto Fujishima, Aki Emi, Ning Ma, Masayuki Isa, Edamatsu Hironori, Kataoka Tohru
2018 Keystone Symposia Conference   Feb 2018   
Development of Anti-Cancer and Anti-Inflammatory Drugs Targeting Phospholipase Cε(ポスター発表)
Yoshikawa Yoko, Naoto Fujishima, Aki Emi, Ning Ma, Masayuki Isa, Edamatsu Hironori, Kataoka Tohru
2018 Keystone Symposia Conference   Feb 2018   Keystone Symposia on Molecular and Cellular Biology
Novel effect of Ras inhibitor and its application to cancer therapy
森元 智行, Yoshikawa Yoko, 白川 慶徳, MORI ICHIRO, Kataoka Tohru, Shima Fumi
2017年度生命科学系学会合同年次大会(第40回日本分子生物学会年会 第90回日本生化学会大会)   Dec 2017   日本分子生物学会日本生化学会
Anti-Cancer and anti-inflammatory effect of specific inhibitors for Phospholipase Ce (PLCe)
藤島 尚人, Yoshikawa Yoko, 衣斐 亜希, 馬 寧, 伊佐 真幸, Edamatsu Hironori, Kataoka Tohru
2017年度生命科学系学会合同年次大会(第40回日本分子生物学会年会 第90回日本生化学会大会)   Dec 2017   
Structural basis for the intramolecular interaction to assemble the c-Raf-1 recognition site in posttranslationally modified H-Ras•GTP
Matsumoto Shigeyuki, 柯 浩亮, 村嶋 陽亮, Taniguchi Haruka, 宮本 涼生, Yoshikawa Yoko, 津田 智恵美, 熊坂 崇, 溝端 栄一, Edamatsu Hironori, Kataoka Tohru
2017年度生命科学系学会合同年次大会(第40回日本分子生物学会年会 第90回日本生化学会大会)   Dec 2017   

Teaching Experience