Hisao Masai

J-GLOBAL         Last updated: Nov 30, 2018 at 11:05
 
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Name
Hisao Masai
E-mail
masai-hsigakuken.or.jp
Affiliation
, Tokyo Metropolitan Institute of Medical Science
Section
Genome Dynamics Projedt
Job title
Project Leader
Degree
Ph.D.

Research Areas

 
 

Academic & Professional Experience

 
Apr 2018
 - 
Today
Director General, Tokyo Metropolitan Institute of Medical Science
 
2005
   
 
- Visiting Professor, Tokyo University of Science
 
2005
   
 
- Visiting Professor, Tokyo Medical and Dental University
 
2005
   
 
- Project Leader, Genome Dynamics Project, Tokyo Metropolitan
 
2004
   
 
- Visiting Professor, Department of Integrative Biosciences,
 
Jul 1995
 - 
Dec 2000
Assistant Professor, Institute of Medical Science University of Tokyo
 
1995
 - 
2000
Associate Professor, Department of Molecular and Developmental
 
2000
   
 
- Laboratory head, Department of Cell Biology, Tokyo Metropolitan
 
2000
   
 
- Visiting Lecturer, Nogoya University
 
1997
 - 
1999
Visiting Associate Professor, Bioresponse Regulation Laboratory,
 
Apr 1990
 - 
Jul 1995
Associate Professor, Tokyo Metropolitan Institute of Medical Science
 
1990
 - 
1995
Assistant professor, Department of Molecular and Developmental
 
1986
   
 
Post doctoral fellow at Department of Molecular Biology,
 
 
   
 
Institute of Medical Science
 
 
   
 
Graduate School of Frontier Sciences, The University of Tokyo
 
 
   
 
Institute of Medical Science
 
 
   
 
Virus Institute, University of Kyoto
 
 
   
 
Biology Institute of Medical Science, University of Tokyo
 
 
   
 
Biology Institute of Medical Science, University of Tokyo
 
 
   
 
Palo Alto, California, USA
 

Education

 
 
 - 
1987
Biochemistry, Graduate School, Division of Science, University of Tokyo, graduate school
 
 
 - 
1981
Department of Biophysics and Biochenistry, Faculty of Science, University of Tokyo
 

Awards & Honors

 
Oct 2012
Arthur Kornberg Memorial Lecture Award, A-IMBN (Asian International Molecular Biology Network)
Winner: Masai Hisao
 

Published Papers

 
Masai H, Kakusho N, Fukatsu R, Ma Y, Iida K, Kanoh Y, Nagasawa K
The Journal of biological chemistry   293(44) 17033-17049   Nov 2018   [Refereed]
Study Break: Cell Timer/Cell Clock
Ghadiri H, Alavi S, Dabirmanesh B, Moriyama K, Khajeh K, Masai H
Iranian biomedical journal   22(6) 360-361   Nov 2018   [Refereed]
Iguchi T, Miyauchi E, Watanabe S, Masai H, Miyatake S
Biochemical and biophysical research communications   501(2) 570-575   Jun 2018   [Refereed]
Moriyama K, Yoshizawa-Sugata N, Masai H
The Journal of biological chemistry   293(10) 3607-3624   Mar 2018   [Refereed]
Masai H, Kanoh Y, Moriyama K, Yamazaki S, Yoshizawa N, Matsumoto S
Genes & genetic systems   92(3) 119-125   Jan 2018   [Refereed]
Masai H, Yang CC, Matsumoto S
Current genetics   63(5) 813-818   Oct 2017   [Refereed]
You Z, Masai H
Nucleic acids research   45(11) 6494-6506   Jun 2017   [Refereed]
Irie T, Asami T, Sawa A, Uno Y, Hanada M, Taniyama C, Funakoshi Y, Masai H, Sawa M
European journal of medicinal chemistry   130 406-418   Apr 2017   [Refereed]
Matsumoto S, Kanoh Y, Shimmoto M, Hayano M, Ueda K, Fukatsu R, Kakusho N, Masai H
Molecular and cellular biology   37(7)    Apr 2017   [Refereed]
Masai H
Cell cycle (Georgetown, Tex.)   16(8) 735-736   Apr 2017   [Refereed]
Toteva T, Mason B, Kanoh Y, Brøgger P, Green D, Verhein-Hansen J, Masai H, Thon G
Proceedings of the National Academy of Sciences of the United States of America   114(5) 1093-1098   Jan 2017   [Refereed]
DNA Replication From Old Principles to New Discoveries Preface
Masai Hisao, Foiani Marco
DNA REPLICATION: FROM OLD PRINCIPLES TO NEW DISCOVERIES   1042 V-VIII   2017   [Refereed]
Moriyama K, Lai MS, Masai H
Advances in experimental medicine and biology   1042 287-310   2017   [Refereed]
An alternative pathway of chromosome replication in Escherichia coli
Tanaka Taku, Seki Yumika, Masai Hisao
GENES & GENETIC SYSTEMS   91(6) 337   Dec 2016   [Refereed]
Kozel C, Thompson B, Hustak S, Moore C, Nakashima A, Singh CR, Reid M, Cox C, Papadopoulos E, Luna RE, Anderson A, Tagami H, Hiraishi H, Slone EA, Yoshino KI, Asano M, Gillaspie S, Nietfeld J, Perchellet JP, Rothenburg S, Masai H, Wagner G, Beeser A, Kikkawa U, Fleming SD, Asano K
Nucleic acids research   44(18) 8704-8713   Oct 2016   [Refereed]
Yang CC, Suzuki M, Yamakawa S, Uno S, Ishii A, Yamazaki S, Fukatsu R, Fujisawa R, Sakimura K, Tsurimoto T, Masai H
Nature communications   7 12135   Jul 2016   [Refereed]
You Z, Ode KL, Shindo M, Takisawa H, Masai H
Cell cycle (Georgetown, Tex.)   15(9) 1213-1226   May 2016   [Refereed]
Tanaka H, Muto A, Shima H, Katoh Y, Sax N, Tajima S, Brydun A, Ikura T, Yoshizawa N, Masai H, Hoshikawa Y, Noda T, Nio M, Ochiai K, Igarashi K
The Journal of biological chemistry   291(12) 6316-6330   Mar 2016   [Refereed]
Nonaka T, Suzuki G, Tanaka Y, Kametani F, Hirai S, Okado H, Miyashita T, Saitoe M, Akiyama H, Masai H, Hasegawa M
The Journal of biological chemistry   291(11) 5473-5483   Mar 2016   [Refereed]
Tanaka T, Nishito Y, Masai H
Biochemical and biophysical research communications   470(3) 546-551   Feb 2016   [Refereed]
Kanoh Y, Matsumoto S, Fukatsu R, Kakusho N, Kono N, Renard-Guillet C, Masuda K, Iida K, Nagasawa K, Shirahige K, Masai H
Nature structural & molecular biology   22(11) 889-897   Nov 2015   [Refereed]
Masai H
Cell cycle (Georgetown, Tex.)   14(19) 3011-3012   Oct 2015   [Refereed]
Iguchi T, Aoki K, Ikawa T, Taoka M, Taya C, Yoshitani H, Toma-Hirano M, Koiwai O, Isobe T, Kawamoto H, Masai H, Miyatake S
Journal of immunology (Baltimore, Md. : 1950)   195(3) 982-993   Aug 2015   [Refereed]
Zech J, Godfrey EL, Masai H, Hartsuiker E, Dalgaard JZ
PloS one   10(7) e0132595   Jul 2015   [Refereed]
Koiwai K, Kubota T, Watanabe N, Hori K, Koiwai O, Masai H
Genes to cells : devoted to molecular & cellular mechanisms   20(3) 242-254   Mar 2015   [Refereed]
Jeffery DC, Kakusho N, You Z, Gharib M, Wyse B, Drury E, Weinreich M, Thibault P, Verreault A, Masai H, Yankulov K
Cell cycle (Georgetown, Tex.)   14(1) 74-85   Jan 2015   [Refereed]
Bellelli R, Castellone MD, Guida T, Limongello R, Dathan NA, Merolla F, Cirafici AM, Affuso A, Masai H, Costanzo V, Grieco D, Fusco A, Santoro M, Carlomagno F
Molecular cell   55(1) 123-137   Jul 2014   [Refereed]
Yamada M, Masai H, Bartek J
Cell cycle (Georgetown, Tex.)   13(12) 1859-1866   Jun 2014   [Refereed]
Renard-Guillet C, Kanoh Y, Shirahige K, Masai H
Seminars in cell & developmental biology   30 110-120   Jun 2014   [Refereed]
Masai H
Cell cycle (Georgetown, Tex.)   13(6) 882-883   Mar 2014   [Refereed]
Yoshizawa-Sugata N, Masai H
Methods in molecular biology (Clifton, N.J.)   1170 279-293   2014   [Refereed]
Tanikawa M, Wada-Hiraike O, Yoshizawa-Sugata N, Shirane A, Hirano M, Hiraike H, Miyamoto Y, Sone K, Ikeda Y, Kashiyama T, Oda K, Kawana K, Katakura Y, Yano T, Masai H, Roy AL, Osuga Y, Fujii T
British journal of cancer   109(12) 3042-3048   Dec 2013   [Refereed]
Matsumoto S, Masai H
Biochemical Society transactions   41(6) 1712-1719   Dec 2013   [Refereed]
Masai H
Journal of molecular biology   425(23) 4663-4672   Nov 2013   [Refereed]
Yamada M, Watanabe K, Mistrik M, Vesela E, Protivankova I, Mailand N, Lee M, Masai H, Lukas J, Bartek J
Genes & development   27(22) 2459-2472   Nov 2013   [Refereed]
Jeffery DC, Wyse BA, Rehman MA, Brown GW, You Z, Oshidari R, Masai H, Yankulov KY
Nucleic acids research   41(18) 8475-8488   Oct 2013   [Refereed]
You Z, De Falco M, Kamada K, Pisani FM, Masai H
PloS one   8(8) e72408   Aug 2013   [Refereed]
Yamazaki S, Hayano M, Masai H
Trends in genetics : TIG   29(8) 449-460   Aug 2013   [Refereed]
Aria V, De Felice M, Di Perna R, Uno S, Masai H, Syväoja JE, van Loon B, Hübscher U, Pisani FM
The Journal of biological chemistry   288(18) 12742-12752   May 2013   [Refereed]
A central coupler for recombination initiation linking chromosome architecture to S-phase checkpoint
Ito Masaru, Miyoshi Tomoichiro, Kugou Kazuto, Yamada Shintaro, Furuichi Masaki, Oda Arisa, Yamada Takatomi, Hirota Kouji, Masai Hisao, Ohta Kunihiro
GENES & GENETIC SYSTEMS   87(6) 403   Dec 2012   [Refereed]
Suzuki T, Tsuzuku J, Hayashi A, Shiomi Y, Iwanari H, Mochizuki Y, Hamakubo T, Kodama T, Nishitani H, Masai H, Yamamoto T
The Journal of biological chemistry   287(48) 40256-40265   Nov 2012   [Refereed]
Miyoshi T, Ito M, Kugou K, Yamada S, Furuichi M, Oda A, Yamada T, Hirota K, Masai H, Ohta K
Molecular cell   47(5) 722-733   Sep 2012   [Refereed]
Yamazaki S, Ishii A, Kanoh Y, Oda M, Nishito Y, Masai H
The EMBO journal   31(18) 3667-3677   Sep 2012   [Refereed]
Oda M, Kanoh Y, Watanabe Y, Masai H
PloS one   7(8) e42375   Aug 2012   [Refereed]
Gaik Theng Toh, Hisao Masai
UCSD Molecule Pages      Aug 2012   [Refereed]
Moriyama K, Yoshizawa-Sugata N, Obuse C, Tsurimoto T, Masai H
The Journal of biological chemistry   287(28) 23977-23994   Jul 2012   [Refereed]
Uno S, You Z, Masai H
Methods (San Diego, Calif.)   57(2) 214-221   Jun 2012   [Refereed]
Barkley LR, Palle K, Durando M, Day TA, Gurkar A, Kakusho N, Li J, Masai H, Vaziri C
Molecular biology of the cell   23(10) 1943-1954   May 2012   [Refereed]
Ito S, Ishii A, Kakusho N, Taniyama C, Yamazaki S, Fukatsu R, Sakaue-Sawano A, Miyawaki A, Masai H
PloS one   7(5) e36372   May 2012   [Refereed]
Hayano M, Kanoh Y, Matsumoto S, Renard-Guillet C, Shirahige K, Masai H
Genes & development   26(2) 137-150   Jan 2012   [Refereed]
Matsumoto S, Hayano M, Kanoh Y, Masai H
The Journal of cell biology   195(3) 387-401   Oct 2011   [Refereed]
Uno S, Masai H
Genes to cells : devoted to molecular & cellular mechanisms   16(8) 842-856   Aug 2011   [Refereed]
Kitamura R, Fukatsu R, Kakusho N, Cho YS, Taniyama C, Yamazaki S, Toh GT, Yanagi K, Arai N, Chang HJ, Masai H
The Journal of biological chemistry   286(26) 23031-23043   Jul 2011   [Refereed]
Masai H
Journal of biochemistry   149(6) 629-631   Jun 2011   [Refereed]
Hayano M, Kanoh Y, Matsumoto S, Masai H
Molecular and cellular biology   31(12) 2380-2391   Jun 2011   [Refereed]
Tanaka T, Yokoyama M, Matsumoto S, Fukatsu R, You Z, Masai H
The Journal of biological chemistry   285(51) 39609-39622   Dec 2010   [Refereed]
Vaziri C, Masai H
Cell cycle (Georgetown, Tex.)   9(24) 4818-4823   Dec 2010   [Refereed]
Matsumoto S, Shimmoto M, Kakusho N, Yokoyama M, Kanoh Y, Hayano M, Russell P, Masai H
Cell cycle (Georgetown, Tex.)   9(23) 4627-4637   Dec 2010   [Refereed]
Day TA, Palle K, Barkley LR, Kakusho N, Zou Y, Tateishi S, Verreault A, Masai H, Vaziri C
The Journal of cell biology   191(5) 953-966   Nov 2010   [Refereed]
Furuya K, Miyabe I, Tsutsui Y, Paderi F, Kakusho N, Masai H, Niki H, Carr AM
Molecular cell   40(4) 606-618   Nov 2010   [Refereed]
Kundu LR, Kumata Y, Kakusho N, Watanabe S, Furukohri A, Waga S, Seki M, Masai H, Enomoto T, Tada S
Nucleic acids research   38(16) 5409-5418   Sep 2010   [Refereed]
Masai H, Tanaka T, Kohda D
BioEssays : news and reviews in molecular, cellular and developmental biology   32(8) 687-697   Aug 2010   [Refereed]
FANCs regulate firing of DNA replication origins.
Masai H
Cell cycle (Georgetown, Tex.)   9(13) 2494   Jul 2010   [Refereed]
Takeishi Y, Ohashi E, Ogawa K, Masai H, Obuse C, Tsurimoto T
Genes to cells : devoted to molecular & cellular mechanisms   15(7) 761-771   Jun 2010   [Refereed]
Shimmoto Michie, Matsumoto Seiji, Odagiri Yukari, Noguchi Eishi, Russell Paul, Masai Hisao
GENES TO CELLS   15(3) 313   Mar 2010   [Refereed]
Masai H, Matsumoto S, You Z, Yoshizawa-Sugata N, Oda M
Annual review of biochemistry   79 89-130   2010   [Refereed]
Regulation of DNA replication program: genetic determinants and plasticity
Masai Hisao
GENES & GENETIC SYSTEMS   84(6) 482   Dec 2009   [Refereed]
Tanaka H, Kubota Y, Tsujimura T, Kumano M, Masai H, Takisawa H
Genes to cells : devoted to molecular & cellular mechanisms   14(8) 949-963   Aug 2009   [Refereed]
Yoshizawa-Sugata N, Masai H
The Journal of biological chemistry   284(31) 20718-20728   Jul 2009   [Refereed]
Shimmoto M, Matsumoto S, Odagiri Y, Noguchi E, Russell P, Masai H
Genes to cells : devoted to molecular & cellular mechanisms   14(6) 669-682   Jun 2009   [Refereed]
[Regulatory network of chromosome cycle].
Masai H
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme   54(4 Suppl) 311-316   Mar 2009   [Refereed]
[Coupling and coordination of events regulating chromosome cycle: overview].
Masai H
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme   54(4 Suppl) 521-523   Mar 2009   [Refereed]
[Regulation of various chromosome transactions by Cdc7 kinase].
Masai H
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme   54(4 Suppl) 524-530   Mar 2009   [Refereed]
Toh, G.K., and Masai, H.
UCSD Nature Molecule Pages      Feb 2009   [Refereed]
Drug design with Cdc7 kinase: a potential novel cancer therapy target.
Sawa M, Masai H
Drug design, development and therapy   2 255-264   Feb 2009   [Refereed]
Hisao Masai
Drug News Perspect.   21(9) 481-488   Nov 2008   [Refereed]
Tanaka T, Masai H
The Journal of biological chemistry   281(6) 3484-3493   Feb 2006   [Refereed]
Kitamura R, Sekimoto T, Ito S, Harada S, Yamagata H, Masai H, Yoneda Y, Yanagi K
Journal of virology   80(4) 1979-1991   Feb 2006   [Refereed]
Sasaki K, Ose T, Tanaka T, Mizukoshi T, Ishigaki T, Maenaka K, Masai H, Kohda D
Biochimica et biophysica acta   1764(1) 157-160   Jan 2006   [Refereed]
Hsk1, an essential activator of DNA replication, interacts with Swi1, a component of the replication fork protection complex, and plays a role in stabilization of arrested replication forks
Matsumoto Seiji, Ogino Keiko, Masai Hisao
CELL STRUCTURE AND FUNCTION   30 40   Jun 2005   [Refereed]
A second human Dbf4/ASK-related protein, Drf1/ASKL1, is required for efficient progression of S and M phases
Yoshizaw Naoko, Ishii Ai, Taniyama Chika, Matsui Etsuko, Masai Hisao
CELL STRUCTURE AND FUNCTION   30 40   Jun 2005   [Refereed]
Yamashita N, Kim JM, Koiwai O, Arai K, Masai H
Genes to cells : devoted to molecular & cellular mechanisms   10(6) 551-563   Jun 2005   [Refereed]
Yoshizawa-Sugata N, Ishii A, Taniyama C, Matsui E, Arai K, Masai H
The Journal of biological chemistry   280(13) 13062-13070   Apr 2005   [Refereed]
Masai H, You Z, Arai K
IUBMB life   57(4-5) 323-335   Apr 2005   [Refereed]
You Z, Masai H
Nucleic acids research   33(9) 3033-3047   2005   [Refereed]
Kurita M, Suzuki H, Masai H, Mizumoto K, Ogata E, Nishimoto I, Aiso S, Matsuoka M
Biochemical and biophysical research communications   324(2) 554-561   Nov 2004   [Refereed]
Schnepp RW, Hou Z, Wang H, Petersen C, Silva A, Masai H, Hua X
Cancer research   64(18) 6791-6796   Sep 2004   [Refereed]
Genetic dissection of mammalian Cdc7 kinase: cell cycle and developmental roles.
Kim JM, Masai H
Cell cycle (Georgetown, Tex.)   3(3) 300-304   Mar 2004   [Refereed]
Kim JM, Yamada M, Masai H
Mutation research   532(1-2) 29-40   Nov 2003   [Refereed]
Furukohri A, Sato N, Masai H, Arai K, Sugino A, Waga S
Journal of biochemistry   134(3) 447-457   Sep 2003   [Refereed]
Sato N, Sato M, Nakayama M, Saitoh R, Arai K, Masai H
Genes to cells : devoted to molecular & cellular mechanisms   8(5) 451-463   May 2003   [Refereed]
Tanaka T, Taniyama C, Arai K, Masai H
Genes to cells : devoted to molecular & cellular mechanisms   8(3) 251-261   Mar 2003   [Refereed]
You Z, Ishimi Y, Masai H, Hanaoka F
The Journal of biological chemistry   277(45) 42471-42479   Nov 2002   [Refereed]
Tanaka T, Mizukoshi T, Taniyama C, Kohda D, Arai K, Masai H
The Journal of biological chemistry   277(41) 38062-38071   Oct 2002   [Refereed]
Masai H, Arai K
Journal of cellular physiology   190(3) 287-296   Mar 2002   [Refereed]
Ishimi Y, Komamura-Kohno Y, Arai K, Masai H
The Journal of biological chemistry   276(46) 42744-42752   Nov 2001   [Refereed]
Ogino K, Takeda T, Matsui E, Iiyama H, Taniyama C, Arai K, Masai H
The Journal of biological chemistry   276(33) 31376-31387   Aug 2001   [Refereed]
Uchiyama M, Arai K, Masai H
Molecular genetics and genomics : MGG   265(6) 1039-1049   Aug 2001   [Refereed]
Uchiyama M, Griffiths D, Arai K, Masai H
The Journal of biological chemistry   276(28) 26189-26196   Jul 2001   [Refereed]

Misc

 
Masai, H., Miyake, T. and Arai, K.;"hsk1+, a Schizosaccharomyces pombe gene related to Saccharomyces cerevisiae CDC7 kinase, is required for chromosomal replication." "hsk1+, a Schizosaccharomyces pombe gene related to Saccharomyces c・・・
EMBO J.   14 3094-3104.    1995
Masai, H., Miyake, T. and Arai, K.;"hsk1+, a Schizosaccharomyces pombe gene related to Saccharomyces cerevisiae CDC7 kinase, is required for chromosomal replication."


"hsk1+, a Schizosaccharomyces pombe gene related to Saccharomyces cerevisiae ...
Masai, H., and Arai, K.;"Frpo, a novel single-stranded DNA promoter for transcription and for primer RNA synthesis of DNA replication."
Cell   89, 897-907    1997
J. Biol. Chem.   275, 29042-29052.    2000
Masai, H., Matsui, E., You, Z., Ishimi,Y., Tamai, K. and Arai, K. "Purification and characterization of human Cdc7-ASK kinase complex expressed in insect cells: In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a c...
Kim, J. M., Nakao, K., Nakamura, K., Saito, I., Katsuki, M., Arai, K. and Masai, H.;"Inactivation of Cdc7 kinase in mouse embryonic stem cells results in S phase arrest and p53-dependent cell death."
EMBO J.   21, 2168-2179    2002
Mizukoshi, T., Tanaka, T., Arai, K., Kohda, D. and Masai, H.;"A critical role of the 3’-terminus of nascent DNA chains in recognition of stalled replication forks."
J. Biol. Chem.   278, 42234-42239    2003

Books etc

 
“DNA Replication, From Old Principles to New Discoveries” (Masai, H. and Foiani, M. Eds) Adv Exp Med Biol.
Masai Hisao (Part:Editor)
Springer   Jan 2018   ISBN:978-981-10-6955-0
Free Preview © 2016 The Initiation of DNA Replication in Eukaryotes
Yoshizawa, N., Yamazaki, S., and *Masai, H. (Part:Contributor, Rif1, a Conserved Chromatin Factor Regulating DNA Replication, DNA Repair, and Transcription)
Springer   Feb 2016   ISBN:978-3-319-24696-3
Title Control of Cellular Physiology by E2F Transciption Factors
Hiroko Fujii-Yamamoto, Masayuki Yamada and Hisao Masai (Part:Contributor, Regulation of DNA replication factors by E2F in cancer and embryonic stem cells)
Research Signpost   2008   ISBN:978-81-308-0230-5
DNA Replication and Mutagenesis
Masai, H. and *Arai, K. (Part:Contributor, Book chapter: "R1 plasmid replication in vitro: repA- and dnaA-dependent initiation at oriR")
Amer Society for Microbiology   Mar 1989   ISBN:978-1555810030

Research Grants & Projects

 
Mechanisms of genome DNA replication and maintenance of genomic stability
Project Year: 2000   

Patents

 
Human H37 protein and cDNA encoding the protein
特願平10-311406
Human H37 protein and cDNA encoding the protein
PCT/JP99/06076
Cdc7-ASK kinase complex, a substrate thereof, an antibody specific to the phosphorylated substrate and a method using these to screen for substances capable of inhibiting Cdc7-ASK kinase activity.
PCT/JP03/02918

Others

 
2013   Editor, Biochemical and Biophysical Research Communications
2011   Faculty1000 member
Apr 2010   Editorial Board Member, World Journal of Biological Chemistr
Apr 2010   Advisory Board, Journal of Biochemistry
Apr 2009   Associate Editor, Genes to Cells