Masuda Tomoyuki

J-GLOBAL         Last updated: Jun 6, 2019 at 03:00
 
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Name
Masuda Tomoyuki
E-mail
tmasumd.tsukuba.ac.jp
Affiliation
University of Tsukuba
Section
Faculty of Medicine
Job title
Associate Professor
Research funding number
70372828

Research Areas

 
 

Academic & Professional Experience

 
Sep 2013
   
 
Associate professor, Faculty of Medicine, University of Tsukuba
 
Mar 2012
 - 
Aug 2013
Associate professor, Department of Histology and Neurobiology, Dokkyo Medical University School of Medicine
 
Dec 2008
 - 
Feb 2012
Lecturer, Department of Neuroanatomy and Embryology, Fukushima Medical University School of Medicine
 

Committee Memberships

 
 
   
 
Japanese Association of Anatomists  trustee
 
 
   
 
The Physiological Society of Japan  trustee
 
 
   
 
Japan Society of Histochemistry and Cytochemistry  trustee
 
 
 - 
2013
Dokkyo Medical Association  trustee
 
 
   
 
Tsukuba Brain Science Association  trustee
 

Awards & Honors

 
Sep 2018
Japan Society of Kansei Engineering, Rakuten Research Award
 
Dec 2015
Univ Tsukuba, Young Excellent Faculty Member Award
 
Dec 2012
Dokkyo Med Univ, 13th Sekiminato Award
 
Jan 2009
Med Assoc Fukushima, 2008 Young Researcher's Award
 
Mar 2004
Univ Tsukuba, 2003 Excellent Investigator Award
 

Published Papers

 
Ishii, Kazuhiro; Nemoto, Kiyotaka; Iwasaki, Nobuaki; Takeda, Tohoru; Masuda, Tomoyuki; Shibata, Yasuyuki; Tamaoka, Akira
European Journal of Neurology   26(1) 136-141   Jan 2019   [Refereed]
[BACKGROUND] Diphenylarsinic acid (DPAA) intoxication caused by drinking contaminated well water was found in the Kamisu, Japan. The symptoms indicated cerebellar-brainstem and temporo-occipital involvement, however, how it affects the human brain...
Masuda, Tomoyuki;Ishii, Kazuhiro;Morishita, Yukio;Iwasaki, Nobuaki;Shibata, Yasuyuki;Tamaoka, Akira
The Journal of Toxicological Sciences   43(5) 291-298   May 2018   [Refereed]
<p>Organic arsenic diphenylarsinic acid (DPAA[V]) accumulates at high concentrations in the liver of primates after its subchronic administration. However, no studies on the hepatic effects of organic arsenic compounds, including DPAA(V), on prima...
Masuda, Tomoyuki; Ishii, Kazuhiro; Nakayama, Tomohiro; Iwasaki, Nobuaki; Shibata, Yasuyuki; Tamaoka, Akira
Neurotoxicology and Teratology   65 26-33   Feb 2018   [Refereed]
In the year 2003, the residents of Kamisu, Japan, were exposed to pentavalent organic arsenic diphenylarsinic acid (DPAA[V]) via their normal drinking water. Following the exposure, they developed cerebellar and brainstem symptoms. Although the re...
Masuda, Tomoyuki
Cell Adhesion & Migration   11(5-6) 524-531   Dec 2017   [Refereed]
Contactin-2/transiently expressed axonal surface glycoprotein-1 (TAG-1) is a cell adhesion molecule belonging to the immunoglobulin superfamily (IgSF). It has six immunoglobulin-like extracellular domains and four fibronectin III-like ones, with a...
Masuda, Tomoyuki;Ishii, Kazuhiro;Seto, Yasuo;Hosoya, Tomoko;Tanaka, Ryuta;Nakayama, Tomohiro;Iwasaki, Nobuaki;Shibata, Yasuyuki;Tamaoka, Akira
Archives of Toxicology   91(8) 2799-2812   Aug 2017   [Refereed]
Diphenylarsinic acid (DPAA) is an organic arsenic compound used for the synthesis of chemical weapons. We previously found that the residents of Kamisu city in Ibaraki Prefecture, Japan, were exposed to DPAA through contaminated well water in 2003...
Yoshimura, Yuko;Ishikawa, Chihiro;Kasegai, Haruki;Masuda, Tomoyuki;Yoshikawa, Masaaki;Shiga, Takashi
Neuroscience Research   115 13-20   Feb 2017   [Refereed]
The possible interactions between serotonergic and glutamatergic systems during neural development and under the pathogenesis of depression remain unclear. We now investigated roles of 5-HT1A receptor in the mRNA expression of AMPA receptor subuni...
Masuda, Tomoyuki;Itoh, Junko;Koide, Takuya;Tomidokoro, Yasushi;Takei, Yosuke;Ishii, Kazuhiro;Akira, Tamaoka
Journal of Clinical Neuroscience   35 47-49   Jan 2017   [Refereed]
A chronic inflammatory condition may underlie neurodegenerative disorders, including Parkinson's disease (PD) and Alzheimer's disease (AD). For example, both PD and AD patients show an increase in transforming growth factor-beta 1 (TGF-(beta 1) le...
Masuda, Tomoyuki;Taniguchi, Masahiko
Cell Adhesion & Migration   10 593-603   Dec 2016   [Refereed]
Semaphorins are a large family of proteins characterized by sema domains and play a key role not only in the formation of neural circuits, but in the immune system, angiogenesis, tumor progression, and bone metabolism. To date, 15 semaphorins have...
JIYAVORANANDA,Sittiphan;ISHIKAWA,Hiroko;SAKAI,Shunsuke;YAMANAKA,Katsuo;YAMANAKA,Toshimasa;MASUDA,Tomoyuki
International Journal of Affective Engineering   15(3) 231-238   Sep 2016   [Refereed]
In recent years, "Yuru-kyara" mascots, a class of mascot characters popularized by their characteristic of "yuru-sa", have played important roles in the promotions of regional events and products. Although previous studies implicated the im...
Yoshikawa, Masaaki;Masuda, Tomoyuki;Kobayashi, Azusa;Senzaki, Kouji;Ozaki, Shigeru;Aizawa, Shin;Shiga, Takashi
Molecular and Cellular Neuroscience   72 114-122   Apr 2016   [Refereed]
The runt-related transcription factor Runx1 regulates cell-type specification and axonal projections of nociceptive dorsal root ganglion (DRG) neurons, whereas bone morphogenetic protein 4 (BMP4) is required for axonal growth during neuronal devel...
Ogihara, Yuuki;Masuda, Tomoyuki;Ozaki, Shigeru;Yoshikawa, Masaaki;Shiga, Takashi
Developmental Neurobiology   76(3) 313-322   Mar 2016   [Refereed]
Somatosensation is divided into proprioception and cutaneous sensation. Dorsal root ganglion (DRG) neurons project their fibers toward peripheral targets including muscles and skin, and centrally to the spinal cord. Proprioceptive DRG neurons tran...
増田, 知之
脳科学辞典   https://bsd.neuroinf.jp/    Jun 2016   [Refereed]
Yoshikawa, Masaaki;Hirabayashi, Mizuki;Ito, Ryota;Ozaki, Shigeru;Aizawa, Shin;Masuda, Tomoyuki;Senzaki, Kouji;Shiga, Takashi
Developmental Neurobiology   75(11) 1295-1314   Nov 2015   [Refereed]
The runt-related transcription factor Runx1 contributes to cell type specification and axonal targeting projections of the nociceptive dorsal root ganglion neurons. Runx1 is also expressed in the central nervous system, but little is known of its ...
Masuda, Tomoyuki;Taniguchi, Masahiko
Congenital Anomalies   55(1) 26-30   Feb 2015   [Refereed]
Semaphorins and their receptors, neuropilins and plexins, were initially characterized as a modulator of axonal guidance during development, but are now recognized as a regulator of a wide range of developmental events including morphogenesis and ...
Masuda, Tomoyuki;Sakuma, Chie;Yaginuma, Hiroyuki;Taniguchi, Masahiko
Cell Adhesion & Migration   8(6) 603-606   Nov 2014   [Refereed]
Elongation of the efferent fibers of dorsal root ganglion (DRG) neurons toward their peripheral targets occurs during development. Attractive or permissive systems may be involved in this elongation. However, the molecular mechanisms that control ...
Masuda, Tomoyuki;Sakuma, Chie;Nagaoka, Atsuko;Yamagishi, Toshiyuki;Ueda, Shuichi;Nagase, Takahiro;Yaginuma, Hiroyuki
Congenital Anomalies   54(1) 63-66   Feb 2014   [Refereed]
Follistatin-like 5 (Fstl5), a member of the follistatin family of genes, encodes a secretory glycoprotein. Previous studies revealed that other members of this family including Fstl1 and Fstl3 play an essential role in development, homeostasis, an...
Namba, Takashi; Kibe, Yuji; Funahashi, Yasuhiro; Nakamuta, Shinichi; Takano, Tetsuya; Ueno, Takuji; Shimada, Akiko; Kozawa, Sachi; Okamoto, Mayumi; Shimoda, Yasushi; Oda, Kanako; Wada, Yoshino; Masuda, Tomoyuki; Sakakibara, Akira; Igarashi, Michihiro; Miyata, Takaki; Faivre-Sarrailh, Catherine; Takeuchi, Kosei; Kaibuchi, Kozo
Neuron   81(4) 814-829   Feb 2014   [Refereed]
Masuda, Tomoyuki;Sakuma, Chie;Ueno, Takayuki;Yamada, Yuriko;Ohmomo, Hideki;Ueda, Shuichi;Yamagishi, Toshiyuki;Yaginuma, Hiroyuki
Congenital Anomalies   53(4) 141-148   Dec 2013   [Refereed]
Huntingtin-interacting protein 1-related (Hip1r) was originally identified due to its homology to Huntingtin-interacting protein 1, which contributes to the development of Huntington's disease (HD). We studied the expression of the mouse Hip1r (mH...
Kobayashi, Nobumi; Homma, Shunsaku; Okada, Tomoaki; Masuda, Tomoyuki; Sato, Noboru; Nishiyama, Keiji; Sakuma, Chie; Shimada, Takako; Yaginuma, Hiroyuki
Journal of Comparative Neurology   521(13) 2987-3002   Sep 2013   [Refereed]
The avian cervical spinal cord includes motoneurons (MNs) that send their axons through the dorsal roots. They have been called dorsal motoneurons (dMNs) and assumed to correspond to MNs of the accessory nerve that innervate the cucullaris muscle ...
Masuda, Tomoyuki; Taniguchi, Masahiko; Sakuma, Chie; Yamagishi, Toshiyuki; Ueda, Shuichi; Kawaguchi, Masahumi; Yaginuma, Hiroyuki
Congenital Anomalies   53(3) 122-126   Sep 2013   [Refereed]
The spinal nerve, which is composed of dorsal root ganglion (DRG) sensory axons and spinal motor axons, forms the dorsal ramus projecting to the dorsal musculature. By using the free-floating immunohistochemistry method, we closely examined the sp...
Yoshikawa, Masaaki;Murakami, Yuuki;Senzaki, Kouji;Masuda, Tomoyuki;Ozaki, Shigeru;Ito, Yoshiaki;Shiga, Takashi
Developmental Neurobiology   73(6) 469-479   Jun 2013   [Refereed]
Masuda, Tomoyuki;Sakuma, Chie;Taniguchi, Masahiko;Kanemoto, Ayae;Yoshizawa, Madoka;Satomi, Kaishi;Tanaka, Hideaki;Takeuchi, Kosei;Ueda, Shuichi;Yaginuma, Hiroyuki;Shiga, Takashi
Brain Research   1480 30-40   Oct 2012   [Refereed]
The spinal nerve, which is composed of dorsal root ganglion (DRG) axons and spinal motor axons, divides into ventral and dorsal rami. Although the development of the ventral ramus has been examined in considerable detail, that of the dorsal ramus ...
Molecular cloning and expression pattern of the splicing variant of chick neuron navigator 2
Masuda, Tomoyuki;Sakuma, Chie;Yamagishi, Toshiyuki;Ueno, Takayuki;Yamada, Yuriko;Yaginuma, Hiroyuki
Saito Ho-on Kai Museum of Natural History Research Bulletin   75 7-17   Mar 2011   [Refereed]
Kobayashi, Kenta; Masuda, Tomoyuki; Takahashi, Masanori; Miyazaki, Jun-ichi; Nakagawa, Masahiro; Uchigashima, Motokazu; Watanabe, Masahiko; Yaginuma, Hiroyuki; Osumi, Noriko; Kaibuchi, Kozo; Kobayashi, Kazuto
European Journal of Neuroscience   33(4) 612-621   Feb 2011   [Refereed]
Cranial motor neurons, which are divided into somatic motor (SM), branchiomotor (BM) and visceral motor (VM) neurons, form distinct axonal trajectories to innervate their synapse targets. Rho GTPase regulates various neuronal functions through one...
Taniguchi, Masahiko; Masuda, Tomoyuki; Mikami, Yoshinori; Kimura, Masafumi; Yoshida, Tomoyuki; Mishina, Masayoshi; Shimizu, Takao
Neuroscience Letters   488(2) 215-220   Jan 2011   [Refereed]
The semaphorin gene family contains numerous secreted and transmembrane proteins. Some of them function as the repulsive and attractive axon guidance molecules during development. Herein, we report the cloning and characterization of a novel membe...
Masuda, Tomoyuki; Sakuma, Chie; Yaginuma, Hiroyuki
Fukushima Journal of Medical Science   55(1) 1-6   Jun 2009   [Refereed]
During development, dorsal root ganglion (DRG) neurons in higher vertebrates extend their axons centrally to the spinal cord through the dorsal root entry zone (DREZ) and peripherally to muscle and skin targets. After entering the spinal cord, DRG...
Masuda, Tomoyuki; Yaginuma, Hiroyuki; Sakuma, Chie; Ono, Katsuhiko
Cell Adhesion & Migration   3(2) 171-173   Apr 2009   [Refereed]
During development, dorsal root ganglion (DRG) neurons extend their axons toward the dorsolateral part of the spinal cord and enter the spinal cord through the dorsal root entry zone (DREZ). After entering the spinal cord, these axons project into...
Molecular mechanisms of patterning initial trajectories of sensory neurons
Masuda, Tomoyuki;Sakuma, Chie;Yaginuma, Hiroyuki
最新医学   64(4) 938-943   Apr 2009   [Refereed]
感覚神経ネットワークを形成する分子メカニズム
増田, 知之
福島医学雑誌   59(1) 41-42   Mar 2009
Masuda, Tomoyuki; Kai, Nobuyuki; Sakuma, Chie; Kobayashi, Kazuto; Koga, Hisashi; Yaginuma, Hiroyuki
Brain Research   1249 61-67   Jan 2009   [Refereed]
During early development, centrally projecting dorsal root ganglion (DRG) neurons extend their axons toward the dorsal spinal cord. We previously reported that this projection is achieved by dorsal spinal cord-derived chemoattraction. However, the...
Masuda, Tomoyuki;Sakuma, Chie;Kobayashi, Kenta;Kikuchi, Kazufumi;Soda, Emi;Shiga, Takashi;Kobayashi, Kazuto;Yaginuma, Hiroyuki
Journal of Neuroscience Research   87(2) 353-359   Jan 2009   [Refereed]
During early development, centrally projecting dorsal root ganglion (DRG) neurons extend their axons toward the dorsal spinal cord. We previously reported the involvement of dorsal spinal cord-derived chemoattraction in this projection (Masuda et ...
Masuda, Tomoyuki; Watanabe, Keisuke; Sakuma, Chie; Ikenaka, Kazuhiro; Ono, Katsuhiko; Yaginuma, Hiroyuki
The Journal of Neuroscience   28(41) 10380-10385   Oct 2008   [Refereed]
During early development, the ventral spinal cord expresses chemorepulsive signals that act on dorsal root ganglion (DRG) axons to help orient them toward the dorsolateral part of the spinal cord. However, the molecular nature of this chemorepulsi...
Kimura, Masafumi; Taniguchi, Masahiko; Mikami, Yoshinori; Masuda, Tomoyuki; Yoshida, Tomoyuki; Mishina, Masayoshi; Shimizu, Takao
Biochemical and Biophysical Research Communications   363(3) 762-768   Nov 2007   [Refereed]
The semaphorin gene family contains a large number of secreted and transmembrane proteins; some function as repulsive and attractive cues of axon guidance during development. Here, we report cloning and characterization of zebrafish transmembrane ...
Masuda, Tomoyuki;Sakuma, Chie;Taniguchi, Masahiko;Kobayashi, Kenta;Kobayashi, Kazuto;Shiga, Takashi;Yaginuma, Hiroyuki
Neuroreport   18(16) 1645-1649   Oct 2007   [Refereed]
Taniguchi, Masahiko; Masuda, Tomoyuki; Fukaya, Masahiro; Kataoka, Hirotaka; Mishina, Masayoshi; Yaginuma, Hiroyuki; Watanabe, Masahiko; Shimizu, Takao
Genes to Cells   10(8) 785-792   Aug 2005   [Refereed]
The semaphorin gene family contains a large number of secreted type or transmembrane type proteins, and some of them function as the repulsive and attractive cues of axon guidance during development. Here we report a novel member of murine class 3...
Masuda, Tomoyuki;Shiga, Takashi
Neuroscience Research   51(4) 337-347   Apr 2005   [Refereed]
Masuda, Tomoyuki;Fukamauchi, Fumihiko;Takeda, Yasuo;Fujisawa, Hajime;Watanabe, Kazutada;Okado, Nobuo;Shiga, Takashi
Molecular and Cellular Neuroscience   25(2) 217-227   Feb 2004   [Refereed]
Masuda, Tomoyuki;Tsuji, Hiroshi;Taniguchi, Masahiko;Yagi, Takeshi;Tessier-Lavigne, Marc;Fujisawa, Hajime;Okado, Nobuo;Shiga, Takashi
Developmental Biology   254(2) 289-302   Jan 2003   [Refereed]
Initial trajectories of dorsal root ganglion (DRG) axons are shaped by chemorepulsive signals from surrounding tissues. Although we have previously shown that axonin-1/SC2 expression on DRG axons is required to mediate a notochord-derived chemorep...
Shiga, Takashi;Inoue, Kikuyo;Masuda, Tomoyuki
Anatomy and Embryology   205(3) 223-228   Jan 2002   [Refereed]
Islet-1 and Islet-2 are members of a family of homeodomain-containing transcription factors, and Islet-1 has been shown to be involved in differentiation of several cell types. The expression pattern of Islet-1 and Islet-2 was examined in the pres...
Inoue, Ken-ichi;Ozaki, Shigeru;Shiga, Takashi;Ito, Kosei;Masuda, Tomoyuki;Okado, N.;Iseda, T.;Kawaguchi, S.;Ogawa, M.;Bae, S. C.;Yamashita, N.;Itohara, S.;Kudo, N.;Ito, Y.
Nature Neuroscience   5(10) 946-954   Jan 2002   [Refereed]
Dorsal root ganglion (DRG) neurons specifically project axons to central and peripheral targets according to their sensory modality. The Runt-related genes Runx1 and Runx3 are expressed in DRG neuronal subpopulations, suggesting that they may regu...
Masuda, Tomoyuki;Okado, Nobuo;Shiga, Takashi
Developmental Biology   224(2) 112-121   Jan 2000   [Refereed]
Previous studies have suggested that the developing notochord secretes diffusible axon guidance molecules that repel dorsal root ganglion (DRG) neurites (R. Keynes et al., 1997, Neuron 18, 889-897; K. Nakamoto and T. Shiga, 1998, Dev. Biol. 202, 3...

Books etc

 
Recent Research Developments in Neurochemistry, Vol. 8
Masuda, Tomoyuki;Yaginuma, Hiroyuki (Part:Contributor, Formation of peripheral nerve pathways by chemorepulsive and chemoattractive cues with special reference to innervation of the dorsal ramus)
Research Signpost   Nov 2014   
Melatonin: Therapeutic value and Neuroprotection
Ueda,Shuichi;Inoue,Ken-ichi;Ehara,Ayuka;Masuda,Tomoyuki (Part:Contributor, Neuroprotective effects of melatonin in the nigrostriatal and mesolimbic dopaminergic systems in the Zitter rat)
CRC press   Oct 2014   
Axons: Cell Biology, Molecular Dynamics and Roles in Neural Repair and Rehabilitation
Masuda, Tomoyuki;Shiga, Takashi;Yaginuma, Hiroyuki (Part:Contributor, Sensory axonal guidance by chemorepulsive and chemoattractive cues in the higher vertebrates)
Nova Science Publishers   Dec 2013   
Laminins: Structure, Biological Activity and Role in Disease
Masuda, Tomoyuki;Yaginuma, Hiroyuki;Shuichi, Ueda (Part:Contributor, Laminins as a modulator of the axonal response to guidance cues)
Nova Science Publishers   Aug 2013   
生物学辞典
増田, 知之 (Part:Contributor, 生物学辞典)
東京化学同人社   Dec 2010   ISBN:4807907352

Conference Activities & Talks

 
有機ヒ素中毒による血流変化について
石井, 一弘;根本清貴;岩崎信明;武田 徹;増田知之;柴田康行;玉岡 晃
第60回日本神経学会学術大会   22 May 2019   
有機ヒ素DPAA(ジフェニルアルシン酸)によるTau 蛋白発現変化の研究
石井, 一弘;増田, 知之;伊藤, 順子;伊関, 美緒子;菅原, 由佳;冨所, 康志;佐原, 成彦;池内, 健;玉岡, 晃
第37回日本認知症学会学術集会   12 Oct 2018   
Altered expression of total and phosphorylated tau by organic arsenic compounds
Ishii, Kazuhiro;Itoh, Junko;Masuda, Tomoyuki;Tomidokoro, Yasushi;Sahara, Naruhiko;Ikeuchi, Takeshi;Tamaoka, Akira
第59回日本神経学会学術大会   24 May 2018   
Hepatic histopathological changes and dysfunction in humans and nonhuman primates following exposure to organic arsenic diphenylarsinic acid
Masuda, Tomoyuki;Ishii, Kazuhiro;Iwasaki, Nobuaki;Tamaoka, Akira
第123回日本解剖学会全国学術集会   30 Mar 2018   
有機ヒ素diphenylarsinic acidは母体から胎盤を経由して仔に移行する
増田, 知之;岩崎, 信明;柴田, 康行;中山, 智博;玉岡, 晃;石井, 一弘
第95回日本生理学会大会   28 Mar 2018   
Hepatic histopathological changes following subchronic administration of diphenylarsinic acid to cynomolgus monkeys
Masuda, Tomoyuki;Ishii, Kazuhiro;Iwasaki, Nobuaki
第58回日本組織細胞化学会総会・学術集会   23 Sep 2017   
マウス成体脳における5型セマフォリンの発現様式
増田, 知之;谷口, 雅彦;佐久間, 千恵
第58回日本組織細胞化学会総会・学術集会   23 Sep 2017   
カメの脊髄神経~ボディプランの改変が神経系に及ぼす影響~ [Invited]
川口, 将史;真喜屋, 宏美;川崎, 能彦;増田, 知之
第88回日本動物学会富山大会シンポジウム   21 Sep 2017   
Non-proportional accumulation of diphenylarsinic acid in the central nervous system following subchronic administration to rats
Masuda, Tomoyuki;Ishii, Kazuhiro;Hosoya, Tomoko;Tanaka, R.;Nakayama, T.;Iwasaki, N.;Shibata, Y.;Tamaoka, A.
XXIII World Congress of Neurology (WCN 2017)   18 Sep 2017   
Transforming growth factor-beta1 levels in the cerebrospinal fluid of patients with neurodegenerative diseases
Ishii, Kazuhiro;Masuda, Tomoyuki;Itoh, Junko;Koide, T.;Tomidokoro, Y.;Takei, Y.;Tamaoka, A.
XXIII World Congress of Neurology (WCN 2017)   17 Sep 2017   

Patents

 
特許第6278524号 : AXON ATTRACTANT OR GROWTH PROMOTER
増田, 知之;石井, 一弘