Toshihiro Tsuruda - My portal

Profile Information

Affiliation: Professor, Faculty of Medicine School of Medicine Department of Hemovascular Medicine and Artificial Organs, University of Miyazaki
: (Concurrent)Other Staff, Faculty of Medicine Medicine educational reform promotion center

Degree: 学士（医学）(Mar, 1992, 宮崎医科大学)
博士（医学）(Mar, 2000, 宮崎医科大学)

Researcher number: 10389570
J-GLOBAL ID: 200901073154442435
researchmap Member ID: 5000081498

Research Interests

Cardiovascular medicine

Research Areas

Life sciences / Cardiology /

Research History

Feb, 2018 - Present

Associate Professor, Faculty of Madicine School of Madicine Internal medicine course circulation body fluid control study field, University of Miyazaki
Apr, 2012 - Present

Other Staff, Faculty of Madicine Medicine educational reform promotion center, University of Miyazaki
Jan, 2013 - Jan, 2018

Lecturer, Faculty of Madicine College Hospital The first internal medicine department, University of Miyazaki
Apr, 2007 - Dec, 2012

Assistant Professor, Faculty of Madicine School of Madicine, University of Miyazaki
Apr, 2004 - Mar, 2007

Minami Kyushu University
Sep, 2000 - Mar, 2003

Researcher, Mayo Clinic Rochester
Apr, 2000 - Sep, 2000

職員（医療系）, 野崎東病院
Jun, 1995 - Mar, 1996

Medical Staff, Miyakonojo Medical Association Hospital
Jun, 1994 - May, 1995

職員（医療系）, 国立療養所宮崎病院

Education

- Mar, 2000

Graduate School, Division of Medicine, Miyazaki Medical College
- Mar, 1992

Faculty of Medicine, Miyazaki Medical College

Committee Memberships

Oct, 2016 - Present

評議員, （社）日本高血圧学会
Jun, 2015 - Present

日本老年医学会代議員, 日本老年医学会
Aug, 2016

九州支部主催第314回九州地方会事務局長, （社）日本内科学会
Nov, 2014 - Dec, 2015

日本心血管内分泌代謝学会幹事, 日本心血管代謝内分泌学会
Apr, 2010 - Nov, 2014

評議員, 日本心血管代謝内分泌学会

Awards

2017

第53回高血圧関連疾患モデル学会会長賞, 高血圧関連疾患モデル学会

鶴田敏博
Jun, 2016

第120回日本循環器学会九州地方会トランスレーショナルリサーチセッション優秀賞, 日本循環器学会九州支部

鶴田敏博
Apr, 2016

Best Poster in the Basic/ Translational Domain ACC Geriatric Cardiology Member Section, American College of Cardiology

Tsuruda T
Aug, 2015

Best poster award (neurohormones) at European Society of Cardiology Congress, European Society of Cardiology

Tsuruda T
Jan, 2011

第7回 Cardiovascular Translational Research Conference Award, Cardiovascular Translational Research Conference

鶴田敏博
Aug, 2010

武田科学振興財団医学系研究奨励, 武田科学振興財団

鶴田敏博

Papers

Bystander-witnessed cardiopulmonary resuscitation by nonfamily is associated with neurologically favorable survival after out-of-hospital cardiac arrest in Miyazaki City District

Tsuruda T, Hamahata T, Endo G.J, Tsuruda Y, Kaikita K

PLoS ONE, 17(10 October) e0276574, Oct, 2022
Aberrant accumulation of TMEM43 accompanied by perturbed transmural gene expression in arrhythmogenic cardiomyopathy.

Haruki Shinomiya, Hisakazu Kato, Yuki Kuramoto, Nozomi Watanabe, Toshihiro Tsuruda, Tadaaki Arimura, Yohei Miyashita, Yoshiki Miyasaka, Tomoji Mashimo, Ayako Takuwa …

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 35(11) e21994, Nov, 2021 Peer-reviewed
Pericardial effusion in the course of Fabry disease cardiomyopathy: A case report

Tsuruda T, Higashi Y, Gi T, Nakao S

European Heart Journal - Case Reports, 5(10) ytab407, Oct 1, 2021 Peer-reviewedLead authorCorresponding author
心臓移植予定患者のヘリ搬送時に携帯する医薬品リストの整備と運用体制の構築

高橋沙希, 吉川直樹, 鶴田敏博, 鬼塚久充, 横田翼, 関屋裕史, 平原康寿, 北村和雄, 池田龍二

日本病院薬剤師会雑誌, 57(7) 771-775, Jul, 2021 Peer-reviewed
Non-canonical Expression of Cardiac Troponin-T in Neuroendocrine Ethmoid Sinus Carcinoma Following Immune Checkpoint Blockade.

Tsuruda T, Sato Y, Kajihara K, Kawabata T, Kubuki Y, Komaki S, Kikuchi M, Ishikawa T, Tono T, Kitamura K

Frontiers in Cardiovascular Medicine, section Cardio-Oncology., 6 124, Aug 23, 2019 Peer-reviewed
Infliximab as an alternative therapy for refractory adult onset Kawasaki disease: A case report.

Takeshi Kawaguchi, Yuki Rikitake, Toshihiro Tsuruda, Chihiro Kawata, Mao Rikitake, Kosho Iwao, Ayako Aizawa, Yumi Kariya, Motohiro Matsuda, Syunichi Miyauchi …

Medicine, 97(40) e12720, Oct 1, 2018 Peer-reviewed
Interaction between cardiac myosin-binding protein C and formin Fhod3

Sho Matsuyama, Yohko Kage, Noriko Fujimoto, Tomoki Ushijima, Toshihiro Tsuruda, Kazuo Kitamura, Akira Shiose, Yujiro Asada, Hideki Sumimoto, Ryu Takeya

Proceedings of the National Academy of Sciences of the United States of America, 115(19) E4386-E4395, May 8, 2018 Peer-reviewed
Adrenomedullin: Continuing to explore cardioprotection

Toshihiro Tsuruda, Johji Kato, Kenji Kuwasako, Kazuo Kitamura

Peptides, 2018 Peer-reviewedInvited
18F-fluorodeoxyglucose positron emission tomography 10 days before onset of aortic dissection

Toshihiro Tsuruda, Shigeki Nagamachi, Masashi Yamaguchi, Sumiharu Sakamoto, Tetsunori Ishikawa, Kazuo Kitamura

Circulation Journal, 82(4) 1213-1214, 2018 Peer-reviewed
A high-fat diet is deleterious to mice under glycolysis restriction

Yilin Hao, Toshihiro Tsuruda, Yoko Sekita-Hatakeyama, Sumiharu Sakamoto, Kazuo Kitamura

Applied Physiology, Nutrition and Metabolism, 43(4) 419-422, 2018 Peer-reviewed
Getting osteoporotic fracture risk into vascular structure and function: Do you know your FRAX® score?

Toshihiro Tsuruda, Kazuo Kitamura

Circulation Journal, 81(6) 786-787, 2017 Peer-reviewedInvited
Transient Left Ventricular Contractile Dysfunction during the Treatment of Rhabdomyolysis: A Case Report and Literature Review

Toshihiro Tsuruda, Nozomi Shinohara, Miyuki Ogata, Kazuo Kitamura, Hidenobu Ochiai

INTERNAL MEDICINE, 56(20) 2797-2803, 2017 Peer-reviewed
Coexisting Hyponatremia and Decline in Diastolic Blood Pressure Predispose to Atrial Standstill in Hyperkalemic Patients

Takeshi Ideguchi, Toshihiro Tsuruda, Yuji Sato, Kazuo Kitamura

CIRCULATION JOURNAL, 80(8) 1781-1786, Aug, 2016 Peer-reviewed
Cardiac hypertrophy is exacerbated in aged mice lacking the osteoprotegerin gene

Yilin Hao, Toshihiro Tsuruda, Yoko Sekita-Hatakeyama, Syuji Kurogi, Keishi Kubo, Sumiharu Sakamoto, Midori Nakamura, Nobuyuki Udagawa, Tomohisa Sekimoto, Kinta Hatakeyama …

CARDIOVASCULAR RESEARCH, 110(1) 62-72, May, 2016 Peer-reviewed
Angiotensin II Stimulation of Cardiac Hypertrophy and Functional Decompensation in Osteoprotegerin-Deficient Mice

Toshihiro Tsuruda, Yoko Sekita-Hatakeyama, Yilin Hao, Sumiharu Sakamoto, Syuji Kurogi, Midori Nakamura, Nobuyuki Udagawa, Taro Funamoto, Tomohisa Sekimoto, Kinta Hatakeyama …

HYPERTENSION, 67(5) 848-856, May, 2016 Peer-reviewed
Multiple F-18-Fluorodeoxyglucose Positron Emission Tomography Scans Showing Progression of Abdominal Aortic Aneurysm: A Case Report

Toshihiro Tsuruda, Shigeki Nagamachi, Masanori Nishimura, Kunihide Nakamura, Kazuo Kitamura

MEDICINE, 95(19) 3650e, May, 2016 Peer-reviewed
Osteoprotegerin: Osteo-Vascular Connection

Toshihiro Tsuruda

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 22(3) 233-234, 2015 Peer-reviewedInvited
Impact of Age-Dependent Adventitia Inflammation on Structural Alteration of Abdominal Aorta in Hyperlipidemic Mice

Sumiharu Sakamoto, Toshihiro Tsuruda, Kinta Hatakeyama, Takuroh Imamura, Yujiro Asada, Kazuo Kitamura

PLOS ONE, 9(8), Aug, 2014 Peer-reviewed
Osteoprotegerin is Secreted Into the Coronary Circulation: A Possible Association with the Renin-Angiotensin System and Cardiac Hypertrophy

S. Koyama, T. Tsuruda, T. Ideguchi, J. Kawagoe, H. Onitsuka, T. Ishikawa, H. Date, K. Hatakeyama, Y. Asada, J. Kato …

HORMONE AND METABOLIC RESEARCH, 46(8) 581-586, Jul, 2014 Peer-reviewed
Reduced fractional shortening of right ventricular outflow tract is associated with adverse outcomes in patients with left ventricular dysfunction.

Yamaguchi M, Tsuruda T, Watanabe Y, Onitsuka H, Furukawa K, Ideguchi T, Kawagoe J, Ishikawa T, Kato J, Takenaga M …

Cardiovasc Ultrasound, 11(1) 19, Jun 3, 2013 Peer-reviewed

Misc.

骨と心血管を巡る破骨細胞形成抑制因子、「オステオプロテゲリン」

鶴田敏博, 宇田川信之, 北村和雄

循環制御, 39(3) 157-159, 2018 Invited
心不全の基礎研究．心不全の分子機序．神経体液性因子．アドレノメデュリン

鶴田敏博, 北村和雄

日本臨床社, 76(9) 136-143, 2018 Invited
What are the clinical consequences of hyperkalemia on the heart and what are the uses of electrocardiograms in hyperkalemia?

Ideguchi T, Tsuruda T

E-journal of Cardiology Practice, 14 12, Jun, 2016
Guanylate cyclase on renal protection; update

Tsuruda T, Kitamura K

Kidney and Dialysis, 80(4) 556-560, Apr, 2016
ストローマからみた心血管病「ストローマをターゲットとした心血管病の治療」

北村和雄, 鶴田敏博

循環器内科, 74 125-131, Aug, 2013
ストローマからみた心血管病「序文」

北村和雄, 鶴田敏博

循環器内科, 74 123-124, Aug, 2013
心血管系の慢性炎症大動脈周囲炎、後腹膜線維症．（共著）

畠山金太, 鶴田敏博, 島尾義也, 中田博, 浅田祐士郎

別冊BIO Clinica慢性炎症と疾患, 1(1) 52-58, Oct 20, 2012
Adrenomedullin: Roles for structure and function in cardiac or vascular tissues

Toshihiro Tsuruda, Kazuo Kitamura

Current Hypertension Reviews, 7(4) 268-272, Dec, 2011
Roles for structure and function in cardiac or vascular tissues. 「"jointly worked"」

Tsuruda T, Kitamura K

Current Hypertension Reviews, 7(4) 268-272, Sep 2, 2011
炎症・免疫からみた心血管病．腹部大動脈瘤形成と炎症．（共著）

鶴田敏博, 坂元紀陽, 北村和雄

循環器内科, 69(6) 571-4577, Jun, 2011
炎症と動脈硬化-マクロファージ・血管構築細胞群．(共著）

鶴田敏博, 畠山金太, 北村和雄

日本臨牀, 69(1) 45-49, Jan 1, 2011
Mast cells in aortic disease. "jointly worked"

Tsuruda T, Hatakeyama K, Kitamura K

99(2) 245-250, Apr 10, 2010
Inflammatory cells in aortic aneurysm. "jointly worked"

Tsuruda T, Kitamura K

Vascular Biology & Medicine, 10(3) 21-29, Aug, 2009
Adrenomedullin in the progression of abodminal aortic aneurysm. "jointly worked"

Tsuruda T, Kitamura K

5(3) 70-76, Jul 1, 2009
Pathogenesis of abdominal aortic aneurysm: hemodynamics vs. inflammation. "jointly worked"

Tsuruda T, Kitamura K

32(2) 37-43, Jun 23, 2009
Role of mast cells in the atherosclerosis

Toshihiro Tsuruda, Kazuo Kitamura

Annual Review 2009 Circulation, 76-82, Jan 30, 2009

Books and Other Publications

腎保護薬update 可溶性グアニル酸シクラーゼ刺激薬

鶴田敏博

東京医学社, Aug 25, 2021
Current Therapy in Cardiovascular Diseases

(Role: Joint author)

Jan 30, 2020
心不全の基礎研究．心不全の分子機序．神経体液性因子．アドレノメデュリン

鶴田敏博, 宇田川信之, 北村和雄 (Role: Joint author)

日本臨床社, 2018
Mast cell density and distribution in human abdominal aortic aneurysm"jointly worked"

Sakamoto S, Tsuruda T, Hatakeyama K, Sekita Y, Imamura T, Asada Y, Kitamura K (Role: Joint author, pp55-66)

INTECH, Jul 1, 2011 (ISBN: 9789533075235)

Presentations

Tsuruda T, Kitamura K. Osteoprotegerin, but not Receptor Activator of Nuclear Factor kappaB Ligand, is Associated with the Development of Systolic Heart Failure

Kazuo Kitamura

第81回日本循環器学会学術集会, Mar 17, 2017, 日本循環器学会
Connection between Osteoporosis and Heart Failure

Kazuo Kitamura

The 20th Annual Scientific Meeting of the Society of Cardiovascular Endocrinology and Metabolism, Dec 16, 2016, Japanese Society of Cardiovascular Endocrinology and Metabolism
Angiotensin II promotes the eccentric cardiac hypertrophy in osteoprotegerin knockout mice

kazuo Kitamura

The 39th Annual Scientific Meeting of the Japanese Society of Hypertension, Sep 30, 2016, Japanese Society of Hypertension
Angiotensin II stimulation enhances cardiac hypertrophy and functional decompensation in osteoprotegerin-knockout mice

Tsuruda T, Sekita-Hatakeyama Y, Kurogi S, Hao Y, Sakamoto S, Nakamura M, Udagawa N, Sekimoto T, Hatakeyama K, Chosa E, Asada Y, Kitamura K

European Society of Cardiology Congress 2016, Aug 27, 2016, European Society of Cardiology
原発巣の手術から9年後に左室心筋内に再発した転移性悪性黒色腫の1例

財部愛菜, 黒木健吾, 井手口武史, 鬼塚久充, 鶴田敏博, 石川哲憲, 北村和雄, 持田耕介, 天野正宏, 佐藤勇一郎

第314回日本内科学会九州地方会, Aug 6, 2016, 日本内科学会
心不全を契機に診断された、難聴と糖尿病を合併するミトコンドリア心筋症の１例

山本紗子, 鬼塚久充, 児玉成邦, 大窪祟之, 黒木健吾, 小山彰平, 井手口武史, 鶴田敏博, 石川哲憲, 北村和雄, 松浦祐之介, 今村卓郎, 前川和也, 山下篤, 佐藤勇一郎, 浅田祐士郎, 植田初江

第１２０回日本循環器学会九州地方会, Jun 25, 2016, 日本循環器学会
骨代謝因子オステオプロテゲリンの心不全発症への関与

鶴田敏博, 北村和雄

第１２０回日本循環器学会九州地方会, Jun 25, 2016, 日本循環器学会
心不全の発症に関わる骨代謝分子オステオプロテゲリンの役割

鶴田敏博, 畠山陽子, 郝異琳, 黒木修司, 中村美どり, 宇田川信之, 畠山金太, 帖佐悦男, 浅田祐士郎, 北村和雄

第５８回日本老年医学会学術集会, Jun 8, 2016, 日本老年医学会
Cardiac hypertrophy is exacerbated in aged mice lacking the osteoprotegerin gene

Tsuruda T, Hao Y, Kurogi S, Nakamura M, Udagawa N, Chosa E, Asada Y, Kitamura K

American College of Cardiology. Geriatric Cardiology Section Meeting, Apr 3, 2016, American College of Cardiology
Cardiac hypertrophy is exacerbated in aged mice lacking the osteoprotegerin gene

Tsuruda T, Hao Y, Kurogi S, Nakamura M, Udagawa N, Chosa E, Asada Y, Kitamura K

American College of Cardiology. 65th Annual Scientific Session, Apr 2, 2016, American College of Cardiology
Stimulation of cyclic AMP and GMP signaling on coronary adventitial fibrosis

Tsuruda T, Kato J, Kitamura K

第80回日本循環器学会学術集会, Mar 18, 2016, 日本循環器学会
Enhanced glucose metabolism accelerates oxidized LDL incorporation and induces atherosclerosis

Hao Y, Tsuruda T, Asada Y, Kitamura K

第80回日本循環器学会学術集会, Mar 18, 2016, 日本循環器学会
Cardiac hypertrophy is exacerbated in aged mice lacking the osteoprotegerin gene

Tsuruda T, Sakamoto S, Hatakeyama K, Asada Y, Kitamura K

第80回日本循環器学会学術集会, Mar 18, 2016, 日本循環器学会
Deletion of osteoprotegerin gene exacerbates cardiac hypertrophy and systolic dysfunction in aged-mice

Tsuruda T, Hao Y, Sakamoto S, Kurogi S, Udagawa N, Nakamura M, Hatakeyama K, Chosa E, Asada Y, Kitamura K

Deletion of osteoprotegerin gene exacerbates cardiac hypertrophy and systolic dysfunction in aged-mice, Aug 29, 2015, European Society of Cardiology
Coexisting Hyponatremia is Subjected to Present Sinus Arrest in Hyperkalemia

Ideguchi T, Tsuruda T, Kuroki K, Ishikawa T, Kitamura K

第30回日本不整脈学会学術大会, Jul 28, 2015, 日本不整脈学会
外膜の炎症と動脈硬化、血管の陽性リモデリング

鶴田敏博, 北村和雄

第47回日本動脈硬化学会総会・学術集会, Jul 9, 2015, 日本動脈硬化学会
Osteoprotegerin is secreted into the coronary circulation: a possible association with the renin-angiotensin system and cardiac hypertrophy

Koyama S, Tsuruda T, Onistuka H, Ishikawa T, Kitamura K

第79回日本循環器学会学術集会, Apr 24, 2015, 日本循環器学会
多形性VTによる失神を反復しカテーテルアブレーション治療を行った一例

山本紗子, 井手口武史, 西平賢作, 田中浩喜, 黒木建吾, 小山彰平, 鶴田敏博, 鬼塚久充, 石川哲憲, 北村和雄

第308回日本内科学会九州地方会, Jan 10, 2015, 日本内科学会
動脈硬化、動脈瘤の成り立ちとマクロファージの役割

鶴田敏博

第93回宮崎市郡医師会病院心臓病研究会, Dec 9, 2014, 宮崎市郡医師会
Osteoprotegerin might counteract the activation of apoptosis induced by pressure overload in rat heart

Toshihiro Tsuruda, Kazuo Kitamura

ISHR XXI World Congress, Jun 30, 2014, Internal Society for Heart Research

Professional Memberships

Research Projects

Roles of stromal cells in cardiovascular remodeling

Basic Science Research on Life Science, Apr, 2007 - Present
心不全・動脈瘤の発症/進展におけるオステオプロテゲリンの関与

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2014 - Mar, 2017
腹部大動脈瘤の病態解明と細胞内エネルギー制御による内科的治療法の基盤確立

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2011 - Mar, 2014
血管外膜の炎症制御による腹部大動脈瘤の内科的治療戦略の基盤確立

第10回先進医薬研究振興財団循環医学分野研究助成, 民間財団等, Dec, 2012 - Nov, 2013
動脈硬化性腹部大動脈瘤の進展・破裂の機序の解明と新規内科的治療法の開発

財団法人武田科学振興財団, 民間財団等, Apr, 2010 - Mar, 2011
腹部大動脈瘤の形成におけるマスト細胞の関与

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2008 - Mar, 2011
腹部大動脈瘤の進展における血管外膜の炎症と内科的治療法の基盤確率

第１６回バイエル循環器病研究助成, 総務省, Apr, 2008 - Mar, 2009

Industrial Property Rights

特許第5888746号マトリックスメタロプロテアーゼ活性抑制組成物

鶴田敏博
13/818,126 マトリックスメタロプロテアーゼ活性抑制組成物

鶴田敏博
特願2010-187078 マトリックスメタロプロテアーゼ活性抑制組成物

鶴田敏博
PCT/JP2007/063703 動脈瘤の予防及び/又は治療薬

鶴田敏博
特願2006-193689 動脈瘤の予防及び/又は治療薬

鶴田敏博