2008年12月
Reconstruction of transcription-translation dynamics with a model of gene networks
JOURNAL OF THEORETICAL BIOLOGY
- ,
- ,
- ,
- 巻
- 255
- 号
- 4
- 開始ページ
- 378
- 終了ページ
- 386
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.jtbi.2008.09.006
- 出版者・発行元
- ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
A transcription-translation model of gene networks and a method to reconstruct it from gene expression data are proposed. The model is a hybrid system based on the Glass network with continuous-time dynamics and logical interactions. Transcription-translation dynamics is introduced into the Glass network. The reconstruction of gene networks is reduced to the problem of estimating logical functions from binary representations of quantities of mRNAs and proteins. The reconstruction method is applied to the gene expression data of circadian rhythms. The response characteristics of the reconstructed gene network to periodic stimuli are analyzed. The results suggest the existence of a receiver gene that responds to an external signal, consistently with biological knowledge. (C) 2008 Elsevier Ltd. Ail rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.jtbi.2008.09.006
- ISSN : 0022-5193
- PubMed ID : 18845165
- Web of Science ID : WOS:000261525100004