論文

査読有り 責任著者 国際誌
2020年3月

Gut microbial fatty acid metabolites (KetoA and KetoC) affect the progression of nonalcoholic steatohepatitis and reverse cholesterol transport metabolism in mouse model.

Lipids
  • Neng Tanty Sofyana
  • ,
  • Jiawen Zheng
  • ,
  • Yuki Manabe
  • ,
  • Yuta Yamamoto
  • ,
  • Shigenobu Kishino
  • ,
  • Jun Ogawa
  • ,
  • Tatsuya Sugawara

55
2
開始ページ
151
終了ページ
162
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/lipd.12219

Nonalcoholic steatohepatitis (NASH) is a common liver disease that occurs in both alcoholics and nonalcoholics. Oxidative stress is a possible causative factor for liver diseases including NASH. Gut microorganisms, especially lactic acid bacteria, can produce unique fatty acids, including hydroxy, oxo, conjugated, and partially saturated fatty acids. The oxo fatty acid 10-oxo-11(E)-octadecenoic acid (KetoC) provides potent cytoprotective effects against oxidative stress through activation of Nrf2-ARE pathway. The aim of this study was to explore the preventive and therapeutic effects of gut microbial fatty acid metabolites in a NASH mouse model. The mice were divided into 3 experimental groups and fed as follows: (1) high-fat diet (HFD) (2) HFD mixed with 0.1% KetoA (10-oxo-12(Z)-octadecenoic acid), and (3) HFD mixed with 0.1% KetoC. After 3 weeks of feeding, plasma parameters, liver histology, and mRNA expression of multiple genes were assessed. There was hardly any difference in fat accumulation in the histological study; however, no ballooning occurred in 2/5 mice of KetoC group. Bridging fibrosis was not observed in the KetoA group, although KetoA administration did not significantly suppress fibrosis score (p = 0.10). In addition, KetoC increased the expression level of HDL related genes and HDL cholesterol levels in the plasma. These results indicated that KetoA and KetoC may partly affect the progression of NASH in mice models.

リンク情報
DOI
https://doi.org/10.1002/lipd.12219
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32040876
ID情報
  • DOI : 10.1002/lipd.12219
  • PubMed ID : 32040876

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