論文

査読有り 国際誌
2021年1月

Diagnosing Autism Spectrum Disorder Without Expertise: A Pilot Study of 5- to 17-Year-Old Individuals Using Gazefinder.

Frontiers in neurology
  • Kenji J Tsuchiya
  • ,
  • Shuji Hakoshima
  • ,
  • Takeshi Hara
  • ,
  • Masaru Ninomiya
  • ,
  • Manabu Saito
  • ,
  • Toru Fujioka
  • ,
  • Hirotaka Kosaka
  • ,
  • Yoshiyuki Hirano
  • ,
  • Muneaki Matsuo
  • ,
  • Mitsuru Kikuchi
  • ,
  • Yoshihiro Maegaki
  • ,
  • Taeko Harada
  • ,
  • Tomoko Nishimura
  • ,
  • Taiichi Katayama

11
開始ページ
603085
終了ページ
603085
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3389/fneur.2020.603085

Atypical eye gaze is an established clinical sign in the diagnosis of autism spectrum disorder (ASD). We propose a computerized diagnostic algorithm for ASD, applicable to children and adolescents aged between 5 and 17 years using Gazefinder, a system where a set of devices to capture eye gaze patterns and stimulus movie clips are equipped in a personal computer with a monitor. We enrolled 222 individuals aged 5-17 years at seven research facilities in Japan. Among them, we extracted 39 individuals with ASD without any comorbid neurodevelopmental abnormalities (ASD group), 102 typically developing individuals (TD group), and an independent sample of 24 individuals (the second control group). All participants underwent psychoneurological and diagnostic assessments, including the Autism Diagnostic Observation Schedule, second edition, and an examination with Gazefinder (2 min). To enhance the predictive validity, a best-fit diagnostic algorithm of computationally selected attributes originally extracted from Gazefinder was proposed. The inputs were classified automatically into either ASD or TD groups, based on the attribute values. We cross-validated the algorithm using the leave-one-out method in the ASD and TD groups and tested the predictability in the second control group. The best-fit algorithm showed an area under curve (AUC) of 0.84, and the sensitivity, specificity, and accuracy were 74, 80, and 78%, respectively. The AUC for the cross-validation was 0.74 and that for validation in the second control group was 0.91. We confirmed that the diagnostic performance of the best-fit algorithm is comparable to the diagnostic assessment tools for ASD.

リンク情報
DOI
https://doi.org/10.3389/fneur.2020.603085
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33584502
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7876254
ID情報
  • DOI : 10.3389/fneur.2020.603085
  • PubMed ID : 33584502
  • PubMed Central 記事ID : PMC7876254

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