論文

査読有り 国際誌
2021年2月

Platelet-derived growth factor BB: A potential diagnostic blood biomarker for differentiating bipolar disorder from major depressive disorder.

Journal of psychiatric research
  • Keita Idemoto
  • ,
  • Tamaki Ishima
  • ,
  • Tomihisa Niitsu
  • ,
  • Tatsuki Hata
  • ,
  • Sumiko Yoshida
  • ,
  • Kotaro Hattori
  • ,
  • Tadasu Horai
  • ,
  • Ikuo Otsuka
  • ,
  • Hidenaga Yamamori
  • ,
  • Shigenobu Toda
  • ,
  • Yosuke Kameno
  • ,
  • Kiyomitsu Ota
  • ,
  • Yasunori Oda
  • ,
  • Atsushi Kimura
  • ,
  • Tasuku Hashimoto
  • ,
  • Norio Mori
  • ,
  • Mitsuru Kikuchi
  • ,
  • Yoshio Minabe
  • ,
  • Ryota Hashimoto
  • ,
  • Akitoyo Hishimoto
  • ,
  • Kazuyuki Nakagome
  • ,
  • Masaomi Iyo
  • ,
  • Kenji Hashimoto

134
開始ページ
48
終了ページ
56
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.jpsychires.2020.12.051

Bipolar disorder (BD) is frequently misdiagnosed as major depressive disorder (MDD) due to overlapping depressive symptoms. This study investigated whether serum platelet-derived growth factor BB (PDGF-BB) is a differential diagnostic biomarker for BD and MDD. An initial SOMAscan proteomics assay of 1311 proteins in small samples from patients with BD and MDD and healthy controls (HCs) suggested that serum levels of PDGF-BB differed between BD and MDD. We then conducted a two-step, exploratory, cross-sectional, case-control study at our institute and five sites that included a total of 549 participants (157 with BD, 144 with MDD, and 248 HCs). Clinical symptoms were assessed using the Hamilton Depression Rating Scale and the Young Mania Rating Scale. In the initial analysis at our institute, serum PDGF-BB levels in the MDD group (n = 36) were significantly lower than those in the BD (n = 39) and HC groups (n = 36). In the multicenter study, serum PDGF-BB levels in the MDD group were again significantly lower than those in the BD and HC groups, with no significant difference between the BD and HC groups. Treatment with sodium valproate was associated with significantly lower serum PDGF-BB levels in patients with BD. After controlling for confounding factors (sex, age, body mass index, clinical severity, and valproate medication), serum PDGF-BB levels were lower in the MDD group than in the BD group regardless of mood state. Our findings suggest that serum PDGF-BB may be a potential biomarker to differentiate BD and MDD.

リンク情報
DOI
https://doi.org/10.1016/j.jpsychires.2020.12.051
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33360224
ID情報
  • DOI : 10.1016/j.jpsychires.2020.12.051
  • PubMed ID : 33360224

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