Apr, 2016 - Mar, 2019
Cognitive Deficits and Oxytocin Signaling in Cortical Parvalbumin Neurons in Schizophrenia
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B) Grant-in-Aid for Scientific Research (B)
- Grant number
- 16H05372
- Japan Grant Number (JGN)
- JP16H05372
- Grant amount
-
- (Total)
- 15,730,000 Japanese Yen
- (Direct funding)
- 12,100,000 Japanese Yen
- (Indirect funding)
- 3,630,000 Japanese Yen
In the prefrontal cortex (PFC) of schizophrenia subjects, local inhibitory neurons that express parvalbumin (PV) appear to be altered. In the rodent cortex, PV neurons were shown to be modulated by neuropeptide oxytocin (OXT) through the OXT receptor (OXTR). In this study, we first aimed to detect OXTR expression in PV neurons in control human subjects. However, OXTR expression was detected mainly in non-inhibitory neurons in the PFC and anterior cingulate cortex. Although OXTR expression was detected in dopamine neurons in the substantia nigra, the mRNA levels were not different between control and schizophrenia subjects. These findings indicate that OXT signaling might not be involved in altered function of PV or dopamine neurons in subjects with schizophrenia. However, the expression levels of other genes in PV neurons, such as GAD1 and KCNS3, were similarly affected in PV neurons across multiple cortical regions in schizophrenia.
- Link information
- ID information
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- Grant number : 16H05372
- Japan Grant Number (JGN) : JP16H05372