MISC

2019年3月

[A Case of Stage ⅣRectal Cancer with Dyskeratosis Congenita].

Gan to kagaku ryoho. Cancer & chemotherapy
  • Keishi Nakamura
  • Shiro Terai
  • Yoshinao Ohbatake
  • Koichi Okamoto
  • Shinichi Nakanuma
  • Seisho Sakai
  • Jun Kinoshita
  • Isamu Makino
  • Tomoharu Miyashita
  • Hidehiro Tajima
  • Hiroyuki Takamura
  • Itasu Ninomiya
  • Sachio Fushida
  • Tetsuo Ohta
  • 全て表示

46
3
開始ページ
515
終了ページ
517
記述言語
日本語
掲載種別
Scientific Journal

A 27-year-old man was diagnosed with dyskeratosis congenita from DKC1 gene mutation at 9 years of age and had been followed-up regularly.An upper gastrointestinal endoscopy performed for vomiting revealed gastric varices.Further examination resulted in a diagnosis of Stage Ⅳrectal cancer with portal hypertension, splenomegaly, liver, and lung metastasis and he was referred to our department.A laparoscopic splenectomy was performed, followed by a laparoscopic low anterior resection for rectal cancer.Subsequently, resection of the pulmonary and liver metastasis was performed, resulting in macroscopic radical resection.However, 3 months after the hepatectomy, unresectable multiple lung metastasis was detected and he received 5 courses of chemotherapy with cetuximab.A grade 3 skin rash was observed and chemotherapy was discontinued. After 5 courses, he had pneumothorax and received drainage.He had sudden respiratory failure 2 days after pleural adhesion therapy of OK-432 was performed.He was diagnosed with interstitial pneumonia induced by OK-432 and steroid pulse therapy, which resulted in his death without improvement 21 days after admission.

リンク情報
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30914599
ID情報
  • ISSN : 0385-0684
  • PubMed ID : 30914599

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