HIRANO Tomoya

J-GLOBAL         Last updated: Apr 17, 2019 at 02:40
 
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Name
HIRANO Tomoya
E-mail
hira.chemtmd.ac.jp
Affiliation
Tokyo Medical and Dental University
Section
Institute of Biomaterials and Bioengineering Biomolecular Chemistry Organic and Medicinal Chemistry
Job title
Associate Professor
Degree
Doctor of Pharmacy(The University of Tokyo)
Other affiliation
Tokyo Medical and Dental University
Research funding number
20396980
ORCID ID
0000-0003-1196-7199

Research Areas

 
 

Academic & Professional Experience

 
Mar 2009
 - 
Today
Associate Professor, Institute of Biomaterials and Bioengineering Biomolecular Chemistry Organic and Medicinal Chemistry, Tokyo Medical and Dental University
 
Mar 2009
 - 
Today
Associate Professor, Graduate School of Medical and Dental Sciences Medical and Dental Sciences Advanced Therapeutic Sciences Biofunctional Molecular Science, Tokyo Medical and Dental University
 
Sep 2004
 - 
Feb 2009
Assistant Professor, Biomedical Science PhD Program / Graduate School of Biomedical Science, Tokyo Medical and Dental University
 
Jul 2003
 - 
Aug 2004
Visiting Postdoctoral Scholar, University of California San Francisco
 

Education

 
Apr 1999
 - 
Mar 2002
Graduate School, Division of Pharmaceutical Sciences, The University of Tokyo
 
Apr 1997
 - 
Mar 1999
Graduate School, Division of Pharmaceutical Sciences, The University of Tokyo
 
Apr 1993
 - 
Mar 1997
Faculty of Pharmaceutical Science, The University of Tokyo
 

Published Papers

 
Urushibara K, Masu H, Mori H, Azumaya I, Hirano T, Kagechika H, Tanatani A
The Journal of organic chemistry      Nov 2018   [Refereed]
Tomoya Hirano, Takashi Fujiwara, Hideaki Niwa, Michitake Hirano, Kasumi Ohira, Yusuke Okazaki, Shin Sato, Takashi Umehara, Yuki Maemoto, Akihiro Ito, Minoru Yoshida, Hiroyuki Kagechika
ChemMedChem   13(15) 1530-1540   Aug 2018   [Refereed]
The histone methyltransferase SET7/9 methylates not only histone but also non-histone proteins as substrates, and therefore, SET7/9 inhibitors are considered candidates for the treatment of diseases. Previously, our group identified cyproheptadine...
Yukiko Tojo, Ko Urushibara, Sawori Yamamoto, Hirotoshi Mori, Hyuma Masu, Mayumi Kudo, Tomoya Hirano, Isao Azumaya, Hiroyuki Kagechika, Aya Tanatani
J. Org. Chem.   83(8) 4606-4617   Apr 2018   [Refereed]
N-Alkylbenzanilides generally exist in cis conformation both in the crystalline state and in various solvents, and this cis conformational preference can be utilized to construct dynamic helical oligoamides. Here, we synthesized the pyrrole-contai...
Hidetomo Yokoo, Ayumi Ohsaki, Hiroyuki Kagechika, Tomoya Hirano
European Journal of Organic Chemistry   (5) 679-687   Feb 2018   [Refereed]
Yuta Endo, Taku Kasahara, Kenicni Harada, Miwa Kubo, Tadahiro Etoh, Masami Ishibashi, Aki Ishiyama, Masato Iwatsuki, Kazuhiko Otoguro, Satoshi O Mura, Gokithi Akisue, Tomoya Hirano, Hiroyuki Kagechika, Yoshiyasu Fukuyama, Ayumi Ohsaki
J. Nat. Prod.   80(12) 3120-3127   Dec 2017

Misc

 
Tomoya Hirano, Shuichi Mori, Hiroyuki Kagechika
Chemical Record      Aug 2018   [Refereed]
Protein lysine methyltransferases (PKMTs) are epigenetic regulators that modulate gene transcription and physiological functions by catalyzing the post-translational methylation of specific lysine residues of substrate proteins, such as histones. ...
Development of therapeutic strategies based on chemical biological studies of histone methyltransferase
Tomoya Hirano, Shuichi Mori, Hiroyuki Kagechika
27(4) 208-212   Nov 2017   [Refereed]
Development of functional molecules for elucidation of the physiological roles of several nuclear receptors and their endogenous ligands.
Tomoya Hirano
Chem. Pharm. Bull.   61(2) 111-120   2013   [Refereed][Invited]
Nuclear receptors and their endogenous ligands are involved in key biological functions, including development, homeostasis and metabolism, and functional molecules that can modulate receptor activities are of interest for basic research to elucid...
Construction of Coumarin Library for Development of Fluorescent Sensors
Hirano, T. and Kagechika, H.
Combinatorial Methods for Chemical and Biological Sensors   441-451   2009   [Refereed][Invited]
亜鉛イオンを検出する蛍光プローブの開発
平野智也
生物工学会誌   84 170-172   2006   [Refereed][Invited]

Conference Activities & Talks

 
Development of fluorescent sensor aldehyde dehydrogenase
Yusuke Dobashi, Tomoya Hirano, Kazuhiro Imaida, Hiroyuki Kagechika
15 Sep 2018   
Development of photolabile protected group resposible for metal cation
Erika Yamazaki, Tomoya Hirano, Daiki Kato, Hiroyuki Kagechika
15 Sep 2018   
Development of photofunctional molecules that function under a specific range of pH with “OFF-ON-OFF” type of change
Tomoya Hirano, Daiki Kato, Chihiro Komatsu, Yuki Noji, Hiroyuki Kagechika,
Gordon Research Conference, Bioanalytical Sensors, Newport   26 Jun 2018   
Development of novel environment-dependent fluorophore derived from fluorescent natural compounds
Hidetomo Yokoo, Tomoya Hirano, Ayumi Ohsaki, Hiroyuki Kagechika
Gordon Research Conference, Bioanalytical Sensors   26 Jun 2018   
Development of assay system for the activity of histone methytransferase
Tomoya Hirano, Shuchi Mori, Yusuke Okazaki, Takashi Fujiwara, Asuka Takaguchi, Hiroyuki Kagechika
The 13th Annual Meeting of Japanese Society for Chemical Biology   11 Jun 2018   

Research Grants & Projects

 
Development of inhibitors of histone modifying enzymes
Project Year: Apr 2005 - Today
Development of fluorescent sensors
Project Year: Apr 1996 - Today