Takuya Okada - My portal

Profile Information

Affiliation: Assistant Professor, Faculty of Medicine, University of Tsukuba

Degree: Ph.D.(Mar, 2007, University of Tsukuba)
B.S.(Mar, 2001, Tokyo Institute of Technology)

Contact information: okada.takuya.gwu.tsukuba.ac.jp
Researcher number: 60451697
J-GLOBAL ID: 200901032502741877
researchmap Member ID: 5000082171

External link: http://www.md.tsukuba.ac.jp/duo/molneurobiol/

Research Interests

brain, neuron, development, brain function

Research Areas

Life sciences / Medical biochemistry /

Research History

Apr, 2011 - Present

Assistant Professor, Faculty of Medicine, University of Tsukuba
Apr, 2010 - Mar, 2011

Assistant Professor, Graduate School of Comprehensive Human Sciences, University of Tsukuba
Apr, 2007 - Mar, 2010

postdoctoral fellow, Graduate School of Comprehensive Human Sciences, University of Tsukuba

Education

Apr, 2001 - Mar, 2007

Kansei, Behavioral and Brain Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba
Apr, 1997 - Mar, 2001

School of Bioscience and Biotechnology, Tokyo Institute of Technology

Awards

Sep, 2009

つくば医科学研究奨励賞

岡田拓也
Aug, 2008

Best Poster Award, The Japanese Society of Carbohydrate Research Meeting, The Japanese Society of Carbohydrate Research

Takuya Okada
Mar, 2007

筑波大学大学院人間総合科学研究科長賞

岡田拓也

Papers

Lateral habenula glutamatergic neurons projecting to the dorsal raphe nucleus promote aggressive arousal in mice

Takahashi, Aki, Durand-de Cuttoli, Romain, Flanigan, Meghan E, Hasegawa, Emi, Tsunematsu, Tomomi, Aleyasin, Hossein, Cherasse, Yoan, Miya, Ken, Okada, Takuya, Keino-Masu, Kazuko …

Nature communications, 13(1) 4039-4039, Jul 21, 2022
Lateral habenula glutamatergic neurons projecting to the dorsal raphe nucleus promote aggressive arousal in mice

Takahashi, Aki, Durand-de Cuttoli, Romain, Flanigan, Meghan E, Hasegawa, Emi, Tsunematsu, Tomomi, Aleyasin, Hossein, Cherasse, Yoan, Miya, Ken, Okada, Takuya, Keino-Masu, Kazuko …

Nature communications, 13(1) 4039-4039, Jul 21, 2022
Lateral habenula glutamatergic neurons projecting to the dorsal raphe nucleus promote aggressive arousal in mice

Takahashi, Aki, Durand-de Cuttoli, Romain, Flanigan, Meghan E, Hasegawa, Emi, Tsunematsu, Tomomi, Aleyasin, Hossein, Cherasse, Yoan, Miya, Ken, Okada, Takuya, Keino-Masu, Kazuko …

Nature communications, 13(1) 4039-4039, Jul 21, 2022
Diffusion magnetic resonance tractography-based evaluation of commissural fiber abnormalities in a heparan sulfate endosulfatase-deficient mouse brain

Tsuji, Yusuke, Kerever, Aurelien, Furukawa, Toshiki, Kamagata, Koji, Saito, Yuya, Aoki, Shigeki, Hata, Junichi, Okano, Hideyuki, Kobayashi, Kenta, Okada, Takuya …

MAGNETIC RESONANCE IMAGING, 88 123-131, May, 2022
Expression of heparan sulfate endosulfatases in the adult mouse brain : Co-expression of Sulf1 and dopamine D1/D2 receptors

Miya, Ken, Keino-Masu, Kazuko, Okada, Takuya, Kobayashi, Kenta, Masu, Masayuki

Frontiers in Neuroanatomy, 15 726718, Aug, 2021 Peer-reviewed
錐体路の形成と発達

桝正幸, 桝, 和子, 岡田拓也

脳神経内科, 95(1) 7-15, Jul, 2021 Peer-reviewed
Abnormal pyramidal decussation and bilateral projection of the corticospinal tract axons in mice lacking the heparan sulfate endosulfatases, Sulf1 and Sulf2

Aizawa, Satoshi, Okada, Takuya, Keino-Masu, Kazuko, Doan, Tri Huu, Koganezawa, Tadachika, Akiyama, Masahiro, Tamaoka, Akira, Masu, Masayuki

FRONTIERS IN MOLECULAR NEUROSCIENCE, 12 333-333, Jan, 2020 Peer-reviewed
Data for 3D reconstruction of the corticospinal tract in the wild-type and Semaphorin 6A knockout adult brain

Okada, Takuya, Keino-Masu, Kazuko, Suto, Fumikazu, Mitchell, Kevin, Masu, Masayuki

Data in Brief, 23 103718, 2019 Peer-reviewed
Remarkable complexity and variability of corticospinal tract defects in adult Semaphorin 6A knockout mice

Okada, Takuya, Keino-Masu, Kazuko, Suto, Fumikazu, Mitchell, Kevin J, Masu, Masayuki

Brain research, 1710 209-219, Dec, 2018
Desulfation of heparin sulfate plays a Ley role in corticospinal tract formation

岡田, 拓也, 桝和子

Journal of Clinical and Experimental Medicine, 234-236, Jul, 2018
Organ-specific Sulfation Patterns of Heparan Sulfate Generated by Extracellular Sulfatases Sulf1 and Sulf2 in Mice

Satoshi Nagamine, Michiko Tamba, Hisako Ishimine, Kota Araki, Kensuke Shiomi, Takuya Okada, Tatsuyuki Ohto, Satoshi Kunita, Satoru Takahashi, Ronnie G. P. Wismans …

JOURNAL OF BIOLOGICAL CHEMISTRY, 287(12) 9579-9590, Mar, 2012 Peer-reviewed
Different effects of SulfFP1 and SulfFP2 electroporation in rescuing axon guidance defects in SulfFP double mutant mice

Takuya Okada, Kazuko Keino-Masu, Satoshi Nagamine, Satoshi Kunita, Satoru Takahashi, Masayuki Masu

NEUROSCIENCE RESEARCH, 65(Suppl. 1) S160-S160, 2009
Restoration of axon guidance defects in SulfFP-deficient mice by introducing exogenous SulfFPs

Okada, Takuya, Keino-Masu, Kazuko, Nagamine, Satoshi, Kunita, Satoshi, Takahashi, Satoru, Masu, Masayuki

NEUROSCIENCE RESEARCH, 61(Suppl. 1), Jan, 2008
Expression of glypican and syndecan genes in the mouse embryonic brain

Masu, Masayuki, Murakami, Saori, Okada, Takuya, Keino-Masu, Kazuko

NEUROSCIENCE RESEARCH, 61(Suppl. 1), Jan, 2008
Migration and nucleogenesis of mouse precerebellar neurons visualized by in utero electroportion of a green fluorescent protein gene (vol 57, pg 40, 2007)

Takuya Okada, Kazuko Keino-Masu, Masayuki Masu

NEUROSCIENCE RESEARCH, 58(1) 101-101, May, 2007
Migration and nucleogenesis of mouse precerebellar neurons visualized by in utero electroporation of a green fluorescent protein gene.

Okada, T, Keino-Masu, K, Masu, M

Neurosci. Res., 57 40-49, Jan, 2007 Peer-reviewed
Migration and nucleogenesis of mouse precerebellar neurons visualized by in utero electroporation of a green fluorescent protein gene

Takuya Okada, Kazuko Keino-Masu, Masayuki Masu

NEUROSCIENCE RESEARCH, 57(1) 40-49, Jan, 2007
The origin and development of the precerebellar neurons in the spinal trigeminal nucleus

Okada, Takuya, Keino-Masu, Kazuko, Masu, Masayuki

NEUROSCIENCE RESEARCH, 58(Suppl. 1), Jan, 2007
Heparan sulfate 6-O-endosulfatases are required for normal brain development

Okada, Takuya, Nagamine, Satoshi, Keino-Masu, Kazuko, Ohto, Tatsuyuki, Kunita, Satoshi, Takahashi, Satoru, Masu, Masayuki

NEUROSCIENCE RESEARCH, 55(Suppl. 1), Jan, 2006
Histaminergic role in sleep-wake cycle of orexin, adenosine, and prostaglandin E2 and D2

L. Huang, Z, M. Qu, W, Eguchi, N, Chu, M, Okada, T, Sato, Y, Sakata, M, Mochizuki, T, Urade, Y, Hayaishi, O

Sleep and Biological Rhythms, 2(1) S21-S22, May, 2004 Peer-reviewed

Books and Other Publications

Studies on autotaxin signaling in endocytic vesicle biogenesis and embryonic development using whole embryo culture and electroporation.

Masu;M, Koike;S, Okada;T, and, Keino-Masu;K, 岡田, 拓也 (Role: Supervisor (editorial))

Lysophospholipid Receptors: Signaling and Biochemistry. John Wiley & Son Inc. Hoboken, NJ, USA., Jan, 2012

Presentations

Involvement the lateral habenul–dorsal raphe nucleus–ventral tegmental area projection in social instigation-heightened aggression in male mice

Takahashi, Aki

Neuroscience 2021, Nov 8, 2021
Glutamatergic projection from the lateral habenula to the dorsal raphe nucleus escalates aggressive behavior of male mice.

Takahashi, Aki, Flanigan, Meghan E, Tsunematsu, Tomomi, Aleyasin, Hossein, Cherasse, Yoan, Miya, Ken, Okada, Takuya, Keino-Masu, Kazuko, Lazarus, Michael, Tanaka, Kenji F, Yamanaka, Akihiro, Ogawa, Sonoko, Russo, Scott J

The 44th Annual Meeting of the Japan Neuroscience Society/The 1st CJK International Meeting, Jul 28, 2021
Bilateral projection and motor control of the corticospinal tract in mice lacking the heparan sulfate endosulfatases Sulf1/2

Okada,Takuya

第43回日本神経科学大会, Jul 29, 2020
へパラン硫酸エンドスルファターゼSulf1/2欠損マウスにおける皮質脊髄路の両側性投射と運動制御

岡田拓也, 加藤鞠花, 相澤哲史, 桝和子, Doan, Tri, 小金澤, 禎史, 玉岡晃, 桝正幸

第43回日本神経科学大会, Jul 29, 2020
Sulf1/2 double-knockout mice show the tendency not to lose in the tube test

Keino-Masu, Kazuko, Okada, Takuya, Hashimoto, Sayaka, Masu, Masayuki

第43回日本神経科学大会, Jul, 2020
Essential roles of heparan sulfate endosulfatases, Sulf1 and Sulf2, in functional corticospinal tract formation

Okada, Takuya, Aizawa, Satoshi, Keino-Masu, Kazuko, Kuppevel, Toin H. van, Tamaoka, Akira, Masu, Masayuki

Proteoglycans 2019, Sep 29, 2019
Abnormal trajectories of the corticospinal tract and motor dysfunction in mice lacking heparan sulfate endosulfatases Sulf1/2

Aizawa, Satoshi, Okada, Takuya, Keino-Masu, Kazuko, Tamaoka, Akira, Masu, Masayuki

第42回日本神経科学大会, Jul 25, 2019
Developmental defects of the habenula-interpeduncular circuit in double knockout mice for heparan sulfate endosulfatases Sulf1/2

Hashimoto, Sayaka, Okada, Takuya, Miya, Ken, Keino-Masu, Kazuko, Masu, Masayuki

第41回日本神経科学大会, Jul, 2018
Heparan sulfate endosulfatases, Sulf1 and Sulf2, are required for habenula circuit development

Hashimoto, Sayaka, Okada, Takuya, Keino-Masu, Kazuko, Masu, Masayuki

第40回日本神経科学大会, Jul 20, 2017
Desulfation of heparan sulfate is required for corticospinal tract formation

Masu, Masayuki, Okada, Takuya, Nagamine, Satoshi, Kametani, Fuyuki, Ohto, Tatsuyuki, Hasegawa, Masato, van Kuppevelt, Toin, Keino-Masu, Kazuko

第40回日本神経科学学会大会, Jul, 2017

Professional Memberships

Oct, 2010 - Present

Society for Neuroscience
Aug, 2008 - Present

THE JAPANESE SOCIETY OF CARBOHYDRATE RESEARCH
Aug, 2004 - Present

THE JAPAN NEUROSCIENCE SOCIETY

Research Projects

Identification of corticospinal axon branching factor genes

Grant-in-Aid for JSPS Fellows, Japan Society of for the Promotion of Science, Apr, 2003 - Mar, 2005

Takuya Okada
先天的腓骨神経欠損マウスの原因遺伝子同定と発症機序の解明

科学研究費補助金基盤研究（C）, 日本学術振興会

桝和子
皮質脊髄路が両側性投射を持つ遺伝子改変マウスを用いた同側性投射線維の役割解明

科学研究費補助金基盤研究（B）, 日本学術振興会

桝正幸