山口美樹 (Miki Yamaguchi) - マイポータル

基本情報

所属: 札幌医科大学フロンティア医学研究所分子医学部門助教

学位: 医学博士(札幌医科大学)

J-GLOBAL ID: 200901016259302244
researchmap会員ID: 5000082573

外部リンク: http://web.sapmed.ac.jp/molm/index.html

研究キーワード

研究分野

経歴

2008年5月 - 現在

札幌医科大学, フロンティア医学研究所分子医学部門, 助教
1996年5月 - 2008年4月

北海道赤十字血液センター, 研究部
1993年 - 1996年

岸本医科学研究所研究員
1993年 - 1996年

Kishimoto Clinical Laboratory
1996年

- Hokkaido Red Cross BLood Center

学歴

2004年4月 - 2007年9月

札幌医科大学, 医学部, 分子医学研究部門
1994年10月 - 1997年3月

北海道大学, 医学部, 第2内科
- 1988年

湘央学園, 臨床検査技術学科
- 1988年

Sho-oh Life Science, Clinical laboratory test technology school subject

論文

A newly developed anti-Mucin 13 monoclonal antibody targets pancreatic ductal adenocarcinoma cells

Yukari Nishii, Miki Yamaguchi, Yasutoshi Kimura, Tadashi Hasegawa, Hiroyuki Aburatani, Hiroaki Uchida, Koichi Hirata, Yuji Sakuma

INTERNATIONAL JOURNAL OF ONCOLOGY 46(4) 1781-1787 2015年4月査読有り
Pr1E11, a novel anti-TROP-2 antibody isolated by adenovirus-based antibody screening, recognizes a unique epitope

Masahiro Ikeda, Miki Yamaguchi, Kazunori Kato, Kiminori Nakamura, Sagano Shiina, Takako Ichikawa-Ando, Hirofumi Misaka, Kensuke Myojo, Kazuyasu Nakamura, Yoshiyuki Sugimoto …

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 458(4) 877-882 2015年3月査読有り
Development of a sensitive screening method for selecting monoclonal antibodies to be internalized by cells

Mild Yamaguchi, Yukari Nishii, Kiminori Nakamura, Haruka Aoki, Sachie Hirai, Hiroaki Uchida, Yuji Sakuma, Hirofumi Hamada

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 454(4) 600-603 2014年11月査読有り
Bone Marrow Stromal Cell Line Promotes the Proliferation of Mast Cell Progenitors Derived from Cord Blood CD34(+) Cells under Serum-free Conditions with a Combination of Both Cell-cell Interaction and Soluble Factors

Mitsuhiro Fujihara, Hiroshi Azuma, Hisami Ikeda, Miki Yamaguchi, Hirofumi Hamada

ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY 39(2) 51-58 2011年4月査読有り
Elevated Ca²+ influx-inducing activity toward mast cells in pretransfusion sera from patients who developed transfusion-related adverse reactions.

Azuma H, Yamaguchi M, Takahashi D, Fujihara M, Sato S, Kato T, Ikeda H

Transfusion. 2009 Aug;49(8):1754-61. 49(8) 1754-1761 2009年8月査読有り
Biocompatibility Study of Hemoglobin Vesicles, Cellular-Type Artificial Oxygen Carriers, with Human Umbilical Cord Hematopoietic Stem/Progenitor Cells Using an In Vitro Expansion System

Miki Yamaguchi, Mitsuhiro Fujihara, Shinobu Wakamoto, Hiromi Sakai, Shinji Takeoka, Eishun Tsuchida, Hirofumi Hamada, Hiroshi Azuma, Hisami Ikeda

ASAIO JOURNAL 55(3) 200-205 2009年5月査読有り
Influence of hemoglobin vesicles, cellular-type artificial oxygen carriers, on human umbilical cord blood hematopoietic progenitor cells in vitro

Miki Yamaguchi, Mitsuhiro Fujihara, Shinobu Wakamoto, Hiromi Sakai, Shinji Takeoka, Eishun Tsuchida, Hiroshi Azuma, Hisami Ikeda

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 88A(1) 34-42 2009年1月査読有り
Generation of a considerable number of functional mast cells with a high basal level of Fc epsilon RI expression from cord blood CD34(+) cells by co-culturing them with bone marrow stromal cell line under serum-free conditions

M. Yamaguchi, H. Azuma, M. Fujihara, H. Hamada, H. Ikeda

SCANDINAVIAN JOURNAL OF IMMUNOLOGY 65(6) 581-588 2007年6月査読有り
Effects of hemoglobin vesicles, a liposomal artificial oxygen carrier, on hematological responses, complement and anaphylactic reactions in rats

Hideki Abe, Hiroshi Azuma, Miki Yamaguchi, Mitsuhiro Fujihara, Hisami Ikeda, Hiromi Sakai, Shinji Takeoka, Eishun Tsuchida

ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY 35(2) 157-172 2007年査読有り
Generation of inflammatory cytokines and chemokines from peripheral blood mononuclear cells by HLA Class II antibody-containing plasma unit that was associated with severe nonhemolytic transfusion reactions

Hisako Sakagawa, Toru Miyazaki, Mitsuhiro Fujihara, Shinichiro Sato, Miki Yamaguchi, Kanji Fukai, Masanobu Morioka, Toshiaki Kato, Hiroshi Azuma, Hisami Ikeda

TRANSFUSION 47(1) 154-161 2007年1月査読有り
Effects of hemoglobin vesicles on resting and agonist-stimulated human platelets in vitro

S Wakamoto, M Fujihara, H Abe, M Yamaguchi, H Azuma, H Ikeda, S Takeoka, E Tsuchida

ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY 33(2) 101-111 2005年査読有り
Cytotoxic difference of T cells expanded with anti-CD3 monoclonal antibody in the presence and absence of anti-CD28 monoclonal antibody

Y Yamada-Ohnishi, H Azuma, N Urushibara, M Yamaguchi, M Fujihara, T Kobata, H Ikeda

STEM CELLS AND DEVELOPMENT 13(3) 315-322 2004年6月査読有り
Thrombopoietin upregulates nucleolin mRNA and protein in thrombopoietin-dependent megakaryocytic cell line, UT-7/TPO.

Ito T, Fujihara M, Oda A, Wakamoto S, Yamaguchi M, Komatsu N, Miyazaki H, Azuma H, Ikeda H, Ikebuchi K

Mol Cell Biochem. 2003 May;247(1-2):75-82. 247(1-2) 75-82 2003年5月査読有り
Possible contribution of apoptosis-inducing factor (AIF) and reactive oxygen species (ROS) to UVB-induced caspaseindependent cell death in the T cell line Jurkat

H Murahashi, H Azuma, N Zamzami, KJ Furuya, K Ikebuchi, M Yamaguchi, Y Yamada, N Sato, M Fujihara, G Kroemer …

JOURNAL OF LEUKOCYTE BIOLOGY 73(3) 399-406 2003年3月査読有り
Bone marrow stromal cells prepared using AB serum and bFGF for hematopoietic stem cells expansion

M Yamaguchi, F Hirayama, S Wakamoto, M Fujihara, H Murahashi, N Sato, K Ikebuchi, K Sawada, T Koike, M Kuwabara …

TRANSFUSION 42(7) 921-927 2002年7月査読有り
Functional evaluation of ex vivo expanded cord blood lymphocytes: Possible use for adoptive cellular immunotherapy

H Azuma, Y Yamada, N Shibuya-Fujiwary, M Yamaguchi, H Murahashi, M Fujihara, N Sato, K Fukazawa, K Ikebuchi, H Ikeda

EXPERIMENTAL HEMATOLOGY 30(4) 346-351 2002年4月査読有り
Ex vivo expansion of human UC blood primitive hematopoietic progenitors and transplantable stem cells using human primary BM stromal cells and human AB serum

M Yamaguchi, F Hirayama, H Murahashi, H Azuma, N Sato, H Miyazaki, K Fukazawa, K Sawada, T Koike, M Kuwabara …

CYTOTHERAPY 4(2) 109-118 2002年3月査読有り
Inactivation of parvovirus B19 in coagulation factor concentrates by UVC radiation: assessment by an in vitro infectivity assay using CFU-E derived from peripheral blood CD34+cells

H Sugawara, R Motokawa, H Abe, M Yamaguchi, Y Yamada-Ohnishi, J Hirayama, H Sakata, S Sato, N Kamo, K Ikebuchi …

TRANSFUSION 41(4) 456-461 2001年4月査読有り
Serum-free coculture system for ex vivo expansion of human cord blood primitive progenitors and SCID mouse-reconstituting cells using human bone marrow primary stromal cells.

Yamaguchi M, Hirayama F, Kanai M, Sato N, Fukazawa K, Yamashita K, Sawada K, Koike T, Kuwabara M, Ikeda H …

Exp Hematol. 2001 Feb;29(2):174-82. 29(2) 174-182 2001年2月査読有り
Effects of poly(ethyleneglycol)-modified hemoglobin vesicles on N-formyl-methionyl-leucylphenylalanine-induced responses of polymorphonuclear neutrophils in vitro

T Ito, M Fujihara, H Abe, M Yamaguchi, S Wakamoto, S Takeoka, H Sakai, E Tsuchida, H Ikeda, K Ikebuchi

ARTIFICIAL CELLS BLOOD SUBSTITUTES AND IMMOBILIZATION BIOTECHNOLOGY 29(6) 427-437 2001年査読有り

もっとみる

MISC

Cytotoxic Difference of T Cells Expanded with Anti-CD3 Monoclonal Antibody in the Presence and Absence of Anti-CD28 Monoclonal Antibody.

Stem Cells Dev. 13(3):315-22. 2004年
Possible contribution of apoptosis-inducing factor (AIF) and reactive oxygen species (ROS) to UVB-induced caspaseindependent cell death in the T cell line Jurkat

H Murahashi, H Azuma, N Zamzami, KJ Furuya, K Ikebuchi, M Yamaguchi, Y Yamada, N Sato, M Fujihara, G Kroemer …

JOURNAL OF LEUKOCYTE BIOLOGY 73(3) 399-406 2003年3月
Ｉｎｖｉｔｒｏにおけるヘモグロビン小胞体の血小板活性化に対する影響

若本志乃舞, 藤原満博, 阿部英樹, 山口美樹, 武岡真司, 土田英俊, 東寛, 池田久實

日本輸血学会雑誌 49(5) 653-659(5) 653-659 2003年
Thrombopoietin upregulates nucleolin mRNA and protein in thrombopoietin-dependent megakaryocytic cell line, UT-7,TPO.

Mol Cell Biochem. 247(1-2):75-82. 2003年
Ex vivo expansion of human umbilical cord hematopoietic progenitor cells using a coculture system with human telomerase catalytic subunit (hTERT)-transfected human stromal cells.

Blood. 101: 532-540 2003年
Functional evaluation of ex vivo expanded cord blood lymphocytes: possible use for adoptive cellular immunotherapy.

Exp Hematol. 30(4): 346-51. 2002年
Bone marrow stromal cells prepared using AB serum and bFGF for hematopoietic stem cell expansion.

Transfusion. 42(7):921-7 2002年
Ex vivo expansion of human cord blood primitive hematopoietic progenitors and transplantable stem cells using human primary bone marrow stromal cells and human AB serum.

Cytotherapy. Vol.4(2) 109-18. 2002年
Effects of poly(ethyleneglycol)-modified hemoglobin vesicles on N-formyl-methionyl-leucyl-phenylalanine-induced responses of polymorphonuclear neutrophils in vitro.

Art if Cells Blood Substit Immobil Biotechnol. 29(6): 427-37. 2001年
Inactivation of parvovirus B 19 in coagulation factor concentrates by UVC radiation: assessment by an in vitro nfectivity assay using CFU-E derived from peripheral blood CD34+ cells.

Transfusion. 41(4):456-61. 2001年
Serum-free coculture system for ex vivo expansion of human cord blood primitive progenitors and SCID mouse-reconstituting cells using human bone marrow primary stromal cells.

Exp Hematol. 29(2):174-82. 2001年
Comparison of sensitivity to ultraviolet B irradiation between human lymphocytes and hematopoietic stem cells.

Blood. 96(7):2632-4. 2000年
Stromal cell-independent differentiation of human cord blood CD34+CD38- lymphohematopoietic progenitors toward B cell lineage.

Leukemia. 14(4) :727-34. 2000年
A clonal culture assay for human cord blood lymphohematopoietic progenitors.

Hum Immunol. 60(1):75-82. 1999年
Role of physiologic concentrations of stem cell factor in leukemic type growth of myelodysplastic CD34+ cells.

Leuk Res. 23(1):1-11. 1999年
Cell cycle-dependent change of the adhesive character of CD34+ progenitor cells and their VLA-4 expression.

Rinsho Byori. 47(5):439-46 Review. Japanese. 1999年
Platelet-like particle production from cultured human megakaryocytic cell line.

Art if Cells Blood Substit Immobil Biotechnol. 26(5-6):549-58 1998年
Inflammatory cytokine production in whole blood modified by liposome-encapsulated hemoglobin.

Artif Cells Blood Substit Immobil Biotechnol. 26(5-6):559-70. 1998年
Effects of liposome-encapsulated hemoglobin on phorbol ester-induced superoxide production and expression of molecules by monocytes in vitro.

Artif Cells Blood Substit Immobil Biotechnol. 26(5-6):487-95. 1998年
n vitro expansion of CD34+/CD41+ cells from human peripheral blood CD34+/CD4L- cells: role of cytokines for in vitro proliferation and differentiation of megakaryocytic progenitors.

Exp Hematol. 26(12):1140-7. 1998年

もっとみる

所属学協会

共同研究・競争的資金等の研究課題

がん特異性と腫瘍溶解能を増強した組み合えヘルペスウイルスによる治療法の開発

日本学術振興会科学研究費助成事業（基盤研究B） 2014年4月 - 2016年3月

山口美樹
高性能イミュノトキシンを用いた急性骨髄性白血病の標的化治療

日本学術振興会科学研究費助成事業 2011年4月 - 2013年3月

山口美樹
肥満細胞の効率的な培養法の確立

バイオテクノロジー先端技術開発研究 2003年 - 2008年
The establishment of the efficient culture method of the Mast cells.

0095 (Japanese Only) 2003年 - 2008年

産業財産権

特願PCT/2011/063294 WO2011/155579 抗Trop-2抗体

山口美樹, 加藤和則, 濱田洋文