Kazuhiko Nakano

Profile Information

Affiliation: Professor, Graduate School of Dentistry Course for Oral Sciences, Osaka University
: (Concurrent)Professor, Graduate School of Dentistry Course for Oral Sciences

Degree: Ph.D(Osaka University)

Other name(s) (e.g. nickname): NAKANO Kazuhiko
Researcher number: 00379083
J-GLOBAL ID: 200901037373527415
researchmap Member ID: 5000082655

Research Interests

Research Areas

Research History

2014 - Present

大阪大学教授歯学研究科
2011 - 2014

大阪大学准教授歯学研究科
2007 - 2011

大阪大学講師歯学部附属病院
2007 - 2007

大阪大学助教歯学部附属病院
2003 - 2007

大阪大学助手歯学部附属病院
1997 - 2003

Dental Hospital, Osaka University
1996 - 1997

Dental Hospital, Osaka University

Education

Apr, 1990 - Mar, 1996

School of Dentistry, School of Dentistry, Osaka University

Awards

Papers

454

Characterization of the unique oral microbiome of children harboring Helicobacter pylori in the oral cavity

Yuko Ogaya, Tamami Kadota, Masakazu Hamada, Ryota Nomura, Kazuhiko Nakano

Journal of Oral Microbiology, Dec 31, 2024
Role of N1-Domain, Linker, N2-Domain, and Latch in the Binding Activity and Stability of the Collagen-Binding Domain for the Collagen-Binding Protein Cbm from Streptococcus mutans

Akari Nishi, Azumi Hirata, Atsushi Mukaiyama, Shun-ichi Tanaka, Ryota Nomura, Kazuhiko Nakano, Kazufumi Takano

Physchem, Apr 12, 2024
Investigation of periodontal disease development and Porphyromonas gulae FimA genotype distribution in small dogs.

Junya Yasuda, Hidemi Yasuda, Ryota Nomura, Saaya Matayoshi, Hiroaki Inaba, Enrique Gongora, Naoki Iwashita, So Shirahata, Noriyuki Kaji, Tatsuya Akitomo …

Scientific reports, 14(1) 5360-5360, Mar 4, 2024
Effects of mouthwash on periodontal pathogens and glycemic control in patients with type 2 diabetes mellitus.

Saaya Matayoshi, Fumikazu Tojo, Yuto Suehiro, Makoto Okuda, Misato Takagi, Marin Ochiai, Maika Kadono, Yusuke Mikasa, Rena Okawa, Ryota Nomura …

Scientific reports, 14(1) 2777-2777, Feb 2, 2024
Automatic dental age calculation from panoramic radiographs using deep learning: a two-stage approach with object detection and image classification.

Kazuma Kokomoto, Rina Kariya, Aya Muranaka, Rena Okawa, Kazuhiko Nakano, Kazunori Nozaki

BMC oral health, 24(1) 143-143, Jan 31, 2024
Panoramic Radiograph Generation and Image Reconstruction from Latent Vectors Using a Generative Adversarial Network.

Kazuma Kokomoto, Rena Okawa, Kazuhiko Nakano, Kazunori Nozaki

Studies in health technology and informatics, 310 1499-1500, Jan 25, 2024
Inhibitory Effects of Shikonin Dispersion, an Extract of Lithospermum erythrorhizon Encapsulated in β-1,3-1,6 Glucan, on Streptococcus mutans and Non-Mutans Streptococci.

Ryota Nomura, Yuto Suehiro, Fumikazu Tojo, Saaya Matayoshi, Rena Okawa, Masakazu Hamada, Shuhei Naka, Michiyo Matsumoto-Nakano, Rika Unesaki, Kazuya Koumoto …

International journal of molecular sciences, 25(2), Jan 16, 2024
Is oral Streptococcus mutans with collagen-binding protein a risk factor for intracranial aneurysm rupture or formation?

Hirokazu Nakatogawa, Kazuya Hokamura, Ryota Nomura, Kazuhiko Nakano, Kazuo Umemura, Akio Morita, Yoichiro Homma, Tokutaro Tanaka

Cerebrovascular diseases (Basel, Switzerland), Jan 12, 2024
Incompetent lip seal and nail biting as risk factors for malocclusion in Japanese preschool children aged 3-6 years.

Masatoshi Otsugu, Yumi Sasaki, Yusuke Mikasa, Maika Kadono, Hidekazu Sasaki, Takafumi Kato, Kazuhiko Nakano

BMC pediatrics, 23(1) 532-532, Oct 26, 2023 Peer-reviewed
Porphyromonas gingivalis infection in the oral cavity is associated with elevated galactose-deficient IgA1 and increased nephritis severity in IgA nephropathy.

Seigo Ito, Taro Misaki, Yasuyuki Nagasawa, Ryota Nomura, Shuhei Naka, Akiko Fukunaga, Daiki Matsuoka, Saaya Matayoshi, Michiyo Matsumoto-Nakano, Kazuhiko Nakano

Clinical and experimental nephrology, Oct 9, 2023 Peer-reviewed
The number of erupted teeth as a risk factor for dental caries in eighteen-month-old children: a cross‑sectional study.

Masatoshi Otsugu, Yusuke Mikasa, Maika Kadono, Taro Matsuoka, Katsura Matsunami, Motomi Nakamura, Yuko Ohno, Takafumi Kato, Kazuhiko Nakano

BMC oral health, 23(1) 671-671, Sep 16, 2023 Peer-reviewed
Structure, Stability and Binding Properties of Collagen-Binding Domains from Streptococcus mutans

Akari Nishi, Hikaru Matsui, Azumi Hirata, Atsushi Mukaiyama, Shun-ichi Tanaka, Takuya Yoshizawa, Hiroyoshi Matsumura, Ryota Nomura, Kazuhiko Nakano, Kazufumi Takano

Chemistry, 5(3) 1911-1920, Sep 1, 2023 Peer-reviewed
Inhibitory Effect of Adsorption of Streptococcus mutans onto Scallop-Derived Hydroxyapatite.

Momoko Usuda, Mariko Kametani, Masakazu Hamada, Yuto Suehiro, Saaya Matayoshi, Rena Okawa, Shuhei Naka, Michiyo Matsumoto-Nakano, Tatsuya Akitomo, Chieko Mitsuhata …

International journal of molecular sciences, 24(14), Jul 12, 2023 Peer-reviewed
In vitro analysis of durability of S-PRG filler-containing composite crowns for primary molar restoration

Yutaro Nakase, Satoshi Yamaguchi, Ernesto B. Benalcázar Jalkh, Pablo J. Atria, Lukasz Witek, Estevam A. Bonfante, Hefei Li, Takahiko Sakai, Rena Okawa, Kazuhiko Nakano …

Dental Materials, Jul, 2023
腎炎のあたらしい"モデル動物"の開発ラットおよびマウスを用いた口腔細菌のIgA腎症発症への影響の検討

野村良太, 長澤康行, 三崎太郎, 仲周平, 仲野道代, 仲野和彦

日本腎臓学会誌, 65(3) 210-210, May, 2023
口腔内のcnm遺伝子陽性S.mutansとIgA腎症患者の糖鎖異常IgA沈着の関連性

三崎太郎, 仲周平, 鈴木仁, 李明峰, 青木良輔, 長澤康行, 松岡大貴, 伊藤誓悟, 野村良太, 仲野道代 …

日本腎臓学会誌, 65(3) 271-271, May, 2023
腎炎のあたらしい"モデル動物"の開発ラットおよびマウスを用いた口腔細菌のIgA腎症発症への影響の検討

野村良太, 長澤康行, 三崎太郎, 仲周平, 仲野道代, 仲野和彦

日本腎臓学会誌, 65(3) 210-210, May, 2023
口腔内のcnm遺伝子陽性S.mutansとIgA腎症患者の糖鎖異常IgA沈着の関連性

三崎太郎, 仲周平, 鈴木仁, 李明峰, 青木良輔, 長澤康行, 松岡大貴, 伊藤誓悟, 野村良太, 仲野道代 …

日本腎臓学会誌, 65(3) 271-271, May, 2023
Development of Rat Caries-Induced Pulpitis Model for Vital Pulp Therapy

H. Huang, M. Okamoto, M. Watanabe, S. Matsumoto, K. Moriyama, S. Komichi, M. Ali, S. Matayoshi, R. Nomura, K. Nakano …

Journal of Dental Research, 102(5) 574-582, May, 2023 Peer-reviewed
Multiple-Ion Releasing Bioactive Surface Pre-Reacted Glass-Ionomer (S-PRG) Filler: Innovative Technology for Dental Treatment and Care.

Satoshi Imazato, Toshiyuki Nakatsuka, Haruaki Kitagawa, Jun-Ichi Sasaki, Satoshi Yamaguchi, Shuichi Ito, Hiroki Takeuchi, Ryota Nomura, Kazuhiko Nakano

Journal of functional biomaterials, 14(4), Apr 21, 2023 Peer-reviewed

Misc.

363

ホタテ貝由来アパタイトのStreptococcus mutansに対する齲蝕予防効果の分析

臼田桃子, 亀谷茉莉子, 秋友達哉, 末廣雄登, 又吉紗綾, 中野将志, 光畑智恵子, 仲周平, 仲野道代, 仲野和彦 …

小児歯科学雑誌, 61, 2023
Molecular biological investigation of the binding of human IgA by collagen-binding protein Cnm

松岡大貴, 仲周平, 後藤花奈, 野村良太, 仲野和彦, 仲野道代

小児歯科学雑誌, 61, 2023
Relationship of collagen-binding protein-positive Streptococcus mutans strain distribution with dental caries incidence in children

奥田真琴, 又吉紗綾, 東條文和, 仲周平, 仲野道代, 野村良太, 仲野和彦

小児歯科学雑誌, 61, 2023
ラットおよびマウスを用いた口腔細菌のIgA腎症発症への影響の検討

野村良太, 長澤康行, 三崎太郎, 仲周平, 仲野道代, 仲野和彦

日本腎臓学会誌(Web), 65(3), 2023
口腔内のcnm遺伝子陽性S.mutansとIgA腎症患者の糖鎖異常IgA沈着の関連性

三崎太郎, 仲周平, 鈴木仁, 李明峰, 青木良輔, 長澤康行, 松岡大貴, 伊藤誓悟, 野村良太, 仲野道代 …

日本腎臓学会誌(Web), 65(3), 2023
Analysis of Streptococcus mutans pathogenic factor collagen-binding protein Cnm

松岡大貴, 仲周平, 後藤花奈, 野村良太, 仲野和彦, 仲野道代

小児歯科学雑誌, 60, 2022
Porphyromonas gingivalis経鼻投与によるIgA腎症モデルマウスの作製

長澤康行, 野村良太, 三崎太郎, 仲周平, 伊藤誓悟, 和唐薫子, 楠博, 山崎博充, 新村健, 仲野道代 …

日本腎臓学会誌(Web), 64(3), 2022
cnm遺伝子陽性S.mutansとC.rectusの口腔内の存在は5年後のIgA腎症患者の腎機能増悪に関連する

三崎太郎, 塩崎友里子, 伊藤大介, 清水吉貴, 鈴木由美子, 仲周平, 野村良太, 長澤康行, 伊藤誓悟, 仲野道代 …

日本腎臓学会誌(Web), 64(3), 2022
Analysis of collagen-binding properties of Streptococcus mutans after killing by antibiotics

末廣雄登, 又吉紗綾, 大継將寿, 野村良太, 仲野和彦

小児歯科学雑誌, 60, 2022
先行乳歯の根管治療後に後継永久歯の歯冠軸傾斜角度に改善がみられた1例

角野舞香, 大継將寿, 佐々木有美, 大川玲奈, 仲野和彦, 仲岡佳彦

小児歯科学雑誌, 60, 2022
死菌処理したStreptococcus mutansのカイコモデルにおける病原性の評価

末廣雄登, 又吉紗綾, 大継將寿, 野村良太, 仲野和彦

小児歯科学雑誌, 60, 2022
Evaluation of oral function, sleep quality, and development in children with incompetent lip seal while sleeping

角野舞香, 三笠祐介, 大継將寿, 大川玲奈, 仲野和彦

小児歯科学雑誌, 60, 2022
扁桃と口腔内の歯周病菌の一致率の検討

長澤康行, 野村良太, 三崎太郎, 仲周平, 伊藤誓悟, 和唐薫子, 木田有利, 名波正義, 倉賀野隆裕, 仲野道代 …

日本腎臓学会誌(Web), 63(4), 2021
Evaluation of pathogenicity of killed Streptococcus mutans to infective endocarditis

末廣雄登, 又吉紗綾, 大継將寿, 野村良太, 仲野和彦

小児歯科学雑誌, 59, 2021
Inhibitory effects of Shikonin on pathogenecity of Streptococcus mutans

櫻井孝子, 末廣雄登, 又吉紗綾, 和唐薫子, 大継將寿, 野村良太, 仲野和彦

小児歯科学雑誌, 59, 2021
Clinical, Biochemical and Genetic Study in Patients with Odontohypophosphatasia in Japan

Takuo Kubota, Yasuhisa Ohata, Yasuki Ishihara, Makoto Fujiwara, Shinji Takeyari, Kenichi Yamamoto, Yukako Nakano, Taichi Kitaoka, Hirofumi Nakayama, Chieko Yamada …

JOURNAL OF BONE AND MINERAL RESEARCH, 35 288-288, Nov, 2020
重度齲蝕を誘発したラットにおけるIgA腎症発症の検討

和唐薫子, 野村良太, 仲野和彦, 仲周平, 仲野道代

小児歯科学雑誌, 58, 2020
歯周病菌レッドコンプレックスのIgA腎症患者扁桃での陽性率の検討

長澤康行, 野村良太, 仲周平, 三崎太郎, 伊藤誓悟, 和唐薫子, 味村泰幸, 木田有利, 名波正義, 蓮池由起子 …

日本腎臓学会誌(Web), 62(4), 2020
う蝕ラットモデルによるIgA腎症様腎炎を発症する可能性

三崎太郎, 伊藤大介, 清水吉貴, 小野雅史, 鈴木由美子, 仲周平, 和唐薫子, 伊藤誓悟, 長澤康行, 野村良太 …

日本腎臓学会誌(Web), 62(4), 2020
小児型低ホスファターゼ症患者に対し幼若永久歯の歯周組織保護を目的としてマウスガードを装着した1例

門田珠実, 大継將寿, 永山佳代子, 大川玲奈, 仲野和彦

小児歯科学雑誌, 58, 2020

Professional Memberships

Research Projects

S. mutans コラーゲン結合タンパクに着目した IgA 腎症発症機構の解明

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2023 - Mar, 2026

仲周平, 仲野和彦, 仲野道代
全身疾患との関連性が高いう蝕病原性細菌の定着環境の解明と定着予防法の追究

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

大継將寿, 仲野和彦, 野村良太
う蝕原性細菌のコラーゲン結合能に着目した低中所得国の全身疾患低減に向けた新戦略

科学研究費助成事業国際共同研究加速基金(国際共同研究強化(B)), 国際共同研究加速基金(国際共同研究強化(B)), 日本学術振興会, Oct, 2021 - Mar, 2025

仲野和彦
う蝕原性細菌が誘発する全身疾患の制御に向けた新たな病原メカニズムの解明

科学研究費助成事業基盤研究(B), 基盤研究(B), 日本学術振興会, Apr, 2021 - Mar, 2024

仲野和彦, 野村良太, 大継將寿
小児期のう蝕および口腔内環境に着目したピロリ菌定着の予防法追究に対する新戦略

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

野村良太, 仲野和彦, 鋸屋侑布子
Elucidation of the effect of Microorganism of the body on the origin and rupture of the intracranial aneurysms and development of preventive measure of the subarachnoid hemorrhage

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2023
歯科領域からの革新的治療法の開発を目指した口腔細菌に起因するIgA腎症の病態解明

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2020 - Mar, 2023

仲周平, 仲野和彦, 仲野道代
Association of dental disease and kidney disease: Examination of oral specimens and renal biopsy / tonsil specimens of IgA nephropathy patients

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Misaki Taro
A study to elucidate the mechanism of intracerebral heorrhage induced by collagen-binding Streptococcus mutans and to develop a novel preventive therapy

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory), Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2019 - Mar, 2021

Ihara Masafumi
Role of interorganelle communication in mineralization

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2019 - Mar, 2021

Iwayama Tomoaki
Elucidation of effects of cariogenic bacteria on organ-linked network due to oral barrier breakdown

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Nakano Kazuhiko
Establishment of international liaison between medical doctors and dentists for the purpose of reduction of stroke in Nigeria and Kenya

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2021

Ihara Masafumi
Mechanism of aggravation of IgA nephropathy by mutans streptococci

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

Naka Shuhei
Clinical investigation of the cerebrovascular diseases aggravation caused by dental caries pathogens and establishing simplified technique for detecting the high risk group.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2019

Tanaka Tokutaro, Umemura Kazuo, Hokamura Kazuya
Study to understand mechanism of hemorrhagic stroke induced by oral bacteria

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2018

IHARA MASAFUMI, SAITO Satoshi, TONOMURA Shuichi
Specification of route of Helicobacter pylori infection and construction of preventive approaches for gastric diseases in pediatric dentistry field

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Nakano Kazuhiko, WATANABE Yoshiyuki
Construction of global standard molecular epidemiological method for identification of the children at risk for severe dental caries

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Nakano Kazuhiko, LAPIRATTANAKUL Jinthana
Basic and clinical approaches for dental problems associated with skeletal diseases

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

OKAWA RENA, NAKANO Kazuhiko, OZONO Keiichi, KITAOKA Taichi, NAKANO Michiyo
Possible involvement of mutans streptococci in development of pediatric kidney disease

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2017

Kazuhiko Nakano
Elucidation of mechanism of non-alcoholic steatohepatitis aggravation caused by mutans streptococci

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2017

Naka Shuhei, NAKANO Kazuhiko, NOMURA Ryota

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