論文

査読有り 国際誌
2020年8月23日

Differences in inflammatory responses of rainbow trout infected by two genotypes of the myxozoan parasite Ceratonova shasta.

Developmental and comparative immunology
  • Laura Taggart-Murphy
  • ,
  • Gema Alama-Bermejo
  • ,
  • Brian Dolan
  • ,
  • Fumio Takizawa
  • ,
  • Jerri Bartholomew

114
開始ページ
103829
終了ページ
103829
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.dci.2020.103829

Two genotypes of the intestinal parasite Ceratonova shasta infect Oncorhynchus mykiss: genotype 0 results in a chronic infection with low mortality while genotype IIR causes disease with high mortality. We determined parasite load and the relative expression of six immune factors (IgT, IgM, IL-6, IL-8, IL-10, IFNG) in fish infected with either genotype over 29 days post-exposure. In genotype IIR infections the host responded with upregulation of inflammatory and regulatory cytokines. In contrast, genotype 0 infection did not elicit an inflammatory response and expression of IFNG and IL-10 was lower. Antibody expression was upregulated in both infections but appeared to have limited efficacy in the virulent genotype IIR infections. Histologically, in genotype 0 infections the parasite migrated through the tissue layers causing inflammation but minimal damage to the mucosal epithelium, which contrasts with the severe pathology found in genotype IIR infections.

リンク情報
DOI
https://doi.org/10.1016/j.dci.2020.103829
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32846161
ID情報
  • DOI : 10.1016/j.dci.2020.103829
  • PubMed ID : 32846161

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