Takeshi Hashimoto - My portal

Profile Information

Affiliation: Assistant Professor, Faculty of Medicine, Kagawa University

Degree: 修士（保健学）(大阪大学)
博士（保健学）(大阪大学)

J-GLOBAL ID: 200901094844079063
researchmap Member ID: 5000083395

Research Interests

Research Areas

Research History

Education

- 2004

Graduate School, Division of Medical Sciences, Osaka University
- 2004

Osaka University

Committee Memberships

Mar, 2014 - Present

評議員, 日本生理学会

Papers

Coagulation factor XI induced Ca2+ response and cell migration in vascular smooth muscle cells

Liu Wenhua, HASHIMOTO Takeshi, YAMASHITA TETSUO, HIRANO Katsuya

The Jpurnal of Physiological Sciences, 68(Supplement 1) S81, Mar, 2018 Peer-reviewed
NAD(P)H and low ionic strength suppresses dissociation of apoptosis-inducing factor from E. coli membrane

YAMASHITA TETSUO, MATSUMOTO Kan, HASHIMOTO Takeshi, IGARASHI Junsuke, KOSAKA Hiroaki, HIRANO Katsuya

The Journal of Physiological Sciences, 67(supplement 1) S178, Mar, 2017 Peer-reviewed
Coagulation factor XIa induces Ca2+ influx via L-type Ca2+ channel in vescular smooth muscle cells

LIU Wenhua, HASHIMOTO Takeshi, YAMASHITA TETSUO, IGARASHI Junsuke, HIRANO Katsuya

The Journal of Physiological Sciences, 67(supplement 1) S176, Mar, 2017 Peer-reviewed
Mifepristone, a stroid receptor antagonist, induces hepatic steatosis in association with upregulation of resistin expression in liver

HASHIMOTO Takeshi, IGARASHI Junsuke, YAMASHITA TETSUO, HIRANO Katsuya

The Journal of Physiological Sciences, 67(supplement 1) S133, Mar, 2017 Peer-reviewed
A novel angiogenic agent COA-Cl promotes VEGF secretion from mouse C2C12 steletal myocytes via the activation of cAMP/PKA/CREB/PGC-1a signaling axia

IGARASHI Junsuke, Ryouji Okamoto, HASHIMOTO Takeshi, YAMASHITA TETSUO, KUBOTA Yasuo, TSUKAMOTO Ikuko, Sakakibara Norikazu, KONISHI Ryoji, HIRANO Katsuya

The Journal of Physiological Sciences, 67(supple (1)) S44, Mar, 2017 Peer-reviewed
Increase in tumor suppressor Arf compensates gene dysregulation in in vitro aged adipocytes

Arif U. Hasan, Koji Ohmori, Takeshi Hashimoto, Kazuyo Kamitori, Fuminori Yamaguchi, Kumi Konishi, Takahisa Noma, Junsuke Igarashi, Tetsuo Yamashita, Katsuya Hirano, Masaaki Tokuda, Tetsuo Minamino, Akira Nishiyama, Masakazu Kohno

BIOGERONTOLOGY, 18(1) 55-68, Feb, 2017 Peer-reviewed
G Protein-Coupled Receptor 87 (GPR87) Promotes Cell Proliferation in Human Bladder Cancer Cells

Zhang X, Liu D, Hayashida Yushi, Okazoe H, Hashimoto T, Ueda N, Sugimoto M, Kakehi Y(Zhang Xia, Liu Dage, Hayashida Yushi, Okazoe H, HASHIMOTO Takeshi, Ueda N, Sugimoto M, Kakehi Y

Int J Mol Sci., 14(10) 24319-31, Oct, 2015 Peer-reviewed
Eicosapentaenoic acid upregulates VEGF-A through both GPR120 and PPAR gamma mediated pathways in 3T3-L1 adipocytes

Arif U. Hasan, Koji Ohmori, Kumi Konishi, Junsuke Igarashi, Takeshi Hashimoto, Kazuyo Kamitori, Fuminori Yamaguchi, Ikuko Tsukamoto, Toru Uyama, Yasuhiro Ishihara, Takahisa Noma, Masaaki Tokuda, Masakazu Kohno

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 406(C) 10-18, May, 2015 Peer-reviewed
A novel angiogenic agent COA-Cl induced PGC-1alpha-mediated VEGF production in cultured human fibroblasts

OKAMOTO RYUJI, IGARASHI Junsuke, YAMASHITA TETSUO, HASHIMOTO Takeshi, SHOJI KAZUYO, KUBOTA Yasuo, TAKATA MAKI, TSUKAMOTO Ikuko, HIRANO Katsuya

The Journal of Physiological Sciences, 65(Supplement 1) S168, Mar, 2015 Peer-reviewed
COA-Cl-induced adipogenesis is associated with an increased cell cycle progression and down-regulation of p27Kip1 in mouse pre-adipocyte 3T3L1 cells

HASHIMOTO Takeshi, IGARASHI Junsuke, TSUKAMOTO Ikuko, YAMASHITA TETSUO, HIRANO Katsuya

The Journal of Physiological Sciences, 65(Supplement 1) S229, Mar, 2015 Peer-reviewed
Involvement of S1P1 receptor pathway in angiogenic effects of a novel adenosine-like nucleic acid analog COA-Cl in cultured human vascular endothelial cells

Junsuke Igarashi, Takeshi Hashimoto, Yasuo Kubota, Kazuyo Shoji, Tokumi Maruyama, Norikazu Sakakibara, Yoh Takuwa, Yoshihiro Ujihara, Yuki Katanosaka, Satoshi Mohri, Keiji Naruse, Tetsuo Yamashita, Ryuji Okamoto, Katsuya Hirano, Hiroaki Kosaka, Maki Takata, Ryoji Konishi, Ikuko Tsukamoto

Pharmacology Research and Perspectives, 2(5) e00068, Oct 1, 2014 Peer-reviewed
Analysis of the binding mode of AIF to the membrane

山下哲生, HASHIMOTO Takeshi, IGARASHI Junsuke, KOSAKA Hiroaki

64(supplement 1) S273, Mar, 2014 Peer-reviewed
Mifepristone induces non-obese non-alcoholic fatty liver disease.

Hashimoto T, Igarashi J, 山下哲生, 小坂博昭

124(Supple (1)) 131P, Mar, 2014 Peer-reviewed
Mifepristone Promotes Adiponectin Production and Improves Insulin Sensitivity in a Mouse Model of Diet-Induced-Obesity

Takeshi Hashimoto, Junsuke Igarashi, Arif U. Hasan, Koji Ohmori, Masakazu Kohno, Yukiko Nagai, Tetsuo Yamashita, Hiroaki Kosaka

PLOS ONE, 8(11) :e79724, Nov, 2013 Peer-reviewed
Dexamethasone induces caveolin-1 in vascular endothelial cells: Implications for attenuated responses to VEGF

Junsuke Igarashi, Takeshi Hashimoto, Kazuyo Shoji, Kozo Yoneda, Ikuko Tsukamoto, Tetsuya Moriue, Yasuo Kubota, Hiroaki Kosaka

American Journal of Physiology - Cell Physiology, 304(8) C790-C800, Apr 15, 2013 Peer-reviewed
Thr239 suppresses ROS production in yeast mitochondrial NADH dehydrogenase (NDH-2)

山下哲生, HASHIMOTO Takeshi, IGARASHI Junsuke, KOSAKA Hiroaki

The Journal of Physiological Sciences, 63(supplement 1) S172, Mar, 2013 Peer-reviewed
Mifepristone increases anti-inflammatory M2 macrophages in obese adipose tissues

Hashimoto T, Igarashi J, Yamashita T, Kosaka H

The Journal of Physiological Sciences, 63 S215, Mar, 2013 Peer-reviewed
Valsartan ameliorates constitutive adipokine expression pattern in mature adipocytes

Arif U, Hasan, Koji Ohmori, Takeshi Hashimoto, Kazuyo Kamitori, Fuminori Yamaguchi, Yasuhiro Ishihara, Naoko Ishihara, Takahisa Noma, 徳田雅明, Masakazu Kohno

Hypertension Research, 1-37, 2013 Peer-reviewed
Mifepristoneは脂肪組織中のM2マクロファージを増加させる

橋本剛, 五十嵐淳介, Arif U Hasan, 大森浩二, 山下哲生, 河野雅和, 小坂博昭

Journal of Japan Society for the Study of Obesity, 18(suppl) 160, Sep, 2012
Mechanism of ROS suppression in yeast single subunit NADH-ubiquinone oxidoreductase (Ndi1)

YAMASHITA TETSUO, HASHIMOTO Takeshi, IGARASHI Junsuke, KOSAKA Hiroaki

The Journal of Physiological Sciences, 62(supplement 1) S188, Mar, 2012 Peer-reviewed

Books and Other Publications

最新医学大辞典第３版

医歯薬出版株式会社, 2005
MEDICAL DICTIONARY

医歯薬出版株式会社, 2005
○×問題でマスター薬理学

医歯薬出版株式会社, 2004
○×問題でマスター薬理学

医歯薬出版株式会社, 2004

Presentations

Mifepristoneは非肥満非アルコール性脂肪肝を発症する

第８７回日本薬理学会, 2014
アディポネクチン分泌促進能を有するMifepristoneの脂肪細胞分化への関与

第９１回日本生理学会, 2014
Mifepristoneは脂肪組織中の抗炎症性M2マクロファージを増加させる

第９０回日本生理学会, 2013
RU486 (Mifepristone)は脂肪細胞からのアディポネクチン分泌を促進させる

第８９回日本生理学会, 2012
RU486:Mifepristoneは血中アディポネクチンを増加させインスリン抵抗性を改善させる

第８５回日本薬理学会, 2012
RU486:Mifepristoneはp27(Kip1)の発現レベルを調節することで脂肪細胞への分化能に影響する

第８４回日本薬理学会, 2011
RU486 (Mifepristone)はサイクリン依存性キナーゼ阻害因子p27kipの発現抑制することで脂肪生成能を増強する

第８８回日本生理学会, 2011
RU486(Mifepristone)によるインスリン抵抗性の改善

第３２回日本肥満学会, 2011
Pioglitazone links PPARg dependent adipogenesis pathways to tumor suppressor p53 pathways through p16

The 3rd Joint Symposium between CMU and KU, 2010
PPAR-gamma enhances adipogenesis by down-regulating a cell cycle inhibitor, p16INK4a, in adipocytes

European Society of Cardiology Congress 2010, 2010

Professional Memberships

Research Projects

トロンビン受容体を標的とした新たなインスリン抵抗性改善策の開発

基盤研究(C), 日本学術振興会, Apr, 2019 - Mar, 2021

橋本剛
新たな非肥満非アルコール性脂肪肝モデル動物の開発と脂肪肝改善法確立

基盤研究(C), 日本学術振興会, Apr, 2017 - Mar, 2019

橋本剛
サイトカインTGF1による血管成熟化機構－ＶＥＧＦＲ２とのクロストーク－

基盤研究(C), 日本学術振興会, Apr, 2013 - Mar, 2015

五十嵐淳介
脂肪組織におけるグルココルチコイドとスフィンゴ脂質分子群とのクロストークの解明

若手研究(B), 日本学術振興会, Apr, 2013 - Mar, 2015

橋本剛
虚血心筋における脂質メディエータースフィンゴシン１リン酸（S1P）の機能解析

基盤研究(C), 日本学術振興会, Apr, 2009 - Mar, 2011

五十嵐淳介
脂肪細胞のライフサイクルにおけるスフィンゴシン1-リン酸(S1P)とS1P受容体の生理的メカニズムの解明

若手研究(B), 日本学術振興会, Apr, 2007 - Mar, 2009

橋本剛
Elucidation of physiological roles of sphingosine 1-phosphate and its receptors in adipose tissue

2004 - 2006