MAEDA Sadatoshi

J-GLOBAL         Last updated: Sep 17, 2019 at 17:17
 
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Name
MAEDA Sadatoshi
Affiliation
Gifu University
Section
Faculty of Applied Biological Sciences
Degree
Ph.D(The University of Tokyo), M.S.(University of Florida)
Research funding number
50377694

Research Areas

 
 

Academic & Professional Experience

 
 
   
 
Research Assistant, Gifu University Faculty of Applied Biological Sciences, Department of Veterinary Medicine
 
2004
   
 
- Research assistant. Faculty of Applied Biological Sciences, Gifu University
 

Education

 
 
 - 
1999
Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo
 
 
 - 
1999
Veterinary Medical Sciences, Department of Small Animal Clinical Sceiences, University of Florida
 
 
 - 
1994
Department of Veterinary Medicine, Faculty of Agriculture and Veterinary Medicine, Nihon University
 

Awards & Honors

 
2003
The president award of the 136th meeting of Japanese Society of Veterinary Science
 

Published Papers

 
Nishida H, Nakata K, Maeda S, Kamishina H
The Journal of veterinary medical science   81(6) 906-910   Jun 2019   [Refereed]
Nakata K, Heishima K, Sakai H, Yamato O, Furusawa Y, Nishida H, Maeda S, Kamishina H
BMC veterinary research   15(1) 192   Jun 2019   [Refereed]
Narita M, Nishida H, Asahina R, Nakata K, Yano H, Ueda T, Inden M, Akiyoshi H, Maeda S, Kamishina H
American journal of veterinary research   80(5) 449-454   May 2019   [Refereed]
Akiyama S, Asahina R, Ohta H, Tsukui T, Nishida H, Kamishina H, Maeda S
Veterinary immunology and immunopathology   209 17-21   Mar 2019   [Refereed]
Nishida H, Yamazaki M, Sakai H, Maeda S, Kamishina H
The Journal of veterinary medical science      Jan 2019   [Refereed]
Kamishina H, Sugawara T, Nakata K, Nishida H, Yada N, Fujioka T, Nagata Y, Doi A, Konno N, Uchida F, Maeda S
PloS one   14(5) e0216445   2019   [Refereed]
Fujioka T, Nakata K, Nishida H, Sugawara T, Konno N, Maeda S, Kamishina H
Veterinary surgery : VS      Dec 2018   [Refereed]
Kimura S, Yamazaki M, Tomohisa M, Mori T, Yanai T, Maeda S, Kamishina H
The Journal of veterinary medical science      Nov 2018   [Refereed]
Yokota S, Kobatake Y, Noda Y, Nakata K, Yamato O, Hara H, Sakai H, Nishida H, Maeda S, Kamishina H
Neuroscience letters      Sep 2018   [Refereed]
Keiji Teramoto, Ryota Asahina, Hidetaka Nishida, Hiroaki Kamishina, Sadatoshi Maeda
Veterinary Dermatology   29    Aug 2018
© 2018 ESVD and ACVD Background: Previous studies indicate that tight junctions are involved in the pathogenesis of canine atopic dermatitis (cAD). An in vitro skin model is needed to elucidate the specific role of tight junctions in cAD. A 3D epi...
Yui Kobatake, Hiroki Sakai, Hiroki Sakai, Hiroki Sakai, Hidetaka Nishida, Yosuke Uematsu, Sadatoshi Maeda, Sadatoshi Maeda, Hiroaki Kamishina, Hiroaki Kamishina, Hiroaki Kamishina
Journal of Veterinary Medical Science   80 1277-1280   Aug 2018
©2018 The Japanese Society of Veterinary Science. An 8-year-old castrated male cat presented with acute ataxia and paresis in all four limbs. The cat also exhibited signs of autonomic nervous system impairment. Magnetic resonance imaging revealed ...
Ikeuchi M, Asahina R, Nishida H, Kamishina H, Kitoh K, Sakai H, Maeda S
Veterinary dermatology      Aug 2018   [Refereed]
Ryota Asahina, Hidetaka Nishida, Hiroaki Kamishina, Sadatoshi Maeda
Veterinary Dermatology   29    Jun 2018
© 2018 ESVD and ACVD Background: In humans, interleukin (IL)-33 plays a critical role in the enhancement of allergic skin inflammation. However, it currently remains unclear whether IL-33 is involved in the pathogenesis of canine atopic dermatitis...
Ryota Asahina, Hidetaka Nishida, Hiroaki Kamishina, Sadatoshi Maeda
Veterinary Dermatology   29    Apr 2018
© 2017 ESVD and ACVD Background: Interleukin (IL)-33 has been implicated in the pathogenesis of canine atopic dermatitis, a Type 2 T helper cell (Th2)-associated disease. In humans, IL-33 mediates its biological effects through the receptor suppre...
Kyohei Hara, Aki Iio, Ryota Asahina, Maiko Takahashi, Takashi Mori, Hidetaka Nishida, Hiroaki Kamishina, Hiroki Sakai, Katsuya Kitoh, Takuya Mizuno, Hajime Tsujimoto, Sadatoshi Maeda
Journal of Dermatological Science   88 254-256   Nov 2017
M. Sakamoto, S. Shibata, R. Asahina, K. Yamazoe, H. Kamishina, K. Ishigaki, K. Asano, S. Maeda
Journal of Small Animal Practice   58 419   Jul 2017
Ryota Asahina, Sadatoshi Maeda
Veterinary Dermatology   28    Feb 2017
© 2016 ESVD and ACVD Background: Dysfunction of the physical and chemical barriers of the skin may play roles in the pathogenesis of atopic dermatitis (AD) by facilitating penetration of antigens through the skin and consequently evoking aberrant ...
Yui Kobatake, Hiroki Sakai, Hiroki Sakai, Toshihiro Tsukui, Osamu Yamato, Moeko Kohyama, Jun Sasaki, Shinsuke Kato, Makoto Urushitani, Sadatoshi Maeda, Sadatoshi Maeda, Hiroaki Kamishina, Hiroaki Kamishina, Hiroaki Kamishina
Journal of the Neurological Sciences   372 369-378   Jan 2017
© 2016 Elsevier B.V. Canine degenerative myelopathy (DM) is a fatal neurodegenerative disorder. Dogs with typical clinical signs carry homozygous mutations in the superoxide dismutase 1 (SOD1) gene; therefore, DM is regarded as a naturally-occurri...
Kohei Nakata, Harumi Miura, Hiroki Sakai, Hiroki Sakai, Hiroki Sakai, Takashi Mori, Takashi Mori, Takashi Mori, Sanae Shibata, Sanae Shibata, Hidetaka Nishida, Hidetaka Nishida, Sadatoshi Maeda, Sadatoshi Maeda, Hiroaki Kamishina, Hiroaki Kamishina, Hiroaki Kamishina
Journal of Veterinary Medical Science   79 999-1002   Jan 2017
© 2017 The Japanese Society of Veterinary Science. A 7-year-old cat was referred with pelvic limb ataxia. Radiography and CT revealed bone resorption of the L1 vertebral arch, and myelography identified a compressive extradural lesion. The mass wa...
Kanae Oyake, Yui Kobatake, Sanae Shibata, Sanae Shibata, Hiroki Sakai, Hiroki Sakai, Miyoko Saito, Osamu Yamato, Kazuya Kushida, Sadatoshi Maeda, Sadatoshi Maeda, Hiroaki Kamishina, Hiroaki Kamishina
Journal of Veterinary Medical Science   78 1323-1327   Aug 2016
© 2016 The Japanese Society of Veterinary Science. Canine degenerative myelopathy (DM) is characterized by progressive degeneration of the spinal cord. Although atrophic changes in the intercostal muscles were previously reported in the late stage...
Noriyuki Nagata, Masashi Yuki, Masashi Yuki, Ryota Asahina, Hiroki Sakai, Sadatoshi Maeda
Journal of Veterinary Medical Science   78 1333-1337   Aug 2016
© 2016 The Japanese Society of Veterinary Science. A 12-year-old male entire Miniature Pinscher presented with excoriations at various body sites, progressively forming ulcers and enlarging until arrested by treatment. Based on the clinical presen...
Mayu Sakamoto, Ryota Asahina, Hiroaki Kamishina, Sadatoshi Maeda
Veterinary Dermatology   27    Jun 2016
© 2016 ESVD & ACVD. Background: Colonization, overgrowth and subsequent infection by Staphylococcus spp. is frequently observed in canine atopic dermatitis (CAD), where it contributes to the intensity of cutaneous inflammation. The mechanisms by...
Eiji Naito, Daichi Kudo, Shin ichiro Sekine, Kazuhiro Watanabe, Yui Kobatake, Naritaka Tamaoki, Masatoshi Inden, Kazuki Iida, Yusuke Ito, Isao Hozumi, Toshiyuki Shibata, Sadatoshi Maeda, Hiroaki Kamishina
In Vitro Cellular and Developmental Biology - Animal   51 1012-1022   Nov 2015
© 2015, The Society for In Vitro Biology. Dental pulp cells (DPCs) of various species have been studied for their potentials of differentiation into functional neurons and secretion of neurotrophic factors. In canine, DPCs have only been studied f...
S. Nakamae, Y. Kobatake, R. Suzuki, T. Tsukui, S. Kato, O. Yamato, H. Sakai, M. Urushitani, S. Maeda, H. Kamishina
Neuroscience   303 229-240   Sep 2015
© 2015 IBRO. Canine degenerative myelopathy (DM) is an adult-onset progressive neurodegenerative disorder that has recently been linked to mutations in the superoxide dismutase 1 (SOD1) gene. We generated a polyclonal antibody against canine SOD1 ...
Ryota Asahina, Harumi Kamishina, Hiroaki Kamishina, Sadatoshi Maeda
Veterinary Dermatology   26    Jan 2015
& ACVD. Background: Pro-inflammatory cytokines and chemokines produced by activated keratinocytes play an important role in the pathogenesis of canine atopic dermatitis (AD) as well as human AD. Recent studies suggest that keratinocytes activated ...
Tadahisa Mashita, Tadahisa Mashita, Hiroaki Kamishina, Hiroaki Kamishina, Yuya Nakamoto, Yosuke Akagi, Ataru Nakanishi, Yusuke Harasaki, Tsuyoshi Ozawa, Takashi Uemura, Yui Kobatake, Yui Kobatake, Shunsuke Shimamura, Shunsuke Shimamura, Naoki Kitamura, Sadatoshi Maeda, Sadatoshi Maeda, Yuji Uzuka, Yuji Uzuka, Gerry Shaw, Jun Yasuda, Jun Yasuda
Journal of Veterinary Medical Science   77 433-438   Jan 2015
©2015 The Japanese Society of Veterinary Science. The aim of this study was to evaluate the prognostic value of concurrent measurement of serum phosphorylated neurofilament heavy subunit (pNF-H) concentration and intramedullary T2W hyperintensity ...
Aki Iio, Tsutomu Motohashi, Takahiro Kunisada, Yuma Yasuhira, Hiroaki Kamishina, Sadatoshi Maeda
Veterinary Dermatology   25    Jan 2014
Background: Previous studies reported the involvement of CC chemokine receptor 4 (CCR4)-positive CD4+ cells in the pathogenesis of canine atopic dermatitis. In humans, CCR4 is selectively expressed on type 2 helper T (Th2) cells; however, a subset...
Naoki Chimura, Aki Iio, Eiji Ozaki, Takashi Mori, Yusuke Ito, Nobuo Murayama, Masahiko Nagata, Kaori Ide, Koji Nishifuji, Hiroaki Kamishina, Sadatoshi Maeda
Veterinary Dermatology   24    Dec 2013
Background: Mycosis fungoides (MF) is the most common form of canine epitheliotropic cutaneous lymphoma, which is characterized by the accumulation of neoplastic CD8+ T cells. Given that multifocal skin lesions are commonly seen in MF, neoplastic ...
Yui Kobatake, Yui Kobatake, Takayoshi Miyabayashi, Naoko Yada, Shingo Kachi, George Ohta, Hiroki Sakai, Sadatoshi Maeda, Hiroaki Kamishina
Journal of Veterinary Medical Science   75 1379-1381   Nov 2013
A 12-week-old female Wire-haired miniature dachshund presented with non-progressive ataxia and hypermetria. Due to the animal's clinical history and symptoms, cerebellar malformations were suspected. Computed tomography (CT) and magnetic resonance...
Tsuyoshi Kimura, Machiko Sekido, Aki Iio, Naoki Chimura, Sanae Shibata, Harumi Kamishina, Hiroaki Kamishina, Sadatoshi Maeda
Veterinary Dermatology   24    Jun 2013
Background: A previous study demonstrated that the cysteine protease of Dermatophagoides farinae induced production of granulocyte-macrophage colony-stimulating factor (GM-CSF) in a canine epidermal keratinocyte progenitor cell line (CPEK); howeve...
Shingo Maeda, Sadatoshi Maeda, Koichi Ohno, Noriyuki Kaji, Masatoshi Hori, Yasuhito Fujino, Hajime Tsujimoto
Veterinary Immunology and Immunopathology   153 17-25   Mar 2013
Although the molecular basis of the allergenicity remains to be fully elucidated, the ability of allergens to elicit allergic responses is at least partly attributed to their proteolytic activity. Protease-activated receptor-2 (PAR-2) is a G prote...
Shingo Miyawaki, Makoto Washizu, Sadatoshi Maeda, Sanae Shibata, Kazuhiro Watanabe, Kazuaki Yamazoe
Journal of Veterinary Medical Science   74 1191-1193   Sep 2012
Portal vein aneurysm (PVA) is a rare abnormal dilatation of the portal vein, which has not been reported in dogs. We describe the findings of ultrasound and computed tomography in a case of PVA in a young male toy poodle, with the final diagnosis ...
Tsuyoshi Kimura, Machiko Sekido, Naoki Chimura, Sanae Shibata, Naho Kondo, Harumi Kamishina, Hiroaki Kamishina, Sadatoshi Maeda
Journal of Veterinary Medical Science   74 1033-1036   Aug 2012
House dust mite (HDM) allergens are the most common allergens for induction of IgE-mediated hypersensitivity. Recently, epicutaneous sensitization with HDM allergens has been emphasized in the development of atopic dermatitis (AD) by producing var...
Toshihiro Tsukui, Masahiro Sakaguchi, Keigo Kurata, Sadatoshi Maeda, Keitaro Ohmori, Kenichi Masuda, Hajime Tsujimoto, Shigehiro Iwabuchi
Journal of Veterinary Medical Science   74 851-856   Jul 2012
To detect allergen-specific IgE in dogs with allergic diseases, we developed a recombinant canine high affinity IgE receptor α chain (FcεRIα)-based IgE detection system. Using the recombinant protein of canine FcεRIα expressed by an Escherichia co...
Naoki Chimura, Naho Kondo, Sanae Shibata, Tsuyoshi Kimura, Takashi Mori, Yuki Hoshino, Nobuo Murayama, Masahiko Nagata, Kaori Ide, Koji Nishifuji, Hiroaki Kamishina, Sadatoshi Maeda
Veterinary Immunology and Immunopathology   144 329-336   Dec 2011
Canine epitheliotropic cutaneous lymphoma (cECL) is characterized by infiltration of neoplastic lymphocytes in the skin with a specific tropism for the epidermis. Migration of lymphocytes is strictly controlled by interactions between chemokines a...
Naoki Chimura, Sanae Shibata, Tsuyoshi Kimura, Naho Kondo, Takashi Mori, Yuki Hoshino, Hiroaki Kamishina, Sadatoshi Maeda
Journal of Veterinary Medical Science   73 1101-1104   Sep 2011
Since blood cells produce various soluble factors like cytokines or chemokines, gene expression analysis in whole blood could be important to investigate disease pathogenesis. In gene expression analysis with quantitative real-time RT-PCR, accurat...
Sanae Shibata, Sadatoshi Maeda, Naho Kondo, Naoki Chimura, Akiko Inoue, Tsuneo Fukata
Veterinary Immunology and Immunopathology   139 90-98   Feb 2011
A CC chemokine, CCL17/TARC, has been shown to be a factor in the immunopathogenesis of canine atopic dermatitis (cAD). In canine keratinocytes, the transcription of CCL17 mRNA is preferentially induced by tumor necrosis factor-alpha (TNF-α); howev...
Sanae Shibata, Sadatoshi Maeda, Naho Kondo, Akiko Inoue, Shingo Maeda, Naoki Chimura, Tsuneo Fukata
Veterinary Dermatology   22 24-30   Feb 2011
Recombinant canine interferon-γ (rCaIFN-γ) produced by a baculovirus expression system has therapeutic efficacy against atopic dermatitis in dogs. Although the mechanism of action of rCaIFN-γ is not completely understood, rCaIFN-γ is thought to do...
Kenji Ohya, Kenji Ohya, Hideko Okuda, Sadatoshi Maeda, Tsuyoshi Yamaguchi, Tsuyoshi Yamaguchi, Hideto Fukushi, Hideto Fukushi
Veterinary Microbiology   146 366-370   Dec 2010
Chlamydophila felis is a causative agent of acute and chronic conjunctivitis and pneumonia in cats. Cats can be vaccinated with killed or attenuated C. felis. However, current serodiagnostics cannot distinguish these cats from naturally infected c...
N. Nishii, M. Takasu, M. Kojima, T. Hachisu, K. Wakabayashi, A. Iwasawa, S. Maeda, Y. Ohba, H. Kitagawa
Domestic Animal Endocrinology   38 138-145   Apr 2010
A substance interfering with the enzyme-linked immunosorbent assay (ELISA) for feline insulin concentration was investigated in healthy cats. An insulin-binding substance isolated from feline serum showed 2 bands at 25 and 50 kDa in SDS-PAGE, sugg...
ShibataSanae(Gifu University),Maeda Sadatoshi(Gifu University),Maeda Shingo(Gifu University),Chimura Naoki(Gifu University),Kondo Naho(Gifu University),Fukata Tsuneo(Gifu University)
Research in Veterinary Science   88 422-426   Dec 2009
Keratinocytes produce inflammatory mediators that are involved in the pathogenesis of skin disorders such as atopic dermatitis (AD). In particular, the CC chemokines, thymus and activation regulated chemokine (TARC)/CCL17 and mucosae-associated ep...
Simpson Andrew(University of Florida),Maeda Sadatoshi(Gifu University),Marsella Rosanna(University of Florida)
Journal of Veterinary Medical Science   71 1177-1181   Oct 2009
The immunopathology behind atopic dermatitis (AD) involves a myriad of inflammatory cells and their mediators. Thymus and activation-regulated chemokine (TARC) plays a significant role in the inflammatory phase by recruiting CCR4+ TH2 cells. In ad...
Maeda Shingo(Gifu University),Maeda Sadatoshi(Gifu University),Shibata Sanae(Gifu University),Chimura Naoki(Gifu University),Fukata Tsuneo(Gifu University)
Journal of Veterinary Medical Science   71 577-582   Jun 2009
Protease-activated receptor-2 (PAR-2) belongs to a new G protein-coupled receptor subfamily and is activated by serine proteases. PAR-2 has been demonstrated to play an important role in inflammation and immune response in allergic diseases. In th...
Maeda Shingo(Gifu University),Maeda Sadatoshi(Gifu University),Shibata Sanae(Gifu University),Chimura Naoki(Gifu University),Fukata Tsuneo(Gifu University)
Veterinary Immunology and Immunopathology   131 298-302   May 2009
House dust mite (HDM) allergens are the most common allergens involved in the induction of IgE-mediated hypersensitivity. Recently, epicutaneous sensitization with HDM allergens has been emphasized in the development of atopic dermatitis (AD); how...
Mizuno Takuya(Yamaguchi University),Kanbayashi Satoshi(Yamaguchi University),Okawa Takumi(Yamaguchi University),Maeda Sadatoshi(Gifu University),Okuda Masaru(Yamaguchi University)
Veterinary Immunology and Immunopathology   131 140-143   May 2009
The newly discovered cytokine, interleukin-31 (IL-31), belongs to the short-chain cytokine group. It was reported that transgenic expression of IL-31-induced pruritus, similar to atopic dermatitis, in mice, further, excessive amounts of IL-31 was ...
Nobutaka Yasuda, Kenichi Masuda, Sadatoshi Maeda
Journal of Veterinary Medical Science   70 989-992   Sep 2008
In this study, percentages of CCR4+ cells in peripheral CD4 + T-lymphocytes were examined with flow cytometry in 46 healthy beagles between 3 months and 7 years of age. The percentage of CCR4+ cells varied from 9.9% to 33.5%. The mean percentage w...
Yasuhito Kuwahara, Naohito Nishii, Masaki Takasu, Yasunori Ohba, Sadatoshi Maeda, Hitoshi Kitagawa
Journal of Veterinary Medical Science   70 865-867   Aug 2008
The clinical utility of the urine albumin/creatinine ratio (UAC) using a simplified analyzer for estimation of proteinuria was studied in cats and dogs. Measurement results for diluted feline and canine albumin standard solutions showed linearity....
Sanae Shibata, Sadatoshi Maeda, Hiromi Tsuchida, Tsuneo Fukata
Journal of Veterinary Medical Science   70 853-855   Aug 2008
Epidermal keratinocytes have the potential to produce inflammatory mediators that are considered to play an important role in skin diseases such as atopic dermatitis (AD). Thus, cell lines of canine epidermal keratinocytes are useful for studying ...
Yasunori Ohba, Tomonori Iguchi, Yoshino Hirose, Masaki Takasu, Naohito Nishii, Sadatoshi Maeda, Hitoshi Kitagawa
Journal of Veterinary Medical Science   70 829-831   Aug 2008
A 24-day-old female Holstein calf had a soft, painless fluctuating swelling on the median plane in the frontal region, but did not show any clinical symptoms including neurological signs. Computer tomography (CT) distinctly showed the cyst filled ...
Yasunori Ohba, Masaki Takasu, Naohito Nishii, Eri Takeda, Sadatoshi Maeda, Tetsuo Kunieda, Hitoshi Kitagawa, Hitoshi Kitagawa
Journal of Veterinary Medical Science   70 297-299   Mar 2008
Using a DNA-based diagnostic test for factor XI deficiency in Japanese black cattle, we surveyed 123 cattle (42 sires and 81 dams) in Gifu and Hyogo prefectures, and calculated gene frequencies. In sires, we drew up the pedigree network of the cat...
Sadatoshi Maeda, Sadatoshi Maeda, Hiromi Tsuchida, Sanae Shibata, Tetsuji Kawakami, Toshihiro Tsukui, Yasunori Ohba, Tsuneo Fukata, Hitoshi Kitagawa
Journal of Veterinary Medical Science   70 51-55   Jan 2008
Chemokines are important regulators of the selective recruitment of inflammatory cells into sites of allergic inflammation. Since canine atopic dermatitis (AD) shares many clinical features of human AD, patterns of chemokine production in dogs may...
Maeda Sadatoshi(Gifu University),Tsuchida Hiromi(Gifu University),Marsella Rosanna(University of Florida)
Veterinary Dermatology   18 422-426   Dec 2007
The kinetics of cytokine expression was evaluated in whole blood from high-IgE beagles previously sensitized to house dust mites (HDM) and known to develop clinical signs compatible with atopic dermatitis (AD) upon allergen exposure. Six high-IgE ...
Masaki Takasu, Yasunori Ohba, Yasunori Ohba, Tomonori Iguchi, Naohito Nishii, Sadatoshi Maeda, Hitoshi Kitagawa
Journal of Veterinary Medical Science   69 985-987   Sep 2007
A propionate tolerance test (PTT) was used to determine the pathophysiology of a Japanese Black steer with hyperglycemia. In the hyperglycemic steer, a low insulin secretion was confirmed by a glucose tolerance test (GTT), so that the hyperglycemi...
Naohito Nishii, Masaki Takasu, Ok Kar Soe, Sadatoshi Maeda, Yasunori Ohba, Miho Inoue-Murayama, Hitoshi Kitagawa
Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology   147 690-697   Aug 2007
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors implicated in lipid metabolism. In this study, the full-length cDNA of canine PPARβ and γ were sequenced, and expression of PPARs was evaluated in norma...
Thierry Olivry, Thierry Olivry, Thierry Olivry, Rosanna Marsella, Rosanna Marsella, Toshiroh Iwasaki, Toshiroh Iwasaki, Ralf Mueller, Ralf Mueller, Emmanuel Bensignor, Didier Carlotti, Douglas J. DeBoer, Craig Griffin, Richard Halliwell, Bruce Hammerberg, Peter Hill, Hilary Jackson, Sadatoshi Maeda, Kenichi Masuda, Tim Nuttall, Pascal Prélaud, Candace Sousa, Ton Willemse
Veterinary Dermatology   18 78-86   Apr 2007
In dogs, atopic dermatitis (AD) is a common and chronic allergic skin disease that often necessitates treatment with pharmacological interventions. In the last 30 years, numerous clinical trials testing the efficacy of anti-inflammatory drugs have...
Masaki Takasu, Yasuko Kishima, Naohito Nishii, Yasunori Ohba, Sadatoshi Maeda, Kiyoshi Miyazawa, Tetsuma Murase, Hitoshi Kitagawa, Hitoshi Kitagawa
Journal of Veterinary Medical Science   69 69-72   Jan 2007
To evaluate the energy condition of cattle with growth retardation, propionate (PTT) and arginine tolerance tests (ATT) were carried out. The insulin/glucagon concentration ratio immediately before PTT or ATT in the cattle with growth retardation ...
Naohito Nishii, Hiroyuki Nodake, Masaki Takasu, Okkar Soe, Yasunori Ohba, Sadatoshi Maeda, Yoshihiko Ohtsuka, Tsutomu Honjo, Masayuki Saito, Hitoshi Kitagawa
American Journal of Veterinary Research   67 2006-2011   Dec 2006
Objective - To evaluate postprandial changes in the leptin concentration of CSF in dogs during development of obesity. Animals - 4 male Beagles. Procedures - Weight gain was induced and assessments were made when the dogs were in thin, optimal, an...
Masaki Takasu, Kinji Shirota, Naohiro Uchida, Tomonori Iguchi, Naohito Nishii, Yasunori Ohba, Sadatoshi Maeda, Kiyoshi Miyazawa, Tetsuma Murase, Hitoshi Kitagawa
Journal of Veterinary Medical Science   68 519-521   Jun 2006
We encountered an extremely rare tumor, a pericardial mesothelioma, in a neonatal calf. The patient calf showed severe abdominal distention, and died immediately after birth. The thoracic cavity was contained a huge heart with a large amount of pe...
Rosanna Marsella, Rosanna Marsella, Thierry Olivry, Sadatoshi Maeda
Veterinary Dermatology   17 111-120   Apr 2006
The cellular and cytokine dynamics of reactions triggered by atopy patch testing with house dust mites were studied in six high-IgE beagles. Sites were scored and biopsied at 6, 24, 48, and 96 h, and samples were processed for histopathology, immu...
Naohito Nishii, Masaki Takasu, Yasunori Ohba, Sadatoshi Maeda, Katsuya Kitoh, Yoshihiko Ohtsuka, Tsutomu Honjo, Masayuki Saito, Hitoshi Kitagawa
American Journal of Veterinary Research   67 266-270   Feb 2006
Objective - To investigate effects of short- and long-term administration of glucocorticoids, feeding status, and serum concentrations of insulin and cortisol on plasma leptin concentrations in dogs. Animals - 20 nonobese dogs. Procedure - For exp...
Masaki Takasu, Masato Yayota, Miwa Nakano, Naohito Nishii, Yasunori Ohba, Keiji Okada, Sadatoshi Maeda, Kiyoshi Miyazawa, Hitoshi Kitagawa
Journal of Veterinary Medical Science   67 1269-1271   Dec 2005
To evaluate the nutriture of Japanese black cattle with growth retardation, a metabolic profile test was carried out in 8 cattle with growth retardation and in 10 cattle with normal growth. During our observation for 1 month before blood sampling,...
Nobutaka Yasuda, Toshihiro Tsukui, Kenichi Masuda, Kenichi Masuda, Shinpei Kawarai, Keitaro Ohmori, Sadatoshi Maeda, Hajime Tsujimoto
Journal of Veterinary Medical Science   67 1075-1079   Oct 2005
The receptors for endothelin (ET) family, ETA and ET B, were molecularly cloned and the expression of ETA and ETB as well as preproendothelin-1 (PPET-1, precursor of ET-1) was examined in normal canine tissues by RT-PCR. The entire open reading fr...
Keitaro Ohmori, Kenichi Masuda, Sadatoshi Maeda, Yukiko Kaburagi, Keigo Kurata, Koichi Ohno, Douglas J. DeBoer, Hajime Tsujimoto, Masahiro Sakaguchi
Veterinary Immunology and Immunopathology   104 249-256   Apr 2005
Allergic reactions after vaccination are considered as an important practical problem in dogs; however, their immunological mechanism has not been well understood. The present study was designed to investigate the relationship between IgE reactivi...
Sadatoshi Maeda, Toshihiro Tsukui, Koh Ichi Saze, Kenichi Masuda, Koichi Ohno, Hajime Tsujimoto, Shigehiro Iwabuchi
Veterinary Immunology and Immunopathology   103 83-92   Jan 2005
A monoclonal antibody to canine thymus and activation-regulated chemokine (TARC/CCL17) was developed to examine the association of TARC with the immunopathogenesis of canine atopic dermatitis (AD). Recombinant canine TARC was prepared using an E. ...
Masuda Kenichi(RIKEN)
Veterinary Immunology and Immunopathology   102(1-2) 45-52   Nov 2004
Japanese cedar (Cryptomeria japonica, CJ) pollen has been known to cause atopic dermatitis in dogs in Japan. However, since the mechanism of the CJ antigen recognition is not well understood in dogs, it is difficult to develop effective immunother...
Haruhiko Maruyama, Keisuke Oguma, Sadatoshi Maeda, Rui Kano, Hajime Tsujimoto, Toshihiro Watari, Mikihiko Tokuriki, Atsuhiko Hasegawa
Journal of Veterinary Medical Science   66 1423-1427   Nov 2004
Thrombomodulin (TM) is a glycoprotein localized mainly on endothelial cell surfaces, and is a major regulator of vascular thromboresistance. The entire open reading frame of canine TM cDNA comprises 1737 bp, encoding 578 amino acid residues. Compa...
S. Maeda, S. Maeda, K. Ohmori, N. Yasuda, K. Kurata, M. Sakaguchi, K. Masuda, K. Ohno, H. Tsujimoto
Clin Exp Allergy   34(9) 1467-1473   Sep 2004
Background: Since dogs frequently develop allergic diseases, similar to those in humans, dogs represent a possible animal model for allergy in humans. In human atopic dermatitis (AD), CC chemokine receptor 4 (CCR4) has been shown to play an import...
Keitaro Ohmori, Sadatoshi Maeda, Taro Okayama, Kenichi Masuda, Koichi Ohno, Hajime Tsujimoto
Journal of Veterinary Medical Science   66(6) 739-741   Jun 2004
Activation-induced cytidine deaminase (AID) is essential for class switch recombination, somatic hypermutation, and gene conversion of immunoglobulin gene. In the present study, canine AID cDNA was cloned from the lymph node of a healthy dog by RT...
Sadatoshi MAEDA, Keitaro OHMORI, Keigo KURATA, Masahiro SAKAGUCHI, Kenichi MASUDA, Koichi OHNO, Hajime TSUJIMOTO
J Vet Med Sci   66(3) 337-339   Mar 2004
DNA immunization induces systemic humoral and cellular immune responses to the antigen encoded by cDNA in a plasmid DNA. In the present study, a plasmid DNA encoding cDNA of β-galactosidase (β-gal), pCAGGS-lacZ, was inoculated intramuscularly to a...
Keigo Kurata, Sadatoshi Maeda, Sho Yasunaga, Kenichi Masuda, Masahiro Sakaguchi, Koichi Ohno, Hajime Tsujimoto
Journal of Veterinary Medical Science   66(1) 25-29   Jan 2004
Three dogs clinically diagnosed with allergic rhinitis (AR) were examined for their immunological findings. House dust mites (HDM) such as Dermatophagoides farinae (DF) and D. pteronyssinus (DP) were identified as positive allergens in the 3 dogs ...
Sadatoshi Maeda, Sadatoshi Maeda, Takayoshi Miyabayashi, Janet K. Yamamoto, Gregory D. Roberts, Allan J. Lepine, Roger M. Clemmons
J Vet Med Sci   65(12) 1373-1376   Dec 2003
To investigate temporal dynamic changes in the synthesis of chondroitin 6-sulfate (CS6) and chondroitin 4-sulfate (CS4) in vitro, normal articular cartilage of femoral heads was harvested from three dogs. Chondrocytes were isolated and cultured in...
Tomoe Kimura, Rui Kano, Sadatoshi Maeda, Hajime Tsujimoto, Masahiko Nagata, Atsuhiko Hasegawa
Veterinary Dermatology   14(5) 269-273   Oct 2003
One of the mechanisms of eosinophil infiltration is its induction by chemoattractants such as regulated upon activation, normal T-expressed and secreted (RANTES) which is a cysteine-cysteine chemokine that mediates chemotaxis and activation of eos...
Sadatoshi MAEDA, Taro OKAYAMA, Keitaro OHMORI, Kenichi MASUDA, Koichi OHNO, Hajime TSUJIMOTO
J Vet Med Sci   65(2) 275-278   Feb 2003
Thymus and activation-regulated chemokine (TARC) is a member of CC chemokine and plays an essential role in recruitment of CC chemokine receptor 4 positive Th2 cells to allergic lesion. To investigate the association of TARC in allergic inflammati...
Sadatoshi Maeda, Taro Okayama, Keitaro Omori, Kenichi Masuda, Masahiro Sakaguchi, Koichi Ohno, Hajime Tsujimoto
Vet Immunol Immunopathol   90(3-4) 145-154   Dec 2002
CC chemokine receptor 4 (CCR4) is a G protein-coupled seven transmembrane receptor that is selectively expressed on Th2 cells and plays an important role in the trafficking of Th2 cells into inflammatory sites. In this study, a full-length canine ...
Sadatoshi Maeda, Shunsuke Fujiwara, Keitaro Omori, Koji Kawano, Keigo Kurata, Kenichi Masuda, Koichi Ohno, Hajime Tsujimoto
Vet Immunol Immunopathol   88(1-2) 79-87   Sep 2002
In this study, we investigated the mRNA expression of a chemokine, thymus and activation-regulated chemokine (TARC), and cytokines including IL-1β, IL-4, IFN-γ and TNF-α in skin samples obtained from both dogs with atopic dermatitis (AD) and healt...
Leona Koga, Yoshitaka Kobayashi, Mitsuhiro Yazawa, Sadatoshi Maeda, Kenichi Masuda, Koichi Ohno, Hajime Tsujimoto
Journal of Veterinary Medical Science   64(5) 453-456   May 2002
Vascular endothelial growth factor (VEGF) is an angiogenic factor which targets vascular endothelial cells. In this study, cDNA encoding a feline VEGF (fVEGF) isoform was cloned from a feline lymphoid tumor cell line and sequenced. The fVEGF cDNA ...
Sadatoshi Maeda, Sadatoshi Maeda, Takayoshi Miyabayashi, Janet K. Yamamoto, Gregory D. Roberts, Allan J. Lepine, Roger M. Clemmons
Journal of Veterinary Medical Science   63(9) 1039-1043   Sep 2001
Chondroitin sulfate (CS) isomers, 6-sulfate (CS6) and 4-sulfate (CS4), change their ratio to each other in cartilaginous tissues with aging. In this study, a quantitative measurement method of CS6 and CS4 was developed, using capillary electrophor...
Sadatoshi Maeda, Takuya Mizuno, Kohei Yamashita, Keigo Kurata, Kenichi Masuda, Koichi Ohno, Hajime Tsujimoto
Journal of Veterinary Medical Science   63(9) 1035-1038   Sep 2001
Thymus and activation-regulated chemokine (TARC) is known as a functional ligand for CC chemokine receptor 4 (CCR4), which is selectively expressed on Th2 lymphocytes and induces selective migration of the cells to allergic lesions. In this study,...
K. Ohmori, M. Sakaguchi, Y. Kaburagi, S. Maeda, K. Masuda, K. Ohno, H. Tsujimoto
Veterinary Record   156 87-88

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2011 - 2013    Investigator(s): SADATOSHI MAEDA
The results indicated that the stimulation with house dust mite antigen (HDM) induced the production of GM-CSF in canine keratinocytes, which was suppressed by a cysteine protease inhibitor. Thus, it was demonstrated that cysteine protease activi...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(挑戦的萌芽研究)
Project Year: 2011 - 2012    Investigator(s): Sadatoshi MAEDA
The present results indicated that the skin-homing property of CCR4, CCR7, CCR10 and CXCR3 may contribute to the development of specific accumulation of neoplastic lymphocytes in the skin, which is the new concept of involvement of active skin mig...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2008 - 2010    Investigator(s): Sadatoshi MAEDA
We tried to produce anti-canine IgE antibodies that could inhibit a binding of IgE to mast cells in order to develop a novel therapy for canine atopic dermatitis. Ten clones of the antibodies were generated by immunization of recombinant protein o...
Involvement of chemokines on allergic diseases in animals
Project Year: 2003 - 2004
Japan Society for the Promotion of Science: Grants-in-Aid forScientific Research
Project Year: 2011 - 2013