小野健治 (Kenji Ono) - マイポータル

基本情報

所属: 名古屋市立大学大学院医学研究科神経毒性学分野准教授
: (兼任)脳神経科学研究所

学位: 博士（薬学）(2003年3月名古屋市立大学)
修士（薬学）(2000年3月名古屋市立大学)

連絡先: k_onomed.nagoya-cu.ac.jp
研究者番号: 80329698
J-GLOBAL ID: 200901098897348258
researchmap会員ID: 5000083877

研究キーワード

研究分野

経歴

2026年1月 - 現在

名古屋市立大学大学院医学研究科神経毒性学分野, 准教授
2024年7月 - 2025年12月

名古屋市立大学大学院医学研究科神経毒性学分野, 講師
2013年4月 - 2024年6月

名古屋大学大学院医学研究科薬物動態解析学, 助教
2007年4月 - 2024年6月

名古屋大学環境医学研究所生体適応・防御研究部門脳機能分野, 助教
2005年4月 - 2007年3月

名古屋大学環境医学研究所高次神経統御部門脳生命科学分野助手
2004年4月 - 2005年3月

藤田保健衛生大学総合医科学研究所難病治療共同研究部門助手
2003年4月 - 2004年3月

独立行政法人放射線医学総合研究所博士号取得若手研究員

学歴

2000年4月 - 2003年3月

名古屋市立大学大学院薬学研究科博士後期課程
1998年4月 - 2000年3月

名古屋市立大学大学院薬学研究科博士前期課程
1994年4月 - 1998年3月

名古屋市立大学薬学部薬学科

論文

Size and surface properties of silica micro/nanoparticles are critical in modulating endocytosis-mediated cellular responses in murine RAW-Blue macrophages and N18 neuroblastoma cells

Dipankar Chandra Roy, Kenji Ono, Katsumi Fukamachi, Masumi Suzui

Fundam Toxicol Sci 12(5) 143-154 2025年10月査読有り責任著者
Signal Peptides and Their Fragments in Post-Translation: Novel Insights of Signal Peptides

Kenji Ono

International Journal of Molecular Sciences 2024年12月査読有り
Photosensitizer-singlet oxygen sensor conjugated silica nanoparticles for photodynamic therapy and bioimaging.

Jeladhara Sobhanan, Kenji Ono, Takuya Okamoto, Makoto Sawada, Paul S Weiss, Vasudevanpillai Biju

Chemical science 15(6) 2007-2018 2024年2月7日査読有り
Distribution of Signal Peptides in Microvesicles from Activated Macrophage Cells

Kenji Ono, Junpei Sato, Hiromi Suzuki, Makoto Sawada

International Journal of Molecular Sciences 24(15) 12131 2023年7月28日査読有り招待有り筆頭著者責任著者
Calmodulin as a Key Regulator of Exosomal Signal Peptides

Kenji Ono, Mikio Niwa, Hiromi Suzuki, Nahoko Bailey Kobayashi, Tetsuhiko Yoshida, Makoto Sawada

Cells 12(1) 158 2022年12月30日査読有り招待有り筆頭著者責任著者
Signal Sequence-Dependent Orientation of Signal Peptide Fragments to Exosomes.

Ono K, Niwa M, Suzuki H, Kobayashi NB, Yoshida T, Sawada M

Int J Mol Sci 23(6) 3137 2022年3月15日査読有り筆頭著者責任著者
The sodium-glucose cotransporter-2 inhibitor Tofogliflozin prevents the progression of nonalcoholic steatohepatitis–associated liver tumors in a novel murine model

Naoki Yoshioka, Miyako Tanaka, Kozue Ochi, Akiko Watanabe, Kenji Ono, Makoto Sawada, Tomoo Ogi, Michiko Itoh, Ayaka Ito, Yukihiro Shiraki …

Biomedicine & Pharmacotherapy 140 111738-111738 2021年8月査読有り
Secretion of signal peptides via extracellular vesicles.

Ono K, Niwa M, Suzuki H, Kobayashi NB, Yoshida T, Sawada M

Biochem Biophys Res Commun 560 21-26 2021年6月30日査読有り筆頭著者責任著者
Novel Oxindole-Curcumin Hybrid Compound for Antioxidative Stress and Neuroprotection.

Yoko Hirata, Yuki Ito, Madoka Takashima, Kazuya Yagyu, Kentaro Oh-Hashi, Hiromi Suzuki, Kenji Ono, Kyoji Furuta, Makoto Sawada

ACS chemical neuroscience 11(1) 76-85 2020年1月2日査読有り
Inducible nitric oxide synthase during the late phase of sepsis is associated with hypothermia and immune cell migration

Yudai Takatani, Kenji Ono, Hiromi Suzuki, Masato Inaba, Makoto Sawada, Naoyuki Matsuda

Laboratory Investigation 98(5) 629-639 2018年5月1日査読有り
Visualization of Arc promoter-driven neuronal activity by magnetic resonance imaging

Qi Wu, Kenji Ono, Hiromi Suzuki, Megumi Eguchi, Shun Yamaguchi, Makoto Sawada

Neuroscience Letters 666 92-97 2018年2月14日査読有り
LC-MS/MS imaging with thermal film-based laser microdissection

Michiko Oya, Hiromi Suzuki, Andrea Roxanne J. Anas, Koichi Oishi, Kenji Ono, Shun Yamaguchi, Megumi Eguchi, Makoto Sawada

Analytical and Bioanalytical Chemistry 410(2) 491-499 2018年1月1日査読有り
Extracellular Lactate Dehydrogenase A Release From Damaged Neurons Drives Central Nervous System Angiogenesis

Hsiaoyun Lin, Rieko Muramatsu, Noriko Maedera, Hiroto Tsunematsu, Machika Hamaguchi, Yoshihisa Koyama, Mariko Kuroda, Kenji Ono, Makoto Sawada, Toshihide Yamashita

EBioMedicine 27 71-85-85 2018年1月査読有り
Optogenetic control of cell differentiation in channelrhodopsin-2-expressing OS3, a bipotential glial progenitor cell line

Kenji Ono, Hiromi Suzuki, Ryusei Yamamoto, Hideki Sahashi, Yuhei Takido, Makoto Sawada

NEUROCHEMISTRY INTERNATIONAL 104 49-63 2017年3月査読有り
Soluble Siglec-9 suppresses arthritis in a collagen-induced arthritis mouse model and inhibits M1 activation of RAW264.7 macrophages

Takuya Matsumoto, Nobunori Takahashi, Toshihisa Kojima, Yutaka Yoshioka, Jun Ishikawa, Koichi Furukawa, Kenji Ono, Makoto Sawada, Naoki Ishiguro, Akihito Yamamoto

ARTHRITIS RESEARCH & THERAPY 18(1) 133 2016年6月査読有り
Nanoparticles speckled by ready-to-conjugate lanthanide complexes for multimodal imaging

Vasudevanpillai Biju, Morihiko Hamada, Kenji Ono, Sakiko Sugino, Takashi Ohnishi, Edakkattuparambil Sidharth Shibu, Shohei Yamamura, Makoto Sawada, Shunsuke Nakanishi, Yasushi Shigeri …

NANOSCALE 7(36) 14829-14837 2015年査読有り
Protective effect of INI-0602, a gap junction inhibitor, on dopaminergic neurodegeneration of mice with unilateral 6-hydroxydopamine injection.

Suzuki H, Ono K, Sawada M

J Neural Transm 121(11) 1349-1355 2014年11月査読有り責任著者
Novel Positively Charged Nanoparticle Labeling for In Vivo Imaging of Adipose Tissue-Derived Stem Cells

Hiroshi Yukawa, Shingo Nakagawa, Yasuma Yoshizumi, Masaki Watanabe, Hiroaki Saito, Yoshitaka Miyamoto, Hirofumi Noguchi, Koichi Oishi, Kenji Ono, Makoto Sawada …

PLOS ONE 9(11) e110142 2014年11月査読有り
Glutamate release from astrocyte cell-line GL261 via alterations in the intracellular ion environment

Kenji Ono, Hiromi Suzuki, Madoka Higa, Kaori Tabata, Makoto Sawada

JOURNAL OF NEURAL TRANSMISSION 121(3) 245-257 2014年3月査読有り
Photouncaging Nanoparticles for MRI and Fluorescence Imaging in Vitro and in Vivo

Edakkattuparambil S. Shibu, Kenji Ono, Sakiko Sugino, Ayami Nishioka, Akikazu Yasuda, Yasushi Shigeri, Shin-ichi Wakida, Makoto Sawada, Vasudevanpillai Biju

ACS NANO 7(11) 9851-9859 2013年11月査読有り

もっとみる

MISC

Inducible nitric oxide synthase during the late phase of sepsis is associated with hypothermia and immune cell migration

Yudai Takatani, Kenji Ono, Hiromi Suzuki, Masato Inaba, Makoto Sawada, Naoyuki Matsuda

Laboratory Investigation 98(5) 629-639 2018年5月1日査読有り
Visualization of Arc promoter-driven neuronal activity by magnetic resonance imaging

Qi Wu, Kenji Ono, Hiromi Suzuki, Megumi Eguchi, Shun Yamaguchi, Makoto Sawada

Neuroscience Letters 666 92-97 2018年2月14日査読有り
LC-MS/MS imaging with thermal film-based laser microdissection

Michiko Oya, Hiromi Suzuki, Andrea Roxanne J. Anas, Koichi Oishi, Kenji Ono, Shun Yamaguchi, Megumi Eguchi, Makoto Sawada

Analytical and Bioanalytical Chemistry 410(2) 491-499 2018年1月1日査読有り
Extracellular Lactate Dehydrogenase A Release From Damaged Neurons Drives Central Nervous System Angiogenesis

Hsiaoyun Lin, Rieko Muramatsu, Noriko Maedera, Hiroto Tsunematsu, Machika Hamaguchi, Yoshihisa Koyama, Mariko Kuroda, Kenji Ono, Makoto Sawada, Toshihide Yamashita

EBioMedicine 27 71-85-85 2018年1月査読有り
Optogenetic control of cell differentiation in channelrhodopsin-2-expressing OS3, a bipotential glial progenitor cell line

Kenji Ono, Hiromi Suzuki, Ryusei Yamamoto, Hideki Sahashi, Yuhei Takido, Makoto Sawada

NEUROCHEMISTRY INTERNATIONAL 104 49-63 2017年3月査読有り
Soluble Siglec-9 suppresses arthritis in a collagen-induced arthritis mouse model and inhibits M1 activation of RAW264.7 macrophages

Takuya Matsumoto, Nobunori Takahashi, Toshihisa Kojima, Yutaka Yoshioka, Jun Ishikawa, Koichi Furukawa, Kenji Ono, Makoto Sawada, Naoki Ishiguro, Akihito Yamamoto

ARTHRITIS RESEARCH & THERAPY 18(1) 133 2016年6月査読有り
Nanoparticles speckled by ready-to-conjugate lanthanide complexes for multimodal imaging

Vasudevanpillai Biju, Morihiko Hamada, Kenji Ono, Sakiko Sugino, Takashi Ohnishi, Edakkattuparambil Sidharth Shibu, Shohei Yamamura, Makoto Sawada, Shunsuke Nakanishi, Yasushi Shigeri …

NANOSCALE 7(36) 14829-14837 2015年査読有り
Protective effect of INI-0602, a gap junction inhibitor, on dopaminergic neurodegeneration of mice with unilateral 6-hydroxydopamine injection

Hiromi Suzuki, Kenji Ono, Makoto Sawada

JOURNAL OF NEURAL TRANSMISSION 121(11) 1349-1355 2014年11月査読有り
Novel Positively Charged Nanoparticle Labeling for In Vivo Imaging of Adipose Tissue-Derived Stem Cells

Hiroshi Yukawa, Shingo Nakagawa, Yasuma Yoshizumi, Masaki Watanabe, Hiroaki Saito, Yoshitaka Miyamoto, Hirofumi Noguchi, Koichi Oishi, Kenji Ono, Makoto Sawada …

PLOS ONE 9(11) e110142 2014年11月査読有り
Glutamate release from astrocyte cell-line GL261 via alterations in the intracellular ion environment

Kenji Ono, Hiromi Suzuki, Madoka Higa, Kaori Tabata, Makoto Sawada

JOURNAL OF NEURAL TRANSMISSION 121(3) 245-257 2014年3月査読有り
Photouncaging Nanoparticles for MRI and Fluorescence Imaging in Vitro and in Vivo

Edakkattuparambil S. Shibu, Kenji Ono, Sakiko Sugino, Ayami Nishioka, Akikazu Yasuda, Yasushi Shigeri, Shin-ichi Wakida, Makoto Sawada, Vasudevanpillai Biju

ACS NANO 7(11) 9851-9859 2013年11月査読有り
Singlet-Oxygen-Sensitizing Near-Infrared-Fluorescent Multimodal Nanoparticles

Edakkattuparambil Sidharth Shibu, Sakiko Sugino, Kenji Ono, Hironobu Saito, Ayama Nishioka, Shohei Yamamura, Makoto Sawada, Yoshio Nosaka, Vasudevanpillai Biju

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 52(40) 10559-10563 2013年9月査読有り
In Vivo Imaging of Transplanted Islets Labeled with a Novel Cationic Nanoparticle

Koichi Oishi, Yoshitaka Miyamoto, Hiroaki Saito, Katsutoshi Murase, Kenji Ono, Makoto Sawada, Masami Watanabe, Yasufumi Noguchi, Toshiyoshi Fujiwara, Shuji Hayashi …

PLoS ONE 8(2) e57046 2013年2月22日査読有り
Novel positive-charged nanoparticles for efficient magnetic resonance imaging of islet transplantation.

Koichi Oishi, Hirofumi Noguchi, Hiroaki Saito, Hiroshi Yukawa, Yoshitaka Miyamoto, Kenji Ono, Katsutoshi Murase, Makoto Sawada, Shuji Hayashi

Cell Medicine 3(1) 43-49-49 2012年査読有り
Visualization of iNOS gene expression from activated cells in magnetic resonance imaging

Kenji Ono, Kaori Tabata, Hiromi Suzuki, Makoto Sawada

NEUROSCIENCE RESEARCH 71 E96-E96 2011年
ミクログリアによるBBB非崩壊型の脳へのターゲティングDDS

澤田誠, 鈴木弘美, 小野健治

薬剤学 71(5) 259-267 2011年招待有り
Electrosprayed Synthesis of Red-Blood-Cell-Like Particles with Dual Modality for Magnetic Resonance and Fluorescence Imaging

Koichiro Hayashi, Kenji Ono, Hiromi Suzuki, Makoto Sawada, Makoto Moriya, Wataru Sakamoto, Toshinobu Yogo

SMALL 6(21) 2384-2391 2010年11月査読有り
High-Frequency, Magnetic-Field-Responsive Drug Release from Magnetic Nanoparticle/Organic Hybrid Based on Hyperthermic Effect

Koichiro Hayashi, Kenji Ono, Hiromi Suzuki, Makoto Sawada, Makoto Moriya, Wataru Sakamoto, Toshinobu Yogo

ACS APPLIED MATERIALS & INTERFACES 2(7) 1903-1911 2010年7月査読有り
One-Pot Biofunctionalization of Magnetic Nanoparticles via Thiol-Ene Click Reaction for Magnetic Hyperthermia and Magnetic Resonance Imaging

Koichiro Hayashi, Kenji Ono, Hiromi Suzuki, Makoto Sawada, Makoto Moriya, Wataru Sakamoto, Toshinobu Yogo

CHEMISTRY OF MATERIALS 22(12) 3768-3772 2010年6月査読有り
Quantum dots labeling using octa-arginine peptides for imaging of adipose tissue-derived stem cells

Hiroshi Yukawa, Yukimasa Kagami, Masaki Watanabe, Koichi Oishi, Yoshitaka Miyamoto, Yukihiro Okamoto, Manabu Tokeshi, Noritada Kaji, Hirofumi Noguchi, Kenji Ono …

BIOMATERIALS 31(14) 4094-4103 2010年5月査読有り