KOZAKI Ken-ichi

J-GLOBAL         Last updated: Nov 14, 2015 at 09:42
 
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Name
KOZAKI Ken-ichi
Affiliation
Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Section
Department of Dental Pharmacology
Job title
Professor
Degree
Doctor of Medical Science(Nagoya University School of Medicine/Graduate School of Medicine)

Research Areas

 

Academic & Professional Experience

 
Apr 2014
 - 
Today
Professor, Department of Dental Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
 
Jun 2010
 - 
Mar 2014
Associate Professor, Department of Molecular Cytogenetics, Medical Research Institute, Tokyo Medical and Dental University
 
May 2005
 - 
May 2010
Associate Professor, Department of Genome Medicine, Hard Tissue Genome Research Center, Tokyo Medical and Dental University
 
Apr 2004
 - 
Apr 2005
Associate Professor, Department of Pharmacology, Osaka Dental University
 
Jan 2001
 - 
Mar 2004
Assistant Professor, Department of Pathology, Aichi Medical University School of Medicine
 
Apr 1999
 - 
Dec 2000
Senior Researcher, Division of Molecular Oncology, Aichi Cancer Center Research Institute
 
Apr 1994
 - 
Mar 1999
Researcher, Pathophysiology Unit, Aichi Cancer Center Research Institute
 
Jul 1989
 - 
Mar 1990
Medical staff, Oral and Maxillofacial Surgery, Nagoya University Hospital
 

Education

 
Apr 1990
 - 
Mar 1994
Department of Oral Surgery, Graduate School of Medicine, Nagoya University
 
 
 - 
1994
Oral and Maxillofacial Surgery, Doctoral Course at the Graduate School of Medicine, Nagoya Univercity, Nagoya University School of Medicine / Graduate of Medicine
 
Apr 1983
 - 
Mar 1989
Faculty of Dentistry, Hiroshima University
 
 
 - 
1989
Scool of Dentistry, Hiroshima University
 

Committee Memberships

 
Jun 2014
 - 
Today
Japanese Association for Oral Biology  Councilor member
 
Jan 2011
 - 
Today
Japanese Cancer Association  Councilor member
 

Awards & Honors

 
Nov 2012
basic and clinical cancer research projects, Osaka Cancer Research Foundation
 
Nov 2001
Molecular mechanism and suppression of tumor growth via apoptosis induced specifically to in endothelial cells by anti-angiogenic factor caspin/PEDF/EPC-1, Kowa Life Science Foundation, Kowa Life Science Foundation
 

Published Papers

 
Yanaka Y, Muramatsu T, Uetake H, Kozaki K, Inazawa J
Carcinogenesis   36(11) 1363-1371   Nov 2015   [Refereed]
Fujiwara N, Inoue J, Kawano T, Tanimoto K, Kozaki K, Inazawa J
Cancer research   75(18) 3890-3901   Sep 2015   [Refereed]
Kikuchi R, Kikuchi Y, Tsuda H, Maekawa H, Kozaki KI, Imoto I, Tamai S, Shiotani A, Iwaya K, Sakamoto M, Sekiya T, Matsubara O
Human cell      Apr 2014   [Refereed]
Yamamoto S, Inoue J, Kawano T, Kozaki K, Omura K, Inazawa J
Molecular cancer research : MCR   12 58-68   Jan 2014   [Refereed]
Harazono Y, Muramatsu T, Endo H, Uzawa N, Kawano T, Harada K, Inazawa J, Kozaki K
PloS one   8 e62757   2013   [Refereed]
Furuta M, Kozaki K, Tanimoto K, Tanaka S, Arii S, Shimamura T, Niida A, Miyano S, Inazawa J
PloS one   8 e60155   2013   [Refereed]
Endo H, Muramatsu T, Furuta M, Uzawa N, Pimkhaokham A, Amagasa T, Inazawa J, Kozaki K
Carcinogenesis   34(3) 560-569   Mar 2013   [Refereed]
Matsumura S, Imoto I, Kozaki KI, Matsui T, Muramatsu T, Furuta M, Tanaka S, Sakamoto M, Arii S, Inazawa J
Clinical cancer research : an official journal of the American Association for Cancer Research      May 2012   [Refereed]
Kurasawa Y, Kozaki K, Pimkhaokham A, Muramatsu T, Ono H, Ishihara T, Uzawa N, Imoto I, Amagasa T, Inazawa J
Oncogene   31(15) 1963-1974   Apr 2012   [Refereed]
Ono H, Imoto I, Kozaki K, Tsuda H, Matsui T, Kurasawa Y, Muramatsu T, Sugihara K, Inazawa J
Oncogene   31(47) 4923-4934   Jan 2012   [Refereed]
Ishihara T, Inoue J, Kozaki K, Imoto I, Inazawa J
The Journal of biological chemistry   286(51) 44086-44094   Dec 2011   [Refereed]
Tsuruta T, Kozaki K, Uesugi A, Furuta M, Hirasawa A, Imoto I, Susumu N, Aoki D, Inazawa J
Cancer research   71(20) 6450-6462   Oct 2011   [Refereed]
Uesugi A, Kozaki K, Tsuruta T, Furuta M, Morita K, Imoto I, Omura K, Inazawa J
Cancer research   71(17) 5765-5778   Sep 2011   [Refereed]
Muramatsu T, Imoto I, Matsui T, Kozaki K, Haruki S, Sudol M, Shimada Y, Tsuda H, Kawano T, Inazawa J
Carcinogenesis   32(3) 389-398   Mar 2011   [Refereed]
Haruki S, Imoto I, Kozaki K, Matsui T, Kawachi H, Komatsu S, Muramatsu T, Shimada Y, Kawano T, Inazawa J
Carcinogenesis   31(6) 1027-1036   Jun 2010   [Refereed]
Furuta M, Kozaki KI, Tanaka S, Arii S, Imoto I, Inazawa J
Carcinogenesis   31(5) 766-776   May 2010   [Refereed]
Begum A, Imoto I, Kozaki K, Tsuda H, Suzuki E, Amagasa T, Inazawa J
Cancer science   100(10) 1908-1916   Oct 2009   [Refereed]
Komatsu S, Imoto I, Tsuda H, Kozaki KI, Muramatsu T, Shimada Y, Aiko S, Yoshizumi Y, Ichikawa D, Otsuji E, Inazawa J
Carcinogenesis   30 1139-1146   Jul 2009   [Refereed]
Qi S, Mogi S, Tsuda H, Tanaka Y, Kozaki K, Imoto I, Inazawa J, Hasegawa S, Omura K
International journal of oral and maxillofacial surgery   37 1047-1053   Nov 2008   [Refereed]
Ishihara T, Tsuda H, Hotta A, Kozaki K, Yoshida A, Noh JY, Ito K, Imoto I, Inazawa J
Cancer science   99 1940-1949   Oct 2008   [Refereed]
Nakamura E, Kozaki K, Tsuda H, Suzuki E, Pimkhaokham A, Yamamoto G, Irie T, Tachikawa T, Amagasa T, Inazawa J, Imoto I
Cancer science   99(7) 1390-1400   Jul 2008   [Refereed]
Kikuchi R, Tsuda H, Kozaki K, Kanai Y, Kasamatsu T, Sengoku K, Hirohashi S, Inazawa J, Imoto I
Cancer research   68 5067-5075   Jul 2008   [Refereed]
Kozaki K, Imoto I, Mogi S, Omura K, Inazawa J
Cancer research   68 2094-2105   Apr 2008   [Refereed]
Suzuki E, Imoto I, Pimkhaokham A, Nakagawa T, Kamata N, Kozaki KI, Amagasa T, Inazawa J
Oncogene   26 7921-7932   Dec 2007   [Refereed]
Tanaka K, Imoto I, Inoue J, Kozaki K, Tsuda H, Shimada Y, Aiko S, Yoshizumi Y, Iwai T, Kawano T, Inazawa J
Oncogene   26 6456-6468   Sep 2007   [Refereed]
Shinoda Y, Kozaki K, Imoto I, Obara W, Tsuda H, Mizutani Y, Shuin T, Fujioka T, Miki T, Inazawa J
Cancer science   98(7) 1078-1086   Jul 2007   [Refereed]
Kawasaki T, Yokoi S, Tsuda H, Izumi H, Kozaki K, Aida S, Ozeki Y, Yoshizawa Y, Imoto I, Inazawa J
Cancer science   98(7) 1070-1077   Jul 2007   [Refereed]
Kozaki K, Imoto I, Pimkhaokham A, Hasegawa S, Tsuda H, Omura K, Inazawa J
Cancer science   97(12) 1351-1358   Dec 2006   [Refereed]
Uchida K, Akita Y, Matsuo K, Fujiwara S, Nakagawa A, Kazaoka Y, Hachiya H, Naganawa Y, Oh-Iwa I, Ohura K, Saga S, Kawai T, Matsumoto Y, Shimozato K, Kozaki K
Immunology   116(1) 53-63   Sep 2005   [Refereed]
Akita Y, Kozaki K, Nakagawa A, Saito T, Ito S, Tamada Y, Fujiwara S, Nishikawa N, Uchida K, Yoshikawa K, Noguchi T, Miyaishi O, Shimozato K, Saga S, Matsumoto Y
The British journal of dermatology   151 472-480   Aug 2004   [Refereed]
Nishimaki H, Kasai K, Kozaki K, Takeo T, Ikeda H, Saga S, Nitta M, Itoh G
Biochemical and biophysical research communications   314(2) 313-320   Feb 2004   [Refereed]
Takasu S, Takahashi T, Okamoto S, Oriuchi N, Nakayashiki N, Okamoto K, Muramatsu H, Hayashi T, Nakahara N, Mizuno M, Wakabayashi T, Higuchi T, Endo K, Kozaki K, Miyaishi O, Saga S, Ueda R, Yoshida J, Yoshikawa K
Journal of neuro-oncology   63 247-256   Jul 2003   [Refereed]
Significant growth inhibition of human lung cancer cells both in vitro and in vivo by the combined use of a selective cyclooxygenase 2 inhibitor, JTE-522, and conventional anticancer agents.
Hida T, Kozaki K, Ito H, Miyaishi O, Tatematsu Y, Suzuki T, Matsuo K, Sugiura T, Ogawa M, Takahashi T, Takahashi T
Clinical cancer research : an official journal of the American Association for Cancer Research   8 2443-2447   Jul 2002   [Refereed]
Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling.
He Y, Kozaki K, Karpanen T, Koshikawa K, Yla-Herttuala S, Takahashi T, Alitalo K
Journal of the National Cancer Institute   94 819-825   Jun 2002   [Refereed]
Koshikawa K, Osada H, Kozaki K, Konishi H, Masuda A, Tatematsu Y, Mitsudomi T, Nakao A, Takahashi T
Oncogene   21 2822-2828   Apr 2002   [Refereed]
Kozaki K, Koshikawa K, Tatematsu Y, Miyaishi O, Saito H, Hida T, Osada H, Takahashi T
Oncogene   20(31) 4228-4234   Jul 2001   [Refereed]
Association between the dopamine D2 receptor A2/A2 genotype and smoking behavior in the Japanese.
Yoshida K, Hamajima N, Kozaki Ki, Saito H, Maeno K, Sugiura T, Ookuma K, Takahashi T
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology   10 403-405   Apr 2001   [Refereed]
Protective function of p27(KIP1) against apoptosis in small cell lung cancer cells in unfavorable microenvironments.
Masuda A, Osada H, Yatabe Y, Kozaki K, Tatematsu Y, Takahashi T, Hida T, Takahashi T, Takahashi T
The American journal of pathology   158 87-96   Jan 2001   [Refereed]
Lunevicius R, Nakanishi H, Ito S, Kozaki K, Kato T, Tatematsu M, Yasui K
Journal of cancer research and clinical oncology   127 193-199   2001   [Refereed]
Polymerase chain reaction with confronting two-pair primers for polymorphism genotyping.
Hamajima N, Saito T, Matsuo K, Kozaki K, Takahashi T, Tajima K
Japanese journal of cancer research : Gann   91 865-868   Sep 2000   [Refereed]
Cyclooxygenase-2 inhibitor induces apoptosis and enhances cytotoxicity of various anticancer agents in non-small cell lung cancer cell lines.
Hida T, Kozaki K, Muramatsu H, Masuda A, Shimizu S, Mitsudomi T, Sugiura T, Ogawa M, Takahashi T
Clinical cancer research : an official journal of the American Association for Cancer Research   6 2006-2011   May 2000   [Refereed]
Establishment and characterization of a human lung cancer cell line NCI-H460-LNM35 with consistent lymphogenous metastasis via both subcutaneous and orthotopic propagation.
Kozaki K, Miyaishi O, Tsukamoto T, Tatematsu Y, Hida T, Takahashi T, Takahashi T
Cancer research   60 2535-2540   May 2000   [Refereed]
Development and distribution of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced aberrant crypt foci in the rat large intestine.
Tsukamoto T, Kozaki K, Nishikawa Y, Yamamoto M, Fukami H, Inoue M, Wakabayashi K, Tatematsu M
Japanese journal of cancer research : Gann   90 720-725   Jul 1999   [Refereed]
Prognostic significance of elevated cyclooxygenase 2 expression in primary, resected lung adenocarcinomas.
Achiwa H, Yatabe Y, Hida T, Kuroishi T, Kozaki K, Nakamura S, Ogawa M, Sugiura T, Mitsudomi T, Takahashi T
Clinical cancer research : an official journal of the American Association for Cancer Research   5 1001-1005   May 1999   [Refereed]
Kato M, Liu W, Yi H, Asai N, Hayakawa A, Kozaki K, Takahashi M, Nakashima I
The Journal of investigative dermatology   111 640-644   Oct 1998   [Refereed]
Konishi H, Takahashi T, Kozaki K, Yatabe Y, Mitsudomi T, Fujii Y, Sugiura T, Matsuda H, Takahashi T, Takahashi T
Oncogene   17(16) 2095-2100   Oct 1998   [Refereed]
Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas.
Hida T, Yatabe Y, Achiwa H, Muramatsu H, Kozaki K, Nakamura S, Ogawa M, Mitsudomi T, Sugiura T, Takahashi T
Cancer research   58 3761-3764   Sep 1998   [Refereed]
Kozaki K, Miyaishi O, Koiwai O, Yasui Y, Kashiwai A, Nishikawa Y, Shimizu S, Saga S
The Journal of biological chemistry   273(24) 15125-15130   Jun 1998   [Refereed]
Molecular analysis of a Myc antagonist, ROX/Mnt, at 17p13.3 in human lung cancers.
Takahashi T, Konishi H, Kozaki K, Osada H, Saji S, Takahashi T, Takahashi T
Japanese journal of cancer research : Gann   89 347-351   Apr 1998   [Refereed]
Miyaishi O, Kozaki K, Iida K, Isobe K, Hashizume Y, Saga S
Journal of cellular biochemistry   68(4) 436-445   Mar 1998   [Refereed]
Ohmiya N, Saga S, Ohbayashi M, Kozaki K, Miyaishi O, Kobayashi M, Kasuya S, Arisawa T, Goto H, Hayakawa T
Histochemistry and cell biology   108 27-34   Jul 1997   [Refereed]
Kojima T, Kozaki K, Saga S, Hashizume Y, Ishiguro N, Iwata H, Miyaishi O
Journal of cellular biochemistry   65(4) 542-549   Jun 1997   [Refereed]
Involvement of transforming growth factor beta1 in autocrine enhancement of gelatinase B secretion by murine metastatic colon carcinoma cells.
Shimizu S, Nishikawa Y, Kuroda K, Takagi S, Kozaki K, Hyuga S, Saga S, Matsuyama M
Cancer research   56 3366-3370   Jul 1996   [Refereed]
Distinct distribution of protein disulfide isomerase family proteins in rat tissues.
Iida KI, Miyaishi O, Iwata Y, Kozaki KI, Matsuyama M, Saga S
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society   44 751-759   Jul 1996   [Refereed]
Establishment and characterization of high- and low-lung-metastatic cell lines derived from murine colon adenocarcinoma 26 tumor line.
Sakata K, Kozaki K, Iida K, Tanaka R, Yamagata S, Utsumi KR, Saga S, Shimizu S, Matsuyama M
Japanese journal of cancer research : Gann   87 78-85   Jan 1996   [Refereed]
Age-related alteration of proline hydroxylase and collagen-binding heat shock protein (HSP47) expression in human fibroblasts.
Miyaishi O, Kozaki K, Saga S, Sato T, Hashizume Y
Mechanisms of ageing and development   85 25-36   Nov 1995   [Refereed]
Age-related attenuation of HSP47 heat response in fibroblasts.
Miyaishi O, Ito Y, Kozaki K, Sato T, Takechi H, Nagata K, Saga S
Mechanisms of ageing and development   77 213-226   Jan 1995   [Refereed]
The localization of basic fibroblast growth factor (FGF-2) in rat submandibular glands.
Hiramatsu Y, Kagami H, Kosaki K, Shigetomi T, Ueda M, Kobayashi S, Sakanaka M
Nagoya journal of medical science   57 143-152   Dec 1994   [Refereed]
Kozaki K, Miyaishi O, Asai N, Iida K, Sakata K, Hayashi M, Nishida T, Matsuyama M, Shimizu S, Kaneda T
Experimental cell research   213(2) 348-358   Aug 1994   [Refereed]
Doubling time of ameloblastoma metastasizing to the lung: report of two cases.
Ueda M, Kosaki K, Kaneda T, Imaizumi M, Abe T
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery   20 320-322   Oct 1992   [Refereed]

Misc

 
Kozaki K, Inazawa J
Cancer science   103 837-845   May 2012   [Refereed][Invited]
Kozaki K, Inazawa J
The Cell   42(6) 232-235   Jun 2010   [Invited]
Kozaki K, Inazawa J
Genome medicine   9(1) 15-22   Feb 2009   [Invited]
Kozaki K, Inazawa J
Journal of Clinical and Experimental Medicine (IGAKU NO AYUMI)   227(1) 62-66   Oct 2008   [Invited]
Kozaki K, Inazawa J
Cancer frontier   10(1) 57-63   2008   [Invited]
Kozaki K, Inazawa J
Genome medicine   6(1) 23-29   Feb 2006   [Invited]
Enhancement of the photodynamic effects on human oral squamous cell carcinoma cell lines by treatment with calcipotriol.
Akita Y, Kozaki K, Takeo T, Ohmura M, Nakagawa A, Yanagishita T, Kazaoka Y, Nozaki T, Yokoo K, Shinohara M, Watanabe D, Kawai T, Yamada S, Tamada Y, Ohura K, Matsumoto Y
Journal of Dermatological Science Supplement   2 S57-S64   2006   [Refereed][Invited]
Increased expression of COX-2 in the development of human lung cancers.
Takahashi T, Kozaki K, Yatabe Y, Achiwa H, Hida T
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer   21 177-181   2002   [Refereed]
Caspin/PEDF/EPC-1 induces apoptosis in endothelial cells.
Fujiwara S, Uchida K, Fukada J, Kawai T, Natsume N, Kurita K, Sugishita H, Azuma M, Yoshikawa K, Kozaki K, Saga S
Aichi-Gakuin Dental Science   14 3-8   2001   [Refereed]
Saga S, Kozaki K, Shimizu S
The Journal of the Japanese Orthopaedic Association   69(8) 1794   Aug 1995   [Invited]
Kozaki K, Ueda M, Nomura T, Ito M, Tohnai I, Mizutani H, Kaneda T
J. Jpn. Stomatol. Soc.   39(3) 632-640   1990   [Refereed]

Books etc

 
Yanagihara N, Suzuki J (Part:Contributor, Clinical application of bioartificial mucosa for maxillofacial surgery)
Kugler Publications   1992   ISBN:9062990843

Conference Activities & Talks

 
Function-based screening of EMT-suppressive microRNA by CDH1/E-cadherin-promoter activity
KOZAKI Ken-ichi, INAZAWA Johji
Symposia “MicroRNA for cancer therapy and diagnosis”, 72st Annual Meeting of Japanese Cancer Association   5 Oct 2013   
Function-based screening of EMT-suppressive microRNA in cancer cells. [Invited]
KOZAKI Ken-ichi
2013 SNUCRI & SNUCH Cancer Symposium   4 May 2013   
Methylation-based screening of tumor-suppressive microRNAs in cancer cells
KOZAKI Ken-ichi, ENDO Hironori, INAZAWA Johji
Symposia “Recent progress of non-coding RNA and cancer”, 71st Annual Meeting of Japanese Cancer Association   20 Sep 2012   
Function-based screening of tumor-suppressive microRNAs silenced by DNA hypermethylation in cancer cells
KOZAKI Ken-ichi, INAZAWA Johji
Symposia “Cancer epigenetics: Breakthroughs in basic research and clinical applications”, 70th Annual Meeting of Japanese Cancer Association   2011   
Function-based screening of tumor-suppressive microRNAs silenced by DNA hypermethylation in cancer cells
KOZAKI Ken-ichi, INAZAWA Johji
2011   
Tumor-suppressive microRNAs silenced by DNA hypermethylation
KOZAKI Ken-ichi, INAZAWA Johji
Symposium “Cancer epigenetics-from basic science to clinical practice”, 68th Annual Meeting of Japanese Cancer Association   2009   
Tumor-suppressive microRNAs silenced by DNA hypermethylation in cancer cells
KOZAKI Ken-ichi, INAZAWA Johji
International Sessions “miRNA dysregulation in cancers, and its clinical applications”, 69th Annual Meeting of Japanese Cancer Association   2010   
Silencing of tumor suppressive microRNAs by tumor specific DNA methylation
KOZAKI Ken-ichi, INAZAWA Johji
2008   
Identification of tumor suppressor microRNA silenced by DNA methylation in oral squamous cell carcinoma [Invited]
KOZAKI Ken-ichi, IMOTO Issei, MOGI Seiki, OMURA Ken, INAZAWA Johji
Oral Cancer Symposium, 120th Anniversary between Japan-Thailand Diplomatic Relations   2007   
Analysis of gene expression concerned in tumor metastasis by means of high- and low-lymphogenous metastatic subclones established from NCI-H460
KOZAKI Ken-ichi, MIYAISHI Osamu, TATEMATSU Yoshio, OSADA Hirotaka, TAKAHASHI Takashi
58th Annual Meeting of Japanese Cancer Association   1999   

Teaching Experience

 
 

Research Grants & Projects

 
Integrative screening of cancer-associated microRNAs for medical application to RNA–based therapeutics
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: Apr 2014 - Mar 2017    Investigator(s): KOZAKI Ken-ichi
Establishment of gene promoter activity detection system for separation of viable and nonviable cells
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(挑戦的萌芽研究)
Project Year: Apr 2014 - Mar 2016    Investigator(s): KOZAKI Ken-ichi
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: Apr 2011 - Mar 2014    Investigator(s): KOZAKI Ken-ichi
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: Apr 2008 - Mar 2011    Investigator(s): KOZAKI Ken-ichi
In this study, we performed function-, methylation- and expression-based screening in oral cancer cell lines, and identified two novel tumor-suppressive microRNAs, miR-218 and miR-585, silenced by DNA hypermethylation in oral cancer. Moreover, we ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(特定領域研究)
Project Year: Apr 2005 - Mar 2010    Investigator(s): INAZAWA Johji
Innovative techniques for detection of genomic and epigenomic aberrations underlying the pathogenesis have been developed and using those techniques numerous cancer-related genes have been successfully identified during the course of the research ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: Apr 2006 - Mar 2008    Investigator(s): KOZAKI Ken-ichi
In the last few years, microRNAs (miRNAs) have started a revolution in molecular biology and emerged as key players in the carcinogenesis. They have been identified in various tumor types, showing that different sets of miRNAs are usually deregula...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: Apr 2004 - Mar 2006    Investigator(s): KOZAKI Ken-ichi
Ameloblastoma is a benign and the most common odontogenic neoplasm, whereas high recurrence rates and possible malignant development have been reported. In the present study, we established two immortalized cell lines, termed HAM1 and 2, by transf...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: Apr 2003 - Mar 2005    Investigator(s): NAKAGAWA Atsuko
Burkitt lymphoma, lymphoblastic lymphoma and anaplastic large cell lymphoma account for 90% or more cases of the pediatric lymphomas. Most of them involve the extranodal sites, and usually they are very aggressive due to the high proliferation rat...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(特定領域研究(C), 特定領域研究)
Project Year: Apr 2000 - Mar 2005    Investigator(s): TAKAHASHI Takashi
In this research project, multi faceted analyses were conducted in order to better understand the molecular pathogenesis of human lung cancers. Consequently, we have successfully obtained the following results.(1) Expression profiling analysis of ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: Apr 2002 - Mar 2004    Investigator(s): SAGA Shinsuke
In the endochondral ossification, chondrocytes in the growth plate change the phenotypes and form proliferative, mature and hypertrophic cartilage. Subsequently, hypertrophic cartilage is replaced by bone tissue through vascular invasion and resor...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(特定領域研究)
Project Year: Apr 2002 - Mar 2003    Investigator(s): KOZAKI Ken-ichi
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: Apr 1999 - Mar 2001    Investigator(s): KOZAKI Ken-ichi
Although a large number of studies have been conducted, yielding considerable information about the metastatic processes, very little is known about how cancer cells propagate distantmetastasis and about target molecules applied to non-surgical th...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: Apr 1999 - Mar 2001    Investigator(s): SAGA Shinsuke
We investigated the physiological and pathophysiological roles of caspin/PEDF/EPC-1 in tumor growth and metastasis as an inhibitor of angiogenesis. Overexpression of caspin in murine and human cancer cell lines with a high capability of lung metas...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(特定領域研究(A))
Project Year: Apr 1999 - Mar 2000    Investigator(s): KOZAKI Ken-ichi
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(特定領域研究(A))
Project Year: Apr 1998 - Mar 1999    Investigator(s): KOZAKI Ken-ichi
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(奨励研究(A))
Project Year: Apr 1997 - Mar 1999    Investigator(s): KOZAKI Ken-ichi