FUJII Shinya

J-GLOBAL         Last updated: Feb 7, 2019 at 11:39
FUJII Shinya
Alternative names
The University of Tokyo
Institute of Molecular and Cellular Biosciences Laboratory of Bioorganic Chemistry
Job title

Research Areas


Academic & Professional Experience

Apr 2012
Nov 2013
Assistant professor, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
Apr 2009
Mar 2012
Assistant professor, Tokyo Medical and Dental University
Aug 2007
Mar 2009
Assistant professor, Tokyo Medical and Dental University
Apr 2004
Jul 2007
Assistant professor, Tokushima Bunri University
Apr 2002
Mar 2004
Researcher, Kyowa Hakko Kogyo Co.Ltd.

Awards & Honors

May 2017
Best Poster Award, 17th International Conference on Heterocycles in Bioorganic Chemistry;
Jun 2016
Award for Young Scientists, The Vitamin Society of Japan
Sep 2015
Award for Young Scientists, The Pharmaceutical Society of Japan Kanto Branch

Published Papers

Design and synthesis of cyclohexenyl-p-carborane derivatives as a new class of progesterone receptor antagonists
Fujii, S.; Yanagida, N.; Mori, S.; Kawachi, E.; Kagechika, H.
Heterocycles   99(1) in press   Jan 2019   [Refereed]
A new LC-MS assay for the quantitative analysis of vitamin K metabolites in human urine
McDonald, M. G.*; Yeung, C. K.; Teitelbaum, A. M.; Johnson, A. L.; Fujii, S.; Kagechika, H.; Rettie, A. E.
J. Lipid Res.   in press   2019   [Refereed]
Structure-activity relationship of novel (benzoylaminophenoxy)phenol derivatives as anti-prostate cancer agents
Kazui, Y.; Fujii, S.*; Yamada, A.; Ishigami-Yuasa, M.; Kagechika, H.; Tanatani, A.
Bioorg. Med. Chem.   26(18) 5118-5127   Oct 2018   [Refereed]
Development of novel silanol-based human pregnane X receptor (PXR) agonists with improved receptor selectivity
Toyama, H.; Shirakawa, H.; Komai, M.; Hashimoto, Y.; Fujii, S.*
Bioorg. Med. Chem.   26(15) 4493-4501   Aug 2018   [Refereed]
Development of biotin-retinoid conjugates as chemical probes for analysis of retinoid function
Fujii, S.*; Mori, S.; Kagechika, H.; Mendoza Parra, M. A.; Gronemeyer, H.
Bioorg. Med. Chem. Lett.   28(14) 2442-2445   Aug 2018   [Refereed]
Efficient lead finding, activity enhancement and preliminary selectivity control of nuclear receptor ligands bearing a phenanthridinone skeleton
Nishiyama, Y.; Fujii, S.; Makishima, M.; Hashimoto, Y.; Ishikawa, M.
Int. J. Mol. Sci.   19(7) 2090   Jul 2018   [Refereed]
Novel androgen receptor full antagonists: Design, synthesis, and a docking study of glycerol and aminoglycerol derivatives that contain p-carborane cages
Kaise, A.; Ohta, K.; Fujii, S.; Oda, A.; Goto, T.; Endo, Y.
Bioorg. Med. Chem.   26(13) 3805-3811   Jul 2018   [Refereed]
Novel non-steroidal progesterone receptor (PR) antagonists with a phenanthridinone skeleton
Nishiyama, Y.; Mori, S.; Makishima, M.; Fujii, S.; Kagechika, H.; Hashimoto, Y.; Ishikawa, M.
ACS. Med. Chem. Lett.   9(7) 641-645   Jul 2018   [Refereed]
Nomura, S.; Endo-Umeda, K.; Fujii, S.; Makishima, M.; Hashimoto, Y.; Ishikawa, M.
Bioorg. Med. Chem. Lett.   28(4) 796-801   Apr 2018   [Refereed]
Mori, S.; Takagaki, R.; Fujii, S.; Urushibara, K.; Tanatani, A.; Kagechika, H.
Chem. Pharm. Bull.   65(11) 1051-1057   Nov 2017   [Refereed]
Yoshioka, H.; Yamada, A.; Nishiyama, Y.; Kagechika, H.; Hashimoto, Y.; Fujii, S.*
Bioorg. Med. Chem.   25(13) 3461-3479   Jul 2017   [Refereed]
Ishigami-Yuasa, M.; Watanabe, Y.; Mori, T.; Masuno, H.; Fujii, S.; Kikuchi, E.; Uchida, S.; Kagechika, H.
Bioorg. Med. Chem.   25(14) 3845-3852   Jul 2017   [Refereed]
Progress in the medicinal chemistry of silicon. –C/Si-Exchange and beyond-
Fujii, S.,* Hashimoto, Y.
Future Med. Chem.   9(5) 485-505   Apr 2017   [Refereed][Invited]
Kaitoh, K.; Toyama, H.; Hashimoto, Y.; Fujii, S. *
Heterocycles   95(1) 547-556   Jan 2017   [Refereed]
Yamada, A.; Kazui, Y.; Yoshioka, H.; Tanatani, A.; Mori, S.; Kagechika, H.; Fujii, S.*
ACS Med. Chem. Lett.   7(12) 1028-1033   Dec 2016   [Refereed]
Kinoshita, M.; Negishi, M.; Sakai, H.; Hirano, T.; Mori, S.; Fujii, S.; Kagechika, H.; Tanatani, A.
Bioorg. Med. Chem.   24(21) 5602-5610   Nov 2016   [Refereed]
Toyama, H.; Sato, S.; Shirakawa, H.; Komai, M.; Hashimoto, Y.; Fujii, S.*
Bioorg. Med. Chem. Lett.   26(7) 1817-1820   Apr 2016   [Refereed]
Inoue, K.; Urushibara, K.; Kanai, M.; Yura, K.; Fujii, S.; Hashimoto, Y.; Ishigami-Yuasa, M.; Mori, S.; Kawachi, E.; Matsumura, M.; Hirano, T.; Kagechika, H.; Tanatani, A.
Eur. J. Med. Chem.   102 310-319   Aug 2015   [Refereed]
Kajita, D.; Nakamura, M.; Matsumoto, Y.; Ishikawa, M.; Hashimoto, Y.; Fujii, S.*
Bioorg. Med. Chem. Lett   25(16) 3350-3354   Aug 2015   [Refereed]


FUJII Shinya
Bitamin   91(1) 28-37   Jan 2017   [Refereed][Invited]
Development of novel hydrophobic pharmacophores based on three-dimensional molecular architectures and elements chemistry
FUJII Shinya
Yakugaku-Zasshi   137(1) 31-41   Jan 2017   [Refereed][Invited]
Systematic synthesis of ω-carboxylated menaquinone derivatives and their anti-inflammatory and anti-hepatocellular carcinoma activities
Shinya Fujii, Akitaka Shimizu, Tomoko Katsurai, Kazuki Oguchi, Hitoshi Shirakawa, Michio Komai, Xian-Yang Qin, Soichi Kojima, Hiroyuki Kagechika
Bitamin   90(5-6) 253-260   Jun 2016   [Refereed][Invited]
Systematic synthesis of oxidative analogs of vitamin K and their biological activities
Fujii, S.; Shimizu, A.; Shirakawa, H.; Komai, M.; Kojima, S.; Kagechika, H.
Annual Reportes of the Institute of Biomaterials and Bioengineering   2015(49) 53-56   2016
Design and synthesis of androgen receptor antagonists based on development of novel pharmacophore
Fujii, S.; Yamada, A.; Mori, S.; Kagechika, H.
18(1) 6-8   Jun 2015   [Invited]
Fujii, S.; Tanatani, A.; Hirano,Kagechika, H.
Bitamin   88(8) 389-395   Aug 2014   [Refereed][Invited]
Characterization and application of hydrophobic functionalities bearing heavier group 14 atoms
Fujii, S.; Masuno, H.; Kagechika, H.
Annual Reportes of the Institute of Biomaterials and Bioengineering   2013(47) 42-45   2014
Development of novel nonsecosteroidal vitamin d derivatives using a carborane as the hydrophobic pharmacophore
Fujii, S.; Masuno, H.; Ito, S.; Hirano, T.; Kagechika, H.
Annual Reportes of the Institute of Biomaterials and Bioengineering   2011(45) 52-55   2012
Development of novel androgen antagonists based on hydrophobic boron clusters
Fujii, S.; Yamada, A.; Ohta, K.; Endo, Y; Kagechika, H.
Drugs of the Future   35 Suppl.A 258-259   2010
Development of androgen receptor ligands by using carborane as novel hydrophobic pharmacophore
Fujii, S.; Endo, Y.; Kagechika, H.
Annual Reportes of the Institute of Biomaterials and Bioengineering   2008(42) 51-54   2009

Research Grants & Projects

JSPS: Grant-in-Aid for Scientific Research
Project Year: Apr 2017 - Mar 2022    Investigator(s): FUJII Shinya
Project Year: Apr 2016 - Mar 2018    Investigator(s): FUJII Shinya