MISC

1994年3月

ASSOCIATION OF DOPAMINE D2 RECEPTOR MOLECULAR VARIANT WITH SCHIZOPHRENIA

LANCET
  • T ARINAMI
  • ,
  • M ITOKAWA
  • ,
  • H ENGUCHI
  • ,
  • H TAGAYA
  • ,
  • S YANO
  • ,
  • H SHIMIZU
  • ,
  • H HAMAGUCHI
  • ,
  • M TORU

343
8899
開始ページ
703
終了ページ
704
記述言語
英語
掲載種別
記事・総説・解説・論説等(学術雑誌)
DOI
10.1016/S0140-6736(94)91581-4
出版者・発行元
LANCET LTD

We have examined a variant of the dopamine D2 receptor gene (Ser311-->Cys) in 156 Japanese schizophrenic patients and 300 controls. The allele frequency of Cys311 was significantly higher in the whole patient group (0.054), among patients with onset before age 25 (0.090), and among those with a family history (0.135) than in the controls (0.018). 3 patients were homozygous for Cys311. The patients with Cys311 showed significantly less severe thought disorder and negative symptoms of schizophrenia than those without Cys311. The Cys311 variant of the D2 receptor may be a genetic risk factor for some types of schizophrenia.


リンク情報
DOI
https://doi.org/10.1016/S0140-6736(94)91581-4
CiNii Articles
http://ci.nii.ac.jp/naid/80007521222
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/7907680
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:A1994NB80900010&DestApp=WOS_CPL

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