MISC

2002年2月

A genome-wide linkage analysis of orchard grass-sensitive childhood seasonal allergic rhinitis in Japanese families

GENES AND IMMUNITY
  • Y Yokouchi
  • ,
  • M Shibasaki
  • ,
  • E Noguchi
  • ,
  • J Nakayama
  • ,
  • T Ohtsuki
  • ,
  • M Kamioka
  • ,
  • K Yamakawa-Kobayashi
  • ,
  • S Ito
  • ,
  • K Takeda
  • ,
  • K Ichikawa
  • ,
  • Y Nukaga
  • ,
  • A Matsui
  • ,
  • H Hamaguchi
  • ,
  • T Arinami

3
1
開始ページ
9
終了ページ
13
記述言語
英語
掲載種別
DOI
10.1038/sj/gene/6363815
出版者・発行元
NATURE PUBLISHING GROUP

Seasonal allergic rhinitis (SAR) is an inflammatory disease of the nose and eyes that follows sensitization to air-born pollens. We conducted a genome-wide linkage screening of 48 Japanese families (188 members) with orchard grass (OG)-sensitive SAR children (67 affected sib-pairs) in a farming community in central Japan where OG was planted for apple farming and OG pollen is a major cause of SAR. We used the GENEHUNTER program to performed nonparametric multipoint linkage analysis for OG-sensitive SAR as a qualitative trait and for log total serum IgE levels and OG-RAST IgE levels as quantitative traits. Genotyping data of 400 microsatellite markers suggested linkage of SAR to chromosomes 1p36.2, 4q13.3, and 9q34.3 (P < 0.001), linkage of serum total IgE levels to 3p24.1, 5q33.1, 12p13.1, and 12q24.2 (P < 0.001), and linkage of OG-RAST IgE levels to 4p16.1, 11q14.3, and 16p12.3 (P < 0.001). Weak evidence for linkage of SAR to 5q33.1 was also observed (P = 0.01). All these regions, with the exception of 9q34.3, have been previously reported to be linked to asthma and/or atopy. These data suggest that, although loci linked to SAR are likely to be common to asthma, a strong contribution by specific gene(s) to OG-sensitive SAR is unlikely.

Web of Science ® 被引用回数 : 41

リンク情報
DOI
https://doi.org/10.1038/sj/gene/6363815
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000174027900003&DestApp=WOS_CPL

エクスポート
BibTeX RIS