2000年4月
A study on the consistency between flagging by statistical tests and biological evaluation
DRUG INFORMATION JOURNAL
- 巻
- 34
- 号
- 2
- 開始ページ
- 501
- 終了ページ
- 509
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1177/009286150003400219
- 出版者・発行元
- DRUG INFORMATION ASSOCIATION
Statistical hypothesis rests are used as a flagging device to highlight differences worth further attention in the evaluation of repeated dose toxicity studies in the rat. Raw data of quantitative parameters of 19 regulatory toxicity studies were collected with their final interpretation of each study An investigation was done on the consistency between flagging by statistical tests and biological significance by final interpretation. Williams's test at 2.5% of the significance level showed as much accuracy (correct results compared,vith the sum of false negative and false positive results) as the rate of Dunnett's test at the 5% significance level. Since a monotonic dose-response relationship is usually assumed in selection of dose levels, Williams's test with ordered alter-native hypotheses is recommended as a routine procedure instead of the currently used Dunnett's test. A supplementary procedure, using Steel's test, was shown to be effective for flagging unexpected 'downturn' dose response.
- リンク情報
- ID情報
-
- DOI : 10.1177/009286150003400219
- ISSN : 0092-8615
- Web of Science ID : WOS:000087220200019