Takamitsu Sasaki - My portal

Profile Information

Affiliation: assistant professor, Department of Environmental and Health Science, University of Shizuoka

Degree: Ph.D.(Doctor of Pharmacy)(Tohoku Pharmaceutical University)

J-GLOBAL ID: 200901012515515743
researchmap Member ID: 5000084559

External link: http://w3pharm.u-shizuoka-ken.ac.jp/eisei/index.html

Research Interests

Research Areas

Life sciences / Pharmaceuticals - health and biochemistry / drug metabolism

Research History

2015 - Present

University of Shizuoka
2004 - 2011

東北薬科大学助手
2004 - 2011

Research Associate, Tohoku Pharmaceutical University
2011

assistant professor, Tohoku Pharmaceutical University
2003 - 2004

昭和大学病院薬剤師
2003 - 2004

Pharmacist, Showa University, Hospital

Education

Awards

2015

Excellent Article in 2015, Japanese Society of Pharmaceutical Health Care and Sciences

SASAKI Takamitsu
2014

DMPK Editors’ Award for the Most Excellent Article in 2013, The Japanese Society for the Study of Xenobiotics

SASAKI Takamitsu
2012

27th JSSX Annual Meeting Best Poster Award, The Japanese Society for the Study of Xenobiotics

SASAKI Takamitsu
2007

若手研究者発表賞, 日本薬学会東北支部

佐々木崇光

Misc.

Hepatocyte Nuclear Factor 6 Activates the Transcription of CYP3A4 in Hepatocyte-like Cells Differentiated from Human Induced Pluripotent Stem Cells

Takamitsu Sasaki, Shogo Takahashi, Yoshihiro Numata, Masayo Narita, Yutaka Tanaka, Takeshi Kumagai, Yuki Kondo, Tannihide Matsunaga, Shigeru Ohmori, Kiyoshi Nagata

DRUG METABOLISM AND PHARMACOKINETICS, 28(3) 250-259, Jun, 2013 Peer-reviewed
Effects of Hypoxia-inducible Factor-1 alpha Chemical Stabilizer, CoCl2 and Hypoxia on Gene Expression of CYP3As in Human Fetal Liver Cells

Eiji Suzuki, Tamihide Matsunaga, Akiko Aonuma, Takamitsu Sasaki, Kiyoshi Nagata, Shigeru Ohmori

DRUG METABOLISM AND PHARMACOKINETICS, 27(4) 398-404, Aug, 2012 Peer-reviewed
Polycyclic Aromatic Hydrocarbons Activate CYP3A4 Gene Transcription through Human Pregnane X Receptor

Takeshi Kumagai, Hiroyuki Suzuki, Takamitsu Sasaki, Shuhei Sakaguchi, Shinichi Miyairi, Yasushi Yamazoe, Kiyoshi Nagata

DRUG METABOLISM AND PHARMACOKINETICS, 27(2) 200-206, Apr, 2012 Peer-reviewed
Progression of Alcoholic and Non-alcoholic Steatohepatitis: Common Metabolic Aspects of Innate Immune System and Oxidative Stress

Shuhei Sakaguchi, Shougo Takahashi, Takamitsu Sasaki, Takeshi Kumagai, Kiyoshi Nagata

DRUG METABOLISM AND PHARMACOKINETICS, 26(1) 30-46, 2011 Peer-reviewed
Association between Cancer Risk and Drug-metabolizing Enzyme Gene (CYP2A6, CYP2A13, CYP4B1, SULT1A1, GSTM1, and GSTT1) Polymorphisms in Cases of Lung Cancer in Japan

Yuichiro Tamaki, Tomio Arai, Haruhiko Sugimura, Takamitsu Sasaki, Masashi Honda, Yuka Muroi, Yoichi Matsubara, Shuichi Kanno, Masaaki Ishikawa, Noriyasu Hirasawa …

DRUG METABOLISM AND PHARMACOKINETICS, 26(5) 516-522, 2011
Functional characterization of 26 CYP2B6 allelic variants (CYP2B6.2-CYP2B6.28, except CYP2B6.22)

Takashi Watanabe, Kanako Sakuyama, Takamitsu Sasaki, Yuya Ishii, Masaaki Ishikawa, Noriyasu Hirasawa, Masahiro Hiratsuka

PHARMACOGENETICS AND GENOMICS, 20(7) 459-462, Jul, 2010 Peer-reviewed
Malondialdehyde-modified low density lipoprotein (MDA-LDL)-induced cell growth was suppressed by polycyclic aromatic hydrocarbons (PAHs).

J. Toxicol. Sci., 35 137-147, 2010 Peer-reviewed
Construction of a System that Simultaneously Evaluates CYP1A1 and CYP1A2 Induction in a Stable Human-derived Cell Line using a Dual Reporter Plasmid

Wataru Sato, Hiroyuki Suzuki, Takamitsu Sasaki, Takeshi Kumagai, Shuhei Sakaguchi, Michinao Mizugaki, Shinichi Miyairi, Yasushi Yamazoe, Kiyoshi Nagata

DRUG METABOLISM AND PHARMACOKINETICS, 25(2) 180-189, 2010 Peer-reviewed
Kinetics of 6-Thioxanthine Metabolism by Allelic Variants of Xanthine Oxidase

Mutsumi Kudo, Takamitsu Sasaki, Masaaki Ishikawa, Noriyasu Hirasawa, Masahiro Hiratsuka

DRUG METABOLISM AND PHARMACOKINETICS, 25(4) 361-366, 2010 Peer-reviewed
Functional Characterization of Genetic Polymorphisms Identified in the Promoter Region of the Xanthine Oxidase Gene

Mutsumi Kudo, Takamitsu Sasaki, Masaaki Ishikawa, Noriyasu Hirasawa, Masahiro Hiratsuka

DRUG METABOLISM AND PHARMACOKINETICS, 25(6) 599-604, 2010
Genetic Variations in the HGPRT, ITPA, IMPDH1, IMPDH2, and GMPS Genes in Japanese Individuals

Mutsumi Kudo, Yuka Saito, Takamitsu Sasaki, Hitomi Akasaki, Yuri Yamaguchi, Moe Uehara, Kiyomi Fujikawa, Masaaki Ishikawa, Noriyasu Hirasawa, Masahiro Hiratsuka

DRUG METABOLISM AND PHARMACOKINETICS, 24(6) 557-564, 2009 Peer-reviewed
Functional Characterization of 17 CYP2D6 Allelic Variants (CYP2D6.2, 10, 14A-B, 18, 27, 36, 39, 47-51, 53-55, and 57)

Kanako Sakuyama, Takamitsu Sasaki, Shuta Ujiie, Kanako Obata, Michinao Mizugaki, Masaaki Ishikawa, Masahiro Hiratsuka

DRUG METABOLISM AND DISPOSITION, 36(12) 2460-2467, Dec, 2008 Peer-reviewed
Functional characterization of 23 allelic variants of thiopurine S-methyltransferase gene (TPMT*2-*24)

Shuta Ujiie, Takamitsu Sasaki, Michinao Mizugaki, Masaaki Ishikawa, Masahiro Hiratsuka

PHARMACOGENETICS AND GENOMICS, 18(10) 887-893, Oct, 2008 Peer-reviewed
Possible relationship between the risk of japanese bladder cancer cases and the CYP4B1 genotype

Takamitsu Sasaki, Miho Horikawa, Kazuhiko Orikasa, Makoto Sato, Yoichi Arai, Yoshitaka Mitachi, Michinao Mizugaki, Masaaki Ishikawa, Masahiro Hiratsuka

JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 38(9) 634-640, Sep, 2008 Peer-reviewed
Functional characterization of human xanthine oxidase allelic variants

Mutsumi Kudo, Toshiko Moteki, Takamitsu Sasaki, Yumiko Konno, Shuta Ujiie, Akemi Onose, Michinao Mizugaki, Masaaki Ishikawa, Masahiro Hiratsuka

PHARMACOGENETICS AND GENOMICS, 18(3) 243-251, Mar, 2008 Peer-reviewed
Genetic polymorphisms and haplotype structures of the human CYP2W1 gene in a Japanese population

Yoshiyuki Hanzawa, Takamitsu Sasaki, Michinao Mizugaki, Masaaki Ishikawa, Masahiro Hiratsuka

DRUG METABOLISM AND DISPOSITION, 36(2) 349-352, Feb, 2008 Peer-reviewed
Characterization of human cytochrome p450 enzymes involved in the metabolism of cilostazol

Masahiro Hiratsuka, Yudai Hinai, Takamitsu Sasaki, Yumiko Konno, Kenichi Imagawa, Masaaki Ishikawa, Michinao Mizugaki

DRUG METABOLISM AND DISPOSITION, 35(10) 1730-1732, Oct, 2007 Peer-reviewed
Genetic polymorphism of aldehyde oxidase in donryu rats

Kunio Itoh, Akiko Masubuchi, Takamitsu Sasaki, Mayuko Adachi, Nobuaki Watanabe, Kiyoshi Nagata, Yasushi Yamazoe, Masahiro Hiratsuka, Michinao Mizugaki, Yorihisa Tanaka

DRUG METABOLISM AND DISPOSITION, 35(5) 734-739, May, 2007 Peer-reviewed
hree novel single nucleotide polymorphisms (SNPs) of CYP2S1 gene in Japanese individuals.

Yoshiyuki HANZAWA, Takamitsu SASAKI, Masahiro HIRATSUKA, Masaaki ISHIKAWA, Michinao MIZUGAKI

Drug Metab. Pharmacokinet., 22(2) 136-140, 2007
Rat strain differences in stereospecific 2-oxidation of RS-8359, a reversible and selective MAO-A inhibitor, by aldehyde oxidase

Takamitsu Sasaki, Akiko Masubuchi, Mayumi Yamamura, Nobuaki Watanabe, Masahiro Hiratsuka, Michinao Mizugaki, Kunio Itoh, Yorihisa Tanaka

BIOPHARMACEUTICS & DRUG DISPOSITION, 27(5) 247-255, Jul, 2006 Peer-reviewed

Professional Memberships

Research Projects

薬剤反応性遺伝子に関する研究

科学研究費補助金, 2004 - 2008
Study on Pharmacogenetics

Grant-in-Aid for Scientific Research, 2004 - 2008
ファルマコジェネティクスに関する研究
Research on Pharmacogenetics
iPS細胞を用いた肝幹細胞の単離及び成人型肝細胞への効率的な分化手法の確立

佐々木崇光
抗癌剤代謝酵素のエピジェネティクス解析による個人差解明

佐々木崇光