Keiko Doi - My portal

Profile Information

Affiliation: Faculty of Medicine, School of Medicine, Fukuoka University

Degree: 博士（農学）(九州大学)

Researcher number: 10341538
J-GLOBAL ID: 200901072628537428
researchmap Member ID: 5000084701

Research Interests

transcription factor

Research Areas

Life sciences / Medical biochemistry / General Medical Chemistry

Papers

Zfat is indispensable for the development of erythroid cells in the fetal liver.

Doi K, Tsunoda T, Koyanagi M, Tanaka Y, Yamano S, Fujikane A, Nishi K, Ishikura S, Shirasawa S

Anticancer Res., 39(8) 4495-4502, 2019 Peer-reviewed
Zfat expression in ZsGreen reporter gene knock-in mice: Implications for a novel function of Zfat in definitive erythropoiesis.

Tsunoda T, Doi K, Ishikura S, Luo H, Nishi K, Matsuzaki H, Koyanagi M, Tanaka Y, Okamura T, Shirasawa S

Int. J. Mol. Med., 42(5) 2595-2603, 2018 Peer-reviewed
Apremilast Induces Apoptosis of Human Colorectal Cancer Cells with Mutant KRAS

Kensuke Nishi, Hao Luo, Shuhei Ishikura, Keiko Doi, Yuri Iwaihara, Lauren Wills, George S. Baillie, Toshifumi Sakata, Senji Shirasawa, Toshiyuki Tsunoda

ANTICANCER RESEARCH, 37(7) 3833-3839, Jul, 2017 Peer-reviewed
An Alpha-kinase 2 Gene Variant Disrupts Filamentous Actin Localization in the Surface Cells of Colorectal Cancer Spheroids.

Kensuke Nishi, Hao Luo, Kazuhiko Nakabayashi, Keiko Doi, Shuhei Ishikura, Yuri Iwaihara, Yasuhiro Yoshida, Kumpei Tanisawa, Tomio Arai, Seijiro Mori, Motoji Sawabe, Masaaki Muramatsu, Masashi Tanaka, Toshifumi Sakata, Senji Shirasawa, Toshiyuki Tsunoda

Anticancer research, 37(7) 3855-3862, Jul, 2017 Peer-reviewed
ROS-induced cleavage of NHLRC2 by caspase-8 leads to apoptotic cell death in the HCT116 human colon cancer cell line.

Nishi K. Iwaihara, Y. Tsunoda, T. Doi, K, Sakata, T. Shirasawa, S. Ishikura S

Cell Death Dis., 8(12) 3218-3218, 2017 Peer-reviewed
Molecular mechanisms of transcriptional regulation by the nuclear zinc-finger protein Zfat in T cells

Shuhei Ishikura, Toshiyuki Tsunoda, Kazuhiko Nakabayashi, Keiko Doi, Midori Koyanagi, Keiko Hayashi, Tomoko Kawai, Yoko Tanaka, Yuri Iwaihara, Hao Luo, Kensuke Nishi, Tadashi Okamura, Senji Shirasawa

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, 1859(11) 1398-1410, Nov, 2016 Peer-reviewed
Resveratrol Overcomes Cellular Resistance to Vemurafenib Through Dephosphorylation of AKT in BRAF-mutated Melanoma Cells

Hao Luo, Masayo Umebayashi, Keiko Doi, Takashi Morisaki, Senji Shirasawa, Toshiyuki Tsunoda

ANTICANCER RESEARCH, 36(7) 3585-3589, Jul, 2016 Peer-reviewed
The nuclear zinc finger protein Zfat maintains FoxO1 protein levels in peripheral T cells by regulating activities of autophagy and Akt signaling pathway.

Ishikura S, Iwaihara Y, Tanaka Y, Luo H, Nishi K, Doi K, Koyanagi M, Okamura T, Tsunoda T, Shirasawa S

J Biol Chem, 291(29) 15282-15291, 2016 Peer-reviewed
Marked Reduction in FoxO1 Protein by its Enhanced Proteasomal Degradation in Zfat-deficient Peripheral T-Cells

Yuri Iwaihara, Shuhei Ishikura, Keiko Doi, Toshiyuki Tsunoda, Takahiro Fujimoto, Tadashi Okamura, Senji Shirasawa

ANTICANCER RESEARCH, 35(8) 4419-4423, Aug, 2015 Peer-reviewed
Establishment of a Three-dimensional Floating Cell Culture System for Screening Drugs Targeting KRAS-mediated Signaling Molecules

Toshiyuki Tsunoda, Shuhei Ishikura, Keiko Doi, Yuri Iwaihara, Hiromasa Hidesima, Hao Luo, Yumiko Hirose, Senji Shirasawa

ANTICANCER RESEARCH, 35(8) 4453-4459, Aug, 2015 Peer-reviewed
Zfat-Deficient CD4(+)CD8(+) Double-Positive Thymocytes Are Susceptible to Apoptosis With Deregulated Activation of p38 and JNK

Shuhei Ishikura, Masahiro Ogawa, Keiko Doi, Hiroshi Matsuzaki, Yuri Iwaihara, Yoko Tanaka, Toshiyuki Tsunoda, Hiromasa Hideshima, Tadashi Okamura, Senji Shirasawa

JOURNAL OF CELLULAR BIOCHEMISTRY, 116(1) 149-157, Jan, 2015 Peer-reviewed
The Roles of ZFAT in Thymocyte Differentiation and Homeostasis of Peripheral Naive T-Cells

Keiko Doi, Shuhei Ishikura, Senji Shirasawa

ANTICANCER RESEARCH, 34(8) 4489-4495, Aug, 2014 Peer-reviewed
Resveratrol Induces Luminal Apoptosis of Human Colorectal Cancer HCT116 Cells in Three-dimensional Culture

Toshiyuki Tsunoda, Shuhei Ishikura, Keiko Doi, Hiroshi Matsuzaki, Yuri Iwaihara, Senji Shirasawa

ANTICANCER RESEARCH, 34(8) 4551-4555, Aug, 2014 Peer-reviewed
Zfat-deficiency results in a loss of CD3 phosphorylation with dysregulation of ERK and Egr activities leading to impaired positive selection.

Ogawa M, Okamura T, Ishikura S, Doi K, Matsuzaki H, Tanaka Y, Ota T, Hayakawa K, Suzuki H, Tsunoda T, Sasazuki T, Shirasawa S

PLoS ONE, 8(10) e76254, 2013 Peer-reviewed
ZFAT plays critical roles in peripheral T cell homeostasis and its T cell receptor-mediated response

Keiko Doi, Takahiro Fujimoto, Tadashi Okamura, Masahiro Ogawa, Yoko Tanaka, Yasumasa Mototani, Motohito Goto, Takeharu Ota, Hiroshi Matsuzaki, Masahide Kuroki, Toshiyuki Tsunoda, Takehiko Sasazuki, Senji Shirasawa

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 425(1) 107-112, Aug, 2012 Peer-reviewed
Inhibition of Phosphodiesterase-4 (PDE4) activity triggers luminal apoptosis and AKT dephosphorylation in a 3-D colonic-crypt model

Toshiyuki Tsunoda, Takeharu Ota, Takahiro Fujimoto, Keiko Doi, Yoko Tanaka, Yasuhiro Yoshida, Masahiro Ogawa, Hiroshi Matsuzaki, Masato Hamabashiri, Darren R. Tyson, Masahide Kuroki, Shingo Miyamoto, Senji Shirasawa

MOLECULAR CANCER, 11(1) 46, Jul, 2012 Peer-reviewed
ALPK2 is Crucial for Luminal Apoptosis and DNA Repair-related Gene Expression in a Three-dimensional Colonic-crypt Model

Yasuhiro Yoshida, Toshiyuki Tsunoda, Keiko Doi, Takahiro Fujimoto, Yoko Tanaka, Takeharu Ota, Masahiro Ogawa, Hiroshi Matsuzaki, Masahide Kuroki, Akinori Iwasaki, Senji Shirasawa

ANTICANCER RESEARCH, 32(6) 2301-2308, Jun, 2012 Peer-reviewed
KRAS up-regulates the expression of miR-181a, miR-200c and miR-210 in a three-dimensional-specific manner in DLD-1 colorectal cancer cells.

Ota T, Doi K, Fujimoto T, Tanaka Y, Ogawa M, Matsuzaki H, Kuroki M, Miyamoto S, Shirasawa S, Tsunoda T

Anticancer Res., 32(6) 2271-2276, 2012 Peer-reviewed
Tespa1 is a novel inositol 1,4,5-trisphosphate receptor binding protein in T and B lymphocytes

Hiroshi Matsuzaki, Takahiro Fujimoto, Takeharu Ota, Masahiro Ogawa, Toshiyuki Tsunoda, Keiko Doi, Masato Hamabashiri, Masatoshi Tanaka, Senji Shirasawa

FEBS OPEN BIO, 2 255-259, 2012 Peer-reviewed
Oncogenic KRAS Regulates miR-200c and miR-221/222 in a 3D-Specific Manner in Colorectal Cancer Cells

Toshiyuki Tsunoda, Yasuo Takashima, Yasuhiro Yoshida, Keiko Doi, Yoko Tanaka, Takahiro Fujimoto, Takashi Machida, Takeharu Ota, Midori Koyanagi, Masahide Kuroki, Takehiko Sasazuki, Senji Shirasawa

ANTICANCER RESEARCH, 31(7) 2453-2459, Jul, 2011 Peer-reviewed

Presentations

マウス胎児肝臓の赤血球分化における転写制御分子Zfatの機能解析

日本人類遺伝学会第64回大会, Nov, 2019
T細胞における転写制御分子Zfatの機能発現機構の解明

第22回バイオ治療法研究会学術集会, Dec, 2018
末梢T細胞のTCR刺激時における転写制御分子Zfatの機能メカニズムの解明

日本人類遺伝学会第63回大会, Oct, 2018
T細胞における転写制御分子ZFATの分子機構の解明

日本人類遺伝学会第62回大会, Nov, 2017
Identification of the genes regulated by ZFAT in T cells through ChIP-seq analysis.

第13回国際人類遺伝学会, Mar, 2016
T細胞における免疫系転写制御分子Zfatの転写制御標的分子の同定

第19回バイオ治療法研究会学術集会, Dec, 2015
ChIP-seq解析によるT細胞におけるZFATの転写制御標的分子の同定

日本人類遺伝学会第60回大会, Oct, 2015
ZFAT欠損CD4+CD8+ double positive胸腺細胞におけるアポトーシス感受性の亢進

日本人類遺伝学会第59回大会, Nov, 2014
転写制御分子ZFAT欠損による胸腺内T細胞分化異常に関するZFAT分子機序の解明

日本人類遺伝学会第58回大会, Nov, 2013
遺伝子改変マウスを利用した転写制御分子ZFATの機能解明

日本人類遺伝学会第57回大会, Oct, 2012
遺伝子欠損マウスを利用した新規転写制御因子ZFATの機能解明

土井佳子, 角田俊之, 高島康郎, 藤本崇宏, 田中陽子, 小柳緑, 吉田康浩, 笹月健彦, 白澤専二

日本人類遺伝学会第55回大会, Oct, 2010
転写制御因子ZFATの機能および転写ネットワークに関する研究

土井佳子, 藤本崇宏, 小柳緑, 高島康郎, 角田俊之, 田中陽子, 吉田康浩, 中林一彦, 笹月健彦, 白澤専二

日本人類遺伝学会第54回大会, Sep, 2009