2016年2月
Renal Function and Hematology in Rats with Congenital Renal Hypoplasia.
Comparative medicine
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- 巻
- 66
- 号
- 1
- 開始ページ
- 10
- 終了ページ
- 20
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- 出版者・発行元
- AMER ASSOC LABORATORY ANIMAL SCIENCE
Renal hypoplasia due to a congenitally reduced number of nephrons progresses to chronic kidney disease and may cause renal anemia, given that the kidneys are a major source of erythropoietin in adults. Hypoplastic kidney (HPK) rats have only about 20% of the normal number of nephrons and develop CKD. This study assessed the renal function and hematologic changes in HPK rats from 70 to 210 d of age. HPK rats demonstrated deterioration of renal excretory function, slightly macrocytic erythropenia at all days examined, age-related increases in splenic hemosiderosis accompanied by a tendency toward increased hemolysis, normal plasma erythropoietin levels associated with increased hepatic and decreased renal erythropoietin production, and maintenance of the response for erythropoietin production to hypoxic conditions, with increased interstitial fibrosis at 140 d of age. These results indicate that increases in splenic hemosiderosis and the membrane fragility of RBC might be associated with erythropenia and that hepatic production of erythropoietin might contribute to maintaining the blood Hgb concentration in HPK rats.
- リンク情報
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- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/26884405
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752031
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000369779400002&DestApp=WOS_CPL
- URL
- http://www.scopus.com/inward/record.url?eid=2-s2.0-85020581168&partnerID=MN8TOARS
- URL
- http://orcid.org/0000-0002-2859-0423
- ID情報
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- ISSN : 1532-0820
- ORCIDのPut Code : 54582496
- PubMed ID : 26884405
- PubMed Central 記事ID : PMC4752031
- SCOPUS ID : 85020581168
- Web of Science ID : WOS:000369779400002