Research Projects

4 2009 - 3 2012

Investigation of the role of giantin in the rat development

Grant-in-Aid for Young Scientists (B)
  • KATAYAMA Kentaro

Grant type
Competitive

Insertional mutation in giantin(Golgb1) gene is responsible for the developmental abnormalities including osteochondrodysplasia and systemic edema in ocd/ocd rat. ocd/ocd rats exhibited the delayed mesenchymal condensation in chondrogenesis, abnormalities of lyphatic vessels and enhanced vascular permeability. The present findings indicate that the important role of giantin in normal embryonic development, especially chondrogenesis, and formation of lymphatic and blood vessels.