論文

査読有り 国際誌
2014年7月

Objectively measured physical activity and inflammatory cytokine levels in middle-aged Japanese people.

Preventive medicine
  • Yuichiro Nishida
  • Yasuki Higaki
  • Naoto Taguchi
  • Megumi Hara
  • Kazuyo Nakamura
  • Hinako Nanri
  • Takeshi Imaizumi
  • Tatsuhiko Sakamoto
  • Mikako Horita
  • Koichi Shinchi
  • Keitaro Tanaka
  • 全て表示

64
開始ページ
81
終了ページ
7
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.ypmed.2014.04.004

OBJECTIVE: Studies using self-reported physical activity (PA) showed that higher PA is associated with lower circulating levels of C-reactive protein; in contrast, studies investigating associations of objective PA and other inflammatory markers are limited. We investigated cross-sectional associations of accelerometer-determined PA with circulating levels of myokine-type inflammatory cytokines in a middle-aged Japanese population. METHOD: A total of 1838 individuals (737 men and 1101 women) aged 40 to 69 years participated in the baseline survey of a population-based cohort study in Saga, Japan (2005-2007). Habitual PA was assessed by a single-axis accelerometer. Serum interleukin (IL)-4, IL-6, IL-8, IL-15, and tumor necrosis factor (TNF)-α were measured by a multiplex enzyme-linked immunosorbent assay. Associations between PA and cytokine levels were assessed by multiple regression analysis and analysis of covariance, with adjustment for potential confounders. RESULTS: Step count and PA level (PAL) were inversely associated with TNF-α and IL-15 even after adjusting for BMI. Similarly, greater PA indices were also independently associated with a lower level of inflammatory cytokine z score as an index of overall inflammation. CONCLUSION: The current results suggest that greater engagement in daily PA may be linked with reduced levels of myokine-type cytokines including IL-15, irrespective of body weight in middle-aged Japanese people.

リンク情報
DOI
https://doi.org/10.1016/j.ypmed.2014.04.004
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/24732722
ID情報
  • DOI : 10.1016/j.ypmed.2014.04.004
  • ISSN : 0091-7435
  • PubMed ID : 24732722

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