2017年9月
Prognostic Significance of Spot Urine Na/K for Longitudinal Changes in Blood Pressure and Renal Function: The Nagahama Study
AMERICAN JOURNAL OF HYPERTENSION
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- 巻
- 30
- 号
- 9
- 開始ページ
- 899
- 終了ページ
- 906
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1093/ajh/hpx075
- 出版者・発行元
- OXFORD UNIV PRESS
BACKGROUNDUrinary sodium-to-potassium ratio (Na/K) represents a simple measure of sodium load and has been reported to be associated with blood pressure (BP) levels in a cross-sectional setting even with spot measurements. The aim of the present large-scale cohort study is to determine prognostic significance of spot urine Na/K for longitudinal changes in BP levels and renal function.METHODSThe present study population consisted of 7,063 individuals from the general population. Clinical parameters were measured at baseline and at a follow-up interval of 5 years.RESULTSMean systolic BP was slightly increased during the follow-up period (overall, 124 +/- 17 to 125 +/- 18 mm Hg; nontreated participants, 119 +/- 15 to 122 +/- 17 mm Hg). Although, the urinary Na/K demonstrated a linear association with BP in a cross-sectional analysis (P < 0.001), analysis of repeated measured BP values identified baseline Na/K* time interaction, i.e., an intraindividual effect, as an inverse determinant (F = 76.9, P < 0.001) independently of hypertension status and fasting conditions possibly due to regression to the mean of temporary high baseline Na/K values at baseline. Spot urine Na/K values were found to be positively associated with renal function in a cross-sectional analysis (P < 0.001). Although baseline Na/K* time interaction showed inverse associated with renal functional decline (F = 85.8, P < 0.001), this inverse association might not represent physiological relationship in likewise fashion with the analysis for BP.CONCLUSIONSSpot urine Na/K may have limited utility as a prognostic marker of longitudinal BP change, as well as renal functional decline.
- リンク情報
- ID情報
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- DOI : 10.1093/ajh/hpx075
- ISSN : 0895-7061
- eISSN : 1941-7225
- PubMed ID : 28498883
- Web of Science ID : WOS:000409081300012