Chie Motono

Profile Information

Affiliation: AIST-Waseda University Computational Bio Big Data Open Innovation Laboratory, National Institute of Advanced Industrial Science and Technology

J-GLOBAL ID: 200901023364660748
researchmap Member ID: 5000086286

External link: http://www.aist.go.jp/RESEARCHERDB/cgi-bin/worker_detail.cgi?call=namae&rw_id=C52205062

Research Areas

Life sciences / Biophysics /

Papers

The origin of esterase activity of Parkinson's disease causative factor DJ-1 implied by evolutionary trace analysis of its prokaryotic homolog HchA

Aiko Watanabe, Fumika Koyano, Kenichiro Imai, Yohei Hizukuri, Shizuka Ogiwara, Tomoya Ito, Jun Miyamoto, Chihiro Shibuya, Mayumi Kimura, Kazuya Toriumi …

Journal of Biological Chemistry, 107476-107476, Jun, 2024 Peer-reviewed
Atg15 is a vacuolar phospholipase that disintegrates organelle membranes.

Yasunori Watanabe, Yurina Iwasaki, Kyoka Sasaki, Chie Motono, Kenichiro Imai, Kuninori Suzuki

Cell reports, 42(12) 113567-113567, Dec 26, 2023
A multipoint guidance mechanism for β-barrel folding on the SAM complex

Hironori Takeda, Jon V. Busto, Caroline Lindau, Akihisa Tsutsumi, Kentaro Tomii, Kenichiro Imai, Yu Yamamori, Takatsugu Hirokawa, Chie Motono, Iniyan Ganesan …

Nature Structural & Molecular Biology, 30(2) 176-187, Jan 5, 2023 Peer-reviewed
Imputation-free reconstructions of three-dimensional chromosome architectures in human diploid single-cells using allele-specified contacts

Yoshito Hirata, Arisa H. Oda, Chie Motono, Masanori Shiro, Kunihiro Ohta

Scientific Reports, 12(1), Dec, 2022 Peer-reviewed
Phosprof: pathway analysis database of drug response based on phosphorylation activity measurements.

Harumi Kagiwada, Chie Motono, Katsuhisa Horimoto, Kazuhiko Fukui

Database : the journal of biological databases and curation, 2022, Aug 22, 2022
Unfolding is the driving force for mitochondrial import and degradation of the Parkinson's disease-related protein DJ-1

Bruno Barros Queliconi, Waka Kojima, Mayumi Kimura, Kenichiro Imai, Chisato Udagawa, Chie Motono, Takatsugu Hirokawa, Shinya Tashiro, Jose M. M. Caaveiro, Kouhei Tsumoto …

Journal of Cell Science, 134(22), Nov 15, 2021
MDContactCom: a tool to identify differences of protein molecular dynamics from two MD simulation trajectories in terms of interresidue contacts.

Chie Motono, Shunsuke Yanagida, Miwa Sato, Takatsugu Hirokawa

Bioinformatics (Oxford, England), Jul 21, 2021
Porin Associates with Tom22 to Regulate the Mitochondrial Protein Gate Assembly.

Haruka Sakaue, Takuya Shiota, Naoya Ishizaka, Shin Kawano, Yasushi Tamura, Kher Shing Tan, Kenichiro Imai, Chie Motono, Takatsugu Hirokawa, Kentaro Taki …

Molecular cell, 73(5) 1044-1055, Mar 7, 2019 Peer-reviewed
2P268 Protein binding pocket and ligand shape comparison(22A. Bioinformatics: Structural genomics,Poster)

Motono Chie, Hirokawa Takatsugu

Seibutsu Butsuri, 53(1) S203, 2013
SAHG, a comprehensive database of predicted structures of all human proteins.

Motono C, Nakata J, Koike R, Shimizu K, Shirota M, Amemiya T, Tomii K, Nagano N, Sakaya N, Misoo K …

Nucleic acids research, 39(Database issue) D487-93, Jan, 2011 Peer-reviewed
1P-236 Virtual screening to separate active ligands from decoys using MD simulation and concavity shape comparing(Bioinformatics:Structural genomics, The 47th Annual Meeting of the Biophysical Society of Japan)

Motono Chie, Hirokawa Takatsugu

Seibutsu Butsuri, 49 S99, 2009
2P-297 Validation of statistical functions for evaluating protein structural models(The 46th Annual Meeting of the Biophysical Society of Japan)

Motono Chie, Hirokawa Takatsugu

Seibutsu Butsuri, 48 S121, 2008
The H-Invitational Database (H-InvDB), a comprehensive annotation resource for human genes and transcripts.

Genome Information Integration Project And H-Invitational, Yamasaki C, Murakami K, Fujii Y, Sato Y, Harada E, Takeda J, Taniya T, Sakate R, Kikugawa S …

Nucleic acids research, 36(Database issue) D793-9, Jan, 2008 Peer-reviewed
Molecular dynamics simulation of prion protein by large scale cluster computing

M Sekijima, C Motono, S Yamasaki, K Kaneko, Y Akiyama

HIGH PERFORMANCE COMPUTING, 2858 476-485, 2003 Peer-reviewed

Misc.

Search for undiscovered protein functional sites based on the spatial distribution of disease-associated missense variants

本野千恵, 本野千恵, 土方敦司, 広川貴次, 広川貴次, 今井賢一郎

日本分子生物学会年会プログラム・要旨集(Web), 45th, 2022
3次元最短経路探索法と教師付き分子動力学計算によるタンパク質-リガンド結合予測

本野千恵, 小河原惇, 五味雅裕, 佐藤美和, 広川貴次

生体分子科学討論会講演要旨集, 43rd, 2016
3次元最短経路探索法を取り入れたSupervised Molecular Dynamicsによるタンパク質-リガンド結合シミュレーション

小河原惇, 本野千恵, 五味雅裕, 佐藤美和, 広川貴次

日本蛋白質科学会年会プログラム・要旨集, 16th, 2016
教師付分子動力学計算を取り入れたタンパク質-リガンド結合予測

本野千恵, 小河原惇, 五味雅裕, 佐藤美和, 広川貴次

メディシナルケミストリーシンポジウム講演要旨集, 33rd, 2015
Thermodynamic and kinetic determinants of Thermotoga maritima cold shock protein stability : a structural and dynamic analysis

MOTONO C.

Proteins, 71 655-669, 2008
1P241 An exhaustive modeling and evaluation system in protein 3D structure prediction pipeline FORTE-SUITE(Bioinformatics-structural genomics,Poster Presentations)

Motono Chie, Hirokawa Takatsugu, Sato Miwa, Fujihara Yasuhiro, Kisoo Kiyotaka, Sakaya Naofumi, Tomii Kentaro, Akiyama Yutaka

Seibutsu Butsuri, 47 S83, 2007
Large-scale identification and characterization of alternative splicing variants of human gene transcripts using 56 419 completely sequenced and manually annotated full-length cDNAs

Jun-ichi Takeda, Yutaka Suzuki, Mitsuteru Nakao, Roberto A. Barrero, Kanako O. Koyanagi, Lihua Jin, Chie Motono, Hiroko Hata, Takao Isogai, Keiichi Nagai …

NUCLEIC ACIDS RESEARCH, 34(14) 3917-3928, 2006
The Molecular Dynamics Simulations of the Conformational Transition of Prion Protein from its Cellular Form to the Anomalous Form using the Earth Simulator

Annual Report of the Earth Simulator Center 2004-2005, 2005
Conformational transition of Prion Protein from its cellular form to the fibril form investigated by molecular dynamics simulations

M Sekijima, C Motono, T Noguchi, K Kaneko, Y Akiyama

BIOPHYSICAL JOURNAL, 88(1) 36A-36A, Jan, 2005
Protein structure prediction using a variety of profile libraries and 3D verification

K Tomii, T Hirokawa, C Motono

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 61(S7) 114-121, 2005
Large-scale analysis of human alternative protein isoforms: pattern classification and correlation with subcellular localization signals

M Nakao, RA Barrero, Y Mukai, C Motono, M Suwa, K Nakai

NUCLEIC ACIDS RESEARCH, 33(8) 2355-2363, 2005
プリオンタンパク質の疾病関連遺伝子置換P102Lのダイナミクスに与える影響について

関嶋政和, 本野千恵, 野口保, 金子清俊, 秋山泰

生物物理, 44(Suppl.1) S122-S122, Nov, 2004
Structural changes in flexible region of the prion protein induced by P102L substitution: Investigation through molecular dynamics simulations

M Sekijima, C Motono, T Noguchi, K Kaneko, Y Akiyama

PROTEIN SCIENCE, 13 170-170, Aug, 2004
The Molecular Dynamics Simulations of the Conformational Transition of Prion Protein from its Cellular Form to the Anomalous Form using the Earth Simulator

Annual Report of the Earth Simulator Center April 2003 - March 2004, 171-174, 2004
Molecular dynamics simulation of dimeric and monomeric forms of human prion protein: Insight into dynamics and properties

M Sekijima, C Motono, S Yamasaki, K Kaneko, Y Akiyama

BIOPHYSICAL JOURNAL, 85(2) 1176-1185, Aug, 2003
Computer simulation study on monomeric and dimeric Human Prion Protein (Hu PrP)

Sekijima M., Motono C., Yamasaki S., Kaneko K., Akiyama Y.

Seibutsu Butsuri, 43 S90, 2003

Research Projects

疾患関連変異のタンパク質構造上の三次元分布を基点とした未知の機能部位探索法の確立

科学研究費助成事業, 基盤研究(B), 日本学術振興会, Apr, 2021 - Mar, 2024

今井賢一郎, 土方敦司, 本野千恵, 足達俊吾

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