Kazuhiko Koike

J-GLOBAL         Last updated: Sep 5, 2019 at 17:02
Kazuhiko Koike
The University of Tokyo
Graduate School of Medicine, Internal Medicine, Department of Gastroenterology
Job title
Professor & Chairman

Research Areas


Committee Memberships

The Japanese Society of Gastroenterology (JSGE)  Director General
The Japanese Medical Science Federation (JMSF)  Director
The Japanese Society of Gastroenterology (JSGE)  Director
The Japan Society of Hepatology (JSH)  Executive Director
The Japan Society of Hepatology (JSH)  Director General
The Japanese Society of Internal Medicine (JSIM)  Director General

Published Papers

Pevonedistat, a first-in-class NEDD8-activating enzyme inhibitor, is a potent inhibitor of hepatitis B virus
Hepatology      2019   [Refereed]
Long-term risk of malignancy in branch duct intraductal papillary mucinous neoplasms.
Gastroenterology      2019   [Refereed]
Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism
Nat Commun   10 947   2019   [Refereed]
Impact of AAV2 and hepatitis B virus integration into genome on development of hepatocellular carcinoma in patients with prior hepatitis B virus infection
Clin Cancer Res      2019   [Refereed]
Altered serum acylcarnitine profile is associated with the status of nonalcoholic fatty liver disease (NAFLD) and NAFLD-related hepatocellular carcinoma.
Sci Rep   9 10663   2019   [Refereed]
A nationwide survey on non-B, non-C hepatocellular carcinoma in Japan: 2011-2015 update
J Gastroenterol   54(367) 376   2019   [Refereed]
Machine-learning Approach for the Development of a Novel Predictive Model for the Diagnosis of Hepatocellular Carcinoma.
Sci Rep   9 7704   2019   [Refereed]
Inhibition of HBV Transcription From cccDNA With Nitazoxanide by Targeting the HBx-DDB1 Interaction.
Cell Mol Gastroenterol Hepatol   7 297-312   2019   [Refereed]
BHLHA15-positive secretory precursor cells can give rise to tumors in intestine and colon in mice
Gastroenterology   156 1066-1081   2019   [Refereed]
Impact of direct-acting antivirals on early recurrence of HCV-related HCC: comparison with interferon-based therapy.
J Hepatol   70 78-86   2019   [Refereed]
Satellite RNA Increases DNA damage and accelerates tumor formation in mouse models of pancreatic cancer.
Mol Cancer Res   16 1255-1262   2018   [Refereed]
CPT2 downregulation adapts HCC to lipid-rich environment and promotes carcinogenesis via acylcarnitine accumulation in obesity.
Gut   67 1493-1504   2018   [Refereed]
Characterization of SPP inhibitors suppressing propagation of HCV and protozoa.
Proc Natl Acad Sci U S A   114 E10782-E10791   2017   [Refereed]
Gastroenterology    152 631-643   2017   [Refereed]
Biliary epithelial injury-induced regenerative response by IL-33 promotes cholangiocarcinogenesis from peribiliary glands
Proc Natl Acad Sci U S A   114 3806-3815   2017   [Refereed]
Quantitation of circulating satellite RNAs in pancreatic cancer patients
JCI Insight   1 e86646   2016   [Refereed]
Satellite RNAs promote pancreatic oncogenic processes via the dysfunction of YBX1
Nat Commun   26 13006-13006   2016   [Refereed]
Nat Genet   46 583-587   2014   [Refereed]

Research Grants & Projects

Comprehensive research on metabolism-associated liver cancer including viral liver diseases
Project Year: 2018 - 2021    Investigator(s): Kazuhiko Koike
Comprehensive research on metabolism-associated liver cancer including those with viral hepatitis
Project Year: 2015 - 2017    Investigator(s): Kazuhiko Koike
Comprehensive research on metabolism-associated liver cancer including hepatitis C
Project Year: 2012 - 2014    Investigator(s): Kazuhiko Koike
Comprehensive research on the interactions between hepatitis viruses and metabolic and immune systems
Health and Labour Sciences Research Grants
Project Year: 2009 - 2011
Impact of HCV-associated metabolic abnormalities on liver disease progression
Grant-in-Aid for Scientific Research
Project Year: 2008 - 2010