Kazuhiko Koike

J-GLOBAL         Last updated: Sep 5, 2019 at 17:02
 
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Name
Kazuhiko Koike
Affiliation
The University of Tokyo
Section
Graduate School of Medicine, Internal Medicine, Department of Gastroenterology
Job title
Professor & Chairman

Research Areas

 
 

Committee Memberships

 
2019
 - 
Today
The Japanese Society of Gastroenterology (JSGE)  Director General
 
2015
 - 
Today
The Japanese Medical Science Federation (JMSF)  Director
 
2013
 - 
Today
The Japanese Society of Gastroenterology (JSGE)  Director
 
2006
 - 
Today
The Japan Society of Hepatology (JSH)  Executive Director
 
2010
 - 
2018
The Japan Society of Hepatology (JSH)  Director General
 
2013
 - 
2016
The Japanese Society of Internal Medicine (JSIM)  Director General
 

Published Papers

 
Pevonedistat, a first-in-class NEDD8-activating enzyme inhibitor, is a potent inhibitor of hepatitis B virus
Hepatology      2019   [Refereed]
Long-term risk of malignancy in branch duct intraductal papillary mucinous neoplasms.
Gastroenterology      2019   [Refereed]
Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism
Nat Commun   10 947   2019   [Refereed]
Impact of AAV2 and hepatitis B virus integration into genome on development of hepatocellular carcinoma in patients with prior hepatitis B virus infection
Clin Cancer Res      2019   [Refereed]
Altered serum acylcarnitine profile is associated with the status of nonalcoholic fatty liver disease (NAFLD) and NAFLD-related hepatocellular carcinoma.
Sci Rep   9 10663   2019   [Refereed]
A nationwide survey on non-B, non-C hepatocellular carcinoma in Japan: 2011-2015 update
J Gastroenterol   54(367) 376   2019   [Refereed]
Machine-learning Approach for the Development of a Novel Predictive Model for the Diagnosis of Hepatocellular Carcinoma.
Sci Rep   9 7704   2019   [Refereed]
Inhibition of HBV Transcription From cccDNA With Nitazoxanide by Targeting the HBx-DDB1 Interaction.
Cell Mol Gastroenterol Hepatol   7 297-312   2019   [Refereed]
BHLHA15-positive secretory precursor cells can give rise to tumors in intestine and colon in mice
Gastroenterology   156 1066-1081   2019   [Refereed]
Impact of direct-acting antivirals on early recurrence of HCV-related HCC: comparison with interferon-based therapy.
J Hepatol   70 78-86   2019   [Refereed]
Satellite RNA Increases DNA damage and accelerates tumor formation in mouse models of pancreatic cancer.
Mol Cancer Res   16 1255-1262   2018   [Refereed]
CPT2 downregulation adapts HCC to lipid-rich environment and promotes carcinogenesis via acylcarnitine accumulation in obesity.
Gut   67 1493-1504   2018   [Refereed]
Characterization of SPP inhibitors suppressing propagation of HCV and protozoa.
Proc Natl Acad Sci U S A   114 E10782-E10791   2017   [Refereed]
Gastroenterology    152 631-643   2017   [Refereed]
Biliary epithelial injury-induced regenerative response by IL-33 promotes cholangiocarcinogenesis from peribiliary glands
Proc Natl Acad Sci U S A   114 3806-3815   2017   [Refereed]
Quantitation of circulating satellite RNAs in pancreatic cancer patients
JCI Insight   1 e86646   2016   [Refereed]
Satellite RNAs promote pancreatic oncogenic processes via the dysfunction of YBX1
Nat Commun   26 13006-13006   2016   [Refereed]
Nat Genet   46 583-587   2014   [Refereed]

Research Grants & Projects

 
Comprehensive research on metabolism-associated liver cancer including viral liver diseases
AMED: 
Project Year: 2018 - 2021    Investigator(s): Kazuhiko Koike
Comprehensive research on metabolism-associated liver cancer including those with viral hepatitis
AMED
Project Year: 2015 - 2017    Investigator(s): Kazuhiko Koike
Comprehensive research on metabolism-associated liver cancer including hepatitis C
MHLW: 
Project Year: 2012 - 2014    Investigator(s): Kazuhiko Koike
Comprehensive research on the interactions between hepatitis viruses and metabolic and immune systems
Health and Labour Sciences Research Grants
Project Year: 2009 - 2011
Impact of HCV-associated metabolic abnormalities on liver disease progression
Grant-in-Aid for Scientific Research
Project Year: 2008 - 2010