2011年
Identification of a mechanism for lung inflammation caused by Mycoplasma pneumoniae using a novel mouse model.
Results in immunology
- 巻
- 1
- 号
- 1
- 開始ページ
- 76
- 終了ページ
- 87
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/j.rinim.2011.11.001
Human Mycoplasma pneumoniae (MP) pneumonia is characterized by alveolar infiltration with neutrophils and lymphocytes and lymphocyte/plasma cell infiltrates in the peri-bronchovascular area (PBVA). No mouse model has been able to mimic the pathological features seen in human MP pneumonia, such as plasma cell-rich lymphocytic infiltration in PBVA. To figure out the mechanism for inflammation by MP infection using a novel mouse model that mimics human MP pneumonia, mice were pre-immunized intraperitoneally with Th2 stimulating adjuvant, alum, alone or MP extracts with an alum, followed by intratracheal challenge with MP extracts. The toll-like receptor-2, which is the major receptor for mycoplasma cell wall lipoproteins, was strongly up-regulated in alveolar macrophages in a latter group after the pre-immunization but prior to the intratracheal challenge. Those findings demonstrated that acceleration of innate immunity by antecedent antigenic stimulation can be an important positive-feedback mechanism in lung inflammation during MP pneumonia.
- リンク情報
- ID情報
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- DOI : 10.1016/j.rinim.2011.11.001
- PubMed ID : 24371556
- PubMed Central 記事ID : PMC3850488