論文

査読有り 国際誌
2011年

Identification of a mechanism for lung inflammation caused by Mycoplasma pneumoniae using a novel mouse model.

Results in immunology
  • Takeshi Saraya
  • Koh Nakata
  • Kazuhide Nakagaki
  • Natsuki Motoi
  • Kuniko Iihara
  • Yasunori Fujioka
  • Teruaki Oka
  • Daisuke Kurai
  • Hiroo Wada
  • Haruyuki Ishii
  • Haruhiko Taguchi
  • Shigeru Kamiya
  • Hajime Goto
  • 全て表示

1
1
開始ページ
76
終了ページ
87
記述言語
英語
掲載種別
DOI
10.1016/j.rinim.2011.11.001

Human Mycoplasma pneumoniae (MP) pneumonia is characterized by alveolar infiltration with neutrophils and lymphocytes and lymphocyte/plasma cell infiltrates in the peri-bronchovascular area (PBVA). No mouse model has been able to mimic the pathological features seen in human MP pneumonia, such as plasma cell-rich lymphocytic infiltration in PBVA. To figure out the mechanism for inflammation by MP infection using a novel mouse model that mimics human MP pneumonia, mice were pre-immunized intraperitoneally with Th2 stimulating adjuvant, alum, alone or MP extracts with an alum, followed by intratracheal challenge with MP extracts. The toll-like receptor-2, which is the major receptor for mycoplasma cell wall lipoproteins, was strongly up-regulated in alveolar macrophages in a latter group after the pre-immunization but prior to the intratracheal challenge. Those findings demonstrated that acceleration of innate immunity by antecedent antigenic stimulation can be an important positive-feedback mechanism in lung inflammation during MP pneumonia.

リンク情報
DOI
https://doi.org/10.1016/j.rinim.2011.11.001
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/24371556
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850488
ID情報
  • DOI : 10.1016/j.rinim.2011.11.001
  • PubMed ID : 24371556
  • PubMed Central 記事ID : PMC3850488

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