2005年3月
Propionibacterium acnes is the most common bacterium commensal in peripheral lung tissue and mediastinal lymph nodes from subjects without sarcoidosis
SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES
- 巻
- 22
- 号
- 1
- 開始ページ
- 33
- 終了ページ
- 42
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- 出版者・発行元
- FONDAZIONE PNEUMOLOGIA U I P ONLUS
Background: In studies of the unknown etiology of sarcoidosis, Propionibacterium acnes (a possible agent) was found in the lungs and lymph nodes of many sarcoldosis patients and some control subjects. P acnes might be commensal not only to the skin, conjunctivae, and intestine, but also to the lungs and lymph nodes of individuals without sarcoidosis. Methods: We cultured peripheral lung tissue and various lymph nodes obtained from patients with diseases other than sarcoidosis. DNA of 45 isolates of P acnes from these patients, 67 isolates from normal skin, conjunctiva, and intestine, and 39 isolates from sarcoid lymph nodes were compared by random amplified polymorphic DNA analysis. Results: P acnes was isolated from half of 43 lungs and 8 of 11 mediastinal lymph nodes, mostly in pure culture. P acnes was isolated from half of 20 gastric and 3 of 12 intestinal lymph nodes; intestinal bacteria were also numerous. In general, fewer than 500 colony-forming units of P acnes per gram tissue were isolated, but 4 lung tissue specimens, 2 of which had a few granulomas, had many more. P acnes strains from a particular site (lung, lymph node, skin or conjunctivae, and intestine) were genetically similar, more than isolates obtained from different sites. Lymph-node isolates from subjects with and without sarcoidosis differed little. Conclusion: These results suggest that P acnes normally resides in peripheral lung tissue and mediastinal lymph nodes and that the strains of P acnes isolated from sarcoid lymph nodes were not specific to sarcoidosis.
- リンク情報
- ID情報
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- ISSN : 1124-0490
- PubMed ID : 15881278
- Web of Science ID : WOS:000227918500005