平敬宏 (Taira Takahiro) - マイポータル

基本情報

学位: 博士（薬学）

J-GLOBAL ID: 200901030780553728
researchmap会員ID: 5000099302

外部リンク: http://www.yamanashi.ac.jp/education/medical/basic/molbio/indexMCB.html

研究キーワード

研究分野

経歴

MISC

Protection against oxidative stress-induced neurodegeneration by a modulator for DJ-1, a wild-type of familial Parkinson’s disease-linked PARK7.

Yanagida,T, Kitamura,Y, Yamane,K, Takahashi,K, Takata,K, Yanagisawa,D, Yasui,H, Taniguchi,T, Taira,T, Honda,T. and …

J. Pharmacol. Sci. 109(3) 463-468 2009年3月
Oxidative stress induction of DJ-1 protein in reactive astrocytes scavenges free radicals and reduces cell injury.

Yanagida,T, Tsushima,J, Kitamura,Y, Yanagisawa,D, Takata,K, Shibaike,T, Yamamoto,A, Taniguchi,T, Yasui,H, Taira,T …

Oxidative Medicine & Cellular Longevity 136 36-42 2009年
DJ-1-binding compounds prevent oxidative stress-induced cell death and movement defect in Parkinson’s disease model rats.

Miyazaki,S, Yanagida,T, Nunome,K, Ishikawa,S, Inden,M, Kitamura,K, Nakagawa,S, Taira,T, Hirota,K, Niwa,M …

J. Neurochem. 105(6) 2418-2434 2008年6月
Comparative study of hydrogen peroxide- and 4-hydroxy-2-nonenal-induced cell death in HT22 cells

Atsushi Ishimura, Kumiko Ishige, Takahiro Taira, Shigeki Shimba, Shin-Ichi Ono, Hiroyoshi Ariga, Masakatsu Tezuka, Yoshihisa Ito

NEUROCHEMISTRY INTERNATIONAL 52(4-5) 776-785 2008年3月
DJ-1 protects against neurodegeneration caused by focal cerebral ischemia and reperfusion in rats

Daijiro Yanagisawa, Yoshihisa Kitamura, Masatoshi Inden, Kazuyuki Takata, Takashi Taniguchi, Shigehiro Morikawa, Masahito Morita, Toshiro Inubushi, Ikuo Tooyama, Takahiro Taira …

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 28(3) 563-578 2008年3月
多機能タンパク質DJ-1と病態

平敬宏

山梨医科学誌 22(1) 1-11 2008年
Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone

Masatoshi Inden, Yoshihisa Kitamura, Hiroki Takeuchi, Takashi Yanagida, Kazuyuki Takata, Yuka Kobayashi, Takashi Taniguchi, Kanji Yoshimoto, Masahiko Kaneko, Yasunobu Okuma …

JOURNAL OF NEUROCHEMISTRY 101(6) 1491-1504 2007年6月
DJ-1 degrades transthyretin and an inactive form of DJ-1 is secreted in familial amyloidotic polyneuropathy.

Taira T

Int. J. Mol. Med. 19 885-893 2007年
Protection against nonylphenol-induced cell death by DJ-1 in cultured Japanese medaka (Oryzias latipes) cells

Hong Mei Li, Takahiro Taira, Chinatsu Maita, Hiroyoshi Ariga, Sanae M. M. Iguchi-Ariga

TOXICOLOGY 228(2-3) 229-238 2006年12月
Distribution of DJ-1, Parkinson’s disease-related protein PARK7, and its alteration in 6-hydroxydopamine-treated hemiparkinsonian rat brain.

Yanagida T

J. Pharmacol. Sci. 102(2) 243-247 2006年10月
PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson’s disease rat model.

Inden M

Neurobiol. Dis. 24(1) 144-158 2006年10月
Distribution of DJ-1, Parkinson’s disease-related protein PARK7, and its alteration in 6-hydroxydopamine-treated hemiparkinsonian rat brain.

Ynagida T他

J. Pharmacol. Sci. 102(2) 243-247 2006年10月
DJ-1 interacts with HIPK1 and affects H2O2-induced cell death

A Sekito, S Koide-Yoshida, T Niki, T Taira, SMM Iguchi-Ariga, H Ariga

FREE RADICAL RESEARCH 40(2) 155-165 2006年2月
Distinct localizations and repression activities of MM-1 isoforms toward c-Myc

Y Hagio, Y Kimura, T Taira, Y Fujioka, SMM Iguchi-Ariga, H Ariga

JOURNAL OF CELLULAR BIOCHEMISTRY 97(1) 145-155 2006年1月
Parkinson病原因遺伝子PARK7とDJ-1遺伝子の機能

神経内科 65 135-139 2006年
Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities

Y Shinbo, T Niki, T Taira, H Ooe, K Takahashi-Niki, C Maita, C Seino, SMM Iguchi-Ariga, H Ariga

CELL DEATH AND DIFFERENTIATION 13(1) 96-108 2006年1月
Expression profiles of genes in DJ-1-knockdown and L166P DJ-1 mutant cells

H Nishinaga, K Takahashi-Niki, T Taira, A Andreadis, SMM Iguchi-Ariga, H Ariga

NEUROSCIENCE LETTERS 390(1) 54-59 2005年12月
Induction of reactive oxygen species by bisphenol A and abrogation of bisphenol A-induced cell injury by DJ-1

H Ooe, T Taira, SMM Iguchi-Ariga, H Ariga

TOXICOLOGICAL SCIENCES 88(1) 114-126 2005年11月
Association of DJ-1 with chaperones and enhanced association and colocalization with mitochondrial Hsp70 by oxidative stress

HM Li, T Niki, T Taira, SMM Iguchi-Ariga, H Ariga

FREE RADICAL RESEARCH 39(10) 1091-1099 2005年10月
Stimulation of transforming activity of DJ-1 by Abstrakt, a DJ-1-binding protein

A Sekito, T Taira, T Niki, SMM Iguchi-Ariga, H Ariga

INTERNATIONAL JOURNAL OF ONCOLOGY 26(3) 685-689 2005年3月

もっとみる

講演・口頭発表等

脳虚血モデルラットにおけるDJ-1の神経保護作用

第81回日本薬理学会 2008年
パーキンソン病モデルラットにおけるDJ-1(PARK7)の発現変動

第80回日本薬理学会 2007年
家族性パーキンソン病原因遺伝子PARK7/DJ-1の6-hydoroxydopamine投与ラットモデルにおけるドパミン神経保護作用

第８０回日本薬理学会 2007年
MM-1 negatively regulates c-Myc function by multiple pathways, including transcriptional repression, stimulation of degradation and supression of Wnt-signal.

20th IUBMB Internatimnal Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress 2006年
Functional analysis of DJ-1 in Familial amyloidotic polyneuropathy

20th IUBMB International Congress of Biochamistry and Molecular Biology anad 11th FAOBMB Congress 2006年
Functional of DJ-1, a causative gene product for familial Parkinson's disease, and its therapeutic application to Parkinson's disease

20th IUBMB Internatimnal Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress 2006年
Expression and neuroprotective effect of DJ-1

20th IUBMB Internatimnal Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress 2006年
DJ-1に結合する低分子化合物の同定とその酸化ストレスによる神経細胞死抑制能

日本分子生物学会2006ファーラム 2006年
c-Myc 結合タンパク質MM-1によるWnt-4遺伝子の発現調節

日本分子生物学会2006フォーラム 2006年

平敬宏

基本情報

研究キーワード

研究分野

経歴

MISC

講演・口頭発表等

所属学協会

共同研究・競争的資金等の研究課題

メニュー