2004年12月
Stereoselective synthesis of tetra-substituted olefins via addition of zinc enolates to unactivated alkynes
ORGANIC LETTERS
- ,
- ,
- ,
- 巻
- 6
- 号
- 26
- 開始ページ
- 4837
- 終了ページ
- 4840
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1021/ol048131i
- 出版者・発行元
- AMER CHEMICAL SOC
[Graphics]
In the presence of a stoichiometric or catalytic amount of diethylzinc, a beta-aminocrotonamide undergoes sequential addition/isomerization reactions with 1-alkyne to produce, upon hydrolysis, an alpha-alkylidene,beta-dicarbonyl compound in a highly stereoselective manner. The method complements the conventional Knoevenagel synthesis of this class of compounds as to the choice of the starting material and the scope and stereochemistry of the product.
In the presence of a stoichiometric or catalytic amount of diethylzinc, a beta-aminocrotonamide undergoes sequential addition/isomerization reactions with 1-alkyne to produce, upon hydrolysis, an alpha-alkylidene,beta-dicarbonyl compound in a highly stereoselective manner. The method complements the conventional Knoevenagel synthesis of this class of compounds as to the choice of the starting material and the scope and stereochemistry of the product.
- リンク情報
- ID情報
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- DOI : 10.1021/ol048131i
- ISSN : 1523-7060
- J-Global ID : 200902217719289569
- Web of Science ID : WOS:000225812300010