MISC

査読有り
2013年11月

Latent IgA deposition from donor kidneys does not affect transplant prognosis, irrespective of mesangial expansion

Clinical Transplantation
  • Tadashi Sofue
  • Masashi Inui
  • Taiga Hara
  • Masahiro Moritoki
  • Satoshi Nishioka
  • Yoko Nishijima
  • Kumiko Moriwaki
  • Yushi Hayashida
  • Nobufumi Ueda
  • Yoshio Kushida
  • Reiji Haba
  • Akira Nishiyama
  • Yoshiyuki Kakehi
  • Masakazu Kohno
  • 全て表示

27
26
開始ページ
14
終了ページ
21
記述言語
英語
掲載種別
DOI
10.1111/ctr.12158

Introduction: Latent mesangial immunoglobulin A (IgA) deposition in the donated kidney has been investigated in the context of kidney transplantation. However, few studies have examined the impact of mesangial expansion accompanied with IgA deposition. Therefore, we investigated the effects of latent IgA deposition and mesangial expansion on transplant prognosis following living-donor kidney transplantation. Methods: We retrospectively analyzed 68 consecutive adult living-donor kidney transplantations performed at Kagawa University Hospital. Biopsies were performed at pre-implantation and at one yr after transplantation. Results: Twenty kidneys exhibited latent IgA deposition in pre-implantation biopsies, including 14 with mesangial expansion. Latent IgA deposition was not associated with renal function or donor urinalysis after donation, irrespective of mesangial expansion. Latent IgA deposition was not significantly associated with graft survival rate, allograft function, abnormal urinalysis, or the recurrence of IgA nephropathy, irrespective of mesangial expansion. At one yr after transplantation, IgA deposition had disappeared in 14/20 allografts. Estimated glomerular function rate &gt
40 mL/min/1.73 m2 was significantly associated with the disappearance of IgA deposition. Conclusions: The present study showed that latent IgA deposition from the donor kidney, irrespective of mesangial expansion, does not affect transplant prognosis following living-donor kidney transplantation. © 2013 John Wiley &amp
Sons A/S. Published by John Wiley &amp
Sons Ltd.

リンク情報
DOI
https://doi.org/10.1111/ctr.12158
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/24299231
ID情報
  • DOI : 10.1111/ctr.12158
  • ISSN : 0902-0063
  • ISSN : 1399-0012
  • PubMed ID : 24299231
  • SCOPUS ID : 84889599903

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