MISC

2007年11月

Stromogenic prostatic carcinoma pattern (carcinomas with reactive stromal grade 3) in needle biopsies predicts biochemical recurrence-free survival in patients after radical prostatectomy

HUMAN PATHOLOGY
  • Nobuyuki Yanagisawa
  • ,
  • Rile Li
  • ,
  • David Rowley
  • ,
  • Hao Liu
  • ,
  • Dov Kadmon
  • ,
  • Brian J. Miles
  • ,
  • Thomas M. Wheeler
  • ,
  • Gustavo E. Ayala

38
11
開始ページ
1611
終了ページ
1620
記述言語
英語
掲載種別
DOI
10.1016/j.humpath.2007.04.008
出版者・発行元
W B SAUNDERS CO-ELSEVIER INC

We previously reported that reactive stromal grading in radical prostatectomies is a predictor of recurrence and that reactive stromal grading 0 and 3 are associated with lower biochemical recurrence-free survival rates than reactive stromal grading 1 and 2. We explored the prognostic significance of reactive stromal grading in preoperative needle biopsies. At Baylor College of Medicine, 224 cases of prostatic carcinoma were diagnosed by needle biopsy. Reactive stromal grading was evaluated on hematoxylin-eosin (H&E)-stained sections on the basis of previously described criteria: grade 0, with 0% to 5% reactive stroma; grade 1, 6% to 15%; grade 2, 16% to 50%; grade 3, 51% to 100%, or at least a 1:1 ratio between glands and stroma. Kaplan-Meier and Cox proportional hazard analyses were used. Reactive stromal grading distribution was as follows: reactive stromal grading 0, 1 case (0.5%); reactive stromal grading 1, 149 cases (66.5%); reactive stromal grading 2, 59 cases (26.3%); reactive stromal grading 3, 15 cases (6.7%). Reactive stromal grading in biopsies was correlated with adverse clinicopathologic parameters in the prostatectomy. Patients with reactive stromal grading I and 2 had better survival than those with 0 and 3 (P = .0034). Reactive stromal grading was an independent predictor of recurrence (hazard ratio = 1.953; P = .0174). Reactive stromal grading is independent of Gleason 4 + 3 and 3 + 4 in patients with a Gleason score of 7. Quantitation of reactive stroma and recognition of the stromogenic carcinoma in H&E-stained biopsies is useful to predict biochemical recurrence in prostate carcinoma patients independent of Gleason grade and prostate-specific antigen. (c) 2007 Published by Elsevier Inc.

Web of Science ® 被引用回数 : 70

リンク情報
DOI
https://doi.org/10.1016/j.humpath.2007.04.008
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000250743300005&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.humpath.2007.04.008
  • ISSN : 0046-8177
  • Web of Science ID : WOS:000250743300005

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