Takashi Kuzuhara

J-GLOBAL         Last updated: May 19, 2015 at 11:25
 
Avatar
Name
Takashi Kuzuhara
URL
http://p.bunri-u.ac.jp/lab08/index.html
Affiliation
Tokushima Bunri University
Section
Faculty of Pharmaceutical Sciences, Department of Pharmaceutics
Job title
Professor
Degree
Ph.D.

Research Areas

 

Education

 
 
   
 
The University of Tokyo
 
 
   
 
The University of Tokyo
 

Published Papers

 
Hatakeyama D, Shoji M, Yamayoshi S, Hirota T, Nagae M, Yanagisawa S, Nakano M, Ohmi N, Noda T, Kawaoka Y, Kuzuhara T
The Journal of Biological Chemistry   289 24980-24994   Sep 2014   [Refereed]
Miki Hiasa, Megumi Kurokawa, Hiroshi Akita, Masatomo Harada, Kengo Niki, Kana Ohta, Masaki Shoji, Noriko Echigo, Takashi Kuzuhara
Journal of Functional Foods   8 188-192   2014   [Refereed]
Hiasa M, Isoda Y, Kishimoto Y, Saitoh K, Kimura Y, Kanai M, Shibasaki M, Hatakeyama D, Kirino Y, Kuzuhara T
British Journal of Pharmacology   169 115-129   May 2013   [Refereed]
Shoji M, Takahashi E, Hatakeyama D, Iwai Y, Morita Y, Shirayama R, Echigo N, Kido H, Nakamura S, Mashino T, Okutani T, Kuzuhara T
PloS one   8 e66337   2013   [Refereed]
Miki Hiasaa, Megumi Kurokawaa, Kana Ohtaa, Tomoyuki Esumib, Hiroshi Akita, Kengo Niki, Yasuyuki Yagi, Noriko Echigo, Dai Hatakeyama, Takashi Kuzuhara
Food Research International   54(1) 72-80   2013   [Refereed]
Tsurumura T, Qiu H, Yoshida T, Tsumori Y, Hatakeyama D, Kuzuhara T, Tsuge H
PloS one   8 e82020   2013   [Refereed]
[The tertiary structures of the domains of influenza RNA polymerase].
Kuzuhara T, Tsuge H
Seikagaku. The Journal of Japanese Biochemical Society   84 780-785   Sep 2012   [Refereed]
Ludwiczuk A, Saha A, Kuzuhara T, Asakawa Y
Phytomedicine   18 491-498   Apr 2011   [Refereed]
Iwai Y, Murakami K, Gomi Y, Hashimoto T, Asakawa Y, Okuno Y, Ishikawa T, Hatakeyama D, Echigo N, Kuzuhara T.
PLoS One   6(5) e19825   2011   [Refereed]
Saha A, Kuzuhara T, Echigo N, Suganuma M, Fujiki H
Cancer Prevention Research   3 953-962   Aug 2010   [Refereed]
Iwai Y, Takahashi H, Hatakeyama D, Motoshima K, Ishikawa M, Sugita K, Hashimoto Y, Harada Y, Itamura S, Odagiri T, Tashiro M, Sei Y, Yamaguchi K, Kuzuhara T
Bioorganic & Medicinal Chemistry   18 5379-5390   Jul 2010   [Refereed]
Yasuaki Kimura, Kenzo Yamatsugu, Motomu Kanai, Noriko Echigo, Takashi Kuzuhara, and Masakatsu Shibasaki
Bulletin of the Korean Chemical Society   31(3) 588-594   2010   [Refereed]
Saha A, Kuzuhara T, Echigo N, Fujii A, Suganuma M, Fujiki H
Biological & pharmaceutical bulletin   33(8) 1291-1299   2010   [Refereed]
The expression of "growth arrest and DNA damage inducible genes 45 and 153" is related to apoptotic induction of cells. GADD45 is an effector gene of the tumor suppressor p53, and GADD153 is associated with cellular function of cancer prevention. ...
Kuzuhara T, Iwai Y, Takahashi H, Hatakeyama D, Echigo N
PLoS currents   1 RRN1052   Oct 2009   [Refereed]
Kuzuhara T, Kise D, Yoshida H, Horita T, Murazaki Y, Utsunomiya H, Tsuge H
Acta crystallographica. Section F, Structural biology and crystallization communications   65 144-146   Feb 2009   [Refereed]
Suganuma M, Yamaguchi K, Ono Y, Matsumoto H, Hayashi T, Ogawa T, Imai K, Kuzuhara T, Nishizono A, Fujiki H
International Journal of Cancer   123 117-122   Jul 2008   [Refereed]
KUZUHARA Takashi, KISE Daisuke, SHIRAKAWA Yayoi, SASADA Kinuko, SUGANUMA Masami, FUJIKI Hirota
Biological & Pharmaceutical Bulletin   31(5) 816-819   May 2008
Green tea is an acknowledged cancer preventive in Japan, and the main constituent of green tea catechins is (-)-epigallocatechin gallate (EGCG). To investigate the bioavailability of EGCG in humans, we generated a monoclonal antibody against EGCG ...
Kuzuhara T, Suganuma M, Fujiki H
Cancer letters   261 12-20   Mar 2008   [Refereed]
Kuzuhara T, Tanabe A, Sei Y, Yamaguchi K, Suganuma M, Fujiki H
Molecular carcinogenesis   46 640-645   Aug 2007   [Refereed]
Kuzuhara T, Suganuma M, Kurusu M, Fujiki H
Journal of cancer research and clinical oncology   133 287-296   May 2007   [Refereed]
Carcinogenic role of tumor necrosis factor-alpha inducing protein of Helicobacter pylori in human stomach.
Suganuma M, Kuzuhara T, Yamaguchi K, Fujiki H
Journal of Biochemistry and Molecular Biology   39 1-8   Jan 2006   [Refereed]
KUZUHARA Takashi, SUGANUMA Masami, TSUGE Hideaki, FUJIKI Hirota
Biological & Pharmaceutical Bulletin   28(11) 2133-2137   Nov 2005
Here we report a primary structure conserved between Helicobacter pylori (H. pylori)-tumor necrosis factorα inducing protein (Tipα) and bacterial penicillin-binding proteins. H. pylori is a Gram-negative bacterium which plays a key part in carcino...
[Mechanisms of gene regulation centered on peptidyl prolyl cis-trans isomerase].
Horikoshi M, Himukai R, Kuzuhara T
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme   49 1195-1203   Jun 2004   [Refereed]
Padmanabhan B, Kuzuhara T, Adachi N, Horikoshi M
The Journal of Biological Chemistry   279 9615-9624   Mar 2004   [Refereed]
Kuzuhara T, Horikoshi M
Nature Structural & Molecular Biology   11 275-283   Mar 2004   [Refereed]
Chimura T, Kuzuhara T, Horikoshi M
Proceedings of the National Academy of Sciences of the United States of America   99 9334-9339   Jul 2002   [Refereed]
Padmanabhan B, Kuzuhara T, Mizuno H, Horikoshi M
Acta crystallographica. Section D, Biological crystallography   56 1479-1481   Nov 2000   [Refereed]
Kang SW, Kuzuhara T, Horikoshi M
Genes to Cells   5 251-263   Apr 2000   [Refereed]
Munakata T, Adachi N, Yokoyama N, Kuzuhara T, Horikoshi M
Genes to Cells   5 221-233   Mar 2000   [Refereed]
Himukai R, Kuzuhara T, Horikoshi M
Journal of Biochemistry   126(5) 879-888   Nov 1999   [Refereed]
Kuzuhara T, Horikoshi M
Biological & Pharmaceutical Bulletin   19(1) 122-126   Jan 1996   [Refereed]
A cDNA encoding human TFIID subunit p30β (hp30β) was isolated and sequenced. Comparison of the deduced 211 amino acid (aa) sequence with that of Drosophila melanogaster p30β (dp30β) showed 45% identity in overall length, and subunits with highly c...
Hasegawa S, Kuzuhara T, Horikoshi M
Gene   164 369-370   Oct 1995   [Refereed]
Kanai A, Kuzuhara T, Sekimizu K, Natori S
Journal of Biochemistry   109(5) 674-677   May 1991   [Refereed]
Two new cDNA clones for S-II-related proteins were isolated from a mouse liver cDNA library. Analyses of these clones suggested that S-II proteins are a family of proteins with relatively conserved C-terminal regions but variable N-terminal region...
Hanzawa H, Shimada I, Kuzuhara T, Komano H, Kohda D, Inagaki F, Natori S, Arata Y
FEBS letters   269 413-420   Sep 1990   [Refereed]
Kuzuhara T, Nakajima Y, Matsuyama K, Natori S
Journal of Biochemistry   107(4) 514-518   Apr 1990   [Refereed]
Sapecin is a 40-residue peptide containing 6 half-cystine residues. The disulfide structure of sapecin was determined by sequencing cystine-containing peptides obtained by digesting sapecin with thermolysin. Results showed that sapecin has a vorti...

Misc

 
KUZUHARA Takashi, TSUGE Hideaki
84(9) 780-785   Sep 2012
Hatakeyama Dai, Iwai Yuuma, Murakami Kouki, Gomi Yasuyuki, Okutani Takeshi, Hashimoto Toshihiro, Asakawa Yoshinori, Okuno Yoshinobu, Ishikawa Toyokazu, Echigo Noriko, Kuzuhara Takashi
Biophysics   51(1)    Aug 2011
Hatakeyama Dai, Iwai Yuma, Takahashi Hitoshi, Motoshima Kazunori, Ishikawa Minoru, Sugita Kazuyuki, Hashimoto Yuichi, Harada Yuichi, Itamura Shigeyuki, Odagiri Takato, Tashiro Masato, Sei Yoshihisa, Yamaguchi Kentaro, Kuzuhara Takashi
Biophysics   50(2)    Aug 2010
井口 美紀, 庄野 文章, 田中 正己, 鈴木 真也, 加来 裕人, 松永 洋一, 橋本 敏弘, 豊田 正夫, 葛原 隆, 梅山 明美, 八木 康行
日本医療薬学会年会講演要旨集   18    Sep 2008
葛原 隆, 藤木 博太
ファルマシア   43(4) 321-326   Apr 2007
葛原 隆, 藤木 博太
ファルマシア   43(4) 321-326   Apr 2007
藤木 博太, 葛原 隆
シュネラー   (59) 18-25   2006
堀越 正美, 日向 亮介, 葛原 隆
蛋白質核酸酵素   49(8) 1195-1203   Jun 2004
HIMUKAI Ryosuke, KUZUHARA Takashi, HORIKOSHI Masami
21    Dec 1998
Protein,nucleic acid and enzyme   43(3) 291-294   Mar 1998
葛原 隆, 堀越 正美
日本分子生物学会年会プログラム・講演要旨集   19    Aug 1996

Books etc

 
Springer   Jul 2013   ISBN:4431543309

Conference Activities & Talks

 
New aspects of green tea catechins in relation to DNA and RNA molecules
Takashi Kuzuhara
ICPH2007 -3rd International Conference on Polyphenols and Health   26 Nov 2007   
DNA and RNA as New Biological Reservoirs of Green tea catechins
Takashi Kuzuhara
The 8th Japan-Korea Joint Symposium on Cancer and Ageing Research   10 Aug 2007   
DNA AND RNA AS NEW BINDING TARGETS OF GREEN TEA CATECHIN [Invited]
Takashi Kuzuhara
Seventh International Skin Carcinogenesis Conference   9 Nov 2006   
Ancestral and carcinogenic peptide proposed by a motif conserved between Helicobacter pylori TNF-α inducing protein (Tipα) and penicillin binding proteins [Invited]
Takashi Kuzuhara
THE 7th KOREA-JAPAN CANCER AND AGING SYMPOSIUM   3 Nov 2005   

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2010 - 2012    Investigator(s): Kuzuhara TAKASHI
The H1N1 influenza A virus of swine-origin caused pandemics throughout the world in2009 and the highly pathogenic H5N1 avian influenza virus has also caused epidemics in Southeast Asia in recent years. The threat of influenza A thus remains a seri...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2005 - 2006    Investigator(s): Takashi KUZUHARA
Stomach cancer has a high mortality rate in East Asia, and is strongly associated with Helicobacter pylori (H.pylori) infection. H.pylori is known to express chemokine genes in the gastric mucosa, chemokines that are important host immune factors ...
endonuclease
RNA polymerase
marchantin
thalidomide
influenza