青木学 (Manabu Aoki) - マイポータル

基本情報

所属: 熊本保健科学大学保健科学部医学検査学科講師

学位: 博士(熊本大学)

J-GLOBAL ID: 200901035348815616
researchmap会員ID: 5000100912

研究キーワード

HIV-1 薬剤耐性

研究分野

ライフサイエンス / ウイルス学 /

論文

Loss of Protease Dimerization Inhibition Activity of Darunavir Is Associated with the Acquisition of Resistance to Darunavir by HIV-1

Yasuhiro Koh, Manabu Aoki, Matthew L. Danish, Hiromi Aoki-Ogata, Masayuki Amano, Debananda Das, Robert W. Shafer, Arun K. Ghosh, Hiroaki Mitsuya

JOURNAL OF VIROLOGY 85(19) 10079-10089 2011年10月査読有り
Novel HIV-1 Protease Inhibitors (PIs) Containing a Bicyclic P2 Functional Moiety, Tetrahydropyrano-Tetrahydrofuran, That Are Potent against Multi-PI-Resistant HIV-1 Variants

Kazuhiko Ide, Manabu Aoki, Masayuki Amano, Yasuhiro Koh, Ravikiran S. Yedidi, Debananda Das, Sofiya Leschenko, Bruno Chapsal, Arun K. Ghosh, Hiroaki Mitsuya

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 55(4) 1717-1727 2011年4月査読有り
Probing Multidrug-Resistance and Protein-Ligand Interactions with Oxatricyclic Designed Ligands in HIV-1 Protease Inhibitors

Arun K. Ghosh, Chun-Xiao Xu, Kalapala Venkateswara Rao, Abigail Baldridge, Johnson Agniswamy, Yuan-Fang Wang, Irene T. Weber, Manabu Aoki, Salcedo Gomez Pedro Miguel, Masayuki Amano …

CHEMMEDCHEM 5(11) 1850-1854 2010年11月査読有り
Novel Protease Inhibitors (PIs) Containing Macrocyclic Components and 3(R),3a(S),6a(R)-bis-Tetrahydrofuranylurethane That Are Potent against Multi-PI-Resistant HIV-1 Variants In Vitro

Yasushi Tojo, Yasuhiro Koh, Masayuki Amano, Manabu Aoki, Debananda Das, Sarang Kulkarni, David D. Anderson, Arun K. Ghosh, Hiroaki Mitsuya

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 54(8) 3460-3470 2010年8月査読有り
Non-Cleavage Site Gag Mutations in Amprenavir-Resistant Human Immunodeficiency Virus Type 1 (HIV-1) Predispose HIV-1 to Rapid Acquisition of Amprenavir Resistance but Delay Development of Resistance to Other Protease Inhibitors

Manabu Aoki, David J. Venzon, Yasuhiro Koh, Hiromi Aoki-Ogata, Toshikazu Miyakawa, Kazuhisa Yoshimura, Kenji Maeda, Hiroaki Mitsuya

JOURNAL OF VIROLOGY 83(7) 3059-3068 2009年4月査読有り
The impact of highly active antiretroviral therapy by the oral route on the CD8 subset in monkeys infected chronically with SHIV89.6P

K Yoshimura, E Ido, H Akiyama, T Kimura, M Aoki, H Suzuki, H Mitsuya, M Hayami, S Matsushita

JOURNAL OF VIROLOGICAL METHODS 112(1-2) 121-128 2003年9月査読有り
Reduction of peptide character of HIV protease inhibitors that exhibit nanomolar potency against multidrug resistant HIV-1 strains

H Tamamura, Y Koh, S Ueda, Y Sasaki, T Yamasaki, M Aoki, K Maeda, Y Watai, H Arikuni, A Otaka …

JOURNAL OF MEDICINAL CHEMISTRY 46(9) 1764-1768 2003年4月査読有り
Genetic evidence of transmission of human T cell lymphotropic virus type 1 between spouses

M Iga, A Okayama, S Stuver, M Matsuoka, N Mueller, M Aoki, H Mitsuya, N Tachibana, H Tsubouchi

JOURNAL OF INFECTIOUS DISEASES 185(5) 691-695 2002年3月査読有り