Shin-ichiro Takebayashi

Profile Information

Affiliation: Professor, Graduate School of Bioresources, Mie University

Degree: Ph. D.(Mie University)

Researcher number: 50392022
ORCID ID: https://orcid.org/0000-0002-1968-9800
J-GLOBAL ID: 200901059637615923
researchmap Member ID: 5000101500

External link: http://kyoin.mie-u.ac.jp/profile/2922.html

Research Interests

Research Areas

Research History

Aug, 2023 - Present

Professor, Graduate School of Bioresources, Mie University
May, 2017 - Present

客員研究員（兼任）, 国立研究開発法人理化学研究所
Mar, 2019 - Jul, 2023

Associate Professor, Graduate School of Bioresources, Mie University
Apr, 2014 - Feb, 2019

Graduate School of Medicine, Mie University
May, 2013 - Mar, 2014

Priority Organization for Innovation and Excellence, Kumamoto University
Jul, 2012 - Apr, 2013

Institute of Molecular Embryology and Genetics, Kumamoto University
Oct, 2007 - Jun, 2012

ポストドクトラルフェロー, 生物科学部門, 米国フロリダ州立大学
Apr, 2002 - Sep, 2007

RIKEN
Apr, 1999 - Mar, 2002

Japan Society for the Promotion of Science

Education

Apr, 1999 - Mar, 2002

Graduate School of Bioresources, Mie University
Apr, 1997 - Mar, 1999

Graduate School of Bioresources, Mie University
Apr, 1993 - Mar, 1997

Faculty of Bioresources, Mie University

Papers

Reorganization of the DNA replication landscape during adipogenesis is closely linked with adipogenic gene expression.

Takuya Hayakawa, Asahi Yamamoto, Taiki Yoneda, Sakino Hori, Nanami Okochi, Kazuhiro Kagotani, Katsuzumi Okumura, Shin-Ichiro Takebayashi

Journal of cell science, 136(2), Jan 15, 2023
scRepli-Seq: A Powerful Tool to Study Replication Timing and Genome Instability.

Megumi Sakamoto, Sakino Hori, Asahi Yamamoto, Taiki Yoneda, Kenji Kuriya, Shin-Ichiro Takebayashi

Cytogenetic and genome research, 162(4) 161-170, 2022
The Temporal Order of DNA Replication Shaped by Mammalian DNA Methyltransferases.

Shin-Ichiro Takebayashi, Tyrone Ryba, Kelsey Wimbish, Takuya Hayakawa, Morito Sakaue, Kenji Kuriya, Saori Takahashi, Shin Ogata, Ichiro Hiratani, Katsuzumi Okumura …

Cells, 10(2), Jan 29, 2021
Camptothecin-Induced Replication Stress Affects DNA Replication Profiling by E/L Repli-Seq.

Takuya Hayakawa, Rino Suzuki, Kazuhiro Kagotani, Katsuzumi Okumura, Shin-Ichiro Takebayashi

Cytogenetic and genome research, 161(8-9) 437-444, 2021
Mapping replication timing domains genome wide in single mammalian cells with single-cell DNA replication sequencing.

Hisashi Miura, Saori Takahashi, Takahiro Shibata, Koji Nagao, Chikashi Obuse, Katsuzumi Okumura, Masato Ogata, Ichiro Hiratani, Shin-Ichiro Takebayashi

Nature protocols, 15(12) 4058-4100, Dec, 2020
The NSD2/WHSC1/MMSET methyltransferase prevents cellular senescence-associated epigenomic remodeling.

Hiroshi Tanaka, Tomoka Igata, Kan Etoh, Tomoaki Koga, Shin-Ichiro Takebayashi, Mitsuyoshi Nakao

Aging cell, Jun 22, 2020 Peer-reviewed
Single-cell DNA replication profiling identifies spatiotemporal developmental dynamics of chromosome organization.

Hisashi Miura, Saori Takahashi, Rawin Poonperm, Akie Tanigawa, Shin-Ichiro Takebayashi, Ichiro Hiratani

Nature genetics, 51(9) 1356-1368, Sep, 2019 Peer-reviewed
DNAメチル化解析によるヒト椎間板変性の分子生物学的機序

明田浩司, 生野彰宏, 岩崎竜也, 須藤隆夫, 山田淳一, 竹上徳彦, 竹林慎一郎, 島岡要, 奥村克純, 須藤啓広

日本整形外科学会雑誌, 93(8) S1779-S1779, Sep, 2019
ゲノムワイドなDNAメチル化状態の変化はヒト椎間板変性に関与する

明田浩司, 生野彰宏, 竹林慎一郎, 奥村克純, 島岡要, 岩崎竜也, 須藤隆夫, 佐野友彦, 竹上徳彦, 須藤啓広

日本整形外科学会雑誌, 93(3) S1177-S1177, Mar, 2019
ヒト椎間板変性に対するエピジェネティクスの関与ゲノムワイドDNAメチル化解析

明田浩司, 生野彰宏, 竹林慎一郎, 奥村克純, 島岡要, 岩崎竜也, 須藤隆夫, 竹上徳彦, 須藤啓広

Journal of Spine Research, 10(3) 157-157, Mar, 2019
Genome-wide stability of the DNA replication program in single mammalian cells.

Saori Takahashi, Hisashi Miura, Takahiro Shibata, Koji Nagao, Katsuzumi Okumura, Masato Ogata, Chikashi Obuse, Shin-Ichiro Takebayashi, Ichiro Hiratani

Nature genetics, 51(3) 529-540, Mar, 2019 Peer-reviewed
Genome-wide analysis of DNA methylation profile identifies differentially methylated loci associated with human intervertebral disc degeneration.

Akihiro Ikuno, Koji Akeda, Shin-Ichiro Takebayashi, Motomu Shimaoka, Katsuzumi Okumura, Akihiro Sudo

PloS one, 14(9) e0222188, 2019 Peer-reviewed
ヒト椎間板変性に対するゲノムワイドDNAメチル化解析

生野彰宏, 明田浩司, 竹林慎一郎, 島岡要, 須藤啓広, 奥村克純

日本生化学会大会プログラム・講演要旨集, 91回 [2P-235], Sep, 2018
ヒト椎間板変性に対するゲノムワイドDNAメチル化解析

明田浩司, 生野彰宏, 竹林慎一郎, 奥村克純, 島岡要, 須藤隆夫, 佐野友彦, 竹上徳彦, 須藤啓広

日本整形外科学会雑誌, 92(8) S1885-S1885, Aug, 2018
Mapping mammalian replication domains using the ion torrent semiconductor sequencing platform.

Takebayashi, S. I, Ogata, S, Ogata, M, Okumura, K

Biosci. Biotechnol. Biochem., 82 2098-2100, 2018 Peer-reviewed
Correlation between histone acetylation and expression of Notch1 in human lung carcinoma and its possible role in combined small-cell lung carcinoma

Wael Abdo Hassan, Shin-Ichiro Takebayashi, Mohamed Osama Ali Abdalla, Kosuke Fujino, Shinji Kudoh, Yamoto Motooka, Yonosuke Sato, Yoshiki Naito, Koichi Higaki, Joeji Wakimoto …

LABORATORY INVESTIGATION, 97(8) 913-921, Aug, 2017 Peer-reviewed
Anatomy of Mammalian Replication Domains

Shin-ichiro Takebayashi, Masato Ogata, Katsuzumi Okumura

GENES, 8(4) E110, Apr, 2017 Peer-reviewed
The SETD8/PR-Set7 Methyltransferase Functions as a Barrier to Prevent Senescence-Associated Metabolic Remodeling

Hiroshi Tanaka, Shin-ichiro Takebayashi, Akihisa Sakamoto, Tomoka Igata, Yuko Nakatsu, Noriko Saitoh, Shinjiro Hino, Mitsuyoshi Nakao

CELL REPORTS, 18(9) 2148-2161, Feb, 2017 Peer-reviewed
Direct visualization of replication dynamics in early zebrafish embryos

Kenji Kuriya, Eriko Higashiyama, Eriko Avsar-Ban, Nanami Okochi, Kaede Hattori, Shin Ogata, Shin-ichiro Takebayashi, Masato Ogata, Yutaka Tamaru, Katsuzumi Okumura

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 80(5) 945-948, May, 2016 Peer-reviewed
Direct Visualization of DNA Replication Dynamics in Zebrafish Cells

Kenji Kuriya, Eriko Higashiyama, Eriko Avsar-Ban, Yutaka Tamaru, Shin Ogata, Shin-ichiro Takebayashi, Masato Ogata, Katsuzumi Okumura

ZEBRAFISH, 12(6) 432-439, Dec, 2015 Peer-reviewed

Misc.

Transcriptional silencing of the genes by methyl-CpG binding protein PCM1 isoforms

FUJITA Naoyuki, TAKEBAYASHI Shin-ichiro, OKUMURA Katsuzumi, SAYA Hideyuki, NAKAO Mitsuyoshi

21 225-225, Dec 1, 1998
Intranuclear localization of SNRPN gene in HL60 cells

NOGAMI Masahiro, KOHDA Atsushi, TAKEBAYASHI Shin-ichiro, OKUMURA Katsuzumi, TAGUCHI Hiroshi, NAKAO Mitsuyoshi, IKEMURA Toshimichi

21 476-476, Dec 1, 1998

Professional Memberships

Research Projects

遺伝子の機能的発現を可能にするクロマチンドメインの構築原理解明

科学研究費助成事業基盤研究(B), 基盤研究(B), 日本学術振興会, Apr, 2022 - Mar, 2025

竹林慎一郎
Elucidation of the construction principle of animal cell chromosomes and their control mechanism

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
非ゲノム複製の破綻がもたらすDNA損傷メカニズムの解明

科学研究費助成事業新学術領域研究(研究領域提案型), 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2020 - Mar, 2022

竹林慎一郎
Stability and flexibility of the DNA replication program revealed by single-cell DNA replication sequencing in vivo

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Takebayashi Shin-ichiro
A novel mechanism to regulate chronic inflammation through metabolic remodeling in obesity and senescence

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

OGATA Masato
染色体機能ドメイン制御の可塑性とその意義

科学研究費助成事業新学術領域研究(研究領域提案型), 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2016 - Mar, 2018

竹林慎一郎
Study on the antitumor mechanism of Rb-dependent mitochondrial metabolic remodeling

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2016

Takebayashi Shin-ichiro
胚発生におけるゲノムDNAメチル化の機能と調節機構

科学研究費助成事業特定領域研究, 特定領域研究, 日本学術振興会, 2003 - 2007

岡野正樹, 竹林慎一郎, 小田昌朗
動物細胞ゲノムの核内構造と遺伝子の機能的発現に関する研究

科学研究費助成事業特別研究員奨励費, 特別研究員奨励費, 日本学術振興会, 1999 - 2001

竹林慎一郎

Profile Information

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Research Areas

Research History

Education

Papers

Misc.

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