2013年2月
Airway distension during lung inflation in healthy and allergic-sensitised mice in vivo
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
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- ,
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- 巻
- 185
- 号
- 3
- 開始ページ
- 639
- 終了ページ
- 646
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.resp.2012.12.002
- 出版者・発行元
- ELSEVIER SCIENCE BV
We evaluated the airway distention during lung inflation of varying size in healthy and allergic-sensitised mice in vivo. Computed tomography (CT) images of healthy and ovalbumin-treated mice were acquired using a synchrotron in vivo CT system when lung pressures was 0 and 20 cmH(2)O, and the morphometric distension (diameter, length, and volume) and the compliance of airway segments (to as small as similar to 150 mu m internal diameter) were calculated. With respect to airway size, in healthy mice, the changes in airway diameter and compliance were larger in the small-airway group. In contrast, in allergic-sensitised mice, there were no significant differences in the changes in airway distension or compliance. Airway wall thickness in allergic-sensitised mice increased significantly in all airway groups, but the change was much larger in the small than in the large-airway group. Compared with healthy airways, the changes in diameter and airway compliance of the allergic-sensitised mice were significantly smaller in the small-airway group. (C) 2012 Elsevier B.V. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.resp.2012.12.002
- ISSN : 1569-9048
- PubMed ID : 23253555
- Web of Science ID : WOS:000315322900019